@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GNRHR_HUMAN: (2016-01-09 )
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
Atome Classification :
(20 SA)
.........10........20........30........40...-.....50........60........70........80........90........100....--..--.110.......120.......130.......140......--.-150-..-......160.......--170...-----....180.---......190...-....200------..-.....210........220.......230.......240.......--------------------------------250.......260.----......270........280...--....290...--------..-----.--.300.......310-.........320......-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MANSASPEQNQ
N
H
C
S
A
INNSIPLMQGNL
P
T
L
T
LS
G
K
I
R
V
T
V
T
F
F
-
L
F
L
L
S
A
TF
N
A
S
F
L
L
K
L
Q
K
W
T
Q
K
K
E
KG
K
K
L
S
R
M
K
L
L
L
K
H
L
T
L
A
N
L
L
E
T
L
I
VMPLDG
M
W
N
I
T
V
Q
--
W
Y--
A
G
E
L
L
C
K
V
L
S
Y
L
K
L
F
S
M
Y
A
P
A
F
M
M
V
V
I
SLDRS
L
A
ITR
P
L
A--L-KS--NS-K
V
G
Q
S
M
V
G
L
A
W
I
L
S
S
V--FAGP
Q
L
-----
Y
I
F
R
M
I
H
L---ADSSG
Q
T
K
V
F
S
Q
-
C
V
T
HC
S
F
------
S
Q
-
W
W
H
Q
A
F
-
Y
N
F
F
T
F
S
C
L
F
I
I
P
L
F
I
M
L
I
CN
A
K
I
I
F
T
L
T
R
V
L
HQDPH
E
L
--------------------------------
Q
LNQSKNNI
P
R
A
R
L
----
K
T
L
K
M
T
V
-
A
F
A
T
S
F
T
V
C
WT
P
Y
Y
V
--
L
G
I
W
Y
WF
D
P
E
--------
M
L
-----
N
--
R
LS
D
P
V
N
H
F
F
F
L
---
F
A
F
L
N
P
C
F
D
P
L
I
Y
G
YFSL-------------------------------------
11
PsiBlast_PDB
87.78
26%
-146
- C2 -
4BV0
1
NTR1_RAT
A:
[19-312]
-----------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
---
K
-------
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
V
Y
N
F
I
W
V
H
HP
W
A
--
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
----
L
-
M
S
--
R
S
-
R
T
-
K
K
F
I
S
A
I
W
L
A
S
A
L
--
L
A
I
P
M
L
-----
F
---
T
V
G
L
---
Q
N
L
S
G
D
G
T
H
P
G
G
-
L
V
C
T
P
I
V
------
D
T
-
A
T
L
K
V
V
-
I
Q
L
N
T
F
M
S
-
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V
H
-------------------------------------------
P
G
R
V
Q
A
L
R
R
----
G
V
L
V
L
R
--
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
D
E
Q
--------
W
T
-----
T
--
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
-------------------------------------
48
Fugue
82.00
18%
-123
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------
S
F
K
C
A
L
T
K
T
G
F
--------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
-
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
----------
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
--
W
I
--
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
--
L
G
R
L
--
K
K
-
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
--
A
I
S
P
-----------
I
L
F
Y
---
S
G
T
G
V
R
K
N
K
T
I
T
-
C
Y
D
T
T
S
D
------
E
Y
-
L
R
S
Y
F
I
-
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
CG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGV
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
----
K
S
I
Y
L
V
I
-
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
--
M
K
T
M
N
L
R
A
R
L
DFQTPAM
C
A
F
-----
N
--
D
R
V
Y
A
T
Y
Q
V
T
R
G
---
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
TFRRR--------------------------------
12
PsiBlast_PDB
75.61
25%
-162
- C2 -
2Y00
13
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
15
PsiBlast_PDB
75.35
25%
-163
- C2 -
2Y03
9
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
--------------------------------
R
--------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
17
PsiBlast_PDB
75.23
25%
-158
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
13
PsiBlast_PDB
75.22
25%
-166
- C2 -
2Y01
12
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
16
PsiBlast_PDB
74.80
25%
-165
- C2 -
2Y04
13
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
14
PsiBlast_PDB
74.71
25%
-161
- C2 -
2Y02
13
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
19
PsiBlast_PDB
74.26
25%
-160
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
18
PsiBlast_PDB
74.07
25%
-161
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[48-285]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
20
PsiBlast_PDB
73.42
25%
-157
- C2 -
2VT4
8
ADRB1_MELGA
A:
[48-283]
------------------------------------------------------------------------------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
--
W
L
--
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
--
Y
-
Q
S
--
L
M
-
T
R
A
R
A
K
V
----
I
I
C
T
V
--
W
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
HWW
R
D
E
D
P
Q
A
L
K
C
Y
Q
-
D
P
G
C
C
D
F
------
V
T
----
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
--------------------------------
R
-------------
E
H
--
K
A
L
K
T
L
G
-
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
V
F
N
R
D
--------
L
----------
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-------------------------------------
10
PsiBlast_PDB
72.30
23%
-132
- C2 -
4MQT
2
ACM2_HUMAN
A:
[43-283]
--------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
-
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
-----------------------
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
--
W
P
--
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
-
K
R
--
T
T
-
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
--
L
W
A
P
A
I
-----
L
F
W
Q
F
I
-------
V
G
V
R
T
V
E
D
G
E
-
C
-----
Y
------
I
Q
-
F
F
S
N
A
A
-
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
----------------------------------------------------
P
S
R
E
----
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
--
M
V
L
I
N
T
F
C
A
P
--------
C
I
-----
P
--
N
T
V
W
T
I
G
Y
W
L
C
Y
---
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
-------------------------------------
8
PsiBlast_PDB
72.20
23%
-144
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[166-397]
----------------------------------------------------------------------------------
N
L
A
L
A
D
T
L
-
V
L
L
T
L
P
F
Q
G
T
D
I
L
L
G
F
--
W
P
--
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-------
T
--
S
S
-
K
A
Q
A
V
N
V
A
I
-
W
A
L
A
S
V
--
V
G
V
P
-
V
-----
A
I
M
G
S
A
Q
V
---
E
D
E
E
------
I
