@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD5_HUMAN: (2016-01-09 )
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV
Atome Classification :
(22 SA)
-------------------------------------------------------.........10........20-------........30........40..---....------------..50........60----.........70..--..-....80----.....--....90.......-.100.......110.......120.......130-------------------------.......140.......150.......160--.......170.......180......----.190......--.200.......210.......220.....---------------..230.......240......----------.250.......260.-......270.----------......280--.......290-.......300......-.310----...-.....320.......-------------330.......340-.........350.---------......360.......370.......380.......390.......400......---------------...410.......420..------.....430---....--....440.......450---------........------------------.460.......470..-------.....----------480--------------........490..----.....500.......510.......520.......530.-------------......540....------...550.......560.......570.......580...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------MARPDPSA
P
P
S
L
L
L
L
L
L
A
Q
L
V-------
G
R
A
AAASKAP
V
C
Q
E
I
T
V
P
M
C
RG---IGYN------------LTHMPNQFNHDTQ-----DEAG
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
CSP-----
D
L
R
F
F
--
L
C
S
MYTPICLPDY-HKPLP
P
C
R
S
V
C
E
R
A
KA
G
C
S
P
L
M
R
Q
YGFAWPERMS-------------------------CDRLPVLGRD
A
E
V
L
C
M
DYNRSEATTAPPRP--FPAKPTLPGPPGAPASGGECPAGG
P
F
----
V
C
KCREP
F
V
P
--
I
L
KESHP
L
Y
NKVRTGQVPNCAVPCYQPSF---------------SAD
E
R
T
F
A
T
F
W
I
G
L
W
S
V
L
C
F
I----------STST
T
V
A
T
F
L
I
D
M
E
R
-FRYPER
P
I
I
F
----------
L
S
A
C
Y
L
C
V
S
--
L
G
F
L
V
R
L
V
VG-H
A
S
V
A
CSREH
N
H
I
H
Y
E-TT
G
-----
P
A
L
-
C
T
I
V
F
L
L
V
Y
F
F
G
M
A
S
-------------
S
I
W
W
V
I
L
S
L
T
W
---
F
L
A
A
G
MKWG
N
E
A
I
---------
A
G
Y
A
Q
Y
F
H
L
A
A
W
L
IP
S
V
K
S
I
T
A
L
ALSSVDGDP
V
A
G
I
C
Y
VGNQ
N
L
N
S
L
--
R
G
F
V
L
G
---------------
P
L
V
L
Y
L
L
V
G
T
L
F
L
L
A
G
F
V
------
S
L
F
R
I
R
S
----
V
I
K
Q--GGT
K
T
D
K
L
E
K
L
M
I
R
I
-----------
G
I
F
T
L
L
Y
T------------------V
P
A
S
I
V
V
A
C
Y
L
Y
E
Q
H
Y
-------
R
E
S
W
E
----------
A
A
---------------
L
T
C
ACPGHDTGQP----RAK
P
E
Y
W
V
L
M
L
K
Y
F
M
C
L
V
V
GITS
G
V
W
I
WSGK
T
V
E
S
W
R
R
F
-------------
T
S
R
CCCRPRRGHK------SGGAMAAGDYPEASAALTGRTGPPGPAA
T
Y
H
K
Q
V
SLSHV
45
Fugue
87.25
24%
-109
- C2 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
------------------------------------------------------------------------------------------------------------------------------------
G
T
A
D
L
-----
E
D
N
W
E
T
L
N
D
N
L
K
V
--
I
E
K
A
D
N
A
A
-----
Q
V
K
D
A
--
L
T
K
M
R
A
A
A
L
D
A
Q
K
-
A
T
P
----
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
-------------------------
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
--
Q
K
----------------------
Y
L
----
S
G
Q
C
E
V
P
L
V
R
--
T
D
N
P
K
S
------
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
-
P
T
S
NE---
T
L
S
-
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
K
A
L
G
T
T
Y
Q
---------
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
----
N
H
P
G
LL
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
-----------
G
I
F
G
F
L
A
F
------------------
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
-------
Q
A
E
W
E
----------
R
S
---------------
F
R
D
Y
V
L
C
Q
A
N
C
E
I
----
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
-------------
W
C
--------------------------------------------------------
4
PsiBlast_PDB
85.54
30%
-142
- C2 -
4N4W
7
SMO_HUMAN
A:
[115-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
--
L
V
R
T
D
N
P
---
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
-----
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
---------
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
N
HPG
L
L
S
E
-----
S
--
K
I
N
E
T
M
L
R
L
-----------
G
I
F
G
F
L
A
F
------------------
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
-------
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
-----------------------------DCEI
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
-------------
W
C
R
L
T
-----------------------------------------------------
3
PsiBlast_PDB
84.69
30%
-140
- C2 -
4JKV
10
C562_ECOLX (first)
A:
[115-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
--
L
V
R
T
D
N
P
---
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
