@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP142_HUMAN: (2016-01-10 )
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--.......220.....--..230.......240.......250.......260.......---270.......280.......290.....--...300------.-----------.----..---.----.-----------.---------------.--310..--------.....320-.....---------...330----.......340---------....----------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------------------..350--.--.......360.......370-.....--..---380.-----...------...390.......400......-----.410.......420..--.....430.......440.......450--------------.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
I
M
ML
P
M
E
QKIQWVPT
S
L
Q
D
I
T
A
V
LGTEAY
T
E
E
D
K
S
M
V
S
H
A
Q
K
S
Q
H
S
C
L
S
H
S
R
WLRSPQVTGG
S
W
D
L
R
I
RPSKDS
S
S
F
R
Q
A
Q
C
L
RKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQ
P
R
V
T
L
LPTPHVS
G
L
S
Q
E
F
E
S
H
W
P
E
I
AERSPC
V
A
G
V
I
P
V
I
Y
Y
S
V
L
L
GLGL
P
V
S
L
L
T
A
V
A
L
A
R
L
A
T
RTRRP
S
Y
Y
Y
L
L
A
LTA
S
D
I
I
I
Q
V
V
I
V
-
F
--
A
G
F
L
L
Q
G
A
V
L
A
R
Q
V
P
--
Q
A
V
V
R
T
A
N
I
L
E
F
A
ANH
A
S
V
W
I
A
I
L
L
TV
D
R
Y
T
A
L
C
H
P
L
H
H
RAA---SSPG
R
T
R
R
A
I
A
A
V
L
S
A
A
L
L
TG
I
-
P
F
Y
W
W
--
L
D
M
WR-------D-----------T----DS---P----R-----------
T
---------------
L
--
D
E
V
L
K
--------
W
A
H
C
L
T
V
--
Y
F
IPC---------
G
V
F
L
VT----
N
S
A
I
I
H
R
L
R
R
---------RGRS----------------------------------------------------------------------------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------------------------------------------------------------LQPR---V--GKS
T
A
I
L
L
G
I
T
T
L
F
T
L
L
W
A
P
-
R
V
F
V
M
--
L
Y
---
H
M
Y
V-----APV------HR
D
W
R
V
H
L
A
L
D
V
A
N
M
V
A
M
L
H
T
A
-----ANF
G
L
Y
C
F
V
S
K
T
F
R
A
T
--
V
R
Q
V
I
H
D
AYLPCTLASQPEGMAAKPVME--------------PPGLPTGAEV
138
Fugue
83.77
24%
-99
- C1 -
4UZ1
5
NOTUM_HUMAN
A:
[9-375]
--------
N
E
D
L
R
L
H
L
L
L
N
T
S
V
T
C
N
D
G
S
P
A
--------
G
Y
Y
L
K
E
S
R
G
S
R
----
R
W
L
L
F
L
E
---
G
G
W
Y
C
----------
F
N
R
E
N
C
D
S
R
Y
D
T
M
R
R
L
M
S
S
-----------
R
D
W
--
P
R
T
R
T
G
T
G
----------
I
L
S
S
Q
P
E
E
N
P
Y
W
W
N
---------
A
N
M
V
F
I
P
Y
C
S
S
D
V
W
S
G
A
S
-------------
S
K
S
E
K
N
E
Y
----
A
F
M
G
A
L
I
I
Q
E
V
V
R
E
-
L
--
L
G
R
G
L
S
G
A
----------------
K
V
L
L
L
A
G
S
S
A
G
G
-
T
G
V
L
L
N
V
D
R
V
A
E
Q
L
E
K
L
G
Y
--------
P
A
I
Q
V
R
G
L
A
D
-------
S
G
-----
W
F
--
L
D
N
K
Q
-------
Y
-----------
R
----
H
T
---
D
----
C
-----------
V
----------------------
D
--------
T
I
T
C
A
P
T
--
E
A
I
R
R
---------
G
I
R
Y
W
-----
N
G
V
V
P
E
R
C
R
R
---------
Q
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
W
N
C
F
F
G
Y
K
V
Y
P
T
L
--
R
S
-
P
V
F
V
V
Q
W
L
F
D
E
A
Q
L
T
V
-----
D
N
V
------
H
L
P
V
Q
E
G
L
R
L
Y
I
Q
N
L
G
R
E
L
R
H
T
L
K
DVP
A
S
F
A
P
A
C
L
S
H
E
I
I
I
R
S
HW
T
D
V
Q
V
K
G
T
S
L
P
R
A
L
H
C
W
D
R
S
L
H
K
T
P
L
K
G
CPV
H
L
V
D
SCPWPHC
N
P
S
C
P
T
G
---
133
Fugue
81.31
17%
-99
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
--------------------------------
V
R
S
P
F
----------------------------
E
A
P
Q
Y
Y
L
-------------------------------------------------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--
T
G
C
N
L
E
G
F
F
A
T
L
G
G
-
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
--
S
R
Y
I
P
-------
E
GMQC
S
C
G
I
DYY
T
----
P
H
---
E
----
E
-----------
T
---------------
N
--
N
E
S
F
V
--------
I
Y
M
F
V
V
H
--
F
I
I
P
L
---------
I
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
---
E
--
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
--
F
Y
---
I
F
T
H
-----
Q
G
S
------
D
F
G
---
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-----
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
--
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
122
HHSearch
80.85
17%
-126
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
-
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
-
P
--
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
--
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
F
G
--
F
N
T
T
G
-------
D
-----------
P
----
T
V
---
C
----
S
-----------
I
---------------
S
--
N
P
D
F
V
--------
I
Y
S
S
V
V
S
--
F
Y
L
P
F
---------
G
V
T
V
L
V
----
Y
A
R
I
Y
V
V
L
K
Q
---------
R
R
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
L
R
---
E
--
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
-
F
F
L
T
H
--
V
L
---
N
T
H
C
-----
Q
T
C
------
H
---
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
-----
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
--
F
L
K
I
L
S
C
---------------------------------------------
116
HHSearch
80.01
17%
-132
* C2 *
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
-
P
--
F
G
A
A
H
I
L
M
K
-
M
W
T
F
G
--
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
HW
Y
R
A
T
H
-------
Q
E
A
I
N
C
Y
A
EE--
T
----
C
C
---
D
----
F
-----------
F
---------------
T
--
N
Q
A
Y
A
--------
I
A
S
S
I
V
S
--
F
Y
V
P
L
---------
V
I
M
V
F
V
----
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
C
L
K
---
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
-
F
F
I
V
N
--
I
V
---
H
V
I
Q
-----
D
N
L
