@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPBAR_HUMAN: (2016-01-10 )
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Atome Classification :
(20 SA)
-----------.........10..--.------------.....20........30........40........50........60.....--.--.-.70..--.---.-------...-.80...-----.....90........100.......110......-----.----120--.--.--------......-----.130.......140..-....-----------------.--150---.---.------......-------.160-----.-------.------.-.-.---------....170-.......180.......190...------....200...------------.-----------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------.--------------.-----------------------------------------------------------------------------------------------210-------------.--------........220-.........230--........240.........250.-------.-------.....260----.....-...270.......280.......290.......300.......310......-.320.......330----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MTPNSTGEVPSPI--P------------KG
A
L
G
L
S
L
A
L
A
S
L
I
I
T
A
N
L
L
L
A
L
G
I
A
W
D
R
RLRSPP
A
G
C
F
F
L
S
L
L
L
A
G
L
L
T
G
L--A--L-PTLPG--L---W-------NQS-R
R
G
Y
W
S
-----
C
L
L
V
Y
LAP
N
F
S
F
L
S
L
L
A
N
L
L
L
VHG
E
R
Y
M
A
V
LRPL-----Q----P----P--G--------
S
I
R
L
A
L
-----
L
L
TWA
G
P
L
L
F
A
SLPAL-GWNH-----------------W--T-----P---G------ANCSSQ-------AI-------F-------P------A-
P
-
Y
---------
L
Y
L
E
V
Y
G
-
L
L
L
P
A
V
G
A
A
A
F
L
S
V
R
V
L
A
T
A
H
R
Q
------
L
Q
D
I
C
R
L
E
R
A
------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------C-------------------------------------------------------------------------------------------------------------------------------------------------R--------------D-----------------------------------------------------------------------------------------------
E
---------------
P
--------
S
A
L
A
R
A
L
T
W
---
R
Q
A
R
AQAGA
M
L
---
L
F
G
LC
W
G
P
Y
--
V
A
T
L
L
L
S
V
L
A
YEQ-------R-------PPL
G
P
G
T
-----
L
L
S
L
L
-SLGSASA
A
A
V
P
V
A
MGLGDQRYT
A
P
W
R
A
A
A
Q
R
C
L
Q
G
L
WGRASRDSPGP
S
I
A
YH-PSSQ
S
S
V
DLDLN------------------------------------------------------------------------------------------------------------
25
HHSearch
87.27
21%
-121
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
----------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
--
A
V-
V
-
P
F
G
A
A
--
H
I
L
-
M
-------
K
M
W
-
T
F
G
N
F
W
-----
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-----
K
----
Y
----
Q
--
S
LLT
K
N
---
K
A
R
V
I
I
-----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-----------------
A
--
T
H
Q
---
E
---
A
I
N
C
Y
A
E
E
T
C
C
D
F
-------
F
T
-------
N
-------
Q
------
A
-
Y
-
A
---------
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
-
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
------
L
N
I
F
E
M
L
R
I
D
------------
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
---------------------
A
K
S
R
W
Y
N
Q
------------------------------------------------------------------------------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
-----------------------------------------------------------------------------------------------
W
---------------
D
--------
A
Y
K
F
C
L
K
E
H
---
K
A
L
K
T
L
G
I
I
M
G
---
T
F
T
L
C
W
L
P
F
--
F
I
V
N
I
V
H
V
I
Q
D
N
L
-----------------
I
R
K
E
V
-----
Y
I
L
L
N
-
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
----
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
80.02
20%
-95
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
--
E
APQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
--
T
-
T
T
L
Y
T
--
S
---
L
-------
H
G
Y
F
V
F
G
P
T
G
-----
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
N
F
R
F
G
----
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E
--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
---------
E
E
T
N
N
E
S
-
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
--
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
------
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------------------------
27
HHSearch
79.91
19%
-136
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
-
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L-
A
--
I
-
P
F
A
I
T
--
I
---
S
-------
T
G
F
-
C
A
A
C
H
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
----
Y
----
N
--
G
L
V
T
G
T
---
R
A
K
G
I
I
-----
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
-----------------
C
--
G
-----
Q
---
S
------
Q
G
C
G
E
G
QVACLFE
D
V
-------
V
-------
P
M
-----
N
-
Y
M
V
---------
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
-
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
------
L
N
I
F
E
M
L
R
I
D
------------
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
--------------------------------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T------------------------------------------------------------------------------------------------------------------------------
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
-----------------------------------------------------------------------------------------------
D
---------------
A
--------
Y
R
S
T
L
Q
K
E
V
---
H
A
A
K
S
L
A
I
I
V
G
---
L
F
A
L
C
W
L
P
L
--
H
I
I
N
C
F
T
F
F