-----
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
-----------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
NHPG
L
L
S
E
--
K
A
A
S
--
K
I
N
E
T
M
L
R
L
-----------
G
I
F
G
F
L
A
F
------------------
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
-------
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
----------------------------CEI-
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
-------------
W
C
--------------------------------------------------------
27
HHSearch
76.58
82%
-108
* C2 *
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
---
I
G
Y
E
------------
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
-----
D
E
A
G
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
C
S
P
-----
D
L
K
F
F
--
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
-------------------------
C
D
R
L
P
E
Q
G
N
P
-
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
75.94
83%
-105
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
---
I
G
Y
E
------------
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
-----
D
E
A
G
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
C
S
P
-----
D
L
K
F
F
--
L
C
S
M
Y
T
P
I
C
L
E
D
Y
K-
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
-------------------------
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.74
82%
-106
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
---
I
G
Y
E
------------
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
-----
D
E
A
G
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
C
S
P
-----
D
L
K
F
F
--
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
-------------------------
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.02
78%
-106
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
---
I
G
Y
E
------------
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
-----
D
E
A
G
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
C
S
P
-----
D
L
K
F
F
--
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
-------------------------
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.57
82%
-107
- C2 -
4F0A
2
FZD8_MOUSE
A:
[8-123]
----------------------------------------------------------------------------------------------
C
Q
E
I
T
V
P
L
C
K
G
---
I
G
Y
N
------------
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
-----
D
E
A
G
L
E
V
H
Q
F
W
P
L
--
V
E
-
I
Q
C
S
P
-----
D
L
K
F
F
--
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
-------------------------
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
73.24
18%
-106
- C2 -
4PKF
4
?
A:
[8-864]
K
V
L
E
Y
KG
K
K
L
N
FTPEDPAEETIPADELHEHLQKPST
A
R
T
K
R
L
K
E
R
CRWKHASAGE
F
I
E
K
S
V
T
A
G
I
E
R
M
R
Y
L
T
E
A
H
K
A
S
EGKP
E
A
I
R
R
A
L
G
L
A
N
V
L
N
K
S
T
L
V
L
Q
E
D
EFI
V
G
Y
H
AEDPN
M
F
P
L
Y
PE
L
S
H
M
A
V
Q
D
Y
L
R
S
D
YSPQP
A
D
E
A
A
A
I
N
E
Y
W
K
P
HS
L
Q
-
S
K
C
Q
P
YFD
P
A
D
L
G
R
M
Y
Q
V
S
S
M
E
A
P
S
F
A
S
G
Y
-
N
S
I
V
P
P
Y
E
T
V
L
E
D
G
L
L
A
R
I
K
L
A
E
K
H
I
A
E
A
Q
A
D
M
S
TFPWNGTKGL
D
N
I
A
K
I
D
N
W
K
A
M
V
I
A
C
K
A
V
I
S
W
A
R
R
Q
G
R
L
C
K
I
V
A
E
N
F
E
T
D
P
K
R
Q
A
E
L
L
E
I
A
D
I
C
Q
R
I
P
A
E
P
C
K
G
L
K
D
A
M
Q
A
K
F
F
T
F
L
I
C
H
A
I
E
R
Y
A
S
G
Y
A
Q
K
E
D
T
L
L
W
P
Y
Y
K
A
S
V
V
D
K
K
F
Q
P
M
S
H
M
D
A
V
E
L
V
E
M
E
R
L
K
I
S
E
HG
A
G
K
S
R
A
Y
R
E
I
F
P
G
S
N
D
L
F
I
L
T
V
G
GTNAKGED
A
C
N
D
M
T
D
A
I
L
E
A
A
K
R
-
I
R
T
A
E
P
S
I
V
F
RYSKKNR
E
K
T
L
R
W
V
F
E
C
I
R
D
G
L
G
Y
P
---
S
I
K
-
H
D
E
I
G
T
E
Q
M
K
E
Y
A
K
F
S
-
L
N
G
NGAT
D
E
E
A
-
H
N
W
V
N
V
L
C
M
S
P
G
I
H
G
RRKTQKTRSE
G
G
G
S
I
F
P
A
K
L
-
L
E
I
---
S
L
N
D
G
Y
D
W
S
Y
A
D
M
QLGPKTGDL
S
S
L
K
S
F
E
D
V
W
E
A
F
R
K
Q
Y
Q
Y
A
I
N
L
C
I
S
T
K
D
V
S
R
Y
F
E
Q
R
F
L
Q
M
P
F
V
S
A
I
D
D
G
C
M
E
L
G
MDACALSE
Q
P
N
G
W
H
N
P
I
T
T
I
V
A
A
N
S
L
V
A
I
K
K
L
V
FEEKKY
T
L
E
Q
L
S
Q
----
A
L
K
A
--
N
W
E
G
F
E
E
M
R
V
D
F
K
R
A
PKWGNDD
D
Y
A
D
G
I
I
T
R
F
Y
E
EI
I
G
G
E
M
R
K
ITNYSG
G
P
V
M
P
T
G
Q
A
V
G
L
Y
M
E
V
G
S
R
TGPTPDG
R
F
G
G
E
----------
A
A
DDGGISPYMGTDKKG
P
T
A
V
L
R
S
V
S
K
V
Q
K
----
N
Q
K
G
N
---
L
L
N
Q
R
L
S
V
P
I
M
R
S
K
H
G
F
E
I
W
N
-
S
Y
I
K
T
W
H
D
L
NID
H
V
Q
F
N
VVS
T
D
E
M
R
A
A
Q
R
E
P
E
K
H
H
D
L
I
V
R
V
S
G
Y
S
A
R
F
V
D
I
P
T
Y
G
Q
N
T
I
I
A
R
Q
E
Q
D
F
S
A
S
D
L
E
F
L
N
V
E
I
-
7
PsiBlast_PDB
68.21
33%
-139
- C2 -
4QIN
1
C562_ECOLX (first)
A:
[9-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
--
L
V
R
T
D
N
P
---
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
-----
