@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GALR1_HUMAN: (2016-01-09 )
MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
Atome Classification :
(20 SA)
.........10........20........30........40.....---...50........60........70........80........90......-..100.......110.......120.......130.......140....---...150.......160......--.170-.......-180----.......190----.---..--.--.--...200.......210.......220.......-230..-.------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------...240------.......250---------.........260...---....270..---..-------...280......-----.290.......300.......310.......320.......330.......340.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELAVGNLSEGNASWPEPPAPEPG
P
L
F
G
I
G
V
E
N
F
V
T
L
V
V
F
G
L
I
F
A
L
---
G
V
LGN
S
L
V
I
T
V
L
ARSKPGKPRS
T
T
N
L
F
I
L
NL
S
I
A
D
L
A
Y
L
L
F
C
IPF
Q
A
T
V
Y
A
-
L
P
T
W
V
L
G
A
F
I
C
K
F
I
H
Y
F
F
T
V
S
M
L
V
S
I
F
T
L
A
A
M
S
V
D
R
Y
V
A
I
V
HSRRSSS
L
---
R
VSRN
A
L
L
G
V
G
C
I
W
A
L
S
I
A
MAS--
P
V
A
Y
-
H
QGLFHP-RAS----NQ
T
F
C
WEQW-----P---DP--R--H--
K
K
A
Y
V
V
C
T
F
V
F
G
Y
L
L
P
L
L
L
I
C
F
C
Y
A
K
V
L
N
H
L
H
K
-
K
L
K
N
M
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
E
ASK------KKTA
Q
T
V
L
-----------
V
V
V
V
V
F
G
I
S
W
L
P
H
H
I
---
I
H
L
W
A
EFGV---FP-------L
T
P
A
S
F
L
F
R
I
T
A
-----
H
C
L
AYSNSSV
N
P
I
I
Y
A
F
L
S
E
N
F
R
K
A
Y
K
Q
V
F
K
C
HIRKDSHLSD
T
K
ESKSRIDTPPSTNCTHV
36
HHSearch
84.89
26%
-138
- C8 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
----------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
---
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
--
L
P
I
Q
M
H
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
----------------
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
-
Q
L
N
I
F
-
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA-
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
C
L
K
E
------
H
K
A
L
K
T
L
G
-----------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
---
V
N
I
V
H
V
I
Q
D
---
N
L
----------
I
R
K
E
V
Y
I
L
L
-----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
55
Fugue
83.85
28%
-126
- C8 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
---
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
--
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
-
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
--
P
I
L
F
-
Y
S
G
-
T
G
V
-
R
K
N
----
K
T
I
T
C
Y
D
T
T
-----
S
---
D
E
Y
L
R
--
S
--
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
-
K
M
K
K
Y
-
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
-------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
E
P
L
R
------
R
K
S
I
Y
L
V
I
-----------
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
---
Q
T
-------
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------
21
PsiBlast_CBE
83.53
33%
-146
- C8 -
4EA3
3
C562_ECOLX (first)
B:
[126-406]
------------------------------------
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
T
L
V
L
L
T
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
---
R
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
--
P
V
A
I
-
M
G
S
--
A
----------
E
I
E
C
L
V
E
I
-----
P
---
T
P
--
Q
--
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
N
L
------
R
R
I
T
R
L
V
L
-----------
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
---
F
V
L
A
Q
G
L
G
V
---
Q
P
-------
S
S
E
T
A
V
A
I
L
R
F
C
-----
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
--------------------------------
40
HHSearch
82.65
27%
-133
- C8 -
3EML
13
ENLYS_BPT4
A:
[22-471]
---------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
---
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
--
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
-
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
VACLF
E
---
D
V
--
V
--
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
-
Q
L
N
I
F
-
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
------
V
H
A
A
K
S
L
A
-----------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
---
I
N
C
F
T
F
F
C
P
---
D
C
-------
S
H
-
A
P
L
W
L
M
Y
L
A
-----
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------
3
PsiBlast_PDB
82.18
33%
-149
- C8 -
4RWA
2
C562_ECOLX (first)
A:
[128-406]
--------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
--
P
I
M
V
--
M
A
V
T
R
P
-
R
-
D
----
G
A
V
V
C
M
L
Q
F
-----
P
---
S
P
--
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
----------G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
L
------
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
V
W
T
L
V
D
I
DRR
D
P
-------
L
V
V
A
A
L
H
L
C
I
A
--------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------
34
HHSearch
82.17
26%
-125
- C8 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-497]
-------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
---
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
--
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
--
P
D
F
I
-
F
A
N
V
S
E
---
A
D
----
D
R
Y
I
C
D
R
F
Y
-----
P
---
N
D
--
L
--
W
--
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
-
S
G
S
N
I
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
K
G
H
Q
K
------
R
K
A
L
K
T
T
V
-----------
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
---
G
I
S
I
D
S
F
I
L
---
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
-----
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------
18
PsiBlast_PDB
81.88
28%
-148
- C8 -
2YCZ
2
ADRB1_MELGA
A:
[16-299]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
--
F
L
P
I
-
M
M
H
W
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
I
R
K
I
-
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------
23
PsiBlast_CBE
81.46
33%
-146
- C8 -
4RWA
1
OPRD_HUMAN
