@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP124_HUMAN: (2016-01-10 )
MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........-----40........50..-------......60..--......70........--80-.....------.-------.-------..90........-----.100-....-...110.......120....--....130.......------------------------140.......150.......160.......170..-----------------------.....180--.......190.-......200-.------......---210---.......220.------------......230..----.....240.....----------..250------------..---------......-----.260.......270.......280.-......290....--....300..---.....310.......--320.......330.......-------------340.....---------..350.......360.......----------------370.......380.......390.......400.......410.......420----------........430.......440.......450.......460-........470.......480.......490......---.500.......510...-....520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------MGAGGRRMRGA
P
A
R
L
L
L
P
L
L
P
W
L
L
L
L
LAPEARGAPGCP
L
-----
S
I
R
SCKCSGERPKG-------LSGGVPGPA
R
--
R
R
V
V
CSGGDLPEPPEP--G--LLPN
G
------
T
-------
V
-------
T
L
L
-LSNN
K
I
TG-----LRNG-S
F
L
G
-
L
S
L
L
E
K
L
D
L
R
N
N
I
I
S
-TVQP--G
A
F
L
G
L
G
E
L
K
R
LDL------------------------SNN
R
I
G
C
L
T
S
E
T
F
Q
G
L
P
R
L
L
RLNISG
N
I
F
S
SLQPG-----------------------VFDELPA
L
--
K
V
V
DLGT
E
F
L
T
-CD
C
H
L
R
W
L
L
-P------WAQNRS---LQL---SEH
T
L
CAY
P
S
A
------------
L
H
A
Q
A
L
G
S
L
Q
E
----
A
Q
L
C
C
E
G
A
L
E
L
H
T
----------
H
H
L
--------------
I
P
---------
S
L
R
Q
V
V
-----FQGDRL
P
F
Q
C
S
A
S
YLGND
T
R
I
R
W
Y
H-NRAPVEG-DEQ
A
G
--
I
L
L
A
E
S
L
I
H
---
D
C
T
F
I
T
S
E
L
T
L
S
H
I
G
--
V
WASG
E
W
E
C
T
V
S
MAQGNAS
K
-------------
K
V
E
I
V
V
L
E---------TSASYC
P
A
E
R
VANNRGDFRW
P
R
----------------
T
L
A
G
I
T
A
Y
Q
S
C
L
QYPFTSVPLGGGAPGT
R
A
S
R
RCDRAGRWEPGDY
S
H
C
L
Y
T
N
-----------
D
I
T
R
V
L
Y
T
F
V
LMPINAS
N
A
L
T
L
A
H
Q
L
R
V
Y
T
AEAA
S
F
S
D
M
M
--
D
V
V
Y
V
A
Q
M
I
Q
K
F
L
G
Y
V
D
Q
I
K
E
L
V
E
V
M
V
D
M
A
SNL
M
L
V
D
---
E
H
L
L
W
L
A
QRE
D
K
A
C
S
R
I
-
V
G
A
L
E
R
IGGAALSPHA
Q
H
I
S
VNA
R
N
V
A
L
E
A
Y
L
IKPH
S
Y
V
G
L
T
C
T
A
F
Q