----------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
-----
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
--
F
Q
E
L
L
C
L
---------------------------------------------
115
HHSearch
78.30
18%
-132
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
-
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
-
N
--
L
Y
T
L
Y
T
V
I
-
G
Y
W
P
L
G
--
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-
P
A
I
L
F
--
W
Q
F
I
V
GVRTVED
G
-----------
E
----
C
Y
---
I
----
Q
-----------
F
F--------------
S
--
N
A
A
V
T
--------
F
G
T
A
I
A
A
--
F
Y
L
P
V
---------
I
I
M
T
V
L
----
Y
W
H
I
S
R
A
S
K
S
---------
R
I
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
P
S
R
---
E
--
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
-
Y
N
V
M
V
--
L
I
---
N
T
F
C
-----
A
P
C
------
I
----
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
-----
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
--
F
K
H
L
L
M
----------------------------------------------
15
PsiBlast_PDB
78.13
20%
-132
- C2 -
4N6H
22
OPRD_HUMAN
A:
[132-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
-
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
-
F
Q
S
A
K
Y
L
M
E
T
W
P
F
G
E
L
L
C
--
K
A
V
L
S
----
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
-------
M
V
M
-------
A
-----------
V
----
T
R
---
P
----
R
-----------
D
GAVVC
M
L
Q
F
P
SP
S
W
Y
W
--
D
T
V
T
K
--------
I
C
V
F
L
F
A
--
F
V
V
P
I
---------
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
---------
S
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
---
L
--
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
--
V
W
---
T
L
-
V
-----
D
I
D
------
R
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
-----
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
--
F
R
Q
L
C
R
K
---
P
C
G
---------------------------------------
121
HHSearch
77.70
15%
-137
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
-
P
--
F
A
I
T
I
S
T
---
G
F
C
A
A
--
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
L
G
--
W
N
N
C
G
Q-------SQ---------
G
----
C
G
---
E
----
G
QVACLFE----
D
---------------
V
VP
M
N
Y
M
V
--------
Y
F
N
F
F
A
C
--
V
L
V
P
L
---------
L
L
M
L
G
V
----
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
---
E
--
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
-----
P
D
C
------
S
--
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------
114
HHSearch
77.60
16%
-115
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-499]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
-
L
-
P
--
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
--
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
-
P
D
F
I
F
--
A
N
V
S
E
-------
A
-----------
D
D
R
Y
I
C
D
---
R
F
Y
PN
D
-----------
L
---------------
W
--
V
V
V
F
Q
--------
F
Q
H
I
M
V
G
--
L
I
L
P
G
---------
I
V
I
L
S
C
----
Y
C
I
I
I
S
K
L
S
H
---------
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
H
Q
---
K
--
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
-
Y
Y
I
G
I
--
S
I
---
D
S
F
I
-----
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
-----
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
--
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------------
134
Fugue
76.14
16%
-100
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
--------------------------------
V
R
S
P
F
------------------------------------------------------------------
E
A
P
Q
Y
Y
L
A
----------------
E
P
W
Q
F
S
M
L
-
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--
T
G
C
N
L
E
G
F
F
A
T
L
G
G
-
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
--
S
R
Y
I
P
-------
E
GMQC
S
C
G
I
DYY
T
----
P
H
---
E
----
E
-----------
T
---------------
N
--
N
E
S
F
V
--------
I
Y
M
F
V
V
H
--
F
I
I
P
L
---------
I
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
Q
QQESA-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
---
E
--
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
A
G
--
V
A
---
F
Y
I
F
-----
T
H
Q
------
G
S
D
F
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-----
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
--
M
V
T
T
L
C
C
G
K
N
P
--
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
--------------
S
Q
V
A
P
A
----
1
PsiBlast_PDB
76.10
22%
-131
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[131-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
L
A
V
C
V
G
-
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
-
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
P
-
F
--
Q
G
----
T
D
I
L
L
G
F
W
P
FG
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
-
P
V
A
I
M
--
G
S
A
Q
V
-------
E
-----------
D
----
E
E
---
I
----
E
-----------
C
---------------
L
--
V
E
I
P
T
PQDY
W
G
P
V
F
A
I
C
I
F
L
FS
F
I
V
P
V
---------
L
V
I
S
V
C
----
Y
S
L
M
I
R
R
L
R
G
V--------
R
L
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
D
R
N
L
--
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
--
A
Q
---
G
L
G
V
-----
Q
P
S
------
S
E
T
A
V
A
I
L
R
F
C
T
A
--
L
G
Y
V
N
S
C
-----
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
--
F
R
--------------------------------------------------
