@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP126_HUMAN: (2016-01-10 )
MMFRSDRMWSCHWKWKPSPLLFLFALYIMCVPHSVWGCANCRVVLSNPSGTFTSPCYPNDYPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTSDAYQVSVAKSISIPELSAFTLCFEATKVGHEDSDWTAFSYSNASFTQLLSFGKAKSGYFLSISDSKCLLNNALPVKEKEDIFAESFEQLCLVWNNSLGSIGVNFKRNYETVPCDSTISKVIPGNGKLLLGSNQNEIVSLKGDIYNFRLWNFTMNAKILSNLSCNVKGNVVDWQNDFWNIPNLALKAESNLSCGSYLIPLPAAELASCADLGTLCQATVNSPSTTPPTVTTNMPVTNRIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISFHLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQKLLKNNESLDEGLRLHTVNVRQLGHCLAMEEPKGYYWPSIQPSEYVLPCPDKPGFSASRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSANITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEALKTIDELAFKIDLNSTSHVNITTRNLALSVSSLLPGTNAISNFSIGLPSNNESYFQMDFESGQVDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDNVSYEHSFNKSGSLRQCFHGQVLVKTGPC
Atome Classification :
(20 SA)
.........10........20........30........40....-....50........60........70........80....-....90--..------......100....---.-----.-----.110.....-------..120.......130......--.140.........-150-------.---------------------------------------------.......160......--.170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290......-------.300.......310.......320...--....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560---.........570.......580...------....590.......600.......610......--------------.620....---...630.--------......640--------.-.......650...-----....660..--.....670.......680.......690.......700.......710.......-----720.......730.......740.......750.......---..760-------.........770...-....780.......790-------........800.......810.......820.......830.......--------------840.......850.......----------860.......870.......880.......890.......900......------.910--........920.......930.----.......940.......950.......960--.......970.......-..980.......990-------------........1000......1010..-....1020-........1030......1040--......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMFRSDR
M
W
S
C
H
W
K
WKPS
P
L
L
F
L
F
A
L
Y
I
M
CVPHSVWGCAN
C
R
V
V
L
-SNPSGTFTSPCYPNDYPNSQ
A
C
M
W
T
LRAPT
G
Y
I
I
Q
I
T
FND-F
D
I
E
EA--P
N
------
C
IYDSLSLDNGES---Q-----
T
-----
K
FCGATAKG-------LSFNSSA
N
E
M
H
V
S
FSSD
F
S
I
Q
--KK--GFN
A
S
Y
I
R
V
-
A
V
--------
S
---------------------------------------------LRN
Q
K
V
I
LPQTSD
A
Y
Q
--
V
S
V
A
KSISIPEL
S
A
F
T
L
C
F
E
A
T
KVGHEDSD
W
T
A
F
SYSN
A
S
F
T
-
Q
L
L
SFGKAKS
G
Y
F
L
S
ISDS
K
C
LLNNALPVK
E
K
E
D
I
F
A
E
S
F
E
Q
L
C
L
V
WNNSLGS
I
G
V
N
F
KRNYETVPCD
S
T
I
S
K
VIPGN
G
K
L
L
LGSNQ
N
-------
E
I
V
S
LKG
D
I
Y
N
F
R
L
W
N
F
T
MN
A
K
I
LSNL--SCNVKG
N
V
VDWQNDFWNIP
N
L
A
L
K
AESNLSCG
S
Y
L
I
PL
P
A
A
E
L
A
S
C
A
D
L
G
T
L
C
Q
A
TVNSPSTTP
P
T
V
TTNMPVT
N
R
I
DKQRND
G
I
I
Y
R
I
S
V
V
I
Q
N
I
L
RHPEV
K
V
Q
S
K
V
A
E
W
L
N
S
T
F
QNW
N
Y