RREGGVPGTRPGSPGQNPPPEPEPPADQ
Q
L
R
F
R
C
TTGRPN
V
S
L
S
S
F
H
IKN
S
V
A
L
A
S
I
QL
P
P
S
L
F
S
SL
P
A
A
LAPPVPPDC
T
L
Q
L
L
V
F
RN
G
R
L
F
HSHSNTSRPGAAGPGKRRGVAT
P
V
I
F
AGTSGCGVGNLT
E
P
V
A
V
S
L
R
H
W
AEGA
E
P
V
A
A
W
WSQEGPGEAGGWTSEG
C
Q
LRSSQPNV
S
A
L
H
C
Q
HLG
N
V
A
V
L
M
E
L
SA
F
P
R
EVGGAGAGLH
P
V
V
Y
P
C
T
A
L
L
L
L
C
L
F
A
T
I
I
T
Y
I
LNHS
S
I
R
VSRK
G
W
H
M
L
L
N
L
C
F
H
I
A
M
T
S
A
V
FAG
G
I
T
L
T
N
Y
Q
M
V
C
Q
AVG
I
T
L
H
Y
S
S
L
S
T
L
L
W
M
G
V
K
A
R
V
L
H
KELTWRAPPPQEGDPALPTP
S
P
M
L
R
F
Y
L
IAGG
I
P
L
I
I
CG
I
T
A
A
V
N
IHNYRDHS
P
Y
C
W
L
V
WRPSLG
A
F
Y
I
P
V
A
L
I
L
L
I
T
W
I
Y
F
L
CAGLRLRGPLAQNPKAGNSRASLEA
G
E
E
LRGSTRLRGSGPLLSDSG
S
L
L
ATGSARVGTPGPPEDGDSLYSPG
V
Q
L
G
A
L
V
T
T
H
F
L
Y
L
A
M
W
A
C
G
A
L
A
V
S
QR
W
L
P
R
V
V
C
S
C
L
Y
G
V
A
A
S
A
L
G
L
F
V
F
T
H
H
C
A
R
R
R
D
V
R
A
S
W
RACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGH
P
L
A
LGPCKLT
N
L
Q
L
A
Q
S
Q
V
C
EAGAAAGGEGEPEPAGTRGNLAHRHPNNVHH
G
R
R
A
H
K
SRAKGHRA
G
E
A
C
G
K
N
R
L
K
A
L
RGGA
A
G
A
L
E
L
L
SSESGSLHNSP
T
D
S
YLGSSRNSPGA
G
L
Q
LEGEPMLTPSEGSDTSAA
P
L
S
E
AGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKY
D
D
V
T
L
M
GAEVASGGCMKTGLWKSETTV
134
Fugue
71.63
18%
-70
- C3 -
2ID5
7
LIGO1_HUMAN
A:
[1-477]
TGCPPR
C
E
C
S
AQDR
A
V
L
C
H
RKRFVAVPEGIPTETR
L
L
D
LGKNRIKTLNQDEFASFPHLE
E
L
E
LNENIVSAVEPGAFNNLFNLR
T
L
G
LRSNRLKLIPLGVFTGLSNLT
K
L
D
ISENKIVILLDYMFQDLYNLK
S
L
E
V
G
D
N
D
L
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
S
H
LH
G
L
I
V
L
R
L
R
H
L
N
I
N
A
-------
I
R
D
Y
S
F
K
R
L
Y
RL
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
--
N
--
C
L
Y
G
L
------
N
-------
L
T------
S
L
S
-
I
T
H
C
N
L
T
A
-----
V
P
Y
L
-
A
V
R
H
-
L
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
-
T
I
E
G
--
S
M
L
H
E
L
L
R
L
Q
E
I
Q
L
------------------------
V
G
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
-----------------------
V
F
H
S
V
G
N
L
--
E
T
L
I
L
D
S
N
P
L
A
-
C
D
C
R
L
L
W
V
F
-
R
------
R
R
W
R
L
N
---
F
N
----
R
Q
Q
P
T
C
A
T
P
E
F
------------
V
Q
G
K
E
F
K
D
F
P
D
----
V
L
L
P
N
Y
F
T
C
R
R
A
R
----------
I
R
D
--------------
R
K
