@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GABR2_HUMAN: (2016-01-09 )
MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.....-...100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....-----..360.......370.......380.......390.......400.......410.....-..420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASPRSSGQPGPPPPPPP
P
P
A
R
L
L
L
L
L
L
L
P
L
L
LPLAPGAWGWARGAPRPPPSSPP
L
S
I
M
GLMP
L
T
K
E
V
AKGSIGR
G
V
L
P
A
V
E
L
A
I
E
Q
IRNESLLR
P
-
Y
F
L
D
L
R
L
YDTECDNA
K
G
L
K
A
F
Y
D
A
I
KYGP
N
H
L
M
V
FGGV
C
P
S
V
T
S
I
I
A
E
S
LQG
W
N
L
V
Q
L
S
FAATTPVLADKKKY
P
Y
F
F
R
TVPSDNAV
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
RV
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
YGEDIEISDTESFSNDPC
T
S
V
K
KLKGN
D
V
R
I
I
L
GQFDQN
M
A
A
K
V
F
C
C
A
YEENMYGS
K
Y
Q
W
I
IPGWYEP
S
W
W
E
Q
V
HTEAN
S
S
R
C
L
R
K
N
L
L
A
A
M
E
G
YIGVDFEPLSSK
Q
I
K
TISGK
T
P
Q
Q
Y
E
R
E
YNNKRSGVGPSKFH
G
Y
-----AY
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
QDFNYT
D
H
T
L
G
R
I
I
L
N
AMNET
N
F
F
G
V
T
G
Q
V
V
F
-RNG
E
R
M
G
T
I
K
F
T
QFQDSREVKVGE
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
FQGSEPPK
D
K
T
I
I
L
E
Q
L
R
K
IS
L
P
L
Y
S
I
L
S
A
L
T
I
L
G
M
I
M
A
S
A
F
L
F
F
N
IKNR
N
Q
K
L
I
KMSSPYMN
N
L
I
I
LG
G
M
L
S
Y
A
S
I
F
L
FGLDGSFV
S
E
K
T
F
E
T
L
C
T
V
R
T
W
I
L
T
VG
Y
T
T
A
F
G
A
M
F
A
K
T
W
R
V
H
A
I
F
K
N
V
K
M
K
K
K
I
IKDQ
K
L
L
V
I
VG
G
M
L
L
I
D
L
C
I
L
I
C
W
Q
A
V
D
P
L
R
R
T
V
E
K
YSMEPDPAGRDI
S
I
R
P
L
L
E
HCENT
H
M
T
I
W
L
G
I
V
Y
A
Y
K
G
L
L
M
L
F
G
C
F
L
AWETRNVSIPALNDS
K
Y
I
G
M
S
V
Y
N
V
G
I
M
C
I
I
G
A
A
V
S
F
L
TRDQP
N
V
Q
F
C
I
V
A
L
V
I
I
F
C
S
T
I
T
L
C
L
V
F
V
P
K
L
I
T
LRTNPDAATQN
R
R
F
Q
FTQNQKKEDSKTST
S
V
T
SVNQA
S
T
S
R
L
E
G
L
QSEN
H
R
L
R
M
K
I
T
E
L
DK
D
L
E
E
V
T
M
Q
L
QDTPEK
T
T
Y
I
K
Q
N
H
Y
Q
E
L
N
D
I
L
NLGNFTESTDG
G
K
A
I
L
K
N
HLDQNP
Q
L
Q
W
NTTEPSRTCK
D
P
I
E
DIN
S
P
E
H
I
Q
R
R
L
SLQL
P
I
L
H
H
A
YLPSIGGV
D
A
S
C
VSPCVSPTASPRHRHVPPS
F
R
V
M
VSGL
2
PsiBlast_PDB
98.98
100%
-98
- C2 -
4F12
4
GABR2_HUMAN
A:
[8-425]
------------------------------------------------
P
P
P
S
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
V
--------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
98.58
100%
-95
- C2 -
4MS4
1
GABR2_HUMAN
B:
[9-425]
-------------------------------------------------
P
P
S
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
----------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
98.46
100%
-98
- C2 -
4MS1
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.40
100%
-98
- C2 -
4F11
-
GABR2_HUMAN
A:
[52-466]
---------------------------------------------------
S
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
V
------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
Y
K
D
D
D
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
98.39
100%
-95
- C2 -
4MR9
2
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
98.39
100%
-98
- C2 -
4MR7
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
98.15
100%
-97
- C2 -
4MS3
1
GABR2_HUMAN
B:
[9-425]
-------------------------------------------------
P
P
S
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
----------