T
V
Y
V
V
N
I
S
F
H
L
SAGE
D
K
I
K
V
KRSLEDEPR
L
V
L
W
A
L
L
V
YNATNNTNL
E
G
K
I
I
Q
Q
K
L
LKNNE
S
L
D
EG
L
R
L
H
T
V
N
V
R
Q
L
G
H
C
LAMEEPKGYYWPSIQPS
E
Y
V
L
PCPDKPGFSA
S
R
I
C
-----
F
YNATN
P
L
V
T
Y
WGPV
D
I
S
N
C
L
K
E
A
N
------
E
V
A
N
Q
I
L
N
LTADGQNLT
S
A
N
I
T
N
I
V
E
Q
V
K
R
I
VN--------------KEE
N
I
D
I
T---
L
G
S
T
L
M
N
--------
I
F
S
N
I
LSS---------S-
D
S
D
L
L
E
S
S
S
E
A
L
K
-----
T
I
D
E
L
A
F
K
I
--DLNST
S
H
V
N
I
T
TR
N
L
A
L
S
V
S
S
LLPGTNAI
S
N
F
S
IGLPSNNE
S
Y
F
Q
M
DFESGQVD
P
-----
L
A
S
VIL
P
P
N
L
L
E
NLSP
E
D
S
V
L
V
R
R
A
Q
F
T
F
FN--KTGLFQD---VGP---------
Q
R
K
T
L
V
S
Y
V
M
A
CSIG-
N
I
T
I
QNLKD
P
V
Q
I
K
I
K
--------HTRTQEVHHP
I
C
A
F
W
DLNKNKSFGGWNTSG
C
V
AHRDSDAS
E
T
V
C
L
C
NH--------------F
T
H
F
G
V
L
MDLPR
S
A
S
QLDAR----------N
T
K
V
L
T
F
I
S
Y
I
G
C
G
I
S
A
I
F
S
A
A
T
L
L
T
Y
V
A
F
E
K
L
R
R
DY
P
S
K
I
L
M
N
L
S
T
A
L
------
L
F
L
---
N
L
L
F
L
L
D
G
W
I
TSFNV
D
G
L
C
-
I
A
----
V
A
V
L
L
H
F
F
L
L
A
T
F
T
W
M
G
L
E
A
I
H
M
Y
I
A
L
V
K
V
--
F
N
T
Y
I
R
R
Y
--
I
L
K
F
C
I
I-GW
G
L
P
A
L
V
V
S
V
V
L
A--------------SRNNNEVYGKESYGKEKGD
E
F
C
W
I-QD
P
V
I
F
---
Y
V
T
C
A
G
Y
F
G
V
M
F
F
L
N
I
A
M
F
I
V
V
--
M
V
Q
I
CGRNGKRSN
R
T
L
R
E
E
V
L
R
N
L
R
S
V
V
S
L
T
F
L
L
G
M
T
W
G
F
A
FFAWGPL
N
I
P
F
M
Y
L
F
S
I
F
N
S
L
Q
G
L
F
I
F
I
F
H
C
A
M
K
E
N
V
Q
K
Q
W
R
Q
HLCCG
R
F
RLADNSDW
S
K
T
A
T
N
I
I
KKSSDNLGKSLSSSSIGSN
S
T
Y
L
T
SKSKSSS
T
T
Y
F
KRNSHTDN
V
S
Y
EHSFNKSG
S
L
R
Q
C
FH
G
Q
V
L
V
KTGPC
51
HHSearch
71.28
30%
-19
- C1 -
3DEM
3
MASP1_HUMAN
A:
[7-211]
-----------------------------------------------
N
M
F
G
Q
I
Q
S
P
G
Y
P
D
S
Y
P
S
D
S
E
V
T
W
N
I
T
V
P
D
G
F
R
I
K
L
Y
F
M
H
-
F
N
L
E
S
S
--
Y
L
------
C
E
Y
D
Y
V
K
V
E
T
E
D
Q
---
V
L----
A
-----
T
F
C
G
R
E
T
T
D
TEQTPGQ
E
V
V
L
S
P
G
S
F
M
S
I
T
F
R
S
D
F
S
N
E
ER
F
T
--
G
F
D
A
H
Y
M
A
V
-
D
V
--------
D
ECKELSCD
H
Y
C
H
N
Y
IG
G
Y
Y
C
S
C
R
FG
Y
I
L
H
TDN
R
T
C
R
V
ECSDNLFT
Q
R
T
G
V
I
T
S
P
D
F
P
N
P
Y
P
KS
S
E
C
L
Y
T
I
E
L
E
E
G
F
M
V
N
L
Q
F
E
D
I
F
D
I
E
D
H
P
E
V
P
C
P
Y
D
Y
I
K
I
K
V
-
G
P
K
V
L
G
P
F
C
G
E
K
A
P
E
P
I
S
T
Q
S
H
S
V
L
I
L
F
H
S
D
N
S
G
E
N
R
G
W
R
L
S
Y
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
70.33
17%
-90
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
--
R
A
---
R
S
---
I
R
C
---------
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
-
R
N
A
T
W
F
V
V
Q
L
T
M
S
P
E
V
--------
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
-
L
S
V
A
----------
K
S
E
L
D
K
A
I
G
R
N
S
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
---
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
-
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
GT
W
D
A
Y
D
R
L
R
--
A
W
M
F
I
C
I
-
G
W
G
V
P
F
P
I
I
V
A
W
A
I
--------------
G
K
L
Y
Y
D
------------
N
E
K
C
W
A
G
K
R
P
G
V
Y
-----
T
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