E
-
C
L
V
E
I
P
T
------
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
--
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
V
----------------------------------------
R
L
L
S
G
S
R
E
K
D
R
N
L
R
----
R
I
T
R
L
V
L
-
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
--
F
V
L
A
Q
G
L
G
V
Q
--------
P
S
-----
S
--
E
T
A
V
A
I
L
R
F
C
T
A
---
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
-------------------------------------
46
Fugue
71.95
15%
-118
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
----
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
--
F
V
--
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
-
R
F
--
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
--
C
A
A
P
P
L
-----
V
--------------
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
-------------------------------------------
K
A
E
K
----
E
V
T
R
M
V
I
-
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
--------
S
D
-----
F
--
G
P
I
F
M
T
I
P
A
F
F
A
---
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A------
3
PsiBlast_PDB
71.02
22%
-136
- C2 -
4LDE
3
A:
[221-447]
--------------------------------------------------------------------------------
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
--
W
T
--
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
--
Y
-
Q
S
L
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-----
H
W
Y
R
A
T
H
---------
Q
E
A
I
--
N
-
C
Y
A
E
E
T
C
------
C
D
-
F
F
T
N
Q
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-------
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
--------------------------------
Q
---
K
F
A
L
K
E
H
K
A
L
----
K
T
L
G
I
I
M
-
G
---
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
H
V
I
Q
D
N
--------
L
I
-----
R
--
K
---
E
V
Y
I
L
L
N
W
---
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
-------------------------------------
6
PsiBlast_PDB
70.83
22%
-142
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[221-447]
--------------------------------------------------------------------------------
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
T
K
T
--
W
T
--
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
--
Y
-
Q
S
LL
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-----
H
W
Y
R
A
T
H
---------
Q
E
A
I
--
N
-
C
Y
A
E
E
T
C
------
C
D
-
F
F
T
N
Q
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-------
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
--------------------------------
Q
---
K
F
A
L
K
E
H
K
A
L
----
K
T
L
G
I
I
M
-
G
---
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
H
V
I
Q
D
N
--------
L
I
-----
R
--
K
---
E
V
Y
I
L
L
N
W
---
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
-------------------------------------
37
HHSearch
70.76
23%
-125
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[42-310]
-------------------------------------
V
I
I
A
Y
A
L
-
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
--
R
--
V
--
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
-
L
P
I
W
A
A
S
K
-
V
N
G
--
W
I
--
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
--
T
-
L
T
--
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
--
L
S
L
P
F
F
-----
L
F
R
Q
A
Y
H
------
P
N
---
N
S
S
P
V
-
C
Y
E
V
L
G
N
------
D
T
-
A
K
W
R
M
V
-
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
------------------------------------------------
M
G
Q
K
H
----
R
A
M
R
V
I
F
-
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
--
V
L
L
A
D
T
L
M
R
T
--------
Q
V
IQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
---
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
-------------------------------------
5
PsiBlast_PDB
70.49
22%
-136
- C2 -
4LDO
3
A:
[221-447]
--------------------------------------------------------------------------------
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
--
W
T
--
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
--
Y
-
Q
S
L
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-----
H
W
Y
R
A
T
H
---------
Q
E
A
I
--
N
-
C
Y
A
E
E
T
C
------
C
D
-
F
F
T
N
Q
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-------
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
--------------------------------
Q
---
K
F
A
L
K
E
H
K
A
L
----
K
T
L
G
I
I
M
-
G
---
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
H
V
I
Q
D
N
--------
L
I
-----
R
--
K
---
E
V
Y
I
L
L
N
W
---
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
-------------------------------------
4
PsiBlast_PDB
70.45
22%
-142
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[221-447]
--------------------------------------------------------------------------------
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
--
W
T
--
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
--
Y
-
Q
S
LL
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-----
H
W
Y
R
A
T
H
---------
Q
E
A
I
--
N
-
C
Y
A
E
E
T
C
------
C
D
-
F
F
T
N
Q
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-------
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
--------------------------------
Q
---
K
F
A
L
K
E
H
K
A
L
----
K
T
L
G
I
I
M
-
G
---
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
H
V
I
Q
D
N
--------
L
I
-----
R
--
K
---
E
V
Y
I
L
L
N
W
---
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
-------------------------------------
47
Fugue
70.39
16%
-100
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
----
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
--
G
Y
FV
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
-
R
F
--
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
--
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
-------------
S
C
-
G
I
D
Y
Y
T
P
------
H
E
-
E
T
N
N
E
S
-
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
---------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
----
E
V
T
R
M
V
I
-
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
---------------
S
--
D
F
G
P
I
F
M
T
I
P
A
F
---
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA