@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GLP1R_HUMAN: (2016-01-09 )
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Atome Classification :
(20 SA)
------------.........10........20........30........40.....---...50...-.....60........70........80........90........100...-----....110.......120.......130.......140...----.-...--------150.......160..----.....170..---------------.....180.......190......-.200.....--...210......-----.220.......230..---..-.---------..240.......250.......260----.......270....-...280......-..290--....---..---.-.300--..----------..-----....310.......320.-------......330.....----------..-----340...---....350....--------...360....------...370--.....---.-----..380.......390-----........--------.400.....-----------..410.......---420.......430..---.....440.......450.......460.------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MAGAP
G
P
L
R
L
A
L
L
L
L
G
M
VGRAGPRPQGA
T
V
S
L
W
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
---
Q
R
SLTEDP-PPATDLFCNRTFDEYACWPDGEPG
S
F
V
NVSC
P
W
YLPWASSVPQG
H
V
Y
R
F
CT-----AE
G
L
W
LQKDNSSLP
W
R
D
L
S
E
C
E
E
SKRGERSSPE
E
Q
L
L
F
L
Y
----
I
-
I
Y
T
--------
V
G
Y
A
L
S
F
S
A
L
V
I
A
S
A
----
I
L
L
G
F
R
H
L
H
C---------------TR
N
Y
I
H
L
N
L
F
A
S
F
I
L
R
A
L
S
V
F
I
K
D
-
A
A
-
L
K
W
M
Y
S
--
T
A
A
Q
Q
H
QWD
G
L
L
-----
S
Y
Q
DS
L
S
C
R
L
V
F
L
L
M
Q
---
Y
C
-
V
---------AA
N
Y
Y
W
L
L
V
E
G
V
Y
L
Y
T
L
L
A
F
S
V
L
S
E
----
Q
W
I
F
R
L
Y
V
SIGWG
V
-
P
L
L
F
V
-V
P
W
G
I
V
-
K
Y
L
Y---EDEG---
C
W
---
T
-RNS---NM----------
N
Y
-----
W
L
I
I
R
L
P
I
L
F
A
I
G
V
N
F
L
I
-------
F
V
R
V
I
C
I
V
V
S
K
L
K
A
----------N
L
-----
M
CKTD
I
---
K
C
R
LAKS
T
L
T
L
--------
I
PLLGT
H
E
V
I
------
F
A
F
V
M
---
D
EHAR---
G
-----
T
L
R
F
I
K
L
F
T
ELS
F
-------
T
S
F
Q
G
L
M
V
--------
A
I
L
Y
C
FVNN-----------
E
V
Q
L
E
F
R
K
S
W
E
R---W
R
L
E
H
L
H
IQRDSSMK---PLKCPTSSLSSGATAGS
S
M
Y
T
A
T
C
QASCS------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.15
54%
-160
- C4 -
4L6R
1
C562_ECOLX (first)
A:
[109-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
E
I
E
V
Q
K
E
V
A
K
M
Y
S
S
F
Q
V
-
M
Y
T
--------
V
G
Y
S
L
S
L
G
A
L
L
L
A
L
A
----
I
L
G
G
L
S
K
L
H
C
---------------
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
L
V
I
D
-
G
L
-
L
R
T
----------------
L
-----
S
D
G
A
V
A
G
C
R
V
A
A
V
F
M
Q
---
Y
G
-
I
---------
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
E
----
R
S
F
F
S
L
Y
L
G
I
G
W
G
A
-
P
M
L
F
V
-
V
P
W
A
V
V
-
K
C
L
F
---
E
N
V
Q
---
C
W
---
T
-
S
N
D
---
N
M
----------
G
F
-----
W
W
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
-------
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
----------
R
Q
-----
M
H
H
T
D
Y
---
K
F
R
L
A
K
S
T
L
T
L
--------
I
P
L
L
G
V
H
E
V
V
------
F
A
F
V
T
---
D
E
H
A
Q
---
G
-----
T
L
R
S
A
K
L
F
F
D
L
F
L
-------
S
S
F
Q
G
L
L
V
--------
A
V
L
Y
C
F
L
N
K
-----------
E
V
Q
S
E
L
R
R
R
W
H
R
---
W
R
L
G
K
V
L
W
E
E
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.97
100%
-66
- C5 -
3IOL
1
GLP1R_HUMAN
A:
[10-109]
----------------------------------------
T
V
S
L
W
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
---
Q
R
S
L
T
E
D
P
-
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
P
Q
G
H
V
Y
R
F
C
T
-----
A
E
G
L
W
L
Q
K
D
N
S
S
L
P
W
R
D
L
S
E
C
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.63
100%
-64
- C5 -
3C5T
2
GLP1R_HUMAN
A:
[5-108]
---------------------------------------
A
T
V
S
L
W
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
---
Q
R
S
L
T
E
D
P
-
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
P
Q
G
H
V
Y
R
F
C
T
-----
A
E
G
L
W
L
Q
K
D
N
S
S
L
P
W
R
D
L
S
E
C
E
E
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.52
100%
-61
- C5 -
3C59
1
GLP1R_HUMAN
A:
[6-108]
----------------------------------------
T
V
S
L
W
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
---
Q
R
S
L
T
E
D
P
-
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
P
Q
G
H
V
Y
R
F
C
T
-----
A
E
G
L
W
L
Q
K
D
N
S
S
L
P
W
R
D
L
S
E
C
E
E
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
62.52
18%
-117
- C2 -
4S3Q
7
?