E
-
V
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
------------------------------------------------------------------------------------------------------
60
Fugue
68.43
19%
-59
* C2 *
4DLQ
16
A:
[18-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
LPALG
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
GEN
A
A
N
I
A
S
E
L
A
R
H
T
R
--
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
---
Y
I
K
A
V
V
E
--------
T
V
D
N
L
L
R
P
EA
L
E
S
W
K
D
M
N
-
A
T
E
Q
V
H
T
A
T
M
L
L
D
-----
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
-
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
RNG
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
L
A
G
E
A
G
T
G
G
--
P
----------
G
G
---------
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
--------
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
-
N
K
T
H
T
T
C
A
C
S
H
--------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
60.11
28%
-8
- C1 -
3KQ4
7
CUBN_HUMAN
B:
[232-397]
--------------------------------------
T
G
C
G
G
N
L
-
T
T
S
S
G
T
F
I
S
P
N
Y
P
M
P
Y
Y
H
S
S
E
C
Y
W
W
L
K
S
S
H
G
S
A
F
E
L
E
F
K
D
-
F
H
L
E
H
H
--
P
N
------
C
T
L
D
Y
L
A
V
Y
D
G
P
S
---
S
NSHLL
T
-----
Q
L
C
G
D
E
K
P
--------
P
L
I
R
S
S
G
D
S
M
F
I
K
L
R
T
D
E
G
Q
Q
--
G
R
--
G
F
K
A
E
Y
R
Q
T
-
C
E
--------
N
VVIVN----------------------------------------
Q
T
Y
G
I
L
E
S
I
G
Y
P
N
P
Y
S
EN
Q
H
C
N
W
T
I
R
A
T
T
G
N
T
V
N
Y
T
F
L
A
F
D
L
E
H
H
I
N
C
S
T
D
Y
L
E
L
Y
D
G
P
R
-
Q
M
G
R
Y
C
G
V
D
L
P
P
P
G
S
T
T
S
S
K
L
Q
V
L
L
L
T
D
G
V
G
R
R
E
K
G
F
Q
M
Q
W
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
59.36
24%
-36
- C1 -
3KQ4
3
CUBN_HUMAN
B:
[1-164]
----------------------------------------
C
G
E
I
L
-
T
E
S
T
G
T
I
Q
S
P
G
H
P
N
V
Y
P
H
G
I
N
C
T
W
H
I
L
V
Q
P
N
H
L
I
H
L
M
F
E
T
-
F
H
L
E
F
H
--
Y
N
------
C
T
N
D
Y
L
E
V
Y
D
T
D
S
ETS
L
-----
G
-----
R
Y
C
G
K
S
I
P
--------
P
S
L
T
S
S
G
N
S
L
M
L
V
F
V
T
D
S
D
L
A
--
Y
E
--
G
F
L
I
N
Y
E
A
I
-
S
A
AT
A
C
L
Q
D
Y
T
---------------------------------------------
D
D
L
G
T
F
T
S
P
N
F
P
N
N
Y
P
N
N
W
E
C
I
Y
R
I
T
V
R
T
G
Q
L
I
A
V
H
F
T
N
F
S
L
E
E
A
I
G
N
Y
Y
T
D
F
L
E
I
R
D
G
G
-
Y
E
K
S
P
L
L
G
I
F
Y
G
S
N
L
P
P
T
I
I
S
H
S
N
K
L
W
L
K
F
K
S
D
Q
I
D
T
R
S
G
F
S
A
Y
W
D
G
S
S
T
G
C
G
G
N
L
T
T
S
S
G
T
F
I
S
P
N
Y
P
M
P
Y
Y
H
S
S
E
C
Y
W
W
L
K
S
S
H
G
S
-------
A
F
E
L
E
F
K
D
F
H
L
E
H
H
P
N
C
T
L
D
Y
L
A
V
Y
D
G
--
P
S
S
N
S
H
L
L
T
Q
L
C
G
D
E
K
P
P
L
I
R
S
S
G
D
S
M
F
I
K
L
R
T
D
E
G
Q
Q
G
R
G
F
K
A
E
Y
R
Q
T
C
E
N
V
V
I
V
N
Q
T
Y
G
I
L
E
S
I
G
Y
P
N
P
Y
S
E
N
Q
H
C
N
W
T
I
R
A
T
T
G
N
T
V
N
Y
T
F
L
A
F
D
L
E
H
H
I
N
C
S
T
D
Y
L
E
L
Y
D
G
P
R
Q
M
G
R
Y
C
G
V
D
L
P
P
P
G
S
T
T
S
S
K
L
Q
V
L
L
L
T
D
G
V
G
R
R
E
K
G
F
Q
M
Q
W
F
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
59.26
16%
-75
* C3 *
4NNB
2
?