---------
A
Q
Q
V
F
V
-----
D
E
G
H
T
V
Q
F
V
C
R
A
D
-
G
D
P
P
P
A
I
L
W
L
S
-
P
R
K
H
L
V
L
-
T
V
F
P
--------------------
D
G
T
L
E
V
R
Y
A
Q
--
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
-------------
P
A
H
L
H
V
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
68.02
31%
-95
- C3 -
2WFH
1
SLIT2_HUMAN
A:
[4-184]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
--------
T
E
C
T
C
L
D
T
------------------------
V
V
R
C
S
N
K
G
L
K
V
L
P
K
------
G
I
P
R
D
------
V
-------
T
-------
E
L
Y
-
L
D
G
N
Q
F
T
L
-----
V
P
-
K
-
E
L
S
N
-
Y
K
H
L
T
L
I
D
L
S
N
N
R
I
S
-
T
L
S
N
--
Q
S
F
S
N
M
T
Q
L
L
T
L
I
L
------------------------
S
Y
N
R
L
R
C
I
P
P
R
T
F
D
G
L
K
S
L
R
L
L
S
L
H
G
N
D
I
S
V
V
P
E
G
-----------------------
A
F
N
D
L
S
A
L
--
S
H
L
A
I
G
A
N
P
L
Y
-
C
D
C
N
M
Q
W
L
S
-
D
------
W
V
K
S
E
Y
---
K
-
E
---
P
G
I
A
R
C
A
G
P
G
E
------------
M
A
D
K
L
L
L
T
T
P
S
----
K
K
F
T
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
67.19
31%
-75
- C3 -
1W8A
-
SLIT_DROME
A:
[545-731]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
C
H
C
E
G
T
------------------------
T
V
D
C
T
G
R
G
L
K
E
I
P
R
------
D
I
P
L
H
------
T
-------
T
-------
E
L
L
-
L
N
D
N
E
L
G
R
-----
I
S
S
D
G
L
F
G
R
-
L
P
H
L
V
K
L
E
L
K
R
N
Q
L
T
-
G
I
E
P
--
N
A
F
E
G
A
S
H
I
Q
E
L
Q
L
------------------------
G
E
N
K
I
K
E
I
S
N
K
M
F
L
G
L
H
Q
L
K
T
L
N
L
Y
D
N
Q
I
S
C
V
M
P
G
-----------------------
S
F
E
H
L
N
S
L
--
T
S
L
N
L
A
S
N
P
F
N
-
C
N
C
H
L
A
W
F
A
-
E
------
W
L
R
K
K
S
---
L
-
N
---
G
G
A
A
R
C
G
A
P
S
K
------------
V
R
D
V
Q
I
K
D
L
P
H
----
S
E
F
K
C
S
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
66.91
23%
-69
- C3 -
2XOT
1
AMGO1_MOUSE
A:
[8-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
V
S
C
P
--------
A
N
C
L
C
A
S
N
I
L
S
C
SKQQLPN
V
P
Q
S
L
P
-
S
Y
T
--
A
L
L
D
L
S
H
N
N
L
S
R
L
R
A
E
--
W
TP
T
R
L
T
N
------
L
-------
H
-------
S
L
L
-
L
S
H
N
H
L
N
F
-----
I
S
S
E
-
A
F
V
P
-
V
P
N
L
R
Y
L
D
L
S
S
N
H
L
H
-
T
L
D
E
--
F
L
F
S
D
L
Q
A
L
E
V
L
L
L
------------------------
Y
N
N
H
I
V
V
V
D
R
N
A
F
E
D
M
A
Q
L
Q
K
