@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP139_HUMAN: (2016-01-10 )
MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
Atome Classification :
(20 SA)
------------.........10........20...---.....30---........40.........50........60...-....-.70.......---.80----.---.---.---.----.-...90...-.....100.......110........120.......130.......---140.......150.------------------------......--160...---..-..170------.-----.--------.----------...------.----.----.--180.---------.---------..----..------...190-----....--------....200.......210---.---..---...--------------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------------------------------------------.--.220...----....230----...---......240.......250..----------------..------..------.260.------.....--.270.......280.......290.......300.......310.......320.......330.......340.......350.-------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MEHT
H
A
H
L
AANSSLSWWSPGSACG---LG
F
V
P
V
V
---
Y
Y
S
L
L
L
C
LG-L
P
A
N
I
L
T
V
I
I
L
S
Q
L
V
A
R
R
QKSSY
N
-
Y
L
L
A
-
L
A
A
A
D
I
L
V
L
F
---
F
I
V
----
F
---
V
---
D
---
F
----
L
-
L
E
D
F
I
L
NM-QMPQV
P
D
K
I
I
E
V
L
E
FS-SI
H
T
S
I
W
I
T
V
PLTI
D
R
Y
I
A
V
CHPLKYHTV---SYP
A
R
T
R
K
V
I
V
S
V
Y
------------------------
I
T
C
F
LT--SI
P
Y
Y
W---WP-NIW--------
T
-----
E
--------
D
----------
Y
I
S
------
T
----
S
----
V
--
H
--
H
---------
V
---------
L
I
----
W
I
------
H
C
F
T
V
------
Y
L
V
P
--------
C
S
I
F
F
I
L
N
S
I
I
V
Y
K
L
-----R---RK---SN
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
R
G
YSTG
K
----
T
T
A
I
L
------
F
T
I
---
T
S
I
F
A
T
LW
A
P
R
I
I
M
I
L
Y
H
L
YG----------------AP------IQ------N
R
W
L
V
------
H
I
M
S
D
--
I
A
N
M
L
A
L
L
N
T
A
I
N
F
F
L
Y
C
F
I
S
K
R
F
R
T
M
A
A
A
T
L
K
A
F
F
K
CQKQ
P
V
Q
F
YTNH
N
F
S
ITSSPWISPA
N
S
H
C
I
K
M
L
V
Y
QYDKNGK
P
I
KVSP-------------------------------------------------------------------------------------------------
54
Fugue
88.67
20%
-115
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
---
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
--
K
K
L
R
T
P
L
N
-
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
----
L
---
Y
---
T
---
S
----
L
-
H
G
Y
F
V
F
G
------
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
------------------------
M
A
L
A
C
A
--
A
P
P
L
V
G
---
W
S
-
R
Y
I
--------
P
-----
E
GMQC
S
C
G
I
D
----------
Y
Y
T
------
P
----
H
EETN
N
--
E
--
S
---------
F
---------
V
I
----
Y
M
------
F
V
V
H
-------
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----
K
---
E
A
---
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
A
E
K
E
----
V
T
R
M
V
------
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-------------------------
Q
------
G
S
D
F
G
------
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
----
C
G
K
N
P
-----
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------------------------
33
HHSearch
88.18
22%
-142
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-494]
---------------------------------
A
N
F
---
N
K
I
F
L
P
T
---
I
Y
S
I
I
F
L
T
G
-
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
-
T
D
K
-
Y
R
L
H
-
L
S
V
A
D
L
L
F
V
I
---
T
L
P
----
F
W
--
A
---
V
---
D
----
A
-
V
A
N
W
Y
F
G
N
-
F
L
----
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
------------------------
I
P
A
L
L
L
--
T
I
P
D
F
I
---
F
A
-
N
V
S
--------
E
A
D---
D
--------
R
----------
Y
I
C
------
D
----
R
----
F
--
Y
--
P
---------
N
D
L
W
V
V
V
---
F
Q
----
F
Q
------
H
I
M
V
G
------
L
I
L
P
--------
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-----
S
---
H
S
---
G
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
--
K
G
H
Q
K
R
K
----
A
L
K
T
T
------
V
I
L
---
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
----------------
L
L
EI
I
K
Q
G
C
E
------
F
E
N
T
V
------
H
K
W
I
S
--
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
86.55
19%
-150
* C3 *
2RH1
16
ADRB2_HUMAN (first)
A:
[40-476]
----------------------------------------
V
V
G
M
G
I
---
V
M
S
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-
T
N
Y
-
F
I
T
S
-
L
A
C
A
D
L
V
M
G
L
---
A
V
V
----
P
---
F
G
A
A
H
---
I
----
L
-
M
K
M
W
T
F
G
N
-
F
W
----
C
E
F
W
T
S
I
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
------------------------
I
V
S
G
L
T
--
S
F
L
P
I
Q
---
M
H
W
Y
R
A
TH------
Q
-----
E
--------
A
----------
I
N
C
Y
A
EETC
C
----
D
----
F
--
F
TN
Q
---------
A
---------
Y
A
----
I
A
------
S
S
I
V
S
------
F
Y
V
P
--------
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----
K
---
R
Q
---
L
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
K
--
F