A:
[2-691]
---------------
E
S
K
R
L
D
N
A
A
L
A
A
G
-
I
S
P
N
Y
I
N
A
H
G
K
P
Q
S
I
S
------
A
E
T
K
R
R
L
---
L
D
A
M
H
Q
T
P
-
V
P
N
V
M
V
Y
T
S
G
K
K
M
P
M
V
V
E
G
S
G
E
Y
S
W
L
L
T
T
E
E
G
--
T
Q
Y
K
G
H
V
T
G
G
K
A
F
N
L
P
T
KLPE
G
Y
H
T
L
T
L
T
Q
D
D
Q
R
A
H
C
R
V
I
V
A
P
K
R
C
Y
E
P
Q
A
L
L
N
K
Q
K
L
W
G
A
C
----
V
Q
L
Y
T
LRSEKNWG
I
G
D
F
G
D
L
K
A
M
L
V
D
V
A
K
R
GG
S
F
I
G
L
N
P
I
H
A
LYPANPESASPYSPS
S
R
R
W
L
N
V
I
Y
I
D
---
V
N
A
V
E
D
F
H
L
S
-
E
E
-
A
Q
A
W
W
Q
--
L
P
T
T
Q
Q
T
L
Q
Q
A
R
D
ADWV
D
Y
S
T
V
T
A
L
K
M
T
A
L
R
M
A
---
W
K
-
G
F
A
Q
RDD
E
Q
M
A
A
F
R
Q
F
V
A
E
Q
G
D
S
L
F
W
Q
A
A
F
D
A
L
H
A
----
Q
Q
V
K
E
D
E
M
R
W
G
W
P
A
W
P
E
M
Y
Q
N
V
D
S
P
E
V
-
R
Q
F
C
---
E
E
H
---------
R
-
D
D
V
---
D
F
----------
Y
L
-----
W
L
Q
W
L
A
Y
S
Q
F
A
A
C
W
E
I
S
Q
G
Y
EMPIG
L
Y
R
D
L
A
V
G
V
A
E
G
G
A
----------
E
T
-----
W
C
D
R
E
L
YCL
K
A
S
V
G
A
P
P
D
I
L
GPLGQNWG
L
P
P
M
D
P
H
I
I
T
A
R
AY
E
P
F
I
E
L
L
---
R
A
N
M
Q
NC-
G
-----
A
L
R
I
D
H
V
M
S
M
L
R
L
WWIPYGE
T
A
D
Q
G
A
Y
V
H
Y
P
V
D
D
L
L
S
I
L
A
L
E
S
K
R
H
R
C
M
V
I
G
EDLG
T
V
P
V
E
I
V
G
K
L
R
S
S
G
V
Y
S
Y
K
V
L
Y
F
E
N
D
H
E
K
T
FRA
P
K
A
Y
P
E
Q
S
M
A
V
A
A
T
--
H
D
L
P
T
L
R
G
Y
W
E
C
G
D
L
T
L
G
K
T
L
GLYPD
E
V
V
L
R
G
L
Y
Q
D
R
E
L
A
K
Q
G
L
L
D
A
L
H
K
Y
GCLPKRAGHKASLMSMT
P
T
L
N
R
G
L
Q
R
Y
I
A
D
SNSA
L
L
G
L
Q
P
E
D
W
L
DMAEPVNIPGTSYQYKNWRRKLSAT
L
E
S
M
F
A
D
D
G
V
N
K
L
L
K
D
L
D
R
R
R
R
S
AH
21
PsiBlast_CBE
60.14
33%
-107
- C4 -
4K5Y
2
CRFR1_HUMAN
C:
[285-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
I
C
I
G
W
G
V
-
P
F
P
I
I
-
V
A
W
A
I
G
-
K
L
Y
Y
---
D
N
E
K
---
C
W
---
A
G
K
R
P
---
G
V
----------
Y
T
-----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
-------
L
F
N
I
V
R
I
L
M
T
K
L
R
A
----------
S
T
-----
T
S
E
T
I
Q
---
A
R
K
A
V
K
A
T
L
V
L
--------
L
P
L
L
G
I
-
T
Y
M
------
L
A
F
V
N
PGE
D
E
V
S
R
---
V
-----
V
F
I
Y
F
N
A
F
L
E
-----------
S
F
Q
G
F
F
V
--------
S
V
F
A
C
F
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
58.99
15%
-133
- C4 -
2KS9
1
NK1R_HUMAN
A:
[35-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
----
A
-
A
Y
T
--------
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
----
I
I
L
A
H
K
R
M
R
T
---------------
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
-
F
T
-
Y
A
V
H
N
E
--
W
-----------------
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
---
A
A
-
V
---------
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
LS--
A
T
A
T
K
V
V
I
C
V
I
W
V
L
-
A
L
L
L
A
-
F
P
Q
G
Y
Y
-
S
T
T
E
TMP
S
R
V
V
---
C
M
---
I
-
E
W
P
EHP
N
K
IY
E
K
------
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-------
G
I
T
----
L
W
A
S
E
I
P
----------
G
D
SSDRY
H
E
Q
V
S
A
---
K
R
K
V
V
K
M
M
I
V
V
--------
V
C
T
F
A
I
C
W
L
P
------
F
H
I
F
F
---
L
L
P
Y
I
N--
P
DLYLK
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
-------
A
M
S
S
T
M
Y
N
--------
P
I
I
Y
C
C
L
N
D
-----------
R
F
R
L
G
F
K
H
A
F
R
C
---
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
---
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
--------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.11
46%
-44
- C5 -
4LF3
-
GLR_HUMAN
C:
[6-94]
------------------------------------------------
E
K
W
K
L
Y
S
D
Q
C
---
H
H
N
L
S
L
L
P
-
P
P
-
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
D
T
P
A
