@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP173_HUMAN: (2016-01-10 )
MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM
Atome Classification :
(20 SA)
------------......---...10........20........30........40........50........60........70....-....80........90........100.......110....-...120.......130.---......140.......150.....-..160-----.......--..170....--...180----.......190------.........200.......210.......220..---..-------..--------.------230-----------------...-------------..---------------.--.240-.-..----------------------------------..---.--.-.----------------250---------------------------------------..-------------------------------------.---.---.-.---...------------260------..----------------------.-------.-----.-----...-----.---------270.--.-----------..---------.....280.......290.......300........310...--....320.......330.......340.......350.......360.......370.---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MANTTG---
E
P
E
E
VSGALSPP
S
A
S
A
Y
V
K
L
V
L
L
G
L
I
M
C
V
S
L
A
G
N
A
I
L
S
L
L
V
L
K
E
R
ALHKA
P
Y
Y
F
L
L
D
L
C
L
AD
G
I
R
S
A
V
C
-
F
P
F
V
L
A
S
VRHGSS
W
T
F
S
A
L
S
C
K
I
V
A
F
M
A
V
L
F
C
F
H
A
A
F
M
L
F
C
-
I
S
V
T
R
Y
M
A
I
A
H
H
R
F
Y
A
K
---
R
M
T
L
W
T
C
A
A
V
I
C
M
A
W
T
L
S
V
A
MAFP-PVF-------DVG
T
Y
K
F
--
I
REE
D
Q
C
I
F
--
E
H
R
Y
FK----ANDT
L
G
F
M
--------
L
M
L
A
V
L
M
A
A
T
H
A
V
Y
G
K
L
L
L
F
E
Y
R
HRKMKP
V
Q
MVP---AI-------SQ--------N------
W
T
F
-----------------HGP-------------GA---------------T--
G
Q
A
--
A
-
A
N
----------------------------------
W
I
---
A
--G-F----------------G-----------------------------------------RG-------------------------------------P---M---P-P---T
L
L
------------
G
--------IR----------------------Q-------N-----G-----
H
A
A
-----
S
---------
R
--R--L-----------LG---------
M
D
EVK
G
E
K
Q
L
G
R
M
F
Y
A
I
T
L
L
F
L
L
LW
S
P
-
Y
I
V
A
C
Y
W
R
V
F
V
K
A
C--AV
P
H
R
Y
L
A
T
A
V
W
M
S
F
A
Q
A
A
V
N
P
I
V
C
F
L
L
N
K
D
L
K
K
C
L
R
THAPCWGTGGAPAPREPYCVM---
2
PsiBlast_PDB
91.25
20%
-153
- C4 -
4NC3
12
C562_ECOLX
A:
[23-413]
------------------------------
E
E
Q
G
N
K
L
H
W
A
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
-
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
---
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
-------
G
I
E
T
-
V
D
--
N
P
N
N
I
T
C
V
L
--
T
K
E
R
F
G
----
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
---
E
K
-------
A
D
--------
N
------
A
A
Q
-----------------
V
K
D
-------------
A
L
---------------
T
--
K
M
R
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------
D
--------
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
-------
E
-----
A
-----
Q
A
A
-----
A
---------
E
--
Q
--
L
-----------
K
T
T
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
-
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------
1
PsiBlast_PDB
90.12
20%
-152
- C4 -
4IB4
10
5HT2B_HUMAN (first)
A:
[23-413]
------------------------------
E
E
Q
G
N
K
L
H
W
A
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
-
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
---
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
-------
G
I
E
T
-----
N
P
N
N
I
T
C
V
L
--
T
K
E
R
F
G
----
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
---
E
K
-------
A
D
--------
N
------
A
A
Q
-----------------
V
K
D
-------------
A
L
---------------
T
--
K
M
R
--
A
-
A
A
----------------------------------
L
D
---
A
--
Q
K------------------------------------------------------------------------------------------------------------------
K
------------
D
--------
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
-------
E
-----
A
-----
Q
A
A
-----
A
---------
E
--
Q
--
L
-----------
K
T
T
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
-
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------
25
HHSearch
87.48
19%
-167
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
-
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
-
L
L
F
-------
G
F
N
T
T
G
-----
D
P
T
V
C
S
I
--
S
N
P
D
-------
F
V
I
Y
S
S
V
--------
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
D
T
E
--------
G
------
Y
Y
T
I
G
IGHL-----------
L
T
K
-------------
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
TN
G
V
I
--
T
-
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
---
A
L
I
N
-
M
V
F
Q
M------------
G
-----------------------------------------
E
T
-------------------------------------
G
V
A
G
F
---
T
N
S
L
R
M
L
Q
Q
------------
K
R
W
D
E
A
A
V
N
L
A
----------------------
K
S
R
W
Y
N
Q
T
P
-----
N
-----
R
A
K
R
V
I
T
T
F
---------
R
T
G
T
--
W
-----------
D
A
---------
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
-
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
--
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------
21
HHSearch
86.96
17%
-148
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
---
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
-
A
I
L
-------
F
W
Q
F
I
V
G
VR
T
V
E
D
G
E
C
Y
I
--
Q
F
F
S
N
A
----
A
V
T
F
G
T
A
I
--------
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
---
E
G
-------
L
R
L
K
I
Y
K
D
TE
G
------
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
---------
G
R
---------------
N
--
T
N
G
--
V
I
T
K
----------------------------------
D
E
---
A
--
E
-
K
----------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
-------------------------------------
G
---
V
A
G
F
T
-
N
---
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
--------
L
A
----------------------
K
-------
S
-----
R
W
Y
N
Q
T
P
N
R
-----
A
K
R
V
I
T
T
F
R
T
G
--
T
--
W
-----------
D
A
---------
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
-
Y
N
V
M
V
L
I
N
T
F
C