C
L
K
E
H
K
----
A
L
K
T
L
------
G
I
I
---
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----------------
D
N
------
L
----------
I
R
------
K
E
V
Y
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
85.91
18%
-117
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
---
F
S
M
L
-
A
A
---
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
--
K
K
L
R
T
P
L
N
-
Y
I
L
L
-
N
L
A
V
A
D
L
F
M
V
---
F
G
G
----
F
---
T
---
T
---
T
----
L
-
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
------------------------
M
A
L
A
C
A
--
A
P
P
L
V
G
---
W
S
-
R
Y
I
--------
P
-----
E
GMQC
S
C
G
I
D
----------
Y
Y
T
------
P
HEET
N
----
N
--
E
--
S
---------
F
---------
V
I
----
Y
M
------
F
V
V
H
-------
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----
K
---
E
A
---
A
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
------
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-------------------------
Q
------
G
S
D
F
G
------
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
----
C
G
K
N
P
--
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.81
22%
-153
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[126-402]
------------------------------------------
V
T
I
V
---
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
--
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
-
L
A
L
A
D
T
L
V
L
L
---
T
L
P
----
F
Q
G
-
T
---
D
---
I
----
L
-
L
G
F
W
P
F
G
N
-
A
L
C
----
K
T
V
I
A
I
D
Y
Y
-
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
------------------------
A
L
A
S
V
V
--
G
V
P
V
A
I
---
M
G
-
S
A
Q
--------
V
-----
E
--------
D
----------
E
E
I
------
E
----
C
----
L
--
V
--
E
---------
I
---------
P
T
PQDY
W
G
------
P
V
F
A
I
C
I
F
L
FS
F
I
V
P
--------
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-----
R
---
G
V
RLL
S
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
K
D
R
N
L
R
R
----
I
T
R
L
V
------
L
V
V
---
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
----------------
V
Q
------
P
S
------
S
E
T
A
V
------
A
I
L
R
---
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
79.88
19%
-143
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-467]
----------------------------------------
S
S
V
Y
I
T
---
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
-
T
N
Y
-
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
---
L
A
I
----
P
---
F
---
A
---
I
----
T
I
S
T
G
F
C
A
A
C
-
H
G
----
C
L
F
I
A
C
F
V
L
V
-
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
--
G
L
T
P
M
L
---
G
W
-
N
N
C
--------
G
-----
Q
--------
S
----------
Q
G
C
------
G
----
E
----
G
QV
A
--
C
---------
L
FEDVVP
M
N
Y
M
V
----
Y
F
------
N
F
F
A
C
------
V
L
V
P
--------
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----
R
---
R
Q
---
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
T
L
Q
K
E
V
H
----
A
A
K
S
L
------
A
I
I
---
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
----------------
P
D
------
C
--------
S
H
A
P
------
L
W
L
M
Y
--
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.68
18%
-145
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-471]
-------------------------------------------
Y
A
L
---
S
Y
C
A
L
I
L
A
I
-
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
-
T
N
Y
-
L
V
V
S
-
L
A
V
A
D
L
L
V
A
T
---
L
V
M
----
P
---
W
---
V
---
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
-
I
C
----
C
D
V
F
V
T
L
D
V
M
-
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
------------------------
V
L
A
F
A
V
--
S
C
P
L
L
F
---
G
F
-
N
T
T
--------
G
-----
D
--------
P
----------
T
V
C
------
S
----
I
----
S
--
N
--
P
---------
D
---------
F
V
----
I
Y
------
S
S
V
V
S
------
F
Y
L
P
--------
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
-----
K
---
Q
R
---
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
--
V
P
L
R
E
K
K
----
A
T
Q
M
V
------
A
I
V
---
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
----------------
Q
T
------
C
---------
H
V
S
------
P
E
L
Y
S
--
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
78.12
16%
-130
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------------------
P
C
F
R
E
E
N
A
N
F
N
---
K
I
F
L
P
T
I
---
Y
S
I
I
F
L
T
G
I
-
V
G
N
G
L
V
I
L
V
M
--
G
Y
Q
K
K
L
R
S
M
T
D
K
-
Y
R
L
H
-
L
S
V
A
D
L
L
F
V
I
---
T
----------
L
---
P
---
F
----
W
-
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
------------------------
I
P
A
L
L
L
--
T
I
P
D
F
I
---
F
A
-
N
V
S
E
A
DD
R
Y
I
C
D
-----
R
--------
F
----------
Y
P
N
------
D
----
L
----
W
--
V
--
V
---------
V
---------
F
Q
----
F
Q
------
H
I
M
V
G
------
L
I
L
P
--------