C
P
D
C
-------
S
--------
H
A
P
L
W
L
-----
M
Y
L
A
I
-
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
----
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
77.33
18%
-117
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
-
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L-
V
--
M
-
P
W
V
V
Y
--
L
E
V
T
G
-------
G
V
W
-
N
F
S
R
I
C
-----
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-----
H
----
Y
----
Q
--
H
G
T
G
Q
SS
C
R
R
V
A
L
M
I
-----
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
-----------------
T
--
G
-----
D
---
P
------
T
V
C
S
I
S
-------
N
P
----------------------
D
-
F
-
V
---------
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
-
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT---------------------------------------------------------------------------------------------------------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-----------------------------------------------------------------
Q
--------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GT--------------------------------------------------------------------------------
W
---------------
D
--------
A
Y
G
V
P
L
R
E
K
---
K
A
T
Q
M
V
A
I
V
L
G
---
A
F
I
V
C
W
L
P
F
--
F
L
T
H
V
L
N
T
H
C
Q
T
C
-------
H
---------
V
S
P
E
L
-----
Y
S
A
T
T
-
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
----
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
77.04
19%
-93
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
EA
P
------------
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
--
V
-
A
D
L
F
M
--
V
---
F
GG
F
T
T
T
L
Y
T
S
-
L
H
G
Y
F
V
FG
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
----
G
----
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E
--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
---------
E
E
T
N
N
E
S
-
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
------
F
T
------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------
A
-----------------------------------------------------------------------------------------------
A
---------------
A
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
-------
F
--------------------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
-
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------------------------
31
HHSearch
72.35
19%
-110
- C2 -
1U19
14
OPSD_BOVIN
A:
[42-328]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
--
G
G-
F
-
T
T
T
L
Y
T
S
L
---
H
-------
G
Y
F
-
V
F
G
P
T
G
-----
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
----
F
--
R
F
G
E
N
----
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E
GM
Q
------
C
S
C
G
I
D
-------
Y
Y
TPHEETN
N
-------
E
------
S
-
F
-
V
---------
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
------
A
A
Q
Q
Q
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
---------
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
----
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
-
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------
32
HHSearch
70.42
15%
-117
* C2 *
2KS9
1
NK1R_HUMAN
A:
[35-325]
-----------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
--
F
N
-
T
-
V
V
N
F
T
Y
A
V
---
H
-------
N
E
W
-
Y
Y
G
L
F
Y
-----
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-----
Q
----
P
----
R
--
L
S
A
T
-----
A
T
K
V
V
I
-----
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
-----------------
E
TM
P
-----
S
---
R
------
V
V
C
M
I
E
-------
W
P
-------
E
HPNKIY
E
K
------
V
-
Y
-
H
---------
I
C
V
T
V
L
I
-
Y
F
L
P
L
L
-
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
------
E
I
P
G
D
S
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------
Y
H
E
Q
V
S
A
K
R
---
K
V
V
K
M
M
I
V
V
V
C
---
T
F
A
I
C
W
L
P
F
--
H
I
F
F
L
L
P
Y
I
N
P
D
L
-------
Y
L------
K
K
F
I
Q
Q
V
-----
Y
L
A
I
M
-
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
----
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
-
R
Y
L
Q
T
Q
G
S
V
Y
K
V
------------------------------------------------------------------------------------------------------------
26
HHSearch
69.44
17%
-125
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
-
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
--
V
V
-
M
-
P
M
N
I
L
Y
L
L
---
M
-------
S
K
W
-
S
L
G
R
P
L
-----
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-----
R
----
Y
----
L
--
K
YRT
K
T
---
R
A
S
A
T
I
-----
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
--
G
W
N
H
---------------------R----
R
---
E
------
D
K
C
E
T
D
-------
F
Y
-------
D
-------
V
------
T
W
F
-
K
---------
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
-
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
------
C
N
I
F
E
M
L
R
I
D
------------
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
-------------------------------------------------------------------------------------------------------------------
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---------------------------------------------
Q
--------------
T
-----------------------------------------------------------------------------------------------
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
--------
A
Y
L
H