A
P
---
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------
31
HHSearch
86.83
22%
-160
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-334]
------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
---
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
-
P
I
F
-------
G
W
G
A
Y
T
L
--
E
G
V
L
C
N
C
S
F
--
D
Y
I
S
R
D
S
T
T
R
S
N
I
L
C
M
F
I
--------
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
---
L
------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------
K
-----
E
------------
L
--
R
-----------
K
A
---------
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
-
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
--
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
---
17
PsiBlast_PDB
86.82
22%
-179
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
22
HHSearch
86.63
19%
-155
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
-
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
---
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
-
I
L
--------
G
W
N
H
------
R
R
E
D
K
C
E
T
--
D
F
Y
D
V
T
----
W
F
K
V
M
T
A
I
--------
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
---
E
G
-------
L
R
L
K
I
Y
K
D
TE
G
Y
Y
T
I
G
I
G
H
L
LT---------------
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
---------------
N
--
T
N
G
VI
T
-
K
D
----------------------------------
E
A
E
K
L
F
--
N
-
Q
----------------
D
V
D
A
A
V
------------------------------------
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
---
N
---
S
-
L
---
R
M
L
------------
Q
--------
Q
K
R
W
D
E
A
A
V
N
L
A
------------
K
-------
S
R
W
Y
N
Q
T
-----
P
N
R
-----
A
K
R
V
I
-----
T
--
T
F
R
T
GTW--------
D
A
---------
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
-
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
---
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------
12
PsiBlast_PDB
86.63
22%
-179
- C4 -
2Y01
12
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
16
PsiBlast_PDB
86.45
22%
-176
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
18
PsiBlast_PDB
86.09
22%
-179
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
---------------------
11
PsiBlast_PDB
85.84
22%
-179
- C4 -
2Y00
13
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
4
PsiBlast_PDB
85.83
19%
-162
- C4 -
4IAR
2
C562_ECOLX
A:
[24-389]
----------------------------------------
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
T
G
R
-
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
-
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
---
K
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
-
P
F
F
--------
W
R
Q
A
--------
S
E
C
V
V
NT
D
H
I
L
Y
T
----
V
Y
S
T
V
G
A
F
--------
Y
F
P
T
L
L
L
I
---
A
L
Y
G
R
I
Y
V
-
E
A
R
S
R
I
A
D
L
E
D
N
W
E
---
T
L
-------
N
D
--------
N
------
L
K
V
-----------------
I
E
K
-------------
A
D
---------------
N
--
A
A
Q
--
V
-
K
D
----------------------------------
A
L
---
T
--
K
-
M
R
A
A
A
L
D
A
Q
K
A
TPPKL
E
D
-----------------------------------------
K
S
-------------------------------------
P
---
D
---
S
-
P
---
E
M
K
------------
D
--------
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
-------
E
-----
A
-----
Q
A
A
-----
A
---------
E
--
Q
--
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
---------
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
----
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
------------------
13
PsiBlast_PDB
85.70
22%
-178
- C4 -
2Y02
13
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
15
PsiBlast_PDB
85.36
22%
-178
- C4 -
2Y04
13
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
6
PsiBlast_PDB
84.44
22%
-166
- C4 -
2YCW
7
ADRB1_MELGA
A:
[16-294]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
----------------------
K
-------
I
-----
D
-----
R
A
S
-----
K
---------
R
K-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
14
PsiBlast_PDB
84.42
22%
-178
- C4 -
2Y03
9
ADRB1_MELGA
A:
[16-296]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
-------------------------------------------------------------S-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
40
Fugue
84.11
17%
-142
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
VVR
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
V
-
C
K
P
M
S
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
-------
G
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
G
I
--
D
--
Y
Y
T
----
P
H
E
E
T
N
N
E
--------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
F
------------
T
--------
V
K
----------------------
E
-------
A
-----
A
-----
A
S
A
-----
T
---------
T
--
Q
-----------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
5
PsiBlast_PDB
84.08
22%
-175
- C4 -
2VT4
8
ADRB1_MELGA
A:
[16-294]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
-------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
8
PsiBlast_PDB
83.93
22%
-170
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[16-294]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
----------------------
K
-------
I
-----
D
-----
R
A
S
-----
K
---------
R
K
-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
9
PsiBlast_PDB
83.59
22%
-169
- C4 -
2YCY
6
ADRB1_MELGA
A:
[16-294]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
HWWRDE
D
P
Q
A
L
K
C
--
Y
Q
D
P
G
C
C
D
F
VT
N
R
A
Y
A
I
----
A
S
S
I
I
S
F
Y
--------
I
P
L
L
I
M
I
F
V
A
L
R
V
--------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
------------------------------------
D
-----
R
A
S
-----
K
---------
R
K
-
R
--
V
-----------
M
L
---------
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
V
F
T
L
C
W
L
P
-
F
F
L
V
N
I
V
N
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------