@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GLP2R_HUMAN: (2016-01-09 )
MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------.........10.......-----.-------------20----......---...30........---40...--..-...50........60........70..----...----...80......--.--.--90----------.---........100.......110.-..--....120....-...130...-....140......-.150.......160--........170.......180.......190.......200.......210.......220.......230.......240.-------....---..250--------....-----...-260-----.....-.---..270...--....280-------------........290-.-----....----.----.--.-.300...---.-----.------------..310.---...--------------------...------320-.------.---.----...---.330---..--.-------.--.------.----.-----340--....----.....350------.......360----.--........370.------.-------------------.--......380.....-----..390.....-..400..--.....---410----------.---......-------..420.......430...-----....----..440.--......450--........460......---.470.......---..480.......--490.......500..---.....----510.......---------------520..-..--...530.--......--540.......550.------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------MKLGSSRAGPGRGSAGLL-----P-------------
G
-----
V
H
ELPM---GIPAPWGTSP
L
S
F
---HRKCS--LW-APG
R
P
F
L
T
L
V
L
L
V
S
I
K
Q
V
T
G
S
L
L
E
E
T
T
----
R
K
W
----
A
Q
Y
K
Q
A
C
L
R
D
L
--L--K--E-----------P---S
G
I
F
CNGTFDQ
Y
V
CWPHSSPGN-VS--VPCPSYLPWWS-EESS
G
R
A
Y
R
-
H
C
L
AQG
T
W
Q
T
I
E
N
-
A
T
D
IWQDDSECSE---NH
S
F
K
Q
N
V
D
R
Y
A
L
L
S
T
L
Q
L
M
Y
TVGY
S
F
S
L
I
S
L
F
L
A
L
T
L
L
L
F
L
R
K
L
H
CTR
N
Y
I
H
M
N
L
F
A
S
F
I
L
R
T
L
A
V
L
V
K
D
V
V
F
YNSYSKRP-------DNE
N
---
G
W
M
S
Y
--------
L
S
E
M
-----
S
T
S
-
C
R
------
S
V
Q
V
L
-
L
---
H
Y
F
VG
A
N
Y
--
L
W
L
L
V
E
--------------
G
L
Y
L
H
T
LLE---P-----TVLP----E----R--R-L
W
P
R
Y
L
L
---
L
-----
G
------------WA
F
P
V
L
---
F
V
V--------------------PW
G
------
F
A
R
-
A
------H---L----ENT---G
C
W
T---TN--G-------N--
K
------
K
----
I
-----
W
----
W
I
IR----G
P
M
M
L
C
V
T
------
V
N
F
F
I
F
L
K
------
I
--
L
K
L
L
I
S
K
L
K
--
A
------
H
-------------------
Q
--
M
C
F
R
D
Y
K
Y
R
LAK
S
T
-----
L
V
L
I
P
L
L
G
V
H
-
E
I
L
F
S
F
I--T
D
D
Q
V
---
E
------------
G
---
F
A
K
L
I
R
-------
L
F
I
Q
L
T
L
S
S
F
H
G
F
--
L
V
A
-----
L
Q
YG----FAN
G
E
V
--
K
A
E
L
R
K
Y
W
---
V
R
F
L
L
A
RHSG
C
R
A
C
VLG---K
D
--
F
R
F
L
G
K
C
---
P
K
K
LSEG
D
G
A
E
K
--
L
R
K
LQPSLNS
G
R
L
L
H
---
L
A
M
R
G
----
L
G
ELGAQP
Q
Q
---------------
D
HARW-PR--GSS
L
S
EC--SEGDV
T
--
M
A
N
T
M
E
E
I
L
E
ESEI------------------------------------------------
1
PsiBlast_PDB
84.89
51%
-144
- C4 -
4L6R
1
C562_ECOLX (first)
A:
[121-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
S
S
F
Q
V
M
Y
T
V
G
Y
S
L
S
L
G
A
L
L
L
A
L
A
I
L
G
G
L
S
K
L
H
C
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
L
V
I
D
G
L
L
R
T
---------------------------------
L
S
D
G
-----
A
V
A
G
C
R
------
V
A
A
V
F
-
M
---
Q
Y
G
I
V
A
N
Y
--
C
W
L
L
V
E
--------------
G
L
Y
L
H
N
L
L
G
---
L
-----
A
T
L
P
----
E
----
R
--
S
-
F
F
S
L
Y
L
G
---
I
-----
G
------------
W
G
A
P
M
L
---
F
V
V
--------------------
P
W
A
------
V
V
K
-
C
------
L
---
F
----
E
N
V
---
Q
C
W
T
---
S
N
--
D
-------
N
--
M
------
G
----
F
-----
W
----
W
I
L
R
----
F
P
V
F
L
A
I
L
------
I
N
F
F
I
F
V
R
------
I
--
V
Q
L
L
V
A
K
L
R
--
A
------
R
-------------------
Q
--
M
H
H
T
D
Y
K
F
R
L
A
K
S
T
-----
L
T
L
I
P
L
L
G
V
H
-
E
V
V
F
A
F
V
--
T
D
E
H
A
---
Q
------------
G
---
T
L
R
S
A
K
-------
L
F
F
D
L
F
L
S
S
F
Q
G
L
--
L
V
A
-----
V
L
Y
C
----
F
L
N
K
E
V
--
Q
S
E
L
R
R
R
W
---
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
75.47
18%
-93
- C3 -
4S3Q
7
?
