@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP176_HUMAN: (2016-01-10 )
MGHNGSWISPNASEPHNASGAEAAGVNRSALGEFGEAQLYRQFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCLIGTLVQLHHRYSRRNVVSTGSGMAEASLEPSIRSGSQLLEMFHIGQQQIFKPTEDEEESEAKYIGSADFQAKEIFSTCLEGEQGPQFAPSAPPLSTVDSVSQVAPAAPVEPETFPDKYSLQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPKVGRVERKMSRNNKVSIFPKVDS
Atome Classification :
(20 SA)
.........10........20........30........40........50.......---.60........70........80........90...-.....100.......110.......120.......130.......140.......150..-.--.-----.....160.......170..-..--.-----------..180..-..---....190....---.-----..-200.......210.......220..---.....230.......240....-----------------------------.----------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------250-------------------------------------------------------------------------------.-------------.----------------.......260....-...270.......280.......290..---------.-....300.......310.......320.......330.......340.......350......----------------.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGHNGSWISPNASEPHNASGAEAAGV
N
R
S
A
L
GEF
G
E
A
Q
L
Y
R
Q
F
T
T
T
V
Q
V
V
I
F
I
G
S
L
L
G
---
N
F
M
V
L
W
S
T
C
R
T
T
V
F
K
S
V
T
N
R
F
I
K
N
L
A
C
S
G
I
C
A
S
L
V
C
-
V
P
F
D
I
ILSTSP
H
C
C
W
W
I
Y
T
M
L
F
C
K
V
V
K
F
L
H
K
V
F
C
S
V
T
I
LS
F
P
A
I
A
L
D
R
Y
Y
S
V
L
Y
P
L
--
E
R
-
K
--I-----SDAKSR
E
L
V
M
Y
I
W
A
H
A
V
V
AS-V
P
--
V
-----------
F
A
V-T
N
V
-
A
D
---IYAT
S
T
C
T
E
V
W
---
S
-----NS-L
G
H
L
V
Y
V
L
V
Y
N
I
T
T
V
I
V
P
V
V
V
V
F
L
F
---
L
I
L
I
R
R
A
L
S
A
S
QK
K
K
V
I
I
A
A
LR-----------------------------T----------------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------------Q----------------------------------------------------------------------
N
---------------------------------------------------------------------------------
T
-------------
I
----------------SIPYASQ
R
E
A
E
L
H
A
-
T
L
L
S
M
V
M
V
F
I
L
CSV
P
Y
A
T
L
V
V
Y
Q
T
V
LNV---------P-D
T
S
V
F
L
L
L
T
A
V
W
L
P
K
V
S
L
LAN
P
V
L
F
L
T
V
N
K
S
V
R
K
C
L
I
G
T
L
V
Q
L
H
H
R
Y
SRRNVVSTGSGMAEAS----------------LEPSIR
S
G
S
Q
L
L
E
M
F
HI
G
Q
Q
QIFKPTEDE
E
E
S
E
A
KYIGSAD
F
Q
A
K
E
I
F
S
T
C
LEGEQGPQFAPSAPP
L
S
T
V
D
S
V
S
QVAPAAPVEPETFPD
K
Y
S
L
Q
FGFGPFEL
P
P
Q
W
L
S
E
TRNSKKRLLPPLGN
T
P
E
E
L
I
Q
T
KVPK
V
G
R
V
E
R
K
MSRNN
K
V
S
I
F
PKVDS
33
HHSearch
85.06
20%
-126
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
--
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
--
H
Y
-
Q
--
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
--
L
-----------
L
F
G
-
F
N
T
-
T
G
-----
D
P
T
V
C
S
I
S
N
---
P
------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
---
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
-----------------------------
D
E
GLRL
K
I
Y
K
D
------------------------------------------------------------------------------------------------------------------------
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
------------------------
Q
----------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G-------------------------------------------------------------------
T
-------------
W
----------------
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
-
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
---------
C
-
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
80.87
21%
-89
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
--
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
-
S
C
G
-
I
D
---
Y
Y
T
P
H
E
E
T
------------
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-------------------------------------------------------------------------------------------
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------
48
Fugue
80.10
16%
-111
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S-
N
F
-
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
--
L
-----------
V
G
W
-
S
R
Y
-
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
-----
E
E
-
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
---
Y
G
Q
L
----------------
V
F
-----------------------------
T
----------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------------------
E
---------------------------------------------------------------------------------
A
-------------
A
----------------
A
S
A
T
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
78.14
17%
-124
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
-------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
---
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
-
Q
SL
L
-----
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
--
P
-----------
I
Q
M
H
W
Y
R
-
A
T
---
H
Q
E
A
I
N
C
Y
A
E
E
---
T
CC---
D
F
-
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
---
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
-----------------------------
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
--------
K
S
R
W
Y
N
------------------------------------------------------------------------------------------------------------------------------------------
Q
----------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TG-------------------------------------------------------------------
T
-------------
W
----------------
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
78.01
20%
-126
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
----------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
--
R
Y
-
N
G
L
V
-----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
--
P
-----------
M
L
G
-
W
N
N
-
C
G
Q-----
S
Q
G
C
G
E
G
Q
---
V
ACLFE
D
V
-
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
---
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
-----------------------------
G
LRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------
N
----------------------------------------------------------------------
R
A
K
R
V
I
T
T
F
R
TGT---------------------------------------------------------------------
W
-------------
D
