@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GABR1_HUMAN: (2016-01-09 )
MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......--410.......420.......430.......440.....-..450.......460.......470.......480.---......490.......500.......510.......520.......530.......540.......550.......560........570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
L
L
L
L
L
A
P
L
FLRPPGAGGAQTPNATSEG
C
Q
I
IHPPWEGG
I
R
YRGL
T
R
D
Q
V
K
A
I
N
F
LPVD
Y
E
I
E
Y
V
CRG
E
R
EV
V
G
P
K
V
R
K
C
LANGSWTDMD
T
P
S
R
C
V
R
I
C
S
K
S
Y
L
T
LEN
G
K
V
F
L
TGGDLPALDG
A
R
V
D
F
R
CDP
D
F
H
L
VGSS
R
S
I
CSQGQWSTPKP
H
C
Q
VNRTPHSE
R
R
A
V
Y
I
G
A
L
FPMSGGWPG
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
RRDILPDY
E
L
K
L
I
HHDSKCDP
G
Q
A
T
K
Y
L
Y
E
L
L
YND
P
I
K
I
I
L
MPG-C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
SYGSSSPALSNRQRF
P
T
F
F
RTHPSATLHNPT
R
V
K
L
F
E
KWG
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
EAG
I
E
I
T
F
R
Q
SFFSDPAV
P
V
K
N
L
KRQD
A
R
I
I
V
G
L
F
YET
E
A
R
K
V
F
C
E
V
Y
K
E
RLFGK
K
Y
V
W
F
L
I
G
W
YAD
N
W
F
K
I
YDPSI
N
--
C
T
V
D
E
M
T
E
A
VEGH
I
T
T
E
I
V
M
LNPANTR
S
I
SNM
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
KRHPEETGGFQEA
P
L
A
Y
D
A
I
W
A
L
A
L
A
LNK---TSGGGGRSG
V
R
L
E
DFNYNNQ
T
I
T
D
Q
I
Y
R
A
MNSSSFEGV
S
G
H
V
V
FDASGS
R
M
A
W
T
L
I
E
Q
LQGGS
Y
K
KIGYYDSTKDDLS-WSKTDKWIGGSPPAD
Q
T
L
V
I
K
T
F
R
F
L
S
Q
K
L
F
I
S
V
S
V
L
S
S
L
G
I
V
L
A
V
V
C
L
S
F
N
I
Y
N
S
H
V
R
Y
I
QNSQPNLNN
L
T
A
V
G
C
S
L
A
L
A
A
V
FPLGLD
G
Y
HIGRNQFP
F
V
C
Q
A
R
L
W
L
LGLGFSLG
Y
G
S
M
F
T
K
I
W
W
V
H
TVFTK
K
E
E
K
K
E
W
R
KTL
E
P
W
K
L
Y
A
T
V
G
L
L
V
G
M
D
V
L
T
L
A
I
W
Q
I
V
D
P
L
H
R
T
I
E
T
F
A
KEEPKEDI
D
V
S
I
L
P
Q
L
E
H
CSSRK
M
N
T
W
L
G
I
F
Y
G
Y
K
G
L
L
L
L
L
G
I
F
L
A
YETKSVSTEKINDH
R
A
V
G
M
A
I
Y
N
V
A
V
L
C
L
I
TA
P
V
T
M
I
LSSQQ
D
A
A
F
A
F
A
S
L
A
I
V
F
S
S
Y
I
T
L
V
V
L
F
V
P
K
M
R
R
L
I
TRGE
W
Q
S
E
A
Q
D
T
M
KTGSSTNN
N
E
E
E
K
S
R
L
L
E
K
E
N
R
E
L
E
K
I
I
A
E
K
E
E
R
V
S
E
L
R
H
Q
L
Q
S
R
Q
Q
L
R
SRRHPPTPPEPSGGLPRGPPEPPDRLSCDG
S
R
V
H
L
L
YK
7
PsiBlast_PDB
93.58
100%
-97
- C3 -
4MS1
3
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.14
100%
-97
- C3 -
4MR8
3
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.06
100%
-98
- C3 -
4MQF
3
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.99
100%
-98
- C3 -
4MQE
2
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.77
100%
-99
- C3 -
4MRM
3
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.76
100%
-100
- C3 -
4MR9
4
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.52
100%
-100
- C3 -
4MR7
3
GABR1_HUMAN
A:
[1-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.38
100%
-102
- C3 -
4MS4
1
GABR1_HUMAN
A:
[3-412]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.97
100%
-101
- C3 -
4MS3
1
GABR1_HUMAN
A:
[3-412]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
A
V
Y
I
G
A
L
F
P
M
S
G
G
W
P
G
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
-------
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
--
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
V
-
E
K
L
T
K
R
L
------
T
G
G
F
Q
E
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
---
T
S
--------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.49
34%
-77
- C3 -
4MR9
2
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.20
34%
-79
- C3 -
4MQE
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.14
34%
-79
- C3 -
4MS1
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
69.98
34%
-80
- C3 -
4MQF
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.95
34%
-79
- C3 -
4MR8
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.94
34%
-78
- C3 -
4MR7
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
------
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.58
34%
-78
- C3 -
4MRM
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
------SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
---------
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
68.45
34%
-80
- C3 -
4MS4
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
---------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
-
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
68.03
34%
-80
- C3 -
4MS3
1
GABR2_HUMAN
B:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
---------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
-
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.36
34%
-79
- C3 -
4F12
4
GABR2_HUMAN
A:
[33-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
V
-------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
-
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.95
34%
-77
- C3 -
4F11
-
GABR2_HUMAN
A:
[74-464]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
V
-----SR
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
-
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
Y
K
D
D
D
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------