@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD7_HUMAN: (2016-01-09 )
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
Atome Classification :
(20 SA)
.........10........20........30.....-...40......-..50...-.....60........70........80........90.........100.......110--.--.-.--.....120.......130.......140...-....150-...-.-..-.160.......170.......180...------....190.......200-----------.......210.......220..--....--.230--------------......---------...240.......250.......260..--.....270....------------...280..-......290.......300.....-----------------..310.......320.......330..--.....340.......350........360--.....-...---370.......380.......390.......400.--......410.......420.......430.......440.......450.-..--....460..----.......470.......----480.......490..---.....----500.----......510.......520.......530.----------......540.......550-.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRDPGAAA
P
L
S
S
L
G
L
C
A
L
V
L
A
L
L
G
A
L
SAGAGAQPYH-GEKGISVPDHG-FCQPISI-PLCTDIAYNQ
T
I
L
P
N
L
LGHTNQEDAG
L
E
V
H
Q
F
Y
P
L
V
-
K
V
Q
CSP
E
L
R
F
F
L
C
S
M
Y
A
P
V
C
-
T
--
V
--
L
-
D
--QAI
P
P
C
R
S
L
C
E
R
A
R
Q
G
C
E
A
L
M
N
KFGFQW
P
E
R-LRCENFP-VHG-A-G
E
-
I
C
VGQNTSDGSGGPGGGPTAYPTAPYL------PDLPFTALPPGASDGRG-----------RPAFPFSCPRQLKVPPYL
G
Y
R
F--LGER--DC----------------GAPCEP---------GRAN
G
L
M
Y
F
K
E
E
E
R
R
F
A
R
L
W
V
G
V
W
S
V
L
C
--
C
A
S
T
L
F
T
V
L
T
Y
L
------------
V
D
M
R
R-FS-YPER
P
I
I
F
LS
G
C
Y
F
M
V
A
V
A
H
V
A
G
F
-----------------
L
L
E
D
R
A
V
C
V
E
R
FSDDGY
R
T
V
AQGTKKE--G
C
T
I
L
F
M
V
L
Y
F
F
G
M
A
S
S
-
I
W
W
V
I
L
S
L
T
W
---
F
L
A
A
G
-
M
K
W---
G
H
E
A
IEANS
Q
Y
F
H
L
A
AWAVPA
V
K
T
I
T
I
L
A
MGQVD--
G
D
L
L
S
G
V
C
Y
VG
L
S
S
V
D
A
L
R
G
F
V
L
A
P
L
F
V
Y
L
F
I
G
T
S
F
L
L
A
G
F
V
S
L
F
R
I
R
T
I
-
M
K--HDGT
K
--
T
E
----
K
L
E
K
L
M
V
R
I
G
V
F
S
V
L
Y
T----V
P
A
T
I
V
L
A
C
Y
F
Y
E
Q
A
---
F
R
E
H
W
----
E
R
T
W
----
L
L
Q
T
C
K
SYAVPCPPGHFPPMSP
D
F
T
V
F
M
I
K
----------
Y
L
M
T
M
I
V
GITT
G
F
W
I
WSG
K
-
T
L
Q
S
W
R
R
F
Y
H
R
LSHSSKGETAV
47
Fugue
86.68
24%
-102
- C5 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
--------------------------------------------------------------------------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
-
D
--
A
--
Q
-
K
-----
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
-
Q
I
D
D
A
L
K
-
L
A
N
-
E
-
G
K
-
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
------------------------------------------
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
--
E
D
V
E
--
G
C
----------------
G
I
Q
C
Q
N
---------------
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
S
N
R
-
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
S
N
E
T
L
--
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
-
K
A
L
---
G
T
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
-
H
P
GL
L
S
E
K
A
--
A
S
----
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
----
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
---
N
Q
A
E
W
----
E
R
S
F
----------
R
D
Y
V
L
C
Q
A
N
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
----------
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
-
T
L
L
I
W
R
R
T
W
C
------------
2
PsiBlast_PDB
86.31
31%
-134
- C5 -
4N4W
6
SMO_HUMAN
A:
[133-473]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----------------
G
I
Q
C
Q
-------------
N
P
L
--
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
--
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
-
T
T
-----
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
---
N
--
H
P
G
L
L
--
S
E
S---
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
----
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
---
N
Q
A
E
W
----
E
R
S
F
R
D
Y
V
L
C
Q
A
----------
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
----------
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
-
T
L
L
I
W
R
R
T
W
C
R
L
T
---------
21
PsiBlast_CBE
84.79
31%