A:
[2-691]
-----------------------------ES
K
R
L
D
N
A
A
L
A
A
GISP
N
Y
I
N
AHG
K
P
Q
S
I
S
A
E
T
K
R
R
L
L
D
A
MHQTPVPN
V
M
V
Y
T
S
G
K
K
M
P
M
V
V
E
G
S
G
E
Y
S
W
L
L
T
-----
T
EEG
T
Q
Y
K
G
H
V
T
GG
K
-----
A
F
N
L
P
T
---
K
L
P
E
G
Y
H
T
L
T
L
T
Q
DD
Q
R
A
H
C
R
--
V
I
-
V
A
P
K
R
C
Y
E
P
Q
A
L
L
N
K
Q
K
L
W
G
A
C
V
Q
L
Y
T
LRSE
K
N
W
GIGD
F
G
D
L
K
A
M
L
V
D
V
--
A
--
K
--
R
-----------
G
---
G
S
F
I
G
L
N
P
I
--
H
A
L
Y
P
-
A
N
P
E
S
-
A
S
--
P
Y
S
P
S
S
R
R
W
L
N
------
V
I
Y
I
-
D
V
N
A
V
E
D
F
H
L
S
E
E
-
A
Q
A
W
W
Q
L
P
T
T
Q
Q
T
---
L
Q
Q
A
R
D
A
--
D
W
V
D
Y
S
T
V
T
A
L
K
M
T
A
L
R
M
A
W
K
G
F
A
--------------
Q
R
D
D
E
Q
M
A
A
F
R
Q
F
V
A
E
Q
G
D
S
L
F
W
Q
A
A
F
D
A
L
H
A
Q
Q
V
-------
K
E
D
E
MRW
G
W
P
A
W
P
E
M
Y
Q
N
V
D
S
P
E
V
-----
R
Q
F
-
C
E
E
H
R
D
D
V
D
F
Y
L
W
-
L
---
Q
W
L
A
Y
S
Q
F
A
A
C
W
E
I
S
Q
G
Y
EMPI--------
G
L
Y
R
D
L
A
V
G
---
V
AEGG
A
E
T
W
C
----
D
----
R
--
E
-
L
Y
C
L
K
A
S
---
V
-----
G
A
P
PDILGPLGQN
W
G
L
P
P
M
D
P
H
I
I
T
--------------------
A
R
A
Y
E
P
F
I
E
L
L
R
-
A
------
N
---
M
----
Q
N
C
---
G
A
L
R
I
D
H
V
M
--
S
-------
M
--
L
------
R
----
L
-----
W
----
W
I
P
Y
----
G
E
T
A
D
Q
G
A
------
Y
V
H
Y
P
V
D
D
------
L
--
L
S
I
L
A
L
E
S
K
--
R
------
H
-------------------
R
C
-
M
V
I
G
E
D
L
G
T
V
P
V
E
I
-----
V
G
K
L
R
S
S
G
V
Y
-
S
Y
K
V
L
Y
F
--
E
N
D
H
E
---
K
------------
T
---
F
R
A
P
K
A
YPEQ
S
M
A
V
A
A
T
H
D
L
P
T
L
R
G
Y
W
E
C
G
D
-----
L
T
L
G
----
K
T
L
G
L
Y
PD
E
V
V
L
R
G
L
Y
---
Q
D
R
E
L
A
K
Q
G
L
L
D
A
L
H
K
-----------
Y
G
C
L
---
P
K
R
A
G
H
K
---
A
S
--
L
M
S
M
T
P
T
L
N
R
G
L
Q
R
Y
---
I
A
D
S
N
----
S
A
L
L
G
L
Q
P
E
D
W
L
DMAEPVNIPGTSY
Q
Y
K
N
W
-
R
R
KL
S
A
T
L
E
S
M
F
A
D
D
G
V
N
K
--
L
L
K
D
L
D
R
R
R
R
S
A
H
-------------------------------------------------
57
Fugue
72.72
19%
-76
- C2 -
4PO6
4
TYK2_HUMAN
A:
[6-546]
---------------------------------------------------------------------------------G
G
L
K
V
L
L
H
W
A
G
P
G
G
G
E
P
W
V
T
F
SESS
L
-------------
T
-----
A
E
E
V
C
I
---
H
I
A
H
K
V
G
I
T
P
P
C
F
---
N
L
-
F
A
--
L
F
D
A
Q
A
Q
V
W
L
P
P
N
H
I
L
E
I
P
R
D
A
S
L
M
L
Y
F
R
I
----
R
F
Y
------------------------------------------
F
R
N
--------
W
H
G
M
N
P
R
E
-
P
A
--
V
Y
R
C
G
P
P
G
Q
G
M
-
Q
L
L
D
P
A
S
F
E
-
Y
L
F
E
Q
G
K
H
E
F
V
N
D
-
V
A
S
L
W
E
L
S
T
E
-
E
E
---
I
H
H
F
K
N
E
S
L
G
M
A
F
L
H
L
C
H
L
A
L
R
H
G
I
P
L
E
E
V
A
K
K
---------------------
T
S
F
K
D
C
I
P
R
S
F
R
R
H
I
R
Q
----
H
S
A
L
T
R
L
-------
R
L
R
N
---
V
F
R
R
F
--------
L
R
D
F
-----
Q
P
G
-
R
L
------
S
Q
Q
M
V
-
M
---
V
K
Y
L
A
T
L
E
--
R
L
A
P
R
F
--------------
G
T
E
R
V
P
V
C
H
---
L
-----
R
L
L
A
----
Q
----
A
--
E
-
G
E
P
C
Y
I
------------------------------------------------------------------
R
-
D
------