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-----
S
---
H
S
GS-
N
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
L
R
I
D
E
G
L
----
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIG
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
RNTNGVIT
K
D
E
A
E
K
L
F
N
Q
------
D
V
------
D
A
A
V
R
------
G
I
L
R
N
AK
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
---
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
39
HHSearch
77.34
17%
-141
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[59-492]
---------------------------------
K
E
N
---
S
I
K
L
T
S
V
---
V
F
I
L
I
C
C
F
I
-
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
-
M
Y
Y
-
F
I
G
N
-
L
A
L
S
D
L
L
A
G
V
---
A
Y
T
----
A
---
N
---
L
L
L
-
S
----
G
-
A
T
T
Y
K
L
T
P
-
A
Q
----
W
F
L
R
E
G
S
M
F
V
-
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
------------------------
V
I
S
L
I
L
--
G
G
L
P
I
M
---
G
W
-
N
C
I
--------
S
-----
A
--------
L
----------
S
S
C
------
S
----
T
----
V
--
L
--
P
---------
L
YH
K
------
H
Y
----
I
L
------
F
C
T
T
V
------
F
T
L
L
--------
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
-----
R
---
T
R
---
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
S
S
E
N
V
A
----
L
L
K
T
V
------
I
I
V
---
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
----------------
K
V
------
K
--------
T
C
D
I
------
L
F
R
A
E
--
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
76.69
19%
-149
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------
V
F
I
V
L
---
V
A
G
S
L
S
L
V
T
-
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
-
N
N
Y
-
F
L
F
S
-
L
A
C
A
D
L
I
I
G
V
---
F
S
M
----
N
L
Y
T
L
---
Y
---
T
----
V
-
I
G
Y
W
P
L
G
P
-
V
V
----
C
D
L
W
L
A
L
D
Y
V
-
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
------------------------
V
L
S
F
I
L
--
W
A
P
A
I
L
---
F
W
-
Q
F
I
--------
V
GVRTV
E
--------
D
----------
G
E
C
------
Y
----
I
----
Q
--
F
--
F
SN
A
------
A
---------
V
T
----
F
G
------
T
A
I
A
A
------
F
Y
L
P
--------
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-----
K
---
S
R
---
I
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
--
P
P
S
R
E
K
K
----
V
T
R
T
I
------
L
A
I
---
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
----------------
A
P
------
C
I
----------
P
------
N
T
V
W
T
--
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
75.83
16%
-145
- C3 -
2Z73
5
OPSD_TODPA
A:
[30-337]
---------------------------------
P
D
A
---
V
Y
Y
S
L
G
I
---
F
I
G
I
C
G
I
I
G
-
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
-
A
N
M
-
F
I
I
N
-
L
A
F
S
D
F
T
F
S
L
---
V
N
G
FP
L
M
T
---
I
---
S
---
C
----
F
-
L
K
K
W
I
F
G
F
-
A
A
----
C
K
V
Y
G
F
I
G
G
I
-
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
------------------------
L
W
S
V
L
W
--
A
I
G
P
I
F
---
G
W
-
G
A
Y
--------
T
L
E
G--
V
--------
L
----------
C
N
C
------
S
----
F
----
D
--
Y
--
I
SRD
S
T
T
R
--
S
---------
N
I
----
L
C
------
M
F
I
L
G
------
F
F
G
P
--------
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----
S
---
N
H
---
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
----------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
G
A
N
A
E
M
R
----
L
A
K
I
S
------
I
V
I
---
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
----------------
P
L
------
E
---------
W
V
T
------
P
Y
A
A
Q
--
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--------------------------------------------------------------------------------------------------------------------------
38
HHSearch
74.61
18%
-144
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-442]
------------------------------------------
P
L
V
V
---
V
L
S
T
I
C
L
V
T
-
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
-
G
N
L
-
Y
I
V
S
-
L
S
V
A
D
L
I
V
G
A
---
V
V
M
----
P
M
N
I
L
---
Y
---
L
----
L
-
M
S
K
W
S
L
G
R
-
P
L
----
C
L
F
W
L
S
M
D
Y
V
-
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
------------------------
F
L
S
F
L
W
--
V
I
P
I
L
G
---
W
N
-
H
-----------------RR------
E
----------
D
K
C
------
E
----
T
----
D
--
F
--
Y
---------
D
V
T
W
------
F
K
----
V
M
------
T
A
I
I
N
------
F
Y
L
P
--------
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-----
R
---
Q
H
---
C
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
L
--
H
M
N
R
E
R
K
----
A
A
K
Q
L
------
G
F
I
---
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
----------------
K
N
------
C
C
----------
N
------
E
H
L
H
M
--
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
72.44
18%
-126
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-323]
