@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GHSR_HUMAN: (2016-01-09 )
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
Atome Classification :
(20 SA)
.........10........20........30........40........50...----.....60........70--.........80.....-...90.-.-.-.-....100-.......110.......120.......130.......140.......150..---.....160.......170........180.....--.--..190------.-.---.....-------..---200.......210.......220.-.----.....230.......----240.....--..--------------------------------------------------------------------------------------------------------------------------------------------------------250-------------------------------------------------------------------------------------------------------------------------------------------------------...----......260.......270.......280..--...----.-.290.......300.......310........320.......330.......340.......350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MWNATPSEEPG
F
N
L
T
L
A
DLDWDASPGN
D
S
L
G
D
E
L
L
Q
LFP
A
P
L
L
A
G
V
T
A
T
C
V
A
L
F
----
V
V
G
I
A
G
N
L
L
T
M
L
V
V
S
R
---
F
R
E
L
R
T
T
T
N
L
Y
L
S
S
M
A
-
F
S
D
L
L
I
-
F
-
L
-C-M
P
L
D
L
V
R
-
L
WQYRPW
N
F
G
D
L
L
C
K
L
F
Q
F
V
SESC
T
Y
A
T
V
L
T
I
T
A
LS
V
E
R
Y
F
A
I
C
F
P
L
R
A
K
V
V
---
V
TKG
R
V
K
L
V
I
F
V
I
W
A
V
-
A
F
CSAG
P
I
F
V
L
-
V
G
V
EH--E--NGT--------D-P---WDTNE-------CR---
P
T
E
F
A
V
R
S
G
L
L
T
V
M
V
W
V
S
S
I
F
F
F
L
-
P
----
V
F
C
L
T
V
L
Y
S
L
I
G
R
K
L
----
W
R
R
RRGD
A
--
V
V--------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------ASL----RDQ
N
H
K
Q
T
V
K
M
L
A
V
V
V
F
A
F
I
L
C
W
L
P
F
H
V
G
R
Y
--
L
F
S----K-SFEPGS
L
E
I
A
Q
I
S
Q
Y
C
N
L
V
S
F
V
-
L
F
Y
L
S
A
A
I
N
P
I
L
Y
N
I
M
S
K
K
Y
R
V
A
V
F
R
L
LGFEPF
S
Q
R
K
L
S
T
LKDESSRAWTESSINT
4
PsiBlast_PDB
95.80
35%
-158
- C4 -
4XEE
4
?
A:
[35-345]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K-------
S
T
V
H
Y
H
L
G
S
L
A
-
L
S
D
L
L
I
-
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
A
S
L
S
V
E
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
--
R
SA
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
V
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
I
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
----
R
V
Q
A
L
R
H
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
F
Y
A
S
S
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
6
PsiBlast_PDB
95.16
34%
-154
- C4 -
4XES
5
?
A:
[35-345]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
KKS
L
Q
S
L
Q
S
T
V
H
Y
H
L
G
S
L
A
-
L
S
D
L
L
I
-
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
A
S
L
S
V
A
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
--
R
SA
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
V
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
I
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
----
R
V
Q
A
L
R
H
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
F
Y
A
S
S
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
2
PsiBlast_PDB
93.56
36%
-156
- C4 -
3ZEV
6
NTR1_RAT
A:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
KK---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
-
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
H
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
G
--
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
--------------------------
22
PsiBlast_CBE
93.28
36%
-160
- C4 -
3ZEV
2
NTR1_RAT
B:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
------
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
-
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEPG
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
--------------------------
3
PsiBlast_PDB
92.95
36%
-156
- C4 -
4BUO
10
NTR1_RAT
A:
[21-313]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
KK---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
-
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
H
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
----
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
----------------------------
1
PsiBlast_PDB
92.09
36%
-163
- C4 -
4BWB
1
NTR1_RAT
A:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
-
L
S
D
L
L
I
-
L
L
F
-
A
-
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
R
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
G
----
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
V
----
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
------------------------
21
PsiBlast_CBE
91.47
36%
-166
- C4 -
4BWB
1
NTR1_RAT
B:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
KK------
S
R
V
D
Y
Y
L
G
S
L
A
-
L
S
D
L
L
I
-
L
L
F
-
A
-
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
--
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
R
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V
H
Q
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
----
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
V
----
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
----------------------------
24
PsiBlast_CBE
91.35
36%
-162
- C4 -
4BV0
1