A
---
G
----
P
P
T
---
H
E
V
L
---
V
T
--
G
-------
T
--
G
------
G
----
I
-----
Q
----
W
W
P
V
----
E
P
L
-------------
W
A
Y
F
C
D
----------------------------------------------------
F
R
D
I
T
H
V
V
L
K
E
H
-----
C
V
S
I
H
R
Q
D
N
K
-
C
L
E
L
S
L
P
--
S
R
A
A
A
---
L
------------
S
---
F
V
S
L
V
D
-------
G
Y
F
R
L
T
A
D
S
S
H
Y
L
--
C
H
E
VAP
P
R
L
V
M
S
----
I
R
D
G
-
I
--
H
G
P
L
L
E
P
F
---
V
Q
A
K
L
R
P
E
D
G
L
Y
L
I
H
W
S
---
T
S
HP
Y
R
L
I
L
T
V
---
A
Q
R
S
Q
A
P
D
G
M
Q
S
--
L
R
L
R
K
F
P
I
E
Q
A
F
V
L
E
GWG
R
S
F
P
S
----
V
R
E
L
G
A
A
L
Q
G
---------------
C
L
L
R
A
G
D
D
--
C
F
S
L
R
R
C
--
C
L
P
Q
P
G
--
E
T
S
N
L
--
I
I
M
R
G
--------------------------------------------------
58
Fugue
61.81
17%
-79
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
--------------------------------------------------------------------------------H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
-----
V
-------------
A
-----
F
V
L
F
L
R
--------------
A
R
---
S
I
R
C
----------------
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
----
A
T
W
----
F
V
V
Q
L
T
M
S
P
E
V
--
H
--
Q
--
S
------------------------
N
V
G
W
C
R
L
V
T
A
A
Y
N
-
Y
F
--
H
V
T
N
F
F
W
M
F
G
E
-
G
C
Y
L
H
T
A
I
V
-
L
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
IGI
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
G
-
R
N
S
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
E
-------
T
G
V
A
---
G
F
T
N
S
--------
L
R
M
L
Q
Q
KR
W
D
E
A
-
A
V
------
N
L
A
K
S
-
R
---
W
Y
N
Q
T
P
N
R
--
A
K
R
V
I
A
--------------
T
F
R
T
G
T
W
-----------
D
A
Y
D
----
R
----
L
--
R
-
A
W
-
M
F
I
C
---
I
-----
G
------------
W
G
V
P
F
P
---
I
I
V
--------------------
A
W
A
------
I
G
K
-
L
------
Y
---
Y
----
D
N
E
---
K
C
W
A
G--
K
R
--
P
-------
G
--
V
------
Y
----
T
-----
D
----
Y
I
Y
Q
----
G
P
M
A
L
V
L
L
------
I
N
F
I
F
L
F
N
------
I
--
V
R
I
L
M
T
K
L
R
--
A
------
S
-------------------
T
--
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
-----
L
V
L
L
P
L
L
G
I
T
-
Y
M
L
A
F
--------
V
---
N
------------
E
---
V
S
R
V
V
F
-------
I
Y
F
N
A
F
L
E
S
F
Q
G
F
--
F
V
S
-----
V
F
A
C
----
F
L
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.33
42%
-28
- C5 -
3C5T
2
GLP1R_HUMAN
A:
[9-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
E
T
V
----
Q
K
W
----
R
E
Y
R
R
Q
C
Q
R
S
L
--
T
--
E
--
D
-----------
P
PPA
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
--
V
S
C
P
W
Y
L
P
W
A
S
-
S
V
P
Q
G
H
V
Y
R
-
F
C
T
A
E
G
L
W
L
Q
K
D
N
-
S
S
L
P
W
R
D
L
S
E
C
E
E
---
S
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
54.27
42%
-26
- C5 -
3C59
1
GLP1R_HUMAN
A:
[9-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
E
T
V
----
Q
K
W
----
R
E
Y
R
R
Q
C
Q
R
S
L
--
T
--
E
--