---------------------------------------
Q
F
S
M
L
A
A
---
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
-
L
N
Y
-
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
---
G
G
F
----
T
---
T
T
L
Y
T
---
S
----
L
-
H
G
Y
F
V
F
G
P
-
T
G
----
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
------------------------
V
M
A
L
A
C
--
A
A
P
P
L
V
---
G
W
-
S
R
Y
--------
I
P
----
E
--------
G
MQ--------
C
S
C
------
G
----
I
----
D
--
Y
--
Y
TPHEETN
N
E
S
---------
F
V
----
I
Y
------
M
F
V
V
H
------
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----
K
---
E
A
---
A
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QESA-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
A
E
K
E
----
V
T
R
M
V
------
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
----------------
Q
G
------
S
---------
D
F
G
------
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------
42
HHSearch
71.99
17%
-146
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-321]
-----------------------------------------
V
L
W
A
A
---
A
Y
T
V
I
V
V
T
S
-
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
-
T
N
Y
-
F
L
V
N
-
L
A
F
A
E
A
S
M
A
A
---
F
N
T
----
V
---
V
---
N
F
T
Y
A
----
V
-
H
N
E
W
Y
Y
G
L
-
F
Y
----
C
K
F
H
N
F
F
P
I
A
-
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
------------------------
V
L
A
L
L
L
--
A
F
P
Q
G
Y
---
Y
S
-
T
T
E
--------
T
-----
M
PS------
R
----------
V
V
C
------
M
----
I
----
E
--
W
--
P
EHPNKIY
E
K
V
---------
Y
H
----
I
C
------
V
T
V
L
I
------
Y
F
L
P
--------
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----
W
---
A
S
---
E
I
P
GDSSDRY-------------------------------------------------------------------------------------------------------------------------------------------------------
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
Q
V
S
A
K
R
K
----
V
V
K
M
M
------
I
V
V
---
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
----------------
P
D
------
L
Y
------
L
K
K
F
I
------
Q
Q
V
Y
L
--
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
----------------------------------------------------------------------------------------------------------
45
HHSearch
67.83
19%
-129
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-321]
-----------------------------------
L
---
N
K
Y
V
V
I
I
---
A
Y
A
L
V
F
L
L
S
-
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
-
T
D
V
-
Y
L
L
N
-
L
A
L
A
D
L
L
F
A
L
---
T
L
P
----
I
---
W
A
--
A
---
S
----
K
-
V
N
G
W
I
F
G
T
-
F
L
----
C
K
V
V
S
L
L
K
E
V
-
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
------------------------
G
L
S
M
N
L
--
S
L
P
F
F
L
---
F
R
-
Q
A
Y
--------
H
-----
P
NNS-----
S
----------
P
V
C
------
Y
----
E
----
V
--
L
--
G
NDTAKWRM-
V
---------
L
R
----
I
L
------
P
H
T
F
G
------
F
I
V
P
--------
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----
F
---
K
A
---
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
----
A
M
R
V
I
------
F
A
V
---
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
----------------
R
T
------
Q
V
IQE
S
C
E
R
R
N
N
I
------
G
R
A
L
D
--
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.96
24%
-124
- C3 -
3OE9
1
CXCR4_HUMAN (first)
A:
[50-264]
-----------------------------------------
F
L
P
T
I
---
Y
-
S
I
I
F
L
T
G
-
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
-
K
-
Y
R
L
H
-
L
S
V
A
D
L
L
------
F
V
I
----
T
---
L
---
P
---
F
----
W
-
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
------------------------
I
P
A
L
L
L
--
T
I
P
D
F
I
---
F
A
-
N
V
S
--------
E
-----
A
--------
D
D
R
--------
Y
I
C
------
D
----
R
----
F
--
Y
--
P
---------
N
---------
D
L
----
W
V
V
V
F
Q
F
Q
H
I
M
V
G
------
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
N
I
F
E
M
L
-----
R
---
I
D
---
E
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
K
I
Y
---
K
-------
G
Y
------
Y
T
I
---
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
----------------
A
I
------
G
R
------
N
T
N
G
V
------
I
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
-------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.18
25%
-132
- C3 -
4DJH
2
ENLYS_BPT4 (first)
A:
[21-250]
------------------------------------------
I
P
V
I
I
T
A
V
Y
S
V
V
F
V
V
G
-
L
V
G
N
S
L
V
M
F
V
I
I
R
Y
T
--
K
M
K
T
A
T
N
I
Y
I
F
N
-
L
A
L
A
D
A
L
V
T
T
---
T
M
P
----
F
---
Q
---
S
---
T
----
V
----
Y
L
M
N
S
W
P
F
G
D
V
L
C
K
I
V
L
S
I
D
Y
Y
-
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
L
K
A
K
I
I
N
I
C
I
W
L
L
S
S
S
V
G
I
S
A
I
V
L
G
G
T
K
V
R
E
DVD
V
I
E
C
S
L
Q
FP
D
D
D
Y
S
W
---
W
--
D
L
F
--------
M
-----
K
I
C
------
V
----------
F
I
F