L
Y
L
S
Q
N
Q
I
S
R
F
P
V
E
LIKLPKLMLLDLSSNKLKKLP
L
T
D
L
Q
K
L
P
A
W
V
K
N
G
L
Y
L
H
N
N
P
L
E
-
C
D
C
K
L
Y
Q
L
F
S
H
------
W
Q
Y
R
Q
L
S
S
V
M
D
F
---
Q
E
D
L
Y
C
M
H
S
K
K
------------
L
H
N
I
--
F
S
--
L
----
D
F
F
N
C
S
E
Y
K
E
S
------------------------------------------
A
W
E
A
-----
H
L
G
D
T
L
T
I
R
C
D
T
K
Q
-
Q
G
M
T
K
V
-
W
V
S
P
S
N
E
Q
V
L
S
Q
G
S
N
G
S
--
V
-------------
S
V
R
N
G
D
L
F
F
K
K
V
Q
--
V
E
D
G
G
V
Y
T
C
Y
A
M
G
E
T
F
N
E
T
L
-------------
S
V
E
L
K
V
Y
N
---------
F
T
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Fugue
65.78
15%
-74
- C3 -
2Z64
10
TLR4_MOUSE
A:
[1-599]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
I
E
V
V
P
N
--
I
T
Y
Q
C
M
D
Q
K
L
S
K
V
P
D
D
------
I
P
S
S
------
T
-------
K
-------
N
I
D
-
L
S
F
N
P
L
K
I
-----
L
K
S
Y
-
S
F
S
N
-
F
S
E
L
Q
W
L
D
L
S
R
C
E
I
E
-
T
I
E
D
--
K
A
W
H
G
L
H
H
L
S
N
L
I
L
------------------------
T
G
N
P
I
Q
S
F
S
P
G
S
F
S
G
L
T
S
L
E
N
L
V
A
V
E
T
K
L
A
S
L
E
S
F
-----------------------
P
I
G
Q
L
I
T
L
--
K
K
L
N
V
A
H
N
F
I
H
-
S
C
K
L
P
A
Y
F
S
-
N
------
L
T
N
L
V
H
---
V
D
L
---
S
Y
N
Y
I
----
Q
T
------------
I
T
V
N
D
L
Q
F
L
R
E
----
N
P
Q
V
N
L
-
S
L
D
M
S
L
----------
N
P
I
--------------
D
F
IQDQAFQGI
K
L
H
E
L
T
-----
L
R
G
N
F
N
S
S
N
I
M
K
T
C
L
Q
N
L
A
G
L
H
V
H
R
-
L
I
L
G
E
F
K
-
D
E
R
N
L
--
E
I
F
E
P
S
I
M
E
GLC
D
V
T
I
D
E
F
R
L
T
Y
T
N
D
F
--
S
D
D
I
V
K
F
H
C
L
A
N
V
S
A
M
S
L
A
G
VSIKYLEDVPKHF
K
W
Q
S
L
S
I
I
RCQLKQF
P
T
L
D
L
P
F
L
K
S
L
T
L
T
M
N
K
G
S
I
S
F
K
K
V
A
L
PSLS
Y
L
D
L
S
RNA
L
S
F
S
G
C
C
S
Y
S
D
L
G
T
N
S
L
R
H
L
D
L
S
F
-
N
G
A
I
I
M
S
A
N
F
M
G
L
E
E
L
Q
H
L
D
F
Q
H
S
T
L
K
R
VTEFSAFLSLE
K
L
L
Y
L
D
I
S
Y
T
N
T
K
I
D
F
D
G
I
F
L
G
L
T
S
L
N
T
L
K
M
A
G
N
S
F
K
D
N
T
LS
N
V
F
A
N
T
T
N
L
T
F
L
D
L
S
K
C
Q
L
E
Q
I
S
W
G
V
F
D
T
L
H
R
L
Q
L
L
N
MSH
N
N
L
L
F
L
D
S
S
H
Y
N
Q
L
Y
S
L
S
T
L
D
C
S
F
N
R
I
E
T
S
K
G
I
L
Q
H
F
P
K
S
L
A
F
F
N
L
T
N
N
S
V
A
C
I
C
E
H
Q
K
F
L
Q
W
V
K
E
Q
K
Q
F
L
V
N
V
E
Q
-
M
T
C
A
T
P
V
E
M
N
T
S
L
V
L
D
F
N
N
S
T
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.01
35%
-60
- C3 -
4PSJ
-
?
