@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP174_HUMAN: (2016-01-10 )
MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
Atome Classification :
(20 SA)
----.........10..--------------..--------------....20........30........40........50........60........70.-........80-.-..-.....90........100.......110.......120.---..-....---130.-...-.-..140.......150.......-160-.-...--....170-........180.......190.-......200.......210--------------------------------------------.....-----------------------.----.---------------------------------------------------------------------------------------------------------------------------------------------------------------220..------.....----230--.........240---........250.......--260-........270.....----..280-........290.......300.------......310..---.....320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MPAN
Y
T
C
TRPDGD--------------NT--------------
D
F
R
Y
F
I
Y
A
V
T
Y
T
V
IL
V
P
G
L
I
G
N
I
L
A
L
W
V
F
Y
G
Y
M
K
ET
K
R
A
V
I
F
M
I
N
L
A
I
A
D
L
L
Q
V
L
-
S
-
L
P
L
R
I
F
Y
Y
LN-H-DW-PFG
P
G
L
C
M
F
C
F
Y
L
K
Y
V
N
M
Y
A
S
I
Y
F
L
V
C
I
S
V
R
R
F
W
F
L
MY
P
---
F
R
-
F
H
D
C
---
K
Q
K
Y
-
D
L
Y
-
I
-
S
I
A
G
W
L
I
I
C
L
A
C
V
L
F
P
L
LRTSD-DT--S-GN
R
--
T
K
C
F
V
D--LPTRN
V
N
L
A
Q
S
V
V
M
M
T
I
G
E
L
I
G
-
F
V
T
P
L
L
I
V
L
Y
C
T
W
K
T
V
L
S
L--------------------------------------------QDKY
P
-----------------------
M
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
G
E
------
K
Q
K
A
L
----
K
----
M
I
L
T
C
A
G
V
F
L
I
----
C
FAPYHFSF
P
L
D
F
L
VK
S
N
--
E
-
I
-
K
S
C
L
A
R
R
V
I
L
I
F
H
S
V
A
----
L
C
L
A
--
S
L
N
S
C
L
D
P
V
I
Y
YF
S
T
N
E
F
R
R
R
L
------
S
R
Q
D
L
H
D
S
I
Q
L
---
H
A
K
S
F
V
SNHTASTMTPELC
47
Fugue
87.52
29%
-152
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------
S
F
K
C
A
L
T
-----------------
K
T
--------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
-
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---
K
S
-
L
G
R
L
---
K
K
K
N
-
A
I
C
-
I
-
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
-
V
R
--
K
-
N
K
T
--
I
T
C
Y
D
T
--
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG
K
D
Q
F
E
-----------------------
E
----
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-
P
L
------
R
R
K
S
I
----
Y
----
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
FQ
T
-
P
-
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
----
R
G
L
A
--
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------
1
PsiBlast_PDB
85.80
26%
-149
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[45-382]
-------------------------------
K
T
--------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
-
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
----
K
S
L
G
R
L
---
K
K
K
N
-
A
I
C
-
I
-
S
V
L
V
W
L
I
V
V
V
A
--
I
S
P
I
L
F
Y
S
--
G
T
--
G
-
V
R
K
--
N
K
T
I
T
C
--
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
P--------------------------
E
D
G
D
P
DNGVNPGTDFKDIVCPLCG----
V
----
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
----
Y
----
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
FQ
T
-
P
-
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
----
R
G
L
A
--
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------
2
PsiBlast_PDB
82.84
26%
-151
- C2 -
4XNW
2
RUBR_CLOPA
A:
[45-382]
-------------------------------
K
T
--------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
-
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---
L
K
S
L
G
R
L
---
K
K
K
N
-
A
I
C
-
I
-
S
V
L
V
W
L
I
V
V
V
A
--
I
S
P
I
L
F
Y
S
--
G
T
--
G
-
V
R
K
--
N
K
T
I
T
C
--
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
P--------------------------
E
D
G
D
P
DNGVNPGTDFKDIPDDWVCPLCG
V
----
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
----
Y
----
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
FQ
T
-
P
-
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
----
R
G
L
A
--
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------
48
Fugue
81.92
19%
-124
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
--------------
G
V
VRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
---
M
S
-
N
F
R
F
---
G
E
N
H
-
A
I
M
-
G
-
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
--
P
E
G
M
Q
--
C
S
C
G
I
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
S
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
------
E
K
E
V
T
----
R
----
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-
F
-
G
--------
P
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
------
V
T
T
L
C
C
G
K
------
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
5
PsiBlast_PDB
80.51
28%
-165
- C2 -
4N6H
22
OPRD_HUMAN
A:
[132-403]
---------------------------------------------------------
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
-
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
---
V
K
-
A
L
D
F
---
R
T
P
A
-
K
A
K
L
I
-
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
R
--
D
-
G
-
A
--
V
V
C
M
L
Q
--
F
P
S
P
--
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
-
Y
G
L
M
L
L
R
--------------------------------------------
L
R
S
V
R
-----------------------
L
----
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
K
E
------
K
D
R
S
L
R
R
I
T
R
----
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
-----------
I
D
R
R
D
P
L
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
------
R
Q
L
C
R
K
P
C
G
------------------------
7
PsiBlast_PDB
79.75
28%
-161
- C2 -
4RWD
6
C562_ECOLX (first)
A:
[129-400]