M
N
R
E
R
---
K
A
A
K
Q
L
G
F
I
M
A
---
A
F
I
L
C
W
I
P
Y
--
F
I
F
F
M
V
I
A
F
C
K
N
C
-----------------
C
N
E
H
L
-----
H
M
F
T
I
-
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
----
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
69.24
15%
-120
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-341]
--------------------------
Y
------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
--
V
N
G
F
-
P
L
M
T
I
S
C
F
---
L
-------
K
K
W
-
I
F
G
F
A
A
-----
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-----
A
----
A
----
S
--
K
K
M
S
H
R
---
R
A
F
I
M
I
-----
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
-----------------
Y
--
T
L
E
G--
V
---
L
------
C
N
C
S
F
D
-------
Y
I
-------
S
RD
S
T
T
--
R
------
S
-
N
-
I
---------
L
C
M
F
I
L
G
-
F
F
G
P
I
L
-
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
------
E
K
E
M
A
A
M
A
K
R
------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------
N
AK-----------------------------------------------------------------------------------------------------------------------------------------------
E
--------------
L
-----------------------------------------------------------------------------------------------
R
---------------
K
--------
A
Q
A
G
A
N
A
E
M
---
R
L
A
K
I
S
I
V
I
V
S
---
Q
F
L
L
S
W
S
P
Y
--
A
V
V
A
L
L
A
Q
F
G
P
L
E
-------
W
---------
V
T
P
Y
A
-----
A
Q
L
P
V
-
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
-
I
P
A
G
E
-------------------------------------------------------------------------------------------------------------------
24
HHSearch
67.95
18%
-124
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[63-495]
--------------------------
I
------------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
-
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
--
A
--
Y
T
A
N
L
L
L
S-
G
---
A
-------
T
T
Y
-
K
L
T
P
A
Q
-----
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
------------------N
N
F
--------
R
L
F
L
L
I
-----
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
N
C
-----------------
I
--
S
-----
A
---
L
------
S
S
C
S
T
V
-------
L
P
-------
L
Y------
H
------
K
-
H
-
Y
---------
I
L
F
C
T
T
V
-
F
T
L
L
L
L
-
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
------
N
I
F
E
M
L
R
I
D
E
------------
G
LRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------
T
--------------
W
-----------------------------------------------------------------------------------------------
D
---------------
A
--------
Y
A
S
R
S
S
E
N
V
---
A
L
L
K
T
V
I
I
V
L
S
---
V
F
I
A
C
W
A
P
L
--
F
I
L
L
L
L
D
V
G
C
K
V
K
-------
T
-------
C
-
D
I
L
F
R
-----
A
E
Y
F
L
-
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
----
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
67.25
22%
-104
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
-----------------------
N
--
K
------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
-
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
--
T
--
L
-
P
I
W
A
A
--
S
K
--
V
-------
N
G
W
-
I
F
G
T
F
L
-----
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-----
R
----
T
----
L
--
T
Q
K
R
H
----
L
V
K
F
V
C
-----
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
-----------------
Y
--
H
-----
P
NNS
S
------
P
V
C
Y
E
V
-------
L
G
-------
N
-------
D
TAKWRM
V
-
L
-
R
---------
I
L
P
H
T
F
G
-
F
I
V
P
L
F
-
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
------
H
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
---
R
A
M
R
V
I
F
A
V
V
L
---
I
F
L
L
C
W
L
P
Y
--
N
L
V
L
L
A
D
T
L
M
R
T
Q
-------
V
IQE
S
C
E
R
R
N
N
I
G
R
A
-----
L
D
A
T
E
-
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
----
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
67.16
16%
-121
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
----------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
-
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F-
S
--
M
-
N
L
Y
T
L
Y
T
V
---
I
-------
G
Y
W
-
P
L
G
P
V
V
-----
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-----
T
----
Y
----
P
--
V
KRT
T
K
---
M
A
G
M
M
I
-----
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
-----------------
I
--
V
GVRTV
E
---
D
------
G
E
C
Y
I
Q
-------
F
F
-------
S
N------
A
------
A
-
V
-
T
---------
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
-
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
------
I
N
I
F
E
M
L
R
I
D
------------
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS----------------------------------------------------------------------------------------------------------------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
--------------------------------------------------------------------------------------------------------------------------
D
--------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
---------------
D
--------
A
Y
P
P
P
S
R
E
K
---
K
V
T
R
T
I
L
A
I
L
L
---
A
F
I
I
T
W
A
P
Y
--
N
V
M
V
L
I
N
T
F
C
A
P
C
-----------------
I
P
N
T
V
-----
W
T
I
G
Y
-
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
----
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
63.17
15%
-104
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-497]