A:
[107-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
G
LFESLT
T
-------
L
-------
T
Q
L
N
L
S
N
N
Q
I
T
S
-----
L
P
Q
G
-
L
F
E
S
-
L
A
S
L
T
Q
L
N
L
S
N
N
Q
I
T
-
S
L
P
Q
--
G
L
F
E
S
L
T
N
L
T
Q
L
N
L
------------------------
S
N
N
Q
I
T
S
L
P
Q
G
L
F
E
S
L
T
N
L
T
Q
L
N
L
S
N
N
Q
I
T
S
L
P
Q
G
-----------------------
L
F
E
S
L
T
S
L
--
T
Q
L
N
L
S
N
N
Q
I
T
-
S
-------
L
-
P
QGLFES
L
T
N
L
K
Q
---
L
N
L
---
S
G
N
Q
I
Q
S
L
P
Q
G
------------
L
H
E
S
L
T
Q
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.32
36%
-84
- C3 -
4U7L
-
LRIG1_HUMAN
A:
[301-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
N
S
I
S
H
-----
I
A
E
G
-
A
F
K
G
-
L
R
S
L
R
V
L
D
L
D
H
N
E
I
S
G
T
I
E
D
TS
G
A
F
S
G
L
D
S
L
S
K
L
T
L
------------------------
F
G
N
K
I
K
S
V
A
K
R
A
F
S
G
L
E
G
L
E
H
L
N
L
G
G
N
A
I
R
S
V
Q
F
D
-----------------------
A
F
V
K
M
K
N
L
--
K
E
L
H
I
S
S
D
S
F
L
-
C
D
C
Q
L
K
W
L
P
-
P
------
W
L
I
G
R
M
---
L
Q
A
---
F
V
T
A
T
C
A
H
P
E
S
------------
L
K
G
Q
S
I
F
S
V
P
P
----
E
S
F
V
C
D
D
F
L
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.02
29%
-80
- C3 -
4QXE
5
LGR4_HUMAN
A:
[3-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----
C
A
A
P
C
S
C
D
G
D
R
-----------------------
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
------
L
S
A
F
------
T
-------
Q
-------
A
L
D
-
I
S
M
N
N
I
T
Q
-----
L
P
E
G
-
A
F
K
N
-
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
-
F
I
H
P
--
K
A
L
S
G
L
K
E
L
K
V
L
T
L
------------------------
Q
N
N
Q
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
-----------------------
S
F
E
G
L
V
Q
L
--
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
S
N
L
-
P
------
T
L
Q
--
A
---
L
T
L
---
A
L
N
K
I
S
S
I
P
D
F
AFTNLSSLV
V
L
H
L
H
N
N
K
I
R
S
L
------
S
Q
H
C
F
D
G
L
D
N
L
E
T
----------
L
D
L
NYNNLGEFPQAIKA
L
P
---------
S
L
K
E
L
G
-----
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
-
Y
D
N
P
L
S
F
-
V
G
N
S
A
--
F
H
N
L
S
D
L
H
S
---
L
V
I
R
G
A
S
M
V
Q
Q
F
P
N
L
--
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
-------------
N
N
L
C
Q
E
Q
K
---------
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
S
F
N
G
C
H
----------------
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
A
S
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
-----------
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
--
P
V
R
S
I
I
C
P
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
61.53
23%
-80
- C3 -
2ID5
5
LIGO1_HUMAN
A:
[225-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------
L
-------
T
-------
S
L
S
-
I
T
H
C
N
L
T
A
-----
V
P
Y
L
-
A
V
R
H
-
L
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
-
T
I
E
G
--
S
M
L
H
E
L
L
R
L
Q
E
I
Q
L
------------------------
V
G
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
-----------------------
V
F
H
S
V
G
N
L
--
E
T
L
I
L
D
S
N
P
L
A
-
C
D
C
R
L
L
W
V
F
-
R
------
R
R
W
R
L
N
---
F
-
N
---
R
Q
Q
P
T
C
A
T
P
E
F
------------
V
Q
G
K
E
F
K
D
F
P
D
VLLP
N
Y
F
T
C
R
R
A
R
I
R
D
----------------------------
R
K
---------
A
Q
Q
V
F
V
-----
D
E
G
H
T
V
Q
F
V
C
R
A
D
-
G
D
P
P
P
A
I
L
W
L
S
-
P
R
K
H
L
V
---------
L
T
V
------------
F
P
D
G
T
L
E
V
R
Y