A:
[4-527]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
L
Y
I
T
A
A
P
I
G
A
V
P
K
F
L
DPFEATF
I
P
S
F
L
L
E
G
---------
F
F
D
A
D
R
C
A
S
I
A
A
D
L
K
T
D
G
W
E
V
V
P
A
G
G
R
L
L
--
Q
V
G
H
A
Q
P
I
A
H
F
P
K
P
W
L
A
A
L
S
N
K
L
A
R
R
I
V
L
Q
L
T
T
Y
G
W
I
V
S
E
Q
G
D
L
L
W
E
H
E
R
-----------
Q
H
H
Y
L
P
P
A
L
I
E
A
I
E
K
E
S
P
A
L
L
K
N
M
E
E
A
G
W
I
A
C
A
A
G
Y
W
Q
A
GKA
R
S
P
YLPIT
P
E
A
I
T
E
E
T
I
R
S
M
R
A
G
A
A
V
V
-
H
L
H
T
R
D
L
S
D
R
R
R
I
E
I
P
GL
G
V
V
T
V
G
S
Q
R
N
Q
I
V
L
D
D
Y
D
A
I
V
P
M
V
K
K
R
E
P
A
A
I
L
N
L
S
T
S
V
R
G
D
R
H
G
A
R
S
K
L
R
R
A
H
--------------
L
K
F
Y
D
D
V
G
S
A
P
E
V
A
S
L
S
P
A
A
V
V
F
QG
G
G
G
Y
D
N
A
P
D
F
L
D
A
Q
F
D
H
F
E
R
V
G
T
R
P
E
V
E
V
F
N
H
A
I
V
D
N
A
T
S
L
Y
R
D
R
L
L
R
T
G
K
P
V
L
------
F
M
L
VAG
V
D
Q
Y
R
R
D
P
I
T
G
E
V
E
D
D
S
L
I
A
R
V
----
V
R
E
E
I
S
S
L
L
A
D
E
S
A
D
S
H
R
R
A
V
E
L
A
I
G
Q
L
R
P
--
V
V
E
R
L
R
A
S
F
P
V
S
K
I
S
I
L
L
P
G
P
M
Q
N
L
L
V
D
V
A
L
G
L
GLD
G
I
R
V
G
LEDGL
T
V
N
D
A
R
V
P
G
G
V
R
K
A
R
G
T
W
E
Q
V
S
L
V
-
R
E
E
L
L
G
R
G
A
T
I
L
T
A
A
Q
V
R
D
M
F
G
L
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.49
25%
-23
- C1 -
2QQO
3
NRP2_HUMAN
A:
[7-190]
---------------------------------------
D
C
S
K
N
F
-
T
S
P
N
G
T
I
E
S
P
G
F
P
E
K
Y
P
H
N
L
D
C
T
F
T
I
L
A
K
P
K
M
E
I
I
L
Q
F
L
I
-
F
D
L
E
H
D
----------
C
K
Y
D
W
L
D
I
W
D
G
I
P
---
H
-----
V
GPLI
G
K
Y
C
G
-
T
K
T
P
-------
S
E
L
R
S
S
T
G
I
L
S
L
T
F
H
T
D
M
A
V
A
--
K
D
--
G
F
S
A
R
Y
Y
L
V
H------------------------------------------------------------
Q
C
N
V
P
L
G
M
E
S
G
R
--
I
A
N
E
Q
I
S
A
S
S
T
Y
S
D
G
R
W
T
P
Q
Q
S
R
L
H
G
D
D
N
G
W
T
P
N
L
D
S
N
K
E
Y
L
-
Q
V
D
L
R
F
L
T
M
L
T
A
I
A
T
Q
G
A
I
S
R
E
T
Q
N
G
Y
Y
V
K
S
Y
K
L
E
V
S
T
N
G
E
D
W
M
V
Y
R
H
G
K
N
H
K
V
F
Q
A
N
N
D
A
T
E
V
V
L
N
K
L
H
A
P
L
L
T
R
F
V
R
I
R
P
Q
T
W
H
S
G
-------
I
A
L
R
L
E
L
F
G
C
R
V
T
D
A
P
C
S
N
M
L
G
M
L
S
G
L
--
I
A
D
S
Q
I
S
A
S
S
T
Q
E
Y
L
W
S
P
S
A
A
R
L
V
S
S
R
S
G
W
F
P
R
I
P
Q
A
Q
P
G
E
E
W
L
Q
V
D
L
G
T
P
K
T
V
K
G
V
I
I
Q
G
A
R
G
G
I
T
A
V
E
A
R
A
F
V
R
K
F
K
V
S
Y
S
L
N
G
K
D
W
E
Y
I
Q
D
P
R
T
Q
Q
P
K
L
F
E
G
N
M
H
Y
D
T
P
D
I
R
R
F
D
P
I
P
A
Q
Y
V
R
V
Y
P
E
R
W
S
P
A
G
I
G
M
R
L
E
V
L
G
C
D
W
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
58.21
32%
-15
- C1 -
3KQ4
9
F:
[232-366]