NTR1_RAT
B:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
------
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
-
L
S
D
L
L
I
-
L
L
F
-
A
-
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
F
K
H
K
T
----
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
V
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
V
----
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
P
-----------------------
37
HHSearch
90.10
27%
-150
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[43-472]
-----------------------------------------------
L
S
Y
C
A
L
I
----
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
---
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
-
V
A
D
L
L
V
-
A
-
T
L
V
-
M
P
W
V
V
Y
L
-
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
-
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
G
-----------------------
D
P
T
V
-------
C
S
---
I
S
N
P
-------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
-
P
----
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
----
K
Q
R
R
R
K
N
I
--
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
----
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
--
L
N
T
----
H
-
C
--
Q
T
-
C
H
---
V
S
P
E
L
Y
S
A
T
T
W
-
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------
27
HHSearch
90.01
25%
-147
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[28-457]
-----------------------------------------------
L
V
A
G
S
L
S
----
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
---
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
-
C
A
D
L
I
I
-
G
-
V
F
S
-
M
N
L
Y
T
L
Y
-
T
-
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
-
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
--
G
--
V
R
T
--------------
V
E
D
G
E
-------
C
Y
---
I
Q
F
F
S
N
----
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
-
P
----
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
----
K
S
R
I
N
I
F
E
--
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
P
----
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
--
I
N
T
----
F
---
C
A
P
C
-----
I
P
N
T
V
W
T
I
G
Y
W
-
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------
23
PsiBlast_CBE
89.95
36%
-151
- C4 -
4BUO
5
NTR1_RAT
B:
[21-313]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
------
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
-
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
M
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V
H
Q
A
A
F
N
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
G
----
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
C
----
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
--------------------------
5
PsiBlast_PDB
87.82
36%
-166
- C4 -
4BV0
1
NTR1_RAT
A:
[22-316]
---------------------------------------------
V
T
A
I
Y
L
A
L
F
----
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K-------
S
R
V
D
Y
Y
L
G
S
L
A
-
L
S
D
L
L
I
-
L
L
F
-
A
-
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
-----
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
-
S
A
L
L
A
I
P
M
L
F
T
-
V
G
L
Q
N
LS
G
--
D
G
T
--------
H
-
P
---
G
G
L
-
V
-------
C
T
---
P
I
---
V
D
T
A
T
L
K
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
----
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
----
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
--
M
F
V
----
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
-
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
-------------------------
30
HHSearch
86.55
22%
-154
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
----------------------------------------------
V
V
V
L
S
T
I
C
----
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
---
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
-
V
A
D
L
I
V
-
G
-
A
V
V
-
M
P
M
N
I
L
Y
-
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
-
S
F
L
W
V
I
P
I
L
G
W
-
N
H
-------------------------
R
R
E
D
K
-------
C
E
---
T
D
F
Y
D
V
----
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
-
P
----
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
----
R
Q
H
C
N
I
F
E
--
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
----
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
--
V
I
A
----
F
-
C
--
K
N
C
-----
C
N
E
H
L
H
M
F
T
I
W
-
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------
32
HHSearch
82.27
19%
-144
- C4 -
3EML
13
ENLYS_BPT4
A:
[25-472]
----------------------------------------------
I
T
V
E
L
A
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
---
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
-
G
-
V
L
A
-
I
P
F
A
I
T
I
-
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
--
Q
---------------------
S
Q
G
CGEGQVA
C
L
---
F
E
D
V
V
P
---
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
----
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
----
R
R
Q
L
N
I
F
E
--
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
S
----
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
--
F
T
F
----
F
-
C
P
D