D
-----------
P
PPA
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
--
V
S
C
P
W
Y
L
P
W
A
S
-
S
V
P
Q
G
H
V
Y
R
-
F
C
T
A
E
G
L
W
L
Q
K
D
N
-
S
S
L
P
W
R
D
L
S
E
C
E
E
---
S
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
53.49
36%
-20
- C5 -
2QKH
1
GIPR_HUMAN
A:
[28-119]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
G
E
L
Y
----
Q
R
W
----
E
R
Y
R
R
E
C
Q
E
T
L
--
A
--
A
AE
P
-----------
P
---
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
T
A
R
--
A
S
C
P
W
Y
L
P
W
H
H
-
H
V
A
A
G
F
V
L
R
-
Q
C
G
S
D
G
Q
W
G
L
--------
W
R
D
H
T
Q
C
E
N
---
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
53.26
12%
-124
- C4 -
2KS9
1
NK1R_HUMAN
A:
[37-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
-----------------
E
------------
W
Y
Y
G
-----
L
F
Y
-
C
K
------
F
H
N
F
F
-
P
---
I
A
A
V
F
A
S
I
--
Y
S
M
T
A
V
--------------
A
F
D
R
Y
M
A
I
I
---
H
-----
P
L
Q
P
----
R
LS--
A
--
T
-
A
T
K
V
V
I
C
---
V
-----
I
------------
W
V
L
A
L
L
---
L
A
F
--------------------
P
Q
G
------
Y
Y
S
-
T
------
T
ETM
P
----
S
R
V
---
V
C
M
I
EWP
E
H
--
P
-------
N
--
K
IY
E
K
V
-
Y
H
I
C
V
T
-----
V
----
L
I
Y
F
----
L
P
L
L
V
I
G
Y
------
A
Y
T
V
V
G
I
T
------
L
--
W
A
S
E
I
P
G
D
S
--
S
D-----
R
-------------------
Y
--
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
-----
I
V
V
V
C
T
F
A
I
C
-
W
L
P
F
H
I
F
--
F
L
L
P
Y
---
I
NPD---------
L
YLK
K
F
I
Q
Q
V
-------
Y
L
A
I
M
W
L
A
M
S
S
T
M
--
Y
N
P
-----
I
I
Y
C
----
C
L
N
D
R
F
--
R
L
G
F
K
H
A
F
---
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
---
S
T
--
R
Y
L
Q
T
Q
G
---
S
V
Y
K
V
S
R
L
E
T
T
I
--
S
T
V
V
G
A
---------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
52.45
10%
-123
- C4 -
2Z73
5
OPSD_TODPA
A:
[36-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
-
F
L
K
--------------------
K
--------
W
I
F
G
-----
F
A
A
-
C
K
------
V
Y
G
F
I
-
G
---
G
I
F
G
F
M
S
I
--
M
T
M
A
M
I
--------------
S
I
D
R
Y
N
V
I
G
---
R
-----
P
M
A
A
S
K
K
M
S
----
H
--
R
-
R
A
F
I
M
I
I
---
F
-----
V
------------
W
L
W
S
V
L
---
W
A
I
--------------------
G
P
I
------
F
G
W
-
G
A
-----
Y
T
L
E
G
----
V
L
C
---
N
C
S
F
---
D
Y
--
I
-------
S
--
R
D
S
T
T
R
S
N
I
L
C
M
F
-----
I
----
L
G
F
F
----
G
P
I
L
I
I
F
F
------
C
Y
F
N
I
V
M
S
------
V
--
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
-----------------
A
--
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
-----
I
V
I
V
S
Q
F
L
L
S
-
W
S
P
Y
A
V
V
--
A
L
L
A
Q
---
F
GPL---------
E
---
W
V
T
P
Y
A
-------
A
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
-----
M
I
Y
S
----
V
S
H
P
K
F
--
R
E
A
I
S
Q
T
F
---
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
---
K
D
--
A
E
T
E
I
P
A
---
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.32