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
---------
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
----
N
H
A
D
--
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-----------
E
K
A
D
N
A
A
Q
------------------
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
-------
K
A
T
P
P
----------
K
L
---------------
E
D
K
S
P
D
S
P
E
M
K
D
F
----
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
-------------
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
------
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
6
PsiBlast_PDB
66.61
33%
-138
- C2 -
4QIM
1
C562_ECOLX
A:
[9-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
--
L
V
R
T
D
N
P
---
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
-----
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
--------
L
---------
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
----
N
H
A
D
--
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-----------
E
K
A
D
N
A
A
Q
------------------
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
-------
K
A
T
P
P
----------
K
L
---------------
E
D
K
S
P
D
S
P
E
M
K
D
F
----
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
-------------
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
------
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
5
PsiBlast_PDB
66.05
33%
-138
- C2 -
4O9R
1
C562_ECOLX (first)
A:
[9-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
--
L
V
R
T
D
N
P
---
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
---------------
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
----------
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
----------
V
N
A
C
F
F
V
G
S
--
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
-----
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
-------------
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
---------------------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
--
A
G
F
V
L
A
---------------
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
------
T
L
F
S
I
K
S
----
N
H
A
D
--
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-----------
E
K
A
D
N
A
A
Q
------------------
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
-------
K
A
T
P
P
----------
K
L
---------------
E
D
K
S
P
D
S
P
E
M
K
D
F
----
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
-------------
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
------
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
14
PsiBlast_PDB
63.85
37%
-109
- C2 -
5BQE
3
FZD4_HUMAN
C:
[7-126]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
-
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
-
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
63.32
44%
-108
- C2 -
1IJX
1
SFRP3_MOUSE
A:
[3-123]
--------------------------------------------------------------------------------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
---
L
P
W
E
------------
M
T
K
M
P
N
H
L
H
H
S
T
Q
-----
A
N
A
I
L
A
M
E
Q
F
E
G
L
--
L
G
-
T
H
C
S
P
-----
D
L
L
F
F
--
L
C
A
M
Y
A
P
I
C
T
I
D
F
Q
H
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
-------------------------
C
D
E
L
P
V
Y
D
---
R
G
V
C
I
S
P
E
A
I
V
T
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.21
40%
-111
- C2 -
5CM4
2
?
A:
[6-121]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.09
40%
-112
- C2 -
5CM4
2
?
B:
[6-121]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.87
40%
-104
- C2 -
5CL1
2
?
C:
[16-131]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
62.85
38%
-100
- C2 -
5BPQ
1
FZD4_HUMAN
D:
[7-124]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.83
38%
-102
- C2 -
5BPB
1
FZD4_HUMAN
D:
[7-134]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
E
E
V
-----
P
--
L
P
H
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.81
40%
-108
- C2 -
5CL1
2
?
D:
[16-131]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
62.47
38%
-106
- C2 -
5BPQ
1
FZD4_HUMAN
C:
[7-124]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
61.71
38%
-104
- C2 -
5BPQ
1
FZD4_HUMAN
B:
[7-124]
----------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
---
L
G
Y
N
------------
V
T
K
M
P
N
L
V
G
H
E
L
Q
-----
T
D
A
E
L
Q
L
T
T
F
T
P
L
--
I
Q
-
Y
G
C
S
S
-----
Q
L
Q
F
F
--
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
-------------------------
C
S
K
F
P
P
-
Q
N
D
H
N
H
M
C
M
E
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------