N
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
K
V
Q
H
R
F
V
F
K
R
C
G
-----
P
D
G
Q
W
V
R
G
P
R
G
Q
-
P
W
R
D
A
S
Q
C
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.59
41%
-45
- C5 -
2QKH
1
GIPR_HUMAN
A:
[31-119]
---------------------------------------------
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
---
Q
E
T
L
A
A
A
E
-
P
P
-
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
A
A
G
F
V
L
R
Q
C
G
-----
S
D
G
Q
W
G
L
-------
W
R
D
H
T
Q
C
E
N
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.36
46%
-51
- C5 -
4ERS
2
GLR_HUMAN
A:
[7-95]
------------------------------------------------
E
K
W
K
L
Y
G
D
Q
C
---
H
H
N
L
S
L
L
P
-
P
P
-
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
D
T
P
A
N
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
K
V
Q
H
R
F
V
F
K
R
C
G
-----
P
D
G
Q
W
V
R
G
P
R
G
Q
-
P
W
R
D
A
S
Q
C
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
57.07
18%
-84
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
---
Q
L
T
M
S
P
E
V
-
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
---
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
----
I
-
G
R
N
--------
S
N
G
V
I
T
-----
K
D
E
A
----
E
K
L
F
N
Q
D
V
D
A
---------------
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
-
A
L
-
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
-----
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
SRW
Y
N
-
Q
---------
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
W
D
A
Y
D
R
L
R
A
----
W
----
M
F
I
C
I
G
W
G
V
-
P
F
P
I
I
-
V
A
W
A
I
G
-
K
L
Y
Y
---
D
N
E
K
---
C
W
---
A
G
K
R
P
---
G
V
----------
Y
T
-----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
-------
L
F
N
I
V
R
I
L
M
T
K
L
R
A
----------
S
T
-----
T
S
E
T
I
Q
---
A
R
K
A
V
K
A
T
L
V
L
--------
L
P
L
L
G
I
-
T
Y
M
------
L
A
F
V
N
---
E
-------------
V
S
R
V
V
F
I
Y
F
N
A
F
L
-------
E
S
F
Q
G
F
F
V
--------
S
V
F
A
C
F
L
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
56.79
39%
-47
- C5 -
2QKH
1
GIPR_HUMAN
A:
[26-119]
----------------------------------------
G
Q
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
---
Q
E
T
L
A
A
-
A
-
E
P
P
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
A
A
G
F
V
L
R
Q
C
G
-----
S
D
G
Q
W
G
L
-------
W
R
D
H
T
Q
C
E
N
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.14
41%
-32
- C5 -
4HJ0
-
GIPR_HUMAN
A:
[32-120]
---------------------------------------------
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
---
Q
E
T
L
A
A
A
E
-
P
P
-
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
A
A
G
F
V
L
R
Q
C
G
-----
S
D
G
Q
W
G
L
-------
W
R
D
H
T
Q
C
E
N
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.71
36%
-29
- C5 -
3H3G
1
A:
[454-516]
-----------------------------------------------------------------------------
C
L
P
E
W
D
H
I
L
C
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
I
--
Y
D
F
N
H
K
G
H
A
Y
R
R
C
D
-----
R
N
G
S
W
E
L
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
53.64
11%
-77
* C3 *
4JKV
10
C562_ECOLX (first)
A:
[2-470]
--------GTAD
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
-
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
LED
K
S
P
D
S
P
E
M
-
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
Q
-----
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
----
Y
-
I
A
A