---------------------------------------------------------
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
-
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
---
V
K
-
A
L
D
F
---
R
T
P
A
-
K
A
K
L
I
-
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
R
--
D
-
G
-
A
--
V
V
C
M
L
Q
--
F
P
S
P
--
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
-
Y
G
L
M
L
L
R
--------------------------------------------
L
R
S
V
R
-----------------------
L
----
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
K
E
------
K
D
R
S
L
R
R
I
T
R
----
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
-----------
I
D
R
R
D
P
L
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
------
R
Q
L
C
-----------------------------
6
PsiBlast_PDB
78.80
28%
-166
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[129-400]
---------------------------------------------------------
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
-
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
---
V
K
-
A
L
D
F
---
R
T
P
A
-
K
A
K
L
I
-
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
R
--
D
-
G
-
A
--
V
V
C
M
L
Q
--
F
P
S
P
--
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
-
Y
G
L
M
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
------
K
D
R
S
L
R
R
I
T
R
----
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
-----------
I
D
R
R
D
P
L
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
------
R
Q
L
C
-----------------------------
49
Fugue
78.73
20%
-126
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYL
A
E
--------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
---
M
S
-
N
F
R
F
---
G
E
N
H
-
A
I
M
-
G
-
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
--
P
E
G
M
Q
--
C
S
C
G
I
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
Q
QQES
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
------
E
K
E
V
T
----
R
----
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-
F
-
G
--------
P
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
------
V
T
T
L
C
C
G
K
N
P
L
GDD
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
31
HHSearch
77.65
21%
-158
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-496]
--------------------------------
A
--------------
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
V
--
A
-
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
---
T
N
-
S
Q
R
P
---
R
K
L
L
A
E
K
V
-
V
-
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
-
E
---
A
-
D
D
R
--
Y
I
C
D
R
F
--
Y
P
N
D
L
----
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
--------------------------------------------
S
H
S
G
S
-----------------------
N
----
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
K
G
H
Q
------
K
R
K
A
L
----
K
----
T
T
V
I
L
I
L
A
F
F
A
----
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
--
I
I
K
-
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
----
E
A
L
A
--
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
------
Q
H
A
L
T
S
G
R
P
L
E
---
V
L
F
Q
---------------
32
HHSearch
76.42
19%
-139
* C2 *
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
---------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
---
F
K
-
Y
Q
S
L
---
L
T
K
N
K
A
R
V
-
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-
A
T
--
H
-
Q
E
A
--
I
N
C
Y
A
E
--
E
T
C
C
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--------------------------------------------
K
R
Q
L
N
-----------------------
I
----
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
K
F
C
L
K
------
E
H
K
A
L
----
K
----
T
L
G
I
I
M
G
T
F
T
L
----
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
-------------
I
R
K
E
V
Y
I
L
L
----
N
W
I
G
--
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
------
Q
E
L
L
C
L
---------------------------
39
HHSearch
75.81
21%
-154
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
-
V
W
-
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
---
V
H
-
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
-
M
-
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-------
G
D
P
--
T
V
C
S
I
S
--
N
P
----------
D
F
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
--------------------------------------------
K
Q
R
R
R
-----------------------
K
----
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
V
P
L
R
------
E
K
K
A
T
----
Q
----
M
V
A
I
V
L
G
A
F
I
V
----
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
---------
C
H
---
V
S
P
E
L
Y
S
A
T
----
T
W
L
G
--
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
------
L
K
I
L
S
C
---------------------------
40
HHSearch
75.38
20%
-129
- C2 -
2Z73
5
OPSD_TODPA
A:
[30-332]
--------------------------------
P
--------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
-
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
---
M
A
-
A
S
K
K
---
M
S
H
R
R
A
F
I
-
M
-
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-
T
L
--
E
-
G
V
L
--
C
N
C
S
F
D
--
Y
I
S
R
D
---
S
T
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
--------------------------------------------
S
N
H
E
K
-----------------------
E
----
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
N
A
------
E
M
R
L
A
----
K
----
I
S
I
V
I
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
--
W
----------
V
T
P
Y
A
A
Q
L
P
----
V
M
F
A
--
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
------
S
Q
T
F
P
W
V
L
T
C
C
---
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
3
PsiBlast_PDB
75.04
27%
-164
- C2 -
5C1M
7
?