--------------------------------------
T
G
C
G
G
N
L
-
T
T
S
S
G
T
F
I
S
P
N
Y
P
M
P
Y
Y
H
S
S
E
C
Y
W
W
L
K
S
S
H
G
S
A
F
E
L
E
F
K
D
-
F
H
L
E
H
H
--
P
N
------
C
T
L
D
Y
L
A
V
Y
D
G
P
S
---
S
NSHLL
T
-----
Q
L
C
G
D
E
K
P
P
-------
L
-
I
R
S
S
G
D
S
M
F
I
K
L
R
T
D
E
G
Q
Q
--
G
R
--
G
F
K
A
E
Y
R
Q
T
-
C
E
--------
N
---------------------------------------------
V
----
V
I
V
N
Q
T
-------
Y
G
I
L
E
S
I
G
Y
P
N
P
Y
S
E
N
Q
H
C
N
W
T
I
R
A
T
T
G
N
T
V
N
Y
T
F
L
A
F
D
L
E
H
-
H
I
N
C
S
T
D
Y
L
E
L
Y
D
G
P
R
Q
M
G
R
Y
C
G
V
D
L
P
P
P
G
S
T
T
S
S
K
L
Q
V
L
L
L
T
D
G
V
G
R
R
E
K
G
F
Q
M
Q
W
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
58.03
32%
-15
- C1 -
3KQ4
5
CUBN_HUMAN
B:
[232-366]
--------------------------------------
T
G
C
G
G
N
L
-
T
T
S
S
G
T
F
I
S
P
N
Y
P
M
P
Y
Y
H
S
S
E
C
Y
W
W
L
K
S
S
H
G
S
A
F
E
L
E
F
K
D
-
F
H
L
E
H
H
--
P
N
------
C
T
L
D
Y
L
A
V
Y
D
G
P
S
---
S
NSHLL
T
-----
Q
L
C
G
D
E
K
P
P
-------
L
-
I
R
S
S
G
D
S
M
F
I
K
L
R
T
D
E
G
Q
Q
--
G
R
--
G
F
K
A
E
Y
R
Q
T
-
C
E
--------
N
---------------------------------------------
V
----
V
I
V
N
Q
T
-------
Y
G
I
L
E
S
I
G
Y
P
N
P
Y
S
E
N
Q
H
C
N
W
T
I
R
A
T
T
G
N
T
V
N
Y
T
F
L
A
F
D
L
E
H
-
H
I
N
C
S
T
D
Y
L
E
L
Y
D
G
P
R
Q
M
G
R
Y
C
G
V
D
L
P
P
P
G
S
T
T
S
S
K
L
Q
V
L
L
L
T
D
G
V
G
R
R
E
K
G
F
Q
M
Q
W
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.88
25%
-22
- C1 -
2QQK
2
NRP2_HUMAN
A:
[123-309]
------------------------------------
G
S
E
D
C
S
K
N
F
-
T
S
P
N
G
T
I
E
S
P
G
F
P
E
K
Y
P
H
N
L
D
C
T
F
T
I
L
A
K
P
K
M
E
I
I
L
Q
F
L
I
-
F
D
L
---------------
Y
D
W
L
D
I
W
D
G
I
P
---
H
-----
V
GPLI
G
K
Y
C
G
-
T
K
T
P
-------
S
E
L
R
S
S
T
G
I
L
S
L
T
F
H
T
D
M
A
V
A
--
K
D
--
G
F
S
A
R
Y
Y
L
V
H
Q
E
--------
P
---------------------------------------------
L
E
N
F
Q
C
N
V
P
L
G
M
E
S
G
R
--
I
A
N
E
Q
I
S
A
S
S
T
Y
S
D
G
R
W
T
P
Q
Q
S
R
L
H
G
D
D
N
G
W
T
P
N
L
D
S
N
K
E
Y
L
-
Q
V
D
L
R
F
L
T
M
L
T
A
I
A
T
Q
G
A
I
S
R
E
T
Q
N
G
Y
Y
V
K
S
Y
K
L
E
V
S
T
N
G
E
D
W
M
V
Y
R
H
G
K
N
H
K
V
F
Q
A
N
N
D
A
T
E
V
V
L
N
K
L
H
A
P
L
L
T
R
F
V
R
I
R
P
Q
T
W
H
S
G
-------
I
A
L
R
L
E
L
F
G
C
R
V
T
D
A
P
C
S
N
M
L
G
M
L
S
G
L
--
I
A
D
S
Q
I
S
A
S
S
T
Q
E
W
S
P
S
A
A
R
L
V
S
S
R
S
G
W
F
P
R
I
P
Q
A
Q
P
G
E
E
W
L
Q
V
D
L
G
T
P
K
T
V
K
G
V
I
I
Q
G
A
R
A
R
A
F
V
R
K
F
K
V
S
Y
S
L
N
G
K
D
W
E
Y
I
Q
D
P
R
T
Q
Q
P
K
L