------
A
----
F
----
V
--
I
--
P
---------
V
---------
L
I
----
I
I
------
V
C
Y
T
L
------
M
I
L
R
--------
L
K
S
V
R
L
L
S
G
N
I
F
E
M
L
-----
R
---
I
D
---
E
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
K
I
Y
---
K
----
D
T
E
G
Y
------
Y
T
I
---
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
----------------
A
I
------
G
R
------
N
T
N
G
V
------
I
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
-------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.05
24%
-142
- C3 -
3ZEV
3
NTR1_RAT
A:
[116-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
------------------------
L
A
S
A
L
L
--
A
I
P
M
L
F
T
M
G
L
Q
-
N
L
S
--------
G
-----
D
--------
G
THPGG
L
V
C
T
P
I
V
D
------
T
----
A
----
T
--
L
--
K
---------
V
---------
V
I
----
Q
V
------
N
T
F
M
S
------
F
L
F
P
--------
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
H
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
G
R
V
Q
A
L
R
R
----
G
V
L
V
L
------
R
A
V
---
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
----------------
S
--------
D
------
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
--
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
----------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.53
24%
-124
- C3 -
4RWS
-
CXCR4_HUMAN (first)
A:
[49-263]
-----------------------------------------
F
L
P
T
I
---
Y
-
S
I
I
F
L
T
G
-
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
----
S
M
T
D
-
K
-
Y
R
L
H
-
L
S
V
A
D
L
L
------
F
V
I
----
T
---
L
---
P
---
F
----
W
-
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
------------------------
I
P
A
L
L
L
--
T
I
P
D
F
I
---
F
A
-
N
V
S
--------
E
-----
A
--------
D
D
R
--------
Y
I
C
------
C
----
R
----
F
--
Y
--
P
---------
N
---------
D
L
----
W
V
V
V
F
Q
F
Q
H
I
M
V
G
------
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
N
I
F
E
M
L
-----
R
---
I
D
---
E
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
K
I
Y
---
K
----
D
T
E
G
Y
------
Y
T
I
---
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
----------------
A
I
------
G
R
------
N
T
N
G
V
------
I
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
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R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
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A
G
F
T
N
S
L
R
M
L
Q
Q
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A
A
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N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
-------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.45
24%
-142
- C3 -
4BUO
8
NTR1_RAT
A:
[115-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
L
S
V
E
L
Y
L
A
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C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
------------------------
L
A
S
A
L
L
--
A
I
P
M
L
F
T
M
G
L
Q
-
N
L
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--------
G
-----
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--------
G
THPGGLVCTP
I
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------
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----
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----
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--
L
--
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---------
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--------
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-----
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V
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-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG
R
V
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R
R
----
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V
L
V
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------
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A
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---
V
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R
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----------------
S
--------
D
------
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L
F
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H
Y
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--
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P
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L
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R
Q
V
F
L
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T
L
------------------------------------------------------------------------------------------------------------------------------------------------------