-135
- C5 -
4JKV
7
SMO_HUMAN
B:
[133-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----------------
G
I
Q
C
Q
-------------
N
P
L
--
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
--
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
--------------
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
---
N
--
H
P
G
L
L
--
S
E
KAA
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
----
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
---
N
Q
A
E
W
----
E
R
S
F
R
D
Y
V
L
C
Q
A
N
---------
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
----------
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
-
T
L
L
I
W
R
R
T
W
C
R
L
----------
1
PsiBlast_PDB
84.52
31%
-136
- C5 -
4JKV
10
C562_ECOLX (first)
A:
[133-470]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----------------
G
I
Q
C
Q
-------------
N
P
L
--
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
--
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
-
T
T
-----
Y
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
---
N
--
H
P
G
L
L
--
S
E
KAA
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
----
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
---
N
Q
A
E
W
----
E
R
S
F
R
D
Y
V
L
C
Q
A
N
----------
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
----------
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
-
T
L
L
I
W
R
R
T
W
C
------------
55
Fugue
68.91
19%
-85
- C3 -
1YO8
26
TSP2_HUMAN
A:
[4-624]
-------------
D
G
C
L
S
N
P
C
F
P
G
A
Q
C
S
S
F
P
D
G
S
W
S
C
G
F
C
P
V
G
F
L
G
N
G
T
H
C
E
D
L
D
E
C
A
L
V
P
D
I
C
F
S
T
S
K
V
P
----
R
C
V
N
T
Q
P
G
F
H
C
L
P
C
P
P
R
Y
-
R
G
N
Q
P
V
G
V
G
L
E
A
A
K
T
E
K
Q
V
C
-
E
--
P
--
E
-
N
------
P
C
K
D
K
T
H
N
C
H
K
H
A
E
C
I
Y
L
G
---
H
F
S
D
P
M
Y
K
C
E
C
Q
T
G
Y
A
G
-
D
-
G
L
-
I
C
G
E
D
--
S
D
L
D
G
W
P
N
L
N
L
V
C
A
T
N
A
T
Y
H
CIKDNC
P
H
L
P
N
S
G
Q
E
D
F
D
K
D
G
I
G
DACDDDDDNDG
V
T
D
E
K
D
N
C
-
Q
L
L
F
N
P
R
Q
A
D
Y
D
K
DE
V
G
D
R
CD
N
C
PYVHNPAQIDTDNNGE
G
D
A
C
S
V
DIDGDDVFN
E
R
D
N
C
P
Y
V
Y
N
T
D
Q
R
D
T
D
G
D
G
V
G
---
D
H
C
DN
C
P
L
V
H
N
P
D
Q
T
D
V
DNDLVGDQCDNN
E
D
I
D
D
-
D
G
-
H
Q
N
N
Q
----
D
N
C
P
Y
-
I
S
N
A
N
Q
A
D
H
DRDGQGDACDPDDDNDG
V
P
D
D
R
D
N
C
R
L
V
F
N
P
D
Q
E
D
L
D
G
D
G
-
R
G
D
--
I
C
K
D
D
F
D
N
D
N
I
P
D
I
D
D
V
C
P
E
N
N
A
I
S
E
T
D
---
F
R
N
F
Q
M
V
P
L
D
P
K
G
T
T
Q
I
D
P
N
W
V
I
R
H
Q
G
K
E
L
V
Q
T
A
N
S
D
P
G
I
A
V
G
F
D
E
FG
S
V
D
F
S
G
T
F
Y
V
N
T
D
R
D
D
D
Y
A
G
F
V
F
----------------
G
Y
Q
S
S
S
R
F
Y
V
V
M
W
K
--
Q
V
T
Q
T
Y
W
E
D
----
Q
P
T
R
A
Y
G
Y
S
G
V
S
L
K
V
V
N
STTG
T
G
E
H
L
R
N
A
L
W
H
T
G
N
T
P
GQ
V
R
T
L
W
HDPR
N
I
G
W
---------
K
D
Y
T
A
Y
R
W
H
L
T
H
R
P
K
T
G
Y
I
R
V
L
V
H
E
GKQVMADSG
P
I
Y
D
Q
T
Y
A
G
G
R
L
G
L
F
V
F
S
Q
E
M
V
Y
F
S
D
L
K
Y
E
C
R
D
----------
3
PsiBlast_PDB
68.59
56%
-111
- C4 -
4F0A
2
FZD8_MOUSE
A:
[8-115]
--------------------------------------------------
C
Q
E
I
T
V
-
P
L
C
K
G
I
G
Y
N
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
--
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
-
M
R
C
D
R
L
P
-
E
Q
G
-
N
-
P
D
-
T
L
C
M
D
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
67.81
51%
-118
* C4 *
1IJY
-
FZD8_MOUSE
A:
[5-126]
----------------------------------------------
E
L
-
A
C
Q
E
I
T
V
-
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
ED
Y
--
K
----
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
-
M
R
C
D
R
L
P
-
E
Q
G
-
N
-
P
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.03
51%
-118
- C4 -
1IJY
-
FZD8_MOUSE
A:
[8-126]
--------------------------------------------------
C
Q
E
I
T
V
-
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
--
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
-
M
R
C
D
R
L
P
-
E
Q
G
-
N
-
P
D
T
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
66.87
50%
-114
- C4 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
----------------------------------------------
E
L
-
A
C
Q
E
I
T
V
-