F
E
G
N
M
H
Y
D
T
P
D
I
R
R
F
D
P
I
P
A
Q
Y
V
R
V
Y
P
E
R
W
S
P
A
G
I
G
M
R
L
E
V
L
G
C
D
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
56.69
20%
-45
- C1 -
3PVN
3
CRP_HUMAN
A:
[5-202]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
K
A
F
V
F
P
K
E
S
D
T
S
Y
--
V
S
L
K
A
P
L
-
T
K
P
L
K
A
F
T
V
C
L
H
F
Y
T
E
L
S
S
T
R
G
Y
S
I
F
S
Y
A
T
K
R
Q
D
N
E
I
L
I
F
W
S
K
D
I
G
Y
S
F
T
V
G
G
S
E
I
L
F
E
--
V
P
E
V
T
V
------
A
P
V
H
I
C
T
S
W
E
S
A
S
G
I
V
E
F
W
V
D
G
K
P
R
V
R
-
K
S
L
K
K
G
Y
T
V
G
A
E
A
S
I
I
L
G
Q
E
Q
D
SFGGNFE
G
S
Q
S
L
V
G
D
I
G
N
V
N
M
W
D
F
V
L
S
P
D
E
I
N
T
I
Y
L
G
G
P
F
S
P
N
V
L
N
W
R
A
L
K
Y
E
V
Q
G
E
V
F
T
K
P
Q
L
W
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.49
32%
7
- C1 -
3POE
2
A:
[8-113]
-------------------------------------------
L
F
-
T
Q
R
T
G
T
I
T
S
P
D
Y
P
N
P
Y
P
K
S
S
E
C
S
Y
T
I
D
L
E
E
G
F
M
V
T
L
Q
F
E
D
I
F
D
I
E
D
H
--
P
E
VP----
C
P
Y
D
Y
I
K
I
K
A
G
S
K
V--
W
-----
G
-----
P
F
C
G
E
K
S
P
E
--------
P
I
S
T
Q
S
H
S
I
Q
I
L
F
R
S
D
N
S
G
E
--
N
R
--
G
W
R
L
S
Y
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.23
31%
-27
- C1 -
4GZ9
6
NRP1_MOUSE
A:
[128-244]
---------------------------------------
E
C
S
Q
N
Y
-
T
A
P
T
G
V
I
K
S
P
G
F
P
E
K
Y
P
N
S
L
E
C
T
Y
I
I
F
A
P
K
M
S
E
I
I
L
E
F
E
S
-
F
D
L
E
Q
D
--
S
N
PPGGMF
C
R
Y
D
R
L
E
I
W
D
G
F
P
---
E
-----
V
GPHI
G
R
Y
C
G
Q
K
T
P
G
--------
R
I
R
S
S
S
G
V
L
S
M
V
F
Y
T
D
S
A
I
A
--
K
E
--
G
F
S
A
N
Y
S
V
L
-
Q
S
--------
S
---------------------------------------------
I
S
E
D
F
K
C
M
E
A
L
G
M
E
S
G
--
E
I
H
S
D
Q
I
T
A
S
S
Q
Y
G
T
N
W
S
V
E
R
S
R
L
N
Y
P
E
N
G
W
T
P
G
E
D
S
Y
K
E
W
I
-
Q
V
D
L
G
L
L
R
F
V
T
A
V
G
T
Q
G
A
I
S
K
E
T
K
K
K
Y
Y
V
K
T
Y
R
V
D
I
S
S
N
G
E
D
W
I
S
L
K
E
G
N
K
A
I
I
F
Q
G
N
T
N
P
T
D
V
V
L
G
V
F
S
K
P
L
I
T
R
F
V
R
I
K
P
V
S
W
E
T
G
-------
I
S
M
R
F
E
V
Y
G
C
K
I
T
D
Y
P
C
S
G
M
L
G
M
V
S
G
L
--
I
S
D
S
Q
I
T
A
S
N
Q
A
D
R
N
W
M
P
E
N
I
R
L
V
T
S
R
T
G
W
A
L
P
P
S
P
H
P
Y
T
N
E
W
L
Q
V
D
L
G
D
E
K
I
V
R
G
V
I
I
Q
G
G
K
H
R
E
N
K
V
F
M
R
K
F
K
I
A
Y
S
N
N
G
S
D
W
K
T
I
M
D
D
S
K
R
K
A
K
S
F
E
G
N
N
N
Y
D
T
P
E
L
R
T
F
S
P
L
S
T
R
F
I
R
I
Y
P
E
R
A
T
H
S
G
L
G
L
R
M
E
L
L
G
C
E
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
54.93
32%
6
- C1 -
3POG
2
MASP1_RAT
B:
[8-113]
-------------------------------------------