31%
-19
- C5 -
2QKH
1
GIPR_HUMAN
A:
[26-119]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
T
A
G
E
L
Y
----
Q
R
W
----
E
R
Y
R
R
E
C
Q
E
T
L
--
A
A
A
E
--
P
-----------
P
---
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
-
T
A
R
-
A
S
C
P
W
Y
L
P
W
H
H
-
H
V
A
A
G
F
V
L
R
-
Q
C
G
S
D
G
Q
W
--------
G
L
W
R
D
H
T
Q
C
E
N
---
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.95
42%
-36
- C5 -
3IOL
1
GLP1R_HUMAN
A:
[13-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
E
T
V
----
Q
K
W
----
R
E
Y
R
R
Q
C
Q
R
S
L
--
T
--
E
--
D
-----------
P
PPA
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
D
G
E
P
G
S
F
V
N
--
V
S
C
P
W
Y
L
P
W
A
S
-
S
V
P
Q
G
H
V
Y
R
-
F
C
T
A
E
G
L
W
L
Q
K
D
N
-
S
S
L
P
W
R
D
L
S
E
C
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
50.70
13%
-70
* C6 *
2PGG
-
RDRP_IBDV
A:
[31-804]
LLIP
K
V
W
V
P
P
EDPLAS
P
S
R
L
A
K
F
L
R
E
N
G
Y
K
V
L
Q
P
R
S
L
P
E
N
E
E
Y
E
T
D
Q
I
L
PDL
A
W
M
R
Q
I
EGAVLKP
T
L
S
L
PIGD
Q
E
Y
F
P
K
Y
Y
P
T
H
R
P
S
K
E
K
P
N
A
Y
P
P
D
I
A
L
L
-----
K
-------------
Q
-----
M
I
Y
L
F
L
Q
VP
E
A
N
E
G
L
K
D
E
V
T
L
L
---
T
Q
N
I
R
D
K
A
Y
-
G
S
G
T
Y
M
G
Q
A
T
R
L
V
A
M
K
E
V
A
T
G
R
N
P
N
K
D
----
P
L
K
----
L
G
Y
T
F
E
S
I
A
Q
L
--
L
--
D
--
I
T
L
P
V
G
P
P
GEDD
K
---
P
W
V
P
L
T
R
V
P
S
R
M
L
V
L
T
--
G
D
V
D
-
G
D
--
F
E
V
E
D
Y
L
P
K
I
N
L
K
S
S
S
G
L
P
Y
V
G
R
T
K
G
E
T
I
G
E
M
I
A
I
-
S
N
Q
F
L
R
E
L
S
T
L
L
K
---
Q
G
A
G
T
K
G
S
N
K
K
K
L
L
S
M
L
S
D
Y
W
Y
L
S
C
G
L
-
L
F
P
K
A
E
R
Y
D
K
S
T
W
L
T
K
---
T
R
N
I
W
S
A
P
S
P
T
H
L
M
I
S
M
I
T
W
P
V
M
S
N
S
P
N
N
V
L
N
I
E
G
CPSLYKF
N
P
F
R
---
G
G
L
N
R
--------
I
V
E
W
-----
I
L
A
-
P
E
------
E
P
K
A
L
-
V
Y
AD
N
I
Y
I
V
H
S
N
--
T
W
Y
S
I
D
LEKGEANCT
R
Q
H
M
Q
A
A
M
Y
Y
I
L
T
R
---
G
W----
S
D
N
G
----
D
----
P
--
M
-
F
N
Q
T
W
A
T
---
F
-----
A
------------
M
N
I
A
P
A
---
L
V
V
D
S
S
C
L
I
MNLQ
I
K
T
Y
G
QGSGN
A
A
T
------
F
I
N
-
N
------
H
---
L
----
L
S
T
L
V
L
D
Q
W
N
---
L
M
--
R
-------
Q
--
P
------
R
----
P
-----
D
----
S
E
E
F
----
K
S
I
E
D
K
L
G
------
I
N
F
K
I
E
R
S
------
I
D
D
I
R
G
K
L
R
Q
L
V
--
L
------
L
AQPGYLSGGVEPEQSSPTV
E
--
L
D
L
L
G
W
S
A
T
Y
S
K
D
L
-----
G
I
Y
V
P
V
L
D
K
E
-
R
L
F
C
S
A
A
Y
P
K
G
V
G
I
---
E
------------
Q
---
A
Y
K
V
V
R
-------
Y
E
A
L
R
L
V
G
G
W
N
Y
P
--
L
L
N
-----
K
A
C
K
----
N
N
A
G
A
A
--
R
R
H
L
E
A
K
G
---
F
P
L
D
E
F
L
A
E
W
S
E
L
S
E
F
G
---
E
A
--
F
E
G
F
N
-----
I
K
L
T
V
T
S
E
S
L
A
E
--
L
N
K
P
V
P
P
K
P
P
N
V
N
R
P
---
V
N
T
G
G
----
L
K
A
V
S
N
A
L
K
T
---------------
G
R
Y
R
N
-
E
A
--
G
L
S
G
L
V
L
--
L
A
T
A
R
S
--
R
L
Q
D
A
V
K
A
K
A
E
A
E
K
L
H
K
SKPDDPDAD
W
F
E
R
S
E
T
L
S
D
L
L
E
K
A
DIASKVAHS
A
L
V
E
T
S
D
A
L
E
AV
56
Fugue
50.69
21%
-94
- C1 -
4K7J
4
?