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.99
100%
-98
- C2 -
4MQE
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
97.91
100%
-98
- C2 -
4MQF
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
97.84
100%
-98
- C2 -
4MR8
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
-----
I
Q
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
96.93
100%
-95
- C2 -
4MRM
1
GABR2_HUMAN
B:
[12-425]
----------------------------------------------------
S
P
P
L
S
I
M
G
L
M
P
L
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
A
V
E
L
A
I
E
Q
I
R
N
E
S
L
L
R
P
-
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
N
H
L
M
V
F
G
G
V
C
P
S
V
T
S
I
I
A
E
S
L
Q
G
W
N
L
V
Q
L
S
F
A
A
T
T
P
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
I
L
K
L
L
K
H
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
N
D
V
R
I
I
L
G
Q
F
D
Q
N
M
A
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
I
P
G
W
Y
E
P
S
W
W
E
Q
-------
S
R
C
L
R
K
N
L
L
A
A
M
E
G
Y
I
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
G
P
S
K
F
H
G
Y
-----
A
Y
D
G
I
W
V
I
A
K
T
L
Q
R
A
M
E
T
L
H
A
S
--------
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
A
M
N
E
T
N
F
F
G
V
T
G
Q
V
V
F
-
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Y
N
A
V
A
D
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
P
P
K
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.69
33%
-74
- C2 -
4MR9
4
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.47
33%
-75
- C2 -
4MQF
3
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.46
33%
-73
- C2 -
4MRM
3
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.44
33%
-71
- C2 -
4MS1
3
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.35
33%
-73
- C2 -
4MR7
3
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.35
33%
-78
- C2 -
4MS3
1
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
-------
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
------
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.31
33%
-73
- C2 -
4MR8
3
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
74.13
33%
-76
* C2 *
4MS4
1
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
73.75
33%
-72
- C2 -
4MQE
2
GABR1_HUMAN
A:
[21-410]
-------------------------------------------------------------------------
G
Q
A
C
Q
P
A
V
E
M
A
L
E
D
V
N
S
R
R
D
I
L
P
D
Y
E
L
K
L
I
H
H
D
S
K
C
D
P
G
Q
A
T
K
Y
L
Y
E
L
L
Y
N
D
P
I
K
I
I
L
M
P
G
-
C
S
S
V
S
T
L
V
A
E
A
A
R
M
W
N
L
I
V
L
S
Y
G
S
S
S
P
A
L
S
N
R
Q
R
F
P
T
F
F
R
T
H
P
S
A
T
L
H
N
P
T
R
V
K
L
F
E
K
W
G
W
K
K
I
A
T
I
Q
Q
T
T
E
V
F
T
S
T
L
D
D
L
E
E
R
V
K
E
A
G
I
E
I
T
F
R
Q
S
F
F
S
D
P
A
V
P
V
K
N
L
K
R
Q
D
A
R
I
I
V
G
L
F
Y
E
T
E
A
R
K
V
F
C
E
V
Y
K
E
R
L
F
G
K
K
Y
V
W
F
L
I
G
W
Y
A
D
N
W
F
K
I
Y
D
P
S
I
N
---
C
T
V
D
E
M
T
E
A
V
E
G
H
I
T
T
E
I
V
M
L
N
P
A
N
T
R
S
I
S
N
M
T
S
Q
E
F
-
V
E
K
L
T
K
R
L
K
R
H
P
E
E
T
G
G
F
QE
A
P
L
A
Y
D
A
I
W
A
L
A
L
A
L
N
K
T
S
----------
R
L
E
D
F
N
Y
N
N
Q
T
I
T
D
Q
I
Y
R
A
M
N
S
S
S
F
E
G
V
S
G
H
V
V
F
D
A
S
G
S
R
M
A
W
T
L
I
E
Q
L
Q
G
G
S
Y
K
K
I
G
Y
Y
D
S
T
K
D
D
L
S
-
W
S
K
T
D
K
W
I
G
G
S
P
P
A
D
D
Y
K
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------