--------
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
----
F
V
A
D
W
R
N
S
N
R
---------------
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
-
M
D
G
A
R
R
E
I
V
--
C
R
A
D
G
T
M
R
L
G
E
P
-----
T
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
---
Y
A
L
M
---------
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
Q
----
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
-
P
F
V
L
T
-
V
A
I
L
A
V
-
A
Q
V
D
---
G
D
S
V
SG
I
C
F
V
GY
K
-
N
Y
R
---
Y
R
----------
A
G
-----
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
-------
R
G
V
M
T
L
F
S
I
K
S
N
H
P
----------
G
L
-----
L
------------
S
E
K
A
A
S
K
--------
I
N
E
T
M
L
R
L
G
I
------
F
G
F
L
A
---
F
G
F
V
L
---
I
-----
T
F
S
C
H
-
F
Y
D
F
F
N
Q
-------
A
E
W
E
R
S
F
R
--------
D
Y
V
L
C
Q
A
N
C
-----------
E
I
K
--------------------
N
R
P
S
L
L
V
---
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C--------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.16
36%
-30
- C5 -
3C4M
2
MALE_ECOLI (first)
A:
[454-516]
-----------------------------------------------------------------------------
C
L
P
E
W
D
H
I
L
C
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
I
--
Y
D
F
N
H
K
G
H
A
Y
R
R
C
D
-----
R
N
G
S
W
E
L
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.06
36%
-27
- C5 -
3L2J
-
MALE_ECOLI (first)
A:
[450-512]
-----------------------------------------------------------------------------
C
L
P
E
W
D
H
I
L
C
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
I
--
Y
D
F
N
H
K
G
H
A
Y
R
R
C
D
-----
R
N
G
S
W
E
L
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
T
N
E
T
R
E
R
E
V
F
D
R
L
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
53.00
11%
-138
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
----
I
-
F
I
G
--------
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
----
L
F
T
K
T
K
S
L
Q
T
---------------
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
-
S
C
F
L
K
K
--
W
-----------------
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
---
I
F
-
G
---------
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
-
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
---
C
S
---
F
-
D
Y
I
---
S
R
D
S
T
T
R
S
N
I
L
C
M
F
-----
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-------
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
-----
Q
A
G
A
N
A
---
E
M
R
L
A
K
I
S
I
V
I
--------
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
V
A
---
L
L
A
Q
F
GPL
E
-----
W
V
T
P
Y
A
A
Q
L
P
V
M
F
-------
A
K
A
S
A
I
H
N
--------
P
M
I
Y
S
V
S
H
P
-----------
K
F
R
E
A
I
S
Q
T
F
P
W
---
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
---
K
D
A
E
T
E
I
P
A
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
52.30
27%
-36
- C5 -
3N7S
1
CALRL_HUMAN
A:
[14-109]
-----------------------------------------
I
Q
L
G
V
T
R
N
K
I
M
T
A
Q
Y
E
C
---
Y
Q
K
I
M
Q
D
P
I---
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
K
V
T
K
I
C
D
-----
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
52.14
36%
-19
- C5 -
3C4M
2
B:
[454-516]
-----------------------------------------------------------------------------
C
L
P
E
W
D
H
I
L
C
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
I
--
Y
D
F
N
H
K
G
H
A
Y
R
R
C
D
-----
R
N
G
S
W
E
L
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------