B:
[128-403]
--------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
--
P
I
M
V
--
M
A
V
T
R
P
-
R
-
D
----
G
A
V
V
C
M
L
Q
F
-----
P
---
S
P
--
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
---------G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
L
------
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
V
W
T
L
V
D
I
DRR
D
P
-------
L
V
V
A
A
L
H
L
C
I
A
--------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
----------------------------------
1
PsiBlast_PDB
81.12
33%
-144
- C8 -
4EA3
3
C562_ECOLX (first)
A:
[126-405]
------------------------------------
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
T
L
V
L
L
T
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
--
P
V
A
I
-
M
G
S
--
A
Q
-
V
E
D
----
E
E
I
E
C
L
V
E
I
-----
P
---
T
P
--
Q
--
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
V
R
L
L
S
G
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
N
L
------
R
R
I
T
R
L
V
L
-----------
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
---
F
V
L
A
Q
G
L
G
V
---
Q
P
-------
S
S
E
T
A
V
A
I
L
R
F
C
-----
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
----------------------------------
16
PsiBlast_PDB
80.72
28%
-144
- C8 -
2YCW
7
ADRB1_MELGA
A:
[16-299]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
--
F
L
P
I
-
M
M
H
W
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
I
R
K
I
-
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------
22
PsiBlast_CBE
80.56
33%
-139
- C8 -
4RWD
5
OPRD_HUMAN
B:
[128-405]
--------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
--
P
I
M
V
--
M
A
V
T
R
P
-
R
-
D
----
G
A
V
V
C
M
L
Q
F
-----
P
---
S
P
--
S
WY
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
-
V
R
L
L
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
L
------
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F--
V
I
V
W
T
L
V
D
I
DRR
D
P
-------
L
V
V
A
A
L
H
L
C
I
A
--------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
--------------------------------
4
PsiBlast_PDB
80.33
33%
-139
- C8 -
4RWD
6
C562_ECOLX (first)
A:
[128-406]
--------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
--
P
I
M
V
--
M
A
V
T
R
P
-
R
-
D
----
G
A
V
V
C
M
L
Q
F
-----
P
---
S
P
--
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
-
V
R
L
L
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
L
------
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
V
W
T
L
V
D
I
DRR
D
P
-------
L
V
V
A
A
L
H
L
C
I
A
--------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------
9
PsiBlast_PDB
80.03
29%
-154
- C8 -
2Y03
9
ADRB1_MELGA
A:
[16-300]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------
2
PsiBlast_PDB
80.02
33%
-141
- C8 -
4N6H
22
OPRD_HUMAN
A:
[131-410]
--------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
--
P
I
M
V
--
M
A
V
T
R
P
-
R
-
D
----
G
A
V
V
C
M
L
Q
F
-----
P
---
S
P
--
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
-
V
R
L
L
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
L
------
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
V
W
T
L
V
D
I
DRR
D
P
-------
L
V
V
A
A
L
H
L
C
I
A
--------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
--------------------------
19
PsiBlast_PDB
79.98
28%
-144
- C8 -
2YCY
6
ADRB1_MELGA
A:
[16-299]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
--
F
L
P
I
-
M
M
H
W
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
I
R
---
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------
17
PsiBlast_PDB
78.62
28%
-139
- C8 -
2YCX
3
ADRB1_MELGA
A:
[16-294]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
--
F
L
P
I
-
M
M
H
W
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
I
R
K
I
-
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
----------------------------------
11
PsiBlast_PDB
78.54
29%
-150
- C8 -
4AMJ
12
ADRB1_MELGA
A:
[16-300]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------
43
HHSearch
78.46
24%
-141
- C8 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
---
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
--
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
--
P
L
L
F
-
G
F
N
T
T
G
---------
D
P
T
V
C
S
I
S
N
-----
P
---------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
-
R
R
R
K
N
-
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
V
P
L
R
E
------
K
K
A
T
Q
M
V
A
-----------
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
---
T
H
V
L
N
T
H
C
Q
---
T
C
-------
H
--
V
S
P
E
L
Y
S
A
T
-----
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------
7
PsiBlast_PDB
78.45
29%
-153
- C8 -
2Y01
12
ADRB1_MELGA
A:
[16-300]
-------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
-
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
-
E
D
P
----
Q
A
L
K
C
Y
Q
D
------
P
GCC
D
F
--
V
--
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
-
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
---
V
N
I
V
N
V
F
N
R
----
D
-------
L
V
P
-
D
W
L
F
-
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------
33
HHSearch
78.39
22%
-127
- C8 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
----------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
---
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
--
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
--
P
A
I
L
-
F
W
Q
F
I
V
G
V
R
T
V
----
E
D
G
E
C
Y
I
Q
F
-----
F
---
S
---------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
-
R
I
N
I
F
-
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA-
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
P
S
R
E
------
K
K
V
T
R
T
I
L
-----------
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
---
M
V
L
I
N
T
F
C
A
---
P
C
--------
I
--
P
N
T
V
W
T
I
G
-----
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------