A:
[26-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
T
D
--------
Y
G
N
A
-----
S
A
S
--
P
------
W
M
K
K
L
-
Q
---
S
V
A
Q
G
S
G
E
--
T
F
R
I
L
Q
--------------
I
G
D
S
H
T
A
G
D
---
F
-----
F
T
D
S
----
L
----
R
--
K
-
R
L
Q
K
T
W
G
DGG
I
-----
G
------------
W
V
Y
P
A
N
---
V
K
G
--------------------
Q
R
M
------
A
A
V
-
R
------
H
---
N
----
G
N
W
---
Q
S
L
T
---
S
R
--
N
-------
N
--
T
------
G
----
D
-----
F
PLGG
I
L
A
H
TGSG
G
S
M
T
L
T
A
S
DGIASK
Q
R
V
S
L
F
A
K
PLLAE
Q
T
--
L
T
V
N
G
N
T
V
S
--
A
------
N
GG
G
W
---------------
Q
--
V
L
D
T
G
A
A
L
P
L
T
I
H
T
E
M
P
W
D
I
G
F
I
N
I
E
N
P
A
G
G
I
T
V
S
A
M
GI
N
G
A
Q
L
---
T
------------
Q
---
W
S
K
W
-
R
-------
A
D
R
M
N
D
L
A
Q
T
G
A
D
--
L
V
I
-----
L
S
Y
G
T
N
E
A
F
N
N
N
I
D
--
I
A
D
T
E
Q
K
W
L
D
T
V
R
Q
I
R
D
S
L
P
A
A
G
I
L
I
I
G
A
PE
S
L
--
K
N
T
L
G
V
C
GTR
P
V
R
L
T
E
V
Q
Q
M
Q
R
R
V
A
R
Q
G
Q
T
M
F
W
S
---
W
Q
---
N
A
M
G
G
----
I
C
S
M
K
N
W
L
N
Q
---------------
G
W
A
A
--
K
D
--
G
V
H
F
S
A
K
--
G
Y
R
R
A
A
E
M
L
A
D
S
L
E
E
L
V
R
S
A
--------------------------------------------------
60
Fugue
50.65
10%
-74
- C6 -
3MMP
1
RDRP_BPQBE
F:
[7-573]
-------------------------------------------------------------------------------------
S
R
N
S
L
S
A
Q
L
R
R
A
A
N
T
R
-----
I
-------------
E
VEGNL
A
L
S
I
A
N
---
D
L
L
L
A
Y
G
Q
S
P
F
N
S
---
E
A
E
C
I
--
S
F
-
S
P
R
F
D
G
T
P
D
D
F
R
I
N
Y
L
K
A
E
I
M
S
K
Y
D
D
F
----
S
L
G
----
I
D
T
E
A
V
A
W
E
K
F
--
L
--
A
--
A
-----------
E
---
A
E
--
C
A
L
T
N
A
R
L
--
Y
R
P
F
N
F
S
L
-
G
E
--
S
C
I
H
M
A
R
R
K
I
A
-
K
L
I
G
D
V
P
S
V
-
E
G
M
L
R
H
C
R
F
S
G
G
A
-
T
T
T
N
N
R
S
Y
G
H
P
S
F
---
K
F
A
L
P
Q
A
C
T
P
R
A
L
K
Y
V
L
A
L
R
A
S
T
H
F
D
T
R
I
S
D
I
S
P
F
N
K
A
V
T
V
P
K
N
S
K
T
D
R
C
I
A
I
E
P
G
W
N
M
F
F
Q
L
G
I
G
G
I
L
R
D
R
L
R
C
W
G
I
D
L
N
D
-------
Q
T
I
N
---
Q
R
R
A
H
--------
E
G
S
V
-----
T
N
N
-
L
A
------
T
V
D
L
S
A
A
---
S
D
S
I
S
L
A
L
--
C
E
L
L
L
P
--------------
P
G
W
F
E
V
L
M
D
LRS
P
-----
K
G
R
L
----
P
----
D
--
G
-
S
V
V
T
Y
E
K
---
I
SSMGN
G
------------
Y
T
F
E
L
E
---
S
L
I
--------------------
F
A
S
------
L
A
R
-
S
------
V
---
C
----
E
I
L
---
D
L
D
S
---
S
E
------------------------------------
V
T
V
Y
----
G
D
D
I
I
L
P
S
------
C
A
V
P
A
L
R
E
------
V
--
F
K
Y
V
G
F
T
T
N
--
T
------
K
-------------------
K
--
T
-
F
S
E
G
P
F
R
E
S
C
G
K
-----
H
Y
Y
S
G
V
D
------
V
T
P
F
Y
--
I
R
H
R
I
---
V
------------
S
---
P
A
D
L
I
L
-------
V
L
N
N
L
Y
R
W
A
T
I
D
G
--
V
W
D
-----
P
R
A
H
----
S
V
Y
L
K
Y
--
R
K
L
L
P
K
Q
L
---
Q
R
N
T
I
P
D
G
Y
G
D
G
A
L
V
G
S
---
V
L
--
I
N
P
F
A
K
N
---
R
G
W
I
R
Y
V
P
V
I
T
D
--
H
T
R
D
R
E
R
A
E
L
G
S
Y
L
Y
---
D
L
F
S
R
CLSC
D
S
A
D
L
F
A
I
D
Q
---------------
L
I
C