A:
[24-294]
---------------------------------------------------------
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
V
N
Y
L
M
-
G
-
T
W
-
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
---
V
K
-
A
L
D
F
---
R
T
P
R
-
N
A
K
-
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
A
T
T
K
-
Y
R
--
Q
-
G
S
I
DC
T
L
T
F
S
H
--
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
-----
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
--------------------------------------------
K
S
-
V
R
-----------------------
M
----
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
K
E
------
K
D
R
N
L
R
R
I
T
R
----
M
V
L
V
V
V
A
V
F
I
V
----
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
P
--
E
-
T
-
T
----------
F
Q
T
V
S
W
H
F
C
I
A
L
G
--
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
---------------------------------------
33
HHSearch
74.05
27%
-133
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
-------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
--
N
-
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
---
T
R
-
T
L
T
Q
----
K
R
H
L
V
K
F
-
V
-
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
-
H
P
--
N
-
N
S
S
--
P
V
C
Y
E
V
--
L
G
N
D
T
A
--
K
W
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
--------------------------------------------
F
K
A
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
------
K
H
R
A
M
----
R
----
V
I
F
A
V
V
L
I
F
L
L
----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
Q
--
V
-
I
Q
E
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
----
E
I
L
G
--
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
------
L
K
I
L
A
M
H
G
-------------------------
8
PsiBlast_PDB
72.67
25%
-163
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[132-401]
---------------------------------------------------------
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
-
L
P
F
Q
G
T
D
I
L
L
-
G
-
F
W
-
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
--------------
T
S
S
-
K
A
Q
A
V
-
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
G
S
A
--
Q
V
--
E
-
D
E
E
--
I
E
C
L
V
E
--
I
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
--
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
--------------------------------------------
R
G
V
R
L
-----------------------
L
----
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
R
-
E
------
K
D
R
N
L
----
R
----
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
--
S
-
S
-
E
T
A
V
A
---
I
L
R
F
C
T
A
-------
L
G
--
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
------
R
--------------------------------
20
PsiBlast_PDB
72.23
23%
-141
- C- -
3C9L
13
OPSD_BOVIN
A:
[55-332]
--------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
-
F
G
E
N
---
H
A
-----
I
-
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
--
E
-
G
M
Q
--
C
S
C
G
I
D
YY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
Q
----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
A
T
------
T
Q
K
A
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-
F
-
G
P
--------
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
------
E
------------------
17
PsiBlast_PDB
71.92
23%
-152
- C2 -
4BEY
5
OPSD_BOVIN
A:
[58-327]
--------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
D
F
T
T
T
L
Y
T
S
L
H
-
G
-
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
-
F
G
E
N
---
H
A
-----
I
-
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
--
E
-
G
M
Q
--
C
S
C
G
I
D
YY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
Q
----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
A
T
------
T
Q
K
A
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
---
G
V
A
F
Y
I
F
T
H
--
Q
---
G
S
C
F
G
P
----
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------------------------------
18
PsiBlast_PDB
71.50
24%
-150
- C2 -
4A4M
5
OPSD_BOVIN
A:
[58-327]
--------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
-
F
G
E
N
---
H
A
-----
I
-
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
--
E
-
G
M
Q
--
C
S
C
G
I
D
YY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
Q
----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
A
T
------
T
Q
K
A
E
----
K
E
V
T
R
M
V
I
I
Y
V
I
A
F
L
I
----
C
W
L
P
Y
A
---
G
V
A
F
Y
I
F
T
H
--
Q
---
G
S
C
F
G
P
----
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------------------------------
19
PsiBlast_PDB
71.48
23%
-146
- C2 -
3CAP
5
OPSD_BOVIN
A:
[55-326]
--------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MS
N
F
R
-
F
G
E
N
---
H
A
-----
I
-
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
--
E
-
G
M
Q
--
C
S
C
G
I
D
YY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
-----------------------
Q
----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
A
T
------
T
Q
K
A
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-
F
-
G
P
--------
I
F
M
T
I
P
----
A
F
F
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------------------------------
29
HHSearch
71.38
18%
-142
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
--------------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
-
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
---
L
T
-
Y
P
V
K
---
R
T
T
K
M
A
G
M
-
M
-
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
-
V
G
VR
T
-
V
E
D
--
G
E
C
Y
I
Q
--
F
F
S
N
-------
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
--------------------------------------------
K
S
R
I
N
-----------------------
I
----
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
P
P
S
R
------
E
K
K
V
T
----
R
----
T
I
L
A
I
L
L
A
F
I
I
----
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
-------
I
------
P
N
T
V
W
T
I
G
----
Y
W
L
C
--
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
------
K
H
L
L
M
----------------------------