@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD8_HUMAN: (2016-01-09 )
MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70......-..80........90........100........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210------.......220.......230.......240.......250.......260.......270.......280.......290.......300...-....310.......320.......330..-.....340.......350.......360.......370.......380.......390...-....400.......410.......420--........430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560....--...570...--....580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEW
G
Y
L
L
E
V
T
S
L
L
A
A
L
A
L
L
QRSSGAAAA
S
A
K
E
L
A
C
Q
E
I
T
V
P
L
C
KGIGYNYTYMPNQFNHDTQDEAG
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
CSPD
L
K
F
F
L
C
S
MYT
P
I
C
L
E
D
Y-KKPLP
P
C
R
S
V
C
E
R
AKA
G
C
A
P
L
M
R
QYGFAWPDR
M
R
C
DRLPEQGNPD
T
L
C
M
DYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGG------GGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHP
L
Y
NRVKTGQIA
N
C
ALPCHNPFFSQDE
R
A
F
T
V
F
W
I
G
L
W
S
V
L
C
F
V
S
T
F
A
T
V
S
T
F
L
I
D
M
E
R
-FKYPER
P
I
I
F
L
S
A
C
Y
L
F
V
S
V
G
Y
L
V
R
L
VAG-H
E
K
V
A
CSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGR
G
E
Y
E
E
L
G
A
V
E
Q
H
VRYETT
G
P
A
L
-
C
T
V
V
F
L
L
V
Y
F
F
G
M
A
S
S
I
W
W
V
I
L
S
L
T
W
---
F
L
A
A
G
MKWG
N
E
A
I
A
G
Y
S
Q
Y
F
H
L
A
A
W
L
VP
S
V
K
S
I
A
V
L
A
L
SSVDGDP
V
A
G
I
C
YVGNQ
S
L
D
N
L
R
G
F
V
L
A
P
L
V
I
Y
L
F
I
G
T
M
F
L
L
A
G
F
V
S
L
F
R
I
R
S
V
I
KQQDGPT
K
T
H
K
L
E
K
L
M
I
R
L
G
L
F
T
V
L
Y
TV
P
A
A
V
V
V
A
C
L
F
Y
E
QHNRPRWEATHN--CPCLRDLQP--DQARRP
D
Y
A
V
F
M
L
K
Y
F
M
C
L
V
V
GITS
G
V
W
V
WSGK
T
L
E
S
W
R
S
L
C
T
R
C
CWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGG
S
L
Y
S
D
VSTG
L
T
WRSGTASSVSYPKQMPLSQV
4
PsiBlast_PDB
88.19
25%
-106
- C4 -
4N4W
8
SMO_HUMAN
A:
[34-466]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
-------
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
-
S
W
Y
E
D
V
E
-----
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
-------------------------
A
D
G
T
M
R
L
G
E
-------------
P
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
G
L
L
S
E
---
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
----DC
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
-------------------------------------------------------------------------
3
PsiBlast_PDB
87.05
25%
-99
- C4 -
4JKV
10
C562_ECOLX (first)
A:
[34-466]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
-------
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
-
S
W
Y
E
D
V
E
-----
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
-------------------------
A
D
G
T
M
R
L
G
E
-------------
P
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
G
L
L
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
---C-
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
----------------------------------------------------------------------------
45
Fugue
86.59
24%
-98
- C4 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
---------------------------------------------------------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-
A
T
P
----
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
--------------------------------------------------------------------
Q
C
E
V
P
L
V
R
T
D
N
P
K
S
------
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
A
D
G
-------------------------------------
T
M
R
L
G
E
P
T
S
N
E
T
L
S
-
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
K
A
L
G
T
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
G
L
L
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
--
D
Y
V
L
C
Q
A
N
C
--
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
----------------------------------------------------------------------------
24
HHSearch
80.93
98%
-114
- C3 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.73
97%
-114
- C3 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
80.69
98%
-114
- C3 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
80.38
98%
-115
- C3 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
K-
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.81
100%
-108
- C3 -
4F0A
2
FZD8_MOUSE
A:
[8-123]
----------------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
N
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
D
Y
-
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.07
28%
-135
- C4 -
4QIN
1
C562_ECOLX (first)
A:
[6-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
V
P
L
V
R
T
D
N
P
K
-
S
W
Y
E
D
V
E
-----
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
-------------------------
A
D
G
T
M
R
L
G
E
-------------
P
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
--
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
--
P
D
S
P
E
M
K
D
F
--
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
19
PsiBlast_CBE
65.38
39%
-104
- C3 -
5BPQ
1
FZD4_HUMAN
D:
[6-122]
---------------------------------
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.86
39%
-109
- C3 -
5CL1
2
?
C:
[15-131]
---------------------------------
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.63
38%
-109
- C3 -
5BQE
3
FZD4_HUMAN
C:
[5-122]
--------------------------------
R
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
-
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
-
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.55
39%
-112
- C3 -
5BPB
2
FZD4_HUMAN
B:
[6-122]
---------------------------------
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
E
L
E
V
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
64.47
44%
-111
- C3 -
1IJX
1
SFRP3_MOUSE
A:
[3-123]
--------------------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
G
-
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
T
I
D
F
Q
H
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
Y
D
--
R
G
V
C
I
S
P
E
A
I
V
T
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.30
28%
-138
- C4 -
4QIM
1
C562_ECOLX
A:
[6-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
V
P
L
V
R
T
D
N
P
K
-
S
W
Y
E
D
V
E
-----
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
-------------------------
A
D
G
T
M
R
L
G
E
-------------
P
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
--------
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
--
P
D
S
P
E
M
K
D
F
--
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
T
I
G
L
P
T
K
Q
P
I
P
D
C
E
I
K
N
R
P
S
7
PsiBlast_PDB
64.22
39%
-113
- C3 -
5CM4
2
?
A:
[5-121]
---------------------------------
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.13
28%
-137
- C4 -
4O9R
1
C562_ECOLX (first)
A:
[6-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
V
P
L
V
R
T
D
N
P
K
-
S
W
Y
E
D
V
E
-----
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
E
I
V
C
R
-------------------------
A
D
G
T
M
R
L
G
E
-------------
P
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
------------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
--
P
D
S
P
E
M
K
D
F
--
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
T
I
P
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
18
PsiBlast_CBE
63.80
39%
-113
- C3 -
5CM4
2
?
B:
[5-121]
---------------------------------
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_CBE
63.72
39%
-110
- C3 -
5CL1
2
?
D:
[14-131]
--------------------------------
R
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.70
39%
-110
- C3 -
5BQC
3
FZD4_HUMAN
B:
[5-122]
--------------------------------
R
R
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
T
E
K
I
-
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
E
E
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