@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD6_HUMAN: (2016-01-09 )
MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.....-...70........80.......-.--90-........100.......110.......120.-------......-----130.......140.......150.......160.......170.......180.......190.......200.......210.......220....-.-..230.......240.......250...--....260.......270.......280.......290.......300.....---..310.......320.......330.......340.......350.......360.......370.......380.......390.......400-...----.....410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
M
F
T
F
L
L
T
C
I
F
L
P
L
LRGH
S
L
F
TCEPI
T
V
P
R
C
M
K
M
A
YNMT
F
F
P
N
L
M
G
H
YDQ
S
I
A
A
V
E
M
E
H
FLPLAN-LECSP
N
I
E
T
F
L
C
K
A
F
V
P
T
C
I
E
Q-I--HV-VP
P
C
R
K
L
C
E
K
V
Y
S
D
C
K
K
L
I
D
T
FGIRWPEELE
C
-------
D
R
L
Q
YC-----DET
V
P
V
T
FDPHTEFLG
P
Q
K
K
T
E
Q
V
Q
R
D
I
GFW
C
P
R
HLKTSGGQG
Y
K
F
L
G
IDQCAPPCPNMYFK
S
D
E
L
E
F
A
K
S
F
I
G
T
V
S
I
F
C
L
C
A
T
L
F
T
F
L
T
F
L
I
D
V
R
R
-F-RYPER
P
I
I
Y
Y
S
V
C
Y
S
I
V
S
L
M
Y
F
I
G
F
L
LG--DSTACNKADEKLELG
D
T
V
V
LGSQN
K
A
C
T
V
L
F
M
L
L
Y
F
F
T
M
A
G
T
V
W
W
V
I
L
T
I
T
W
---
F
L
AAGRKW
S
C
E
A
I
EQK
A
V
W
F
H
A
VAWGT
P
G
F
L
T
V
M
L
L
A
M
NKVEGDNI
S
G
V
C
F
V
G
L
Y
DLDAS
R
Y
F
V
L
L
P
L
C
L
C
V
F
V
G
L
S
L
L
L
A
G
I
I
S
L
N
H
V
R
Q
V
I
Q
--HDG----R
N
Q
E
K
L
K
K
F
M
I
R
I
G
VFS
G
L
Y
L
V
P
L
V
T
L
L
G
C
Y
V
Y
E
Q
VN
R
I
T
W
E
I
T
W
V
S
D
H
CRQYHIPCPYQAKAKAR
P
E
L
A
L
F
M
I
K
Y
L
M
T
L
I
V
G
I
S
A
V
F
WVGSK
K
T
C
T
E
W
A
G
F
F
K
RNRKRDP
I
S
E
S
R
R
V
L
Q
E
S
C
E
F
F
L
KHNSKVK
H
K
K
KHYKPSS
H
K
L
K
V
I
S
K
SMGTSTGATANHG
T
S
A
V
A
I
TSHDYL
G
Q
E
T
L
T
E
IQTSPE
T
S
M
R
E
V
KADGASTPRL
R
E
QDCGEPAS
P
A
A
S
I
S
RLSGEQVDGKGQAGSV
S
E
S
A
RSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGS
T
S
L
L
V
HPVSGVRKEQGGGCHSDT
1
PsiBlast_PDB
80.82
29%
-139
- C2 -
4JKV
10
C562_ECOLX (first)
A:
[130-465]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
-
R
A
D
G
T
M
R
L
G
E
P
T
--
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
LLSE
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
------
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
80.09
24%
-98
- C2 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
----------------------------------------------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
-
K
------
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
-------
D
A
L
K
L
A
-----
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
-
I
Q
K
Y
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
-
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
K
A
L
G
T
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
S
E
----
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
------
R
D
Y
V
L
C
Q
A
N
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.71
29%
-139
- C2 -
4N4W
6
SMO_HUMAN
A:
[130-465]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
-
R
A
D
G
T
M
R
L
G
E
P
T
--
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
LLSE---
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
------
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
63.69
34%
-87
- C2 -
5BPB
2
FZD4_HUMAN
B:
[7-146]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
M
EGPG
D
E
-------------------
L
E
V
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.79
34%
-90
- C2 -
5BQE
3
FZD4_HUMAN
C:
[7-126]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
-
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
-
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
M
E
G
P
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.74
34%
-90
- C2 -
5BPB
1
FZD4_HUMAN
A:
[7-124]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
M
EGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
61.07
34%
-93
- C2 -
5BPQ
1
FZD4_HUMAN
B:
[7-124]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
MEGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
60.94
34%
-87
- C2 -
5BPQ
1
FZD4_HUMAN
C:
[7-124]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
MEGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.47
31%
-134
- C2 -
4QIN
1
C562_ECOLX (first)
A:
[24-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
-
R
A
D
G
T
M
R
L
G
E
P
T
--
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
L
E
----
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
-----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.97
34%
-89
- C2 -
5BPQ
1
FZD4_HUMAN
A:
[7-124]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
M
EGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
59.43
34%
-85
- C2 -
5BPB
1
FZD4_HUMAN
D:
[7-134]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
MEGPG
D
E
E
V
P
L
---
P
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.33
34%
-87
- C2 -
5BQC
3
FZD4_HUMAN
B:
[7-128]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
M
E
G
PG
D
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
58.44
33%
-94
- C2 -
1IJX
1
SFRP3_MOUSE
A:
[3-121]
---------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
G
-
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
T
I
D
-
F
QH
E
P
-
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
-------
D
E
L
P
V
Y
-----
D
--
R
G
V
C
I
S
P
E
A
I
V
T
A
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
58.19
34%
-81
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
--------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
-
Y
K-
K
P
-
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
-------
D
R
L
P
E
Q
-----
G
N
P
D
T
L
C
M
D
Y
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
58.19
34%
-81
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
--------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
-
Y
K-
K
P
-
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
-------
D
R
L
P
E
Q
-----
G
N
P
D
T
L
C
M
D
Y
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
58.13
34%
-87
- C2 -
5BPQ
1
FZD4_HUMAN
D:
[7-124]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
SKFPPQN
D
H
N
H
M
C
MEGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.95
38%
-88
- C2 -
1IJY
-
FZD8_MOUSE
A:
[6-111]
---------------------
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
-
Y
K-
K
P
-
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
-------
D
R
L
P
E
Q
-----
G
N
P
D
T
L
C
M
D
Y
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.77
37%
-91
- C2 -
5CM4
2
?
A:
[6-109]
-----------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
-------
S
K
F
P
P
Q
-----
N
D
H
N
H
M
C
M
E
G
P
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
57.52
34%
-80
- C2 -
1IJY
-
FZD8_MOUSE
A:
[5-125]
--------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
K
--
K
P
-
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
-------
D
R
L
P
E
Q
-----
G
N
P
D
T
L
C
M
D
Y
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.49
31%
-132
- C2 -
4O9R
1
C562_ECOLX (first)
A:
[24-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
-
R
A
D
G
T
M
R
L
G
E
P
T
--
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
------------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
L
E
----
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
T
I
P
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
-------------------------------------------------------------------------------------------------