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
E-
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
-
M
R
C
D
R
L
P
-
E
Q
G
N
P
-
D
T
-
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.28
46%
-125
- C4 -
1IJX
1
SFRP3_MOUSE
A:
[5-119]
--------------------------------------------------
C
E
P
V
R
I
-
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
-
T
--
I
DF
Q
-
H
--
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
-
L
A
C
D
E
L
P
-
V
Y
D
-
R
-
G
--
V
C
I
S
P
E
A
I
V
T
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
66.21
50%
-110
- C4 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
----------------------------------------------
E
L
-
A
C
Q
E
I
T
V
-
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
--
E
--
D
Y
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
-
M
R
C
D
R
L
P
-
E
Q
G
-
N
P
D
T
-
L
C
M
D
Y
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.62
45%
-115
- C4 -
1IJX
1
SFRP3_MOUSE
A:
[3-122]
-----------------------------------------------
A
-
A
C
E
P
V
R
I
-
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
-
T
--
I
--
D
-
F
QH
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
-
L
A
C
D
E
L
P
-
V
Y
D
---
R
G
-
V
C
I
S
P
E
A
I
V
T
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.07
33%
-131
- C5 -
4QIN
1
C562_ECOLX (first)
A:
[27-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----------------
G
I
Q
C
Q
-------------
N
P
L
--
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
--
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
-
T
T
-----
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
-
H
A
--
D
L
E
D
N
--
W
E
----
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
----
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
---
Q
K
A
T
P
----
P
K
L
E
----
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
----------
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
-
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
22
PsiBlast_CBE
64.39
45%
-119
- C4 -
5CL1
2
?
D:
[16-120]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.19
33%
-137
- C5 -
4O9R
1
C562_ECOLX (first)
A:
[27-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----------------
G
I
Q
C
Q
-------------
N
P
L
--
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
------------
A
D
W
R
N
-
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-----------------
M
D
G
A
R
R
E
I
V
C
R
--
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
-
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
----------------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
--
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
-
H
A
--
D
L
E
D
N
--
W
E
----
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
----
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
---
Q
K
A
T
P
----
P
K
L
E
----
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
----------
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
-
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
9
PsiBlast_PDB
63.81
45%
-117
- C4 -
5CL1
2
?
C:
[16-120]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.79
45%
-120
- C4 -
5BPB
2
FZD4_HUMAN
B:
[7-111]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
G
P
G
D
E
L
E
V
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.34
45%
-121
- C4 -
5BQC
2
FZD4_HUMAN
B:
[7-111]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
G
P
G
D
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.18
45%
-123
- C4 -
5BPB
1
FZD4_HUMAN
D:
[7-111]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
G
P
G
D
E
E
V
P
L
P
H
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.87
45%
-117
- C4 -
5BPB
1
FZD4_HUMAN
A:
[7-111]
--------------------------------------------------
C
D
P
I
R
I
-
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
-
L
N
C
S
K
F
P
-
P
Q
N
-
D
-
H
N
-
H
M
C
M
E
G
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------