@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP119_HUMAN: (2016-01-10 )
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
Atome Classification :
(20 SA)
------------------------------.........10........20........30..-.....---.40....-....50........60..-......70....-....80........90........100.......110.......120.......130.......140........--------150--------....--.-------..160---.-.......170.......180.......190.------------......200---....----------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------.-----------------210.--------------......--..220.......230.......240.......250..---.....260.......270.......280.......290.......300.......310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MESSF
S
F
G
V
I
L
A
V
L
A
S
L
I
I
AT
N
T
L
V
A
V
A
V
L
L
L
I
-HKND
G
---
V
S
L
C
F
T
L
-
N
L
A
V
A
D
T
L
I
G
V
A
I
S
G
L
L
T
-
D
QLSSPSR
P
T
Q
K
-
T
L
C
S
L
R
M
A
F
VT
S
S
A
A
A
S
V
L
T
V
M
L
ITFD
R
Y
L
A
I
K
Q
P
F
R
Y
L
K
I
M
S
G
F
V
A
G
A
C
I
A
G
L
W
L
V
S
Y
L
I
G
F
L
PL-G
I
P
M
F
Q
QT--------AYK--------G
Q
C
S
--
F
-------
F
A
V
F----H-P
H
F
V
L
T
L
S
C
V
G
F
F
P
A
M
L
L
F
V
F
F
Y
C
D
M
L
K
I
A
S
------------
M
H
S
Q
Q
I
R
K
M
---
E
HAG----------------------------------------------------------------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------A-----------------G--G--------------YRSPRT--
P
S
D
F
K
A
L
R
T
V
S
V
L
I
G
S
F
ALS
W
T
P
F
L
I
T
G
I
V
Q
V
A
C
Q
E
C
---
H
L
Y
L
V
L
E
R
Y
L
W
L
L
GV
G
N
S
L
L
N
P
L
I
Y
A
Y
W
Q
K
E
V
R
L
Q
L
Y
H
M
A
L
G
V
K
K
V
L
T
S
F
L
L
F
L
S
ARNCGPERPRESS
C
H
I
V
T
ISSSEFDG
15
PsiBlast_PDB
92.14
27%
-157
- C6 -
4BVN
11
ADRB1_MELGA
A:
[15-284]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------
R
K
T
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
K
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
47
HHSearch
91.84
26%
-144
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
----------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
----
A
I
-
A
K
F
E
R
LQT
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
--
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H-------
Q
E
A
I
N
C
Y
A
E--
E
T
C
C
--
D
-------
F
F
-
T
----
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
N
I
F
E
M
L
---
R
I
D
E
----------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------------------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TG---
T
--
W
--------------
D
A
Y
K
F
C
--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------
11
PsiBlast_PDB
90.89
27%
-159
- C6 -
4AMJ
12
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
13
PsiBlast_PDB
90.83
27%
-159
- C6 -
3ZPR
11
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
------------------------------------------
7
PsiBlast_PDB
90.48
27%
-159
- C6 -
2Y01
12
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
3
PsiBlast_PDB
90.32
27%
-146
- C6 -
2YCX
3
ADRB1_MELGA
A:
[15-283]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
K
I
---
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
S
--
K
--------------
R
K
R
V
M
L
--
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
---------------------------------------------
9
PsiBlast_PDB
90.22
27%
-161
- C6 -
2Y03
9
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
10
PsiBlast_PDB
90.15
27%
-158
- C6 -
2Y04
13
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
2
PsiBlast_PDB
90.06
27%
-148
- C6 -
2YCW
7
ADRB1_MELGA
A:
[15-283]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
K
I
---
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
S
--
K
--------------
R
K
R
V
M
L
--
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------
4
PsiBlast_PDB
89.95
27%
-150
- C6 -
2YCZ
2
ADRB1_MELGA
A:
[15-283]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
K
I
---
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
S
--
K
--------------
R
K
R
V
M
L
--
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------
5
PsiBlast_PDB
89.90
27%
-148
- C6 -
2YCY
6
ADRB1_MELGA
A:
[15-283]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
-----
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
S
--
K
--------------
R
K
R
V
M
L
--
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------
12
PsiBlast_PDB
89.60
27%
-156
- C6 -
3ZPQ
11
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
1
PsiBlast_PDB
89.38
27%
-161
- C6 -
2VT4
8
ADRB1_MELGA
A:
[15-283]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
6
PsiBlast_PDB
89.26
27%
-161
- C6 -
2Y00
13
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
8
PsiBlast_PDB
89.23
27%
-161
- C6 -
2Y02
13
ADRB1_MELGA
A:
[15-285]
-------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
-
I
A
A
I
G
S
T
-
Q
R
L
Q
T
---
L
T
N
L
F
I
T
-
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
--------
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
--
F
---------
V
T
----
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
------------
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
-
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------
14
PsiBlast_PDB
88.66
26%
-157
- C6 -
3SN6
1
R:
[186-475]
-------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
--
E
R
L
Q
T
---
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
-
A
H
I
L
T
K
T
W
T
F
G
N
-
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
--QEAINCY-
A
E
E
--------
T
C
C
D
--
F
-------
F
T
------
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
RQLQKIDKSEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
IRK
E
V
Y
I
L
L
N
---
W
-
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------
46
HHSearch
86.38
23%
-135
- C6 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
----
A
V
-
R
S
E
R
K
LHT
V
G
N
L
Y
I
V
-
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
W
N
H
------------
R
R
E
--------
D
K
C
E
--
T
-------
D
F
Y
D
----
V
-
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
------------
Q
H
C
N
I
F
E
M
L
---
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
------------------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------------------------------------
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
H
M
--
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
---
C
N
E
H
L
H
M
F
T
I
-
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------
53
HHSearch
85.72
22%
-141
- C6 -
3EML
13
ENLYS_BPT4
A:
[22-472]
----------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
----
A
V
-
W
L
N
S
N
LQN
V
T
N
Y
F
V
V
-
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
-
T
I
S
--
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
G
W
N
N
C
G
Q
----------
S
--------
Q
G
C
G
--
E
GQVACLF
E
D
V
V
----
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------------
R
Q
L
N
I
F
E
M
L
---
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
--------------------------------------------------------------------------------------------------------------------------------
P
---------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGT----
W
--
D
--------------
A
Y
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
SH-
A
P
L
W
L
M
Y
L
A
I
-
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
19
PsiBlast_PDB
85.63
27%
-154
- C6 -
4GBR
1
ADRB2_HUMAN
A:
[9-270]
-------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
--
E
R
L
Q
T
---
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
-
A
H
I
L
T
K
T
W
T
F
G
N
-
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
--------
T
C
C
D
--
F
-------
F
T
------
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
Q
K
I
D
K
F
C
L
K
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
IR
K
E
V
Y
I
L
L
N
---
W
-
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------
68
Fugue
85.41
17%
-119
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
---
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
--------
G
M
Q
--------
C
S
C
G
I
D
Y
-------
Y
T
P
H
EETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
-------------------
F
T
V
K
E
A
---
A
A
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
----
V
S
K
T
E
T
S
Q
V
A
P
A
----------------