R
S
-
N
P
--
T
K
I
S
R
S
T
--
G
K
F
D
I
Q
--
Y
I
A
C
S
S
R
V
L
A
----------------------------------------------------
48
HHSearch
50.23
15%
-118
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[44-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
I
W
A
A
S
K
---
V
N
-----------------
G
------------
W
I
F
G
-----
T
F
L
-
C
K
------
V
V
S
L
L
-
K
---
E
V
N
F
Y
S
G
I
--
L
L
L
A
C
I
--------------
S
V
D
R
Y
L
A
I
V
---
H
-----
A
T
R
T
----
L
----
T
Q
K
R
H
L
V
K
F
V
C
L
---
G
-----
C
------------
W
G
L
S
M
N
---
L
S
L
--------------------
P
F
F
------
L
F
R
-
Q
------
A
---
Y
HPNN
S
S
P
---
V
C
Y
E
---
V
L
GN
D
-------
T
A-
K
WRM---
V
----
L
RILPH
T
----
F
G
F
I
----
V
P
L
F
V
M
L
F
------
C
Y
G
F
----------
T
--
L
R
T
L
F
K
A
-------------------------------
H
-----
M
G
Q
K
H
R
A
M
R
V
I
-----
F
A
V
V
L
I
F
L
L
C
-
W
L
P
Y
N
L
V
--
L
L
A
D
T
---
L
M
RTQVIQE
S
C
E
R
R
---
N
N
I
G
R
A
-------
L
D
A
T
E
I
L
G
F
L
H
S
C
--
L
N
P
-----
I
I
Y
A
----
F
I
G
Q
N
F
--
R
H
G
F
L
K
I
L
---
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
48.60
34%
-16
- C5 -
4ERS
2
GLR_HUMAN
A:
[8-95]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
----
K
L
Y
G
D
Q
C
H
H
N
L
S
L
L
--
P
--
P
-----------
P
---
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
-
D
T
P
A
N
-
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
-
K
V
Q
H
R
F
V
F
K
-
R
C
G
P
D
G
Q
W
V
R
G
P
R
-
G
Q
P
-
W
R
D
A
S
Q
C
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.46
34%
-24
- C5 -
4LF3
-
GLR_HUMAN
C:
[7-94]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
----
K
L
Y
S
D
Q
C
H
H
N
L
S
L
L
--
P
--
P
-----------
P
---
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
-
D
T
P
A
N
-
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
-
K
V
Q
H
R
F
V
F
K
-
R
C
G
P
D
G
Q
W
V
R
G
P
R
-
G
Q
-
P
W
R
D
A
S
Q
C
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
47.39
9%
-109
- C4 -
1U19
14
OPSD_BOVIN
A:
[46-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
--
H
-------------
G
---
Y
------------
F
V
F
G
-----
P
T
G
-
C
N
------
L
E
G
F
F
-
A
---
T
L
G
G
E
I
A
L
--
W
S
L
V
V
L
--------------
A
I
E
R
Y
V
V
V
C
---
K
-----
P
M
S
N
----
F
R
F
G
-
E
--
N
-
H
A
I
M
G
V
A
---
F
-----
T
------------
W
V
M
A
L
A
---
C
A
A
--------------------
P
P
L
------
V
G
W
S
R
------
Y
I
P
E
G
----
M
Q
C
---
S
C
G
I
---
D
Y
--
Y
TPHEETN
N
E
-
S
------
F
----
V
-----
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
------
C
Y
G
Q
L
------------
V
F
T
V
K
E
A
A
A
--
Q
------
Q
-------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
-----
I
I
M
V
I
A
F
L
I
C
-
W
L
P
Y
A
G
V
--
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
F
G
P
I
F
-------
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