A
Q
--
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
-------------
P
A
H
L
H
V
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.46
30%
-79
- C3 -
1W8A
-
SLIT_DROME
A:
[554-725]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
C
T
G
R
G
L
K
E
I
P
R
D
------
I
P
L
H
------
T
-------
T
-------
E
L
L
-
L
N
D
N
E
L
G
R
-----
I
S
S
D
-
G
L
F
G
R
L
P
H
L
V
K
L
E
L
K
R
N
Q
L
T
-
G
I
E
P
--
N
A
F
E
G
A
S
H
I
Q
E
L
Q
L
------------------------
G
E
N
K
I
K
E
I
S
N
K
M
F
L
G
L
H
Q
L
K
T
L
N
L
Y
D
N
Q
I
S
C
V
M
P
G
-----------------------
S
F
E
H
L
N
S
L
--
T
S
L
N
L
A
S
N
P
F
N
-
C
N
C
H
L
A
W
F
A
-
E
------
W
L
R
K
K
S
---
L
N
----
G
G
A
A
R
C
G
A
P
S
K
------------
V
R
D
V
Q
I
K
D
L
P
H
----
S
E
F
K
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
61.24
27%
-79
- C3 -
2V70
1
SLIT2_HUMAN
A:
[34-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
A
E
L
R
L
N
N
N
E
F
T
V
L
E
A
T
GI
F
--
K
K
L
P
Q
------
L
-------
R
-------
K
I
N
-
F
S
N
N
K
I
T
D
-----
I
E
E
G
-
A
F
E
G
-
A
S
G
V
N
E
I
L
L
T
S
N
R
L
E
-
N
V
Q
H
--
K
M
F
K
G
L
E
S
L
K
T
L
M
L
------------------------
R
S
N
R
I
T
C
V
G
N
D
S
F
I
G
L
S
S
V
R
L
L
S
L
Y
D
N
Q
I
T
T
V
A
P
G
-----------------------
A
F
D
T
L
H
S
L
--
S
T
L
N
L
L
A
N
P
F
N
-
C
N
C
Y
L
A
W
L
G
-
E
------
W
L
R
K
K
R
---
I
-
V
---
T
G
N
P
R
C
Q
K
P
Y
F
------------
L
K
E
I
P
I
Q
D
V
A
I
----
Q
D
F
T
C
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
HHSearch
61.01
29%
-74
- C3 -
1OZN
3
RTN4R_HUMAN
A:
[107-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
H
T
L
H
L
D
R
C
G
L
Q
E
L
G
P
G
L-
F
--
R
G
L
A
A
------
L
-------
Q
-------
Y
L
Y
-
L
Q
D
N
A
L
Q
A
-----
L
P
D
D
-
T
F
R
D
-
L
G
N
L
T
H
L
F
L
H
G
N
R
I
S
-
S
V
P
E
--
R
A
F
R
G
L
H
S
L
D
R
L
L
L
------------------------
H
Q
N
R
V
A
H
V
H
P
H
A
F
R
D
L
G
R
L
M
T
L
Y
L
F
A
N
N
L
S
A
L
P
T
E
-----------------------
A
L
A
P
L
R
A
L
--
Q
Y
L
R
L
N
D
N
P
W
V
-
C
D
C
R
A
R
P
L
W
-
A
------
W
L
Q
K
F
R
---
G
-
S
---
S
S
E
V
P
C
S
L
P
Q
R
------------
L
A
G
R
D
L
K
R
L
A
A
----
N
D
L
Q
G
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
60.09
22%
-45
- C3 -
3J0A
2
TLR5_HUMAN
A:
[426-740]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
L
--
Q
I
L
I
L
N
Q
N
R
F
S
S
C
S
G
D
--
Q
TP
S
E
N
P
S
------
L
-------
E
-------
Q
L
F
-
L
G
E
N
M
L
Q
L
AWETE
L
C
W
D
-
V
F
E
G
-
L
S
H
L
Q
V
L
Y
L
N
H
N
Y
L
N
-
S
L
P
P
--
G
V
F
S
H
L
T
A
L
R
G
L
S
L
------------------------
N
S
N
R
L
T
V
L
S
H
N
D
L
--
P
A
N
L
E
I
L
D
I
S
R
N
Q
L
L
A
P
N
P
D
-----------------------
V
F
---
V
S
L
--
S
V
L
D
I
T
H
N
K
F
I
-
C
E
C
E
L
S
T
F
I
-
N
------
W
L
N
H
T
N
---
V
T
I
AGP
P
A
D
I
Y
C
V
Y
P
D
S
------------
F
S
G
V
S
L
F
S
L
S
T
----
E
--
G
C
-----
F
S
L
F
I
V
C
T
V
T
L
T
L
F
L
M
--------------
T
I
LTVTKFR--------DHPQG
T
E
P
D
M
Y
K
Y
D
A
Y
L
C
F
S
S
K
D
F
---
T
W
V
-
Q
N
A
L
L
K
H
-
L
D
T
Q
Y
SD
Q
N
R
F
N
L
C
F
E
---
E
R
D
F
V
P
G
E
N
R
I
A
N
I
Q
D
A
I
W
N
S
R
K
I
V
C
L
V
S
R
H
F
L
R
D
G
W
-------------
C
L
E
A
F
S
Y
A
---------
Q
G
R
C
L
S
D
L
N
S
A
L
I
M
V
V
V
G
S
L
S
Q
----------------
Y
Q
L
M
K
H
Q
S
I
R
G
F
V
Q
K
Q
Q
Y
L
R
W
P
E
D
F
Q
D
V
G
W
F
L
H
K
L
S
Q
Q
I
L
K
K
E
K
E
K
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