C
-----
S
H
A
P
L
W
L
M
Y
L
A
I
V
-
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------
29
HHSearch
82.06
21%
-147
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[44-477]
----------------------------------------------
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
---
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
-
G
-
L
A
V
-
V
P
F
G
A
A
H
-
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
--
Q
E
A
--------
I
N
C
---
Y
A
E
E
T
-------
C
C
---
D
F
F
T
-----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
-
P
----
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
----
K
R
Q
L
N
I
F
E
--
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
K
----
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
--
V
H
V
----
I
-
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
-
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------
7
PsiBlast_PDB
81.89
29%
-142
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[123-405]
--------------------------------------------
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
---
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
-
L
A
D
T
L
V
-
L
-
L
-
T
-
L
P
F
Q
G
T
D
-
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
-
A
S
V
V
G
V
P
V
A
I
M
-
G
S
A
Q
V
--
E
--
D
-----------------
E
E
I
E
-------
C
L
V
E
I
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
--
F
I
V
-
P
----
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
----
R
G
V
R
---
L
--
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
----
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
--
A
Q
G
----
L
-
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
----
A
-
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
-
A
C
F
R
------------------------------
11
PsiBlast_PDB
81.03
26%
-159
- C4 -
4RWA
2
C562_ECOLX (first)
A:
[121-406]
-----------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
----
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
---
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
-
L
A
D
A
L
A
-
T
-
S
-
T
-
L
P
F
Q
S
A
K
--
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
-
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
--
R
--
D
G
A
V
V
C
M
L
Q
F
P
S
-
P
S
W
Y
W
D
T
-------------------------
V
T
K
I
C
V
F
L
F
A
F
V
V
-
P
----
I
L
I
I
T
V
C
Y
---
G
L
M
L
----
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
----
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
--
V
W
T
LVDI
D
-
R
R
D
P
--
L
V
V
A
A
L
H
-----
L
C
I
A
-
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
-
R
C
F
R
Q
L
C
---------------------------
10
PsiBlast_PDB
80.93
26%
-150
- C4 -
4N6H
23
C562_ECOLX (first)
A:
[124-412]
-----------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
----
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
---
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
-
L
A
D
A
L
A
-
T
-
S
-
T
-
L
P
F
Q
S
A
K
--
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
-
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
--
R
--
D
G
A
VVC
M
L
Q
F
P
S
-
P
S
W
Y
W
D
T
-------------------------
V
T
K
I
C
V
F
L
F
A
F
V
V
-
P
----
I
L
I
I
T
V
C
Y
---
G
L
M
L
----
L
R
L
R
S
V
R
L
--
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
----
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
--
V
W
T
LVDI
D
-
R
R
D
P
--
L
V
V
A
A
L
H
-----
L
C
I
A
-
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
-
R
C
F
R
Q
L
C
R
K
P
C
G
----------------------
12
PsiBlast_PDB
80.27
26%
-149
- C4 -
4RWD
7
C562_ECOLX (first)
A:
[121-406]
-----------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
----
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
---
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
-
L
A
D
A
L
A
-
T
-
S
-
T
-
L
P
F
Q
S
A
K
--
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
-
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
--
R
--
D
G
A
V
V
C
M
L
Q
F
P
S
-
P
S
W
Y
W
D
T
-------------------------
V
T
K
I
C
V
F
L
F
A
F
V
V
-
P
----
I
L
I
I
T
V
C
Y
---
G
L
M
L
----
L
R
L
R
S
V
R
L
--
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
----
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
--
V
W
T
LVDI
D
-
R
R
D
P
--
L
V
V
A
A
L
H
-----
L
C
I
A
-
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
-
R
C
F
R
Q
L
C
---------------------------
20
PsiBlast_PDB
79.47
25%
-151
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[12-300]
-------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
----
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
---
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
-
C
A
D
L
V
V
G
L
-
L
-
V
-
V
P
F
G
-
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
--
D
--
P
Q
A
L
K
C
Y
Q
---
D
-
P
---
G
C
C
D
F
-------
V
T
---
N
R
A
Y
A
I
A
S
S
I
I
S
---------
F
Y
I
-
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
----
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
----
R
-
D
L
V
P
D
W
L
----------
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------