L
F
-
T
Q
R
T
G
T
I
T
S
P
D
Y
P
N
P
Y
P
K
S
S
E
C
S
Y
T
I
D
L
E
E
G
F
M
V
T
L
Q
F
E
D
I
F
D
I
E
D
H
--
P
E
VP----
C
P
Y
D
Y
I
K
I
K
A
G
S
K
V--
W
-----
G
-----
P
F
C
G
E
K
S
P
E
--------
P
I
S
T
Q
S
H
S
I
Q
I
L
F
R
S
D
N
S
G
E
--
N
R
--
G
W
R
L
S
Y
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.67
31%
-15
- C1 -
4LOR
6
C1S_HUMAN
A:
[5-126]
--------------------------------------------------
G
E
I
L
S
P
N
Y
P
Q
A
Y
P
S
E
V
E
K
S
W
D
I
E
V
P
E
G
Y
G
I
H
L
Y
F
T
H
-
L
D
I
E
L
S
--
E
N
------
C
A
Y
D
S
V
Q
I
I
S
G
D
T
---
E
-----
E
G
----
R
L
C
G
Q
R
S
S
N
NPHSPIV
E
E
F
Q
V
P
Y
N
K
L
Q
V
I
F
K
S
D
F
S
N
E
--
E
R
FT
G
F
A
A
Y
Y
V
A
T
-
D
I
--------
N
---------------------------------------------
E
C
T
D
F
V
D
V
P
C
S
H
F
C
N
N
--
F
I
G
G
Y
F
C
S
C
P
P
E
Y
F
L
H
D
D
M
K
N
C
G
V
N
C
S
G
D
V
F
T
A
L
I
G
E
I
A
S
P
N
-
Y
P
K
P
Y
P
E
N
S
R
C
E
Y
Q
I
R
L
E
K
G
F
Q
V
V
V
T
L
R
R
E
D
F
D
V
E
A
A
D
S
A
G
N
C
L
D
S
L
V
F
V
A
G
D
R
Q
F
G
P
Y
C
G
H
G
F
P
G
P
L
N
I
E
T
K
S
N
A
L
D
I
I
F
Q
T
D
L
T
G
Q
-------
K
K
G
W
K
L
R
Y
H
G
D
P
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
54.38
25%
-28
- C1 -
2QQL
-
NRP2_HUMAN
A:
[145-331]
------------------------------------
G
S
E
D
C
S
K
N
F
-
T
S
P
N
G
T
I
E
S
P
G
F
P
E
K
Y
P
H
N
L
D
C
T
F
T
I
L
A
K
P
K
M
E
I
I
L
Q
F
L
I
-
F
D
L
-------------
C
K
Y
D
W
L
D
I
W
D
G
I
P
---
H
-----
V
GPLI
G
K
Y
C
G
-
T
K
T
P
-------
S
E
L
R
S
S
T
G
I
L
S
L
T
F
H
T
D
M
A
V
A
--
K
D
--
G
F
S
A
R
Y
Y
L
V
H
Q
E
--------
P
---------------------------------------------
L
E
N
F
Q
C
N
V
P
L
G
M
E
S
G
R
--
I
A
N
E
Q
I
S
A
S
S
T
Y
S
D
G
R
W
T
P
Q
Q
S
R
L
H
G
D
D
N
G
W
T
P
N
L
D
S
N
K
E
Y
L
-
Q
V
D
L
R
F
L
T
M
L
T
A
I
A
T
Q
G
A
I
S
R
E
T
Q
N
G
Y
Y
V
K
S
Y
K
L
E
V
S
T
N
G
E
D
W
M
V
Y
R
H
G
K
N
H
K
V
F
Q
A
N
N
D
A
T
E
V
V
L
N
K
L
H
A
P
L
L
T
R
F
V
R
I
R
P
Q
T
W
H
S
G
-------
I
A
L
R
L
E
L
F
G
C
R
V
T
D
A
P
C
S
N
M
L
G
M
L
S
G
L
--
I
A
D
S
Q
I
S
A
S
S
T
Q
E
Y
L
W
S
P
S
A
A
R
L
V
S
S
R
S
G
W
F
P
R
I
P
Q
A
Q
P
G
E
E
W
L
Q
V
D
L
G
T
P
K
T
V
K
G
V
I
I
Q
G
A
R
G
A
R
A
F
V
R
K
F
K
V
S
Y
S
L
N
G
K
D
W
E
Y
I
Q
D
P
R
T
Q
Q
P
K
L
F
E
G
N
M
H
Y
D
T
P
D
I
R
R
F
D
P
I
P
A
Q
Y
V
R
V
Y
P
E
R
W
S
P
A
G
I
G
M
R
L
E
V
L
G
C
D
W
T
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
54.25
31%
-13
- C1 -
4LMF
3
C1S_HUMAN
A:
[5-126]