59.87
31%
-85
- C3 -
2V70
1
SLIT2_HUMAN
A:
[64-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
N
N
K
I
T
D
-----
I
E
E
G
-
A
F
E
G
-
A
S
G
V
N
E
I
L
L
T
S
N
R
L
E
-
N
V
Q
H
--
K
M
F
K
G
L
E
S
L
K
T
L
M
L
------------------------
R
S
N
R
I
T
C
V
G
N
D
S
F
I
G
L
S
S
V
R
L
L
S
L
Y
D
N
Q
I
T
T
V
A
P
G
-----------------------
A
F
D
T
L
H
S
L
--
S
T
L
N
L
L
A
N
P
F
N
-
C
N
C
Y
L
A
W
L
G
-
E
------
W
L
R
K
K
R
---
I
-
V
---
T
G
N
P
R
C
Q
K
P
Y
F
------------
L
K
E
I
P
I
Q
D
V
A
I
----
Q
D
F
T
C
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
59.49
27%
-77
- C3 -
2V9T
-
SLIT2_HUMAN
B:
[301-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
--
T
E
I
R
L
E
Q
N
T
I
K
V
I
P
P
G
--
A
F-
S
P
Y
K
K
------
L
-------
R
-------
R
I
D
-
L
S
N
N
Q
I
S
E
-----
L
A
P
D
-
A
F
Q
G
-
L
R
S
L
N
S
L
V
L
Y
G
N
K
I
T
-
E
L
P
K
--
S
L
F
E
G
L
F
S
L
Q
L
L
L
L
------------------------
N
A
N
K
I
N
C
L
R
V
D
A
F
Q
D
L
H
N
L
N
L
L
S
L
Y
D
N
K
L
Q
T
I
A
K
G
-----------------------
T
F
S
P
L
R
A
I
--
Q
T
M
H
L
A
Q
N
P
F
I
-
C
D
C
H
L
K
W
L
A
-
D
------
Y
L
H
T
N
P
---
I
-
E
---
T
S
G
A
R
C
T
S
P
R
R
------------
L
A
N
K
R
I
G
Q
I
K
S
----
K
K
F
R
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.49
38%
-51
- C3 -
4PQ8
1
?
A:
[107-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
G
------
V
FEKLTNL
T
-------
T
L
N
-
L
S
N
N
Q
L
T
S
-----
L
P
Q
G
-
V
F
E
R
-
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
-
S
L
P
Q
--
G
V
F
E
R
L
T
N
L
T
T
L
N
L
------------------------
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
-----------------------
V
F
E
R
L
T
S
L
--
T
T
L
N
L
S
N
N
Q
L
T
-
S
L
P
Q
G
V
F
E
R
-
L
------
T
N
L
K
T
L
---
N
L
S
---
N
N
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
HHSearch
59.22
37%
-85
- C3 -
2ID5
2
LIGO1_HUMAN
A:
[2-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
P
--------
P
R
C
E
C
S
A
Q
D
----------------------
R
A
V
L
C
H
R
K
R
F
V
A
V
P
E
------
G
I
P
T
E
------
T
-------
R
-------
L
L
D
-
L
G
K
N
R
I
K
T
-----
L
N
Q
D
-
E
F
A
S
-
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
-
A
V
E
P
--
G
A
F
N
N
L
F
N
L
R
T
L
G
L
------------------------
R
S
N
R
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
V
I
L
L
D
Y
-----------------------
M
F
Q
D
L
Y
N
L
--
K
S
L
E
V
G
D
N
D
L
V
-
Y
I
S
H
R
A
F
S
G
-
L
------
N
S
L
E
Q
L
---
T
L
E
---
K
C
N
L
T
S
I
P
T
E
A
------------
L
S
H
L
H
G
L
I
V
L
R
----
L
R
H
L
N
I
N
A
I
R
D
Y
S
----------
F
K
R
--------------
L
Y
---------
R
L
K
V
L
E
-----
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
L
T
S
L
S
I
-
T
H
C
N
L
T
A
-
V
P
Y
L
A
--
V
R
H
L
V
Y
L
R
F
---
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
--
L
H
E
L
L
R
L
Q
E
I
Q
L
V
G
G
Q
L
A
V
V
-------------
E
P
Y
A
F
R
G
L
---------
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
V
F
H
----------------
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
-----------
D
F
P
D
V
L
L
P
N
Y
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
A
--
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
---
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
-
A
H
L
H
V
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
58.97
33%
-57
- C3 -
3RFJ
1
?