----------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
77.13
17%
-120
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-497]
----------------------------------
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
-
A
---
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
S
-
Q
R
P
R
-----
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
--
D
-----------
F
I
F
-
A
N
V
-
S
E
---
A
D
D
R
Y
I
C
D
R
F
Y
---
P
-----
N
D
-
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
---
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
-----------------------------
E
----------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
----------------------------------------------------------------------
T
---------------------------------------------------------------------------------
W
-------------
D
----------------
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
-
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
-
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
76.61
19%
-120
* C2 *
2Z73
5
OPSD_TODPA
A:
[29-338]
-----------------------------------
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
--
A
A
-
S
K
K
M
-----
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
--
P
-----------
I
F
G
-
W
G
A
Y
T
L
---
E
G
V
L
C
N
C
S
F
D
Y
---
I
-----
S
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
---
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
-----------------------------
N
----------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------------------
E
---------------------------------------------------------------------------------
L
-------------
R
----------------
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
---------
E
-
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
----------------
I
P
A
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
76.07
17%
-129
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
---
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
--
R
Y
-
L
KY
R
-----
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
--
I
-----------
L
G
W
-
N
H
--------
R
R
E
D
K
C
E
T
D
F
---
Y
-----
D
V
----
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
---
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
-------------------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------
R
NTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
----------------------------------------------------------------
Q
-------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
-
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
---------
C
--
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
75.71
17%
-123
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
---
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
--
T
Y
-
P
VK
R
-----
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
--
A
-----------
I
L
F
-
W
Q
F
-
I
V
GVR
T
V
E
D
G
E
C
Y
I
Q
F
---
F
-----
S
N
----
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
---
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
-----------------------------
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS----------------------------------------------------------------------------------------------------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
------------------------------------------------------------------------------------------------------------------------
D
----------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
----------------
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
-
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.46
21%
-129
- C2 -
2I35
4
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.13
21%
-125
- C2 -
3DQB
6
GNAT1_BOVIN (first)
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.99
21%
-122
- C2 -
1F88
7
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.38
21%
-127
- C2 -
3PQR
10
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.32
21%
-127
- C2 -
3PXO
5
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.16
21%
-131
- C2 -
3C9L
13
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.93
21%
-127
- C2 -
4PXF
8
OPSD_BOVIN
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.78
21%
-131
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[44-321]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
73.41
14%
-77
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------
P
C
F
R
E
E
N
A
--------------------
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
----
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
NS
Q
R
-
P
--
R
-----
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
--
D
-----------
F
I
F
-
A
N
V
-
S
E
---
A
D
D
R
Y
I
C
D
R
F
Y
---
P
-----
N
D
-
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
---
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
--
I
F
E
M
L
R
-----------------------------
I
D
---------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------
G
----------------------------------------------------------------------
L
---------------------------------------------------------------------------------
R
-------------
L
----------------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
---------
T
-
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
-------
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
---------------
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------
17
PsiBlast_PDB
73.35
21%
-126
- C2 -
1HZX
14
OPSD_BOVIN
A:
[47-322]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
----------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.27
21%
-120
- C2 -
3OAX
17
OPSD_BOVIN
A:
[47-322]
--------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
PL
V
-----------
G
W
S
-
R
Y
I
-
P
E
---
G
M
Q
C
S
C
G
I
D
Y
Y
---
T
PHEET
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------
S
-
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
----------------
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------