117
HHSearch
76.04
16%
-122
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
-
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
-
P
--
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
--
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-
P
I
L
G
W
--
N
H
-----------RRED-------
K
----
C
E
---
T
----
D
-----------
F
---------------
Y
D-
V
T
W
F
K
--------
V
M
T
A
I
I
N
--
F
Y
L
P
T
---------
L
L
M
L
W
F
----
Y
A
K
I
Y
K
A
V
R
Q
---------
H
C
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
M
N
R
---
E
--
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
-
Y
F
I
F
F
--
M
V
---
I
A
F
C
-----
K
N
C
------
C
----
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
-----
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
--
F
K
R
I
L
H
I
---------------------------------------------
9
PsiBlast_PDB
75.58
21%
-134
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-------
P
---------------------------GCGEGQVAC--
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PDCSH
A
P
L
---------
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
---------------------------------------------
20
PsiBlast_PDB
75.52
21%
-132
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
----
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-----------------------------------SQGCGEGQ
V
A
C
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PD
C
S
H
A
P
L
---------
W
L
M
Y
L
A
I
V
L
S
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
H
V
L
------------------------------------------
8
PsiBlast_PDB
75.40
21%
-137
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-------
P
---------------------------GCGEGQVAC--
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PDCSH
A
P
L
---------
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
---------------------------------------------
19
PsiBlast_PDB
75.11
21%
-127
- C2 -
3VG9
8
?
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
----
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-----------------------------------SQGCGEGQV
A
C
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PD
C
S
H
A
P
L
---------
W
L
M
Y
L
A
I
V
L
S
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------
5
PsiBlast_PDB
75.07
21%
-133
- C2 -
3PWH
1
?
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-------
P
---------------------------GCGEGQVAC--
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PDCSH
A
P
L
---------
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
---------------------------------------------
7
PsiBlast_PDB
75.06
21%
-134
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-------
P
---------------------------GCGEGQVAC--
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PDCSH
A
P
L
---------
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
---------------------------------------------
6
PsiBlast_PDB
74.92
21%
-134
- C2 -
3REY
1
AA2AR_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
--
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
--
N
N
C
G
Q
-------
P
---------------------------GCGEGQVAC--
L
---------------
F
--
E
D
V
V
P
--------
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
-
L
H
I
I
N
--
C
F
---
T
F
F
C
PDCSH
A
P
L
---------
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
-----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
--
F
R
K
I
I
R
S
---------------------------------------------
124
HHSearch
74.34
18%
-121
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
-
V
--
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
--
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
Y
--
S
T
T
E
T
-------
M
-----------
P
SRV
V
C
M
I
EW
P
EHPN
K
-----------
I
---------------
Y
--
E
K
V
Y
H
--------
I
C
V
T
V
L
I
--
Y
F
L
P
L
---------
L
V
I
G
Y
A
----
Y
T
V
V
G
I
T
L
W
A
---------
S
E
I
P
GDSSDRYH--------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
S
A
---
K
--
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
-
F
H
I
F
F
--
L
L
---
P
Y
I
N
-----
P
D
L
------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
-----
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
--
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
--------------
T
Q
G
S
V
Y
K
V
S
R
119
HHSearch
72.09
15%
-130
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
-
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
T
-
A
--
N
L
L
L
S
G
A
T
--
T
Y
K
L
T
--
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
-
L
P
I
M
G
--
W
N
C
I
S
AL-----
S
-----------
S
----
C
S
---
T
----
V
-----------
L
---------------
P
L-
Y
H
K
H
Y
--------
I
L
F
C
T
T
V
--
F
T
L
L
L
---------
L
S
I
V
I
L
----
Y
C
R
I
Y
S
L
V
R
T
---------
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA--
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
S
E
---
N
--
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
-
L
F
I
L
L
--
L
L
---
D
V
G
C
-----
K
V
K
------
T
--
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
-----
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
--
F
I
R
I
M
G
R
P
L
-------------------------------------------