A:
[100-221]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
N
G
------
V
-------
F
DKLTNLK
E
L
V
-
L
V
E
N
Q
L
Q
S
-----
L
P
D
G
-
V
F
D
K
-
L
T
N
L
T
Y
L
Y
L
Y
H
N
Q
L
Q
-
S
L
P
K
--
G
V
F
D
K
L
T
N
L
T
R
L
D
L
------------------------
D
N
N
Q
L
Q
S
L
P
E
G
V
F
D
K
L
T
Q
L
K
Q
L
S
L
N
D
N
Q
L
K
S
V
P
D
G
-----------------------
V
F
D
R
L
T
S
L
--
T
H
I
W
L
L
N
N
P
W
D
-
C
A
C
S
D
I
L
Y
L
-
S
------
R
W
I
S
Q
H
---
P
G
L
---
V
F
G
Y
L
N
L
D
P
D
S
------------
A
R
C
S
G
T
N
T
P
V
R
----
A
V
T
E
A
S
T
S
P
S
K
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.60
28%
-84
- C3 -
2V9T
-
SLIT2_HUMAN
B:
[284-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
C
R
G
K
G
L
T
E
I
P
T
N
------
L
P
E
T
------
I
-------
T
-------
E
I
R
-
L
E
Q
N
T
I
K
V
-----
I
P
P
G
-
A
F
S
P
-
Y
K
K
L
R
R
I
D
L
S
N
N
Q
I
S
-
E
L
A
P
--
D
A
F
Q
G
L
R
S
L
N
S
L
V
L
YGNKITELPKSLFEGLFSLQ
L
L
L
L
N
A
N
K
I
N
C
L
R
V
D
A
F
Q
D
L
H
N
L
N
L
L
S
L
Y
D
N
K
L
Q
T
I
A
K
G
-----------------------
T
F
S
P
L
R
A
I
--
Q
T
M
H
L
A
Q
N
P
F
I
-
C
D
C
H
L
K
W
L
A
-
D
------
Y
L
H
T
N
P
---
I
E
T
---
S
-
G
A
R
C
T
S
P
R
R
------------
L
A
N
K
R
I
G
Q
I
K
S
----
K
K
F
R
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
58.50
31%
-84
- C3 -
2V70
1
SLIT2_HUMAN
B:
[64-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
N
N
K
I
T
D
-----
I
E
E
G
-
A
F
E
G
-
A
S
G
V
N
E
I
L
L
T
S
N
R
L
E
-
N
V
Q
H
--
K
M
F
K
G
L
E
S
L
K
T
L
M
L
------------------------
R
S
N
R
I
T
C
V
G
N
D
S
F
I
G
L
S
S
V
R
L
L
S
L
Y
D
N
Q
I
T
T
V
A
P
G
-----------------------
A
F
D
T
L
H
S
L
--
S
T
L
N
L
L
A
N
P
F
N
-
C
N
C
Y
L
A
W
L
G
-
E
------
W
L
R
K
K
R
---
I
-
V
---
T
G
N
P
R
C
Q
K
P
Y
F
------------
L
K
E
I
P
I
Q
D
V
A
I
----
Q
D
F
T
C
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------