--------------------------
K
------------
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
-
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
--
T
--
L
-
P
F
W
A
V
--
D
A
--
V
-------
A
N
W
-
Y
F
G
N
F
L
-----
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-----
N
----
S
----
Q
--
R
P
R
K
L
L
---
A
E
K
V
V
Y
-----
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
V
-----------------
S
E
A
D
-----
D
---
R
------
Y
I
C
D
R
F
-------
Y
P
-------
N
-------
D
L
W
V
V
--
V
-
F
-
Q
---------
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
-
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
------
G
S
N
I
F
E
M
L
R
I
------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
--------------
W
-----------------------------------------------------------------------------------------------
D
---------------
A
--------
Y
G
S
K
G
H
Q
K
R
---
K
A
L
K
T
T
V
I
L
I
L
---
A
F
F
A
C
W
L
P
Y
--
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
-------
E
N
T
V
H
K
W
-----
I
S
I
T
E
-
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
----
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------
49
Fugue
62.51
16%
-97
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------
P
C
F
R
E
E
N
A
N
F
N
--
K
------------
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
-
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
--
T
--
L
-
P
F
W
A
V
--
D
---
A
-------
V
A
N
W
Y
F
G
N
F
L
-----
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-----
N
----
S
----
Q
--
R
--------
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
V
-----------------
S
--
E
-----
A
---
D
------
D
R
Y
I
C
D
-------
R
F
-------
Y
-------
P
N
D
L
W
V
-
V
-
V
-
F
---------
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
SN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
------------
I
-----------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------
D
-----------------------------------------------------------------------------------------------
T
---------------
E
G
Y
Y
T
I
GIG
H
L
L
T
K
S
P
S
L
---
N
A
A
K
S
E
L
D
K
A
I
GRN
T
N
G
V
I
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
-------
R
-------
G
I
L
R
N
A
K
-----
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
8
PsiBlast_PDB
60.56
20%
-119
- C2 -
3DQB
3
GNAT1_BOVIN (first)
A:
[127-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
FRFG
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
EETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
---------
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
60.51
14%
-96
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------
D
E
V
W
--
V
------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
--
A
--
V
---
V
P
F
--
G
---
A
-------
A
H
I
-
L
M
K
M
W
T
FG
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
KYQSL
L
----
T
----
K
--
N
--------
K
A
R
V
I
I
-----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
ATH
Q
E
A
I
N
C
Y
A
EETCCD
F
--
F
-----
T
---
N
------
Q
A
Y
A
I
A
-------
S
S
-------
I
-------
V
------
S
-
F
-
Y
---------
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
------
E
G
L
R
L
K
I
Y
K
D
------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------
Y
-----------------------------------------------------------------------------------------------
Y
---------------
T
--------
I
G
I
G
H
L
L
T
K
SPS
L
N
A
A
K
S
E
L
D
K
A
---
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
-------
D
-------
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL--------------------
10
PsiBlast_PDB
59.96
20%
-115
- C2 -
3PXO
3
OPSD_BOVIN
A:
[127-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
F
R
F
G
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
EETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
---------
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.77
20%
-119
- C2 -
4PXF
5
OPSD_BOVIN
A:
[127-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
FRFG
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
EETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
---------
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.57
20%
-120
- C2 -
3PQR
7
OPSD_BOVIN
A:
[127-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
F
R
F
G
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
EETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
---------
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.32
20%
-120
- C2 -
3CAP
3
OPSD_BOVIN
A:
[127-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
----
N
F
R
F
G
E
--
N
--------
H
A
I
M
G
V
-----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-----------------
Y
--
I
-----
P
E--
G
------
M
Q
C
S
C
G
-------
I
D
-------
Y
-------
Y
------
T
-
P
-
H
EETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
---------
V
I
F
F
C
Y
G
Q
------
L
--
V
F
T
V
K
E
A
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------
Q
-----------------------------------------------------------------------------------------------
Q
---------------
E
--------
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
-------
G
-------
S
D
F
G
P
I
F
-----
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------