-----
V
I
Y
I
----
M
M
N
K
Q
F
--
R
N
C
M
V
T
T
L
---
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
---
K
T
--
E
T
S
Q
V
A
P
---
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
46.98
14%
-146
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[13-199]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
-----------------------------
W
S
L
G
-----
R
P
L
-
C
L
------
F
W
L
S
M
-
D
---
Y
V
A
S
T
A
S
I
--
F
S
V
F
I
L
--------------
C
I
D
R
Y
R
S
V
Q
---
Q
-----
P
L
R
Y
----
L
KYRT
K
--
T
-
R
A
S
A
T
I
L
---
G
-----
A
------------
W
F
L
S
F
L
---
W
V
I
--------------------
P
I
L
------
G
W
N
-
H
----------
R
----
R
E
D
---
K
C
E
T
---
D
F
--
Y
-------
D
--
V
T
W
F
K
V
M
T
----
A
-----
I
----
I
N
F
Y
----
L
P
T
L
L
M
L
W
------
F
Y
A
K
I
Y
K
A
------
V
--
R
Q
H
C
N
I
F
E
M
--
L
------
R
-------------------
I
--
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-----
Y
Y
T
I
G
I
G
H
L
L
-
T
K
S
P
S
L
N
--
A
A
K
S
E
---
L
------------
D
---
K
A
I
G
R
N
-------
T
N
G
V
I
T
K
D
E
A
E
K
L
--
F
N
Q
-----
D
V
D
A
----
A
V
R
G
I
L
--
R
N
A
K
L
K
P
V
---
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
---
Q
M
--
G
E
T
G
V
A
G
---
F
T
N
S
L
R
M
L
Q
Q
K
R
--
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
----
A
K
R
V
I
T
T
F
R
T
---------------
G
T
W
D
A
-
Y
L
--
H
M
N
R
E
R
K
--
A
A
K
Q
L
G
--
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
------------------------------------------------
41
HHSearch
45.77
11%
-136
* C4 *
3UON
2
ACM2_HUMAN (first)
A:
[29-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
-----------------
Y
------------
W
P
L
G
-----
P
V
V
-
C
D
------
L
W
L
A
L
-
D
---
Y
V
V
S
N
A
S
V
--
M
N
L
L
I
I
--------------
S
F
D
R
Y
F
C
V
T
---
K
-----
P
L
T
Y
----
P
VKRT
T
--
K
-
M
A
G
M
M
I
A
---
A
-----
A
------------
W
V
L
S
F
I
---
L
W
A
--------------------
P
A
I
------
L
F
W
-
Q
F
I
V
GVR
T
---
V
----
E
D
G
---
E
C
Y
I
---
Q
F
--
F
-------
S
N
A
A
V
T
F
G
--
T
----
A
-----
I
----
A
A
F
Y
----
L
P
V
I
I
M
T
V
------
L
Y
W
H
I
S
R
A
------
S
--
K
S
R
I
N
I
F
E
M
--
L
------
R
-------------------
I
--
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-----
Y
Y
T
I
G
I
G
H
L
L
-
T
K
S
P
S
L
N
--
A
A
K
S
E
---
L
------------
D
---
K
A
I
G
R
N
-------
T
N
G
V
I
T
K
D
E
A
E
K
L
--
F
N
Q
-----
D
V
D
A
----
A
V
R
G
I
L
--
R
N
A
K
L
K
P
V
---
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
---
Q
M
--
G
E
T
G
V
A
G
---
F
T
N
S
L
R
M
L
Q
Q
K
R
--
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
----
A
K
R
V
I
T
T
F
R
T
---------------
G
T
W
D
A
-
Y
P
--
P
P
S
R
E
K
K
--
V
T
R
T
I
L
--
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
------------------------------------------------