--------------------------------------------------
G
E
I
L
S
P
N
Y
P
Q
A
Y
P
S
E
V
E
K
S
W
D
I
E
V
P
E
G
Y
G
I
H
L
Y
F
T
H
-
L
D
I
E
L
S
--
E
N
------
C
A
Y
D
S
V
Q
I
I
S
G
D
T
---
E
-----
E
G
----
R
L
C
G
Q
R
S
S
N
NPHSPIV
E
E
F
Q
V
P
Y
N
K
L
Q
V
I
F
K
S
D
F
S
N
E
--
E
R
FT
G
F
A
A
Y
Y
V
A
T
-
D
I
--------
N
---------------------------------------------
E
C
T
D
F
V
D
V
P
C
S
H
F
C
N
N
--
F
I
G
G
Y
F
C
S
C
P
P
E
Y
F
L
H
D
D
M
K
N
C
G
V
N
C
S
G
D
V
F
T
A
L
I
G
E
I
A
S
P
N
-
Y
P
K
P
Y
P
E
N
S
R
C
E
Y
Q
I
R
L
E
K
G
F
Q
V
V
V
T
L
R
R
E
D
F
D
V
E
A
A
D
S
A
G
N
C
L
D
S
L
V
F
V
A
G
D
R
Q
F
G
P
Y
C
G
H
G
F
P
G
P
L
N
I
E
T
K
S
N
A
L
D
I
I
F
Q
T
D
L
T
G
Q
-------
K
K
G
W
K
L
R
Y
H
G
D
P
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
54.23
31%
-7
- C1 -
4LMF
2
C1S_HUMAN
C:
[5-126]
--------------------------------------------------
G
E
I
L
S
P
N
Y
P
Q
A
Y
P
S
E
V
E
K
S
W
D
I
E
V
P
E
G
Y
G
I
H
L
Y
F
T
H
-
L
D
I
E
L
S
--
E
N
------
C
A
Y
D
S
V
Q
I
I
S
G
D
T
---
E
-----
E
G----
R
L
C
G
Q
R
S
S
N
NPHSPIV
E
E
F
Q
V
P
Y
N
K
L
Q
V
I
F
K
S
D
F
S
N
E
--
E
R
FT
G
F
A
A
Y
Y
V
A
T
-
D
I
--------
N
---------------------------------------------
E
C
T
D
F
V
D
V
P
C
S
H
F
C
N
N
--
F
I
G
G
Y
F
C
S
C
P
P
E
Y
F
L
H
D
D
M
K
N
C
G
V
N
C
S
G
D
V
F
T
A
L
I
G
E
I
A
S
P
N
-
Y
P
K
P
Y
P
E
N
S
R
C
E
Y
Q
I
R
L
E
K
G
F
Q
V
V
V
T
L
R
R
E
D
F
D
V
E
A
A
D
S
A
G
N
C
L
D
S
L
V
F
V
A
G
D
R
Q
F
G
P
Y
C
G
H
G
F
P
G
P
L
N
I
E
T
K
S
N
A
L
D
I
I
F
Q
T
D
L
T
G
Q
-------
K
K
G
W
K
L
R
Y
H
G
D
P
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
54.21
33%
8
* C1 *
3POJ
4
MASP1_RAT
A:
[3-115]
---------------------------------------
E
C
S
G
N
L
F
T
Q
R
T
G
T
I
T
S
P
D
Y
P
N
P
Y
P
K
S
S
E
C
S
Y
T
I
D
L
E
E
G
F
M
V
T
L
Q
F
E
D
I
F
D
I
E
D
H
PE
V
P
------
C
P
Y
D
Y
I
K
I
K
A
G
S
K
---
V
W----
G
-----
P
F
C
G
E
K
S
P
--------
E
P
I
S
T
Q
S
H
S
I
Q
I
L
F
R
S
D
N
S
G
E
--
N
R
--
G
W
R
L
S
Y
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
53.76
32%
11
- C1 -
3POI
2
B:
[8-113]
-------------------------------------------
L
F
-
T
Q
R
T
G
T
I
T
S
P
D
Y
P
N
P
Y
P
K
S
S
E
C
S
Y
T
I
D
L
E
E
G
F
M
V
T
L
Q
F
E
D
I
F
D
I
E
D
H
--
P
E
VP----
C
P
Y
D
Y
I
K
I
K
A
G
S
K
V--
W
-----
G
-----
P
F
C
G
E
K
S
P
E
--------
P
I
S
T
Q
S
H
S
I
Q
I
L
F
R
S
D
N
S
G
E
--
N
R
--
G
W
R
L
S
Y
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------