@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR15_HUMAN: (2016-01-10 )
MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELTLIDDKPYCAEKKATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRQEHYLPSAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFARRRKRSVSL
Atome Classification :
(20 SA)
.........10........20...------.....30.......--------.40........50...--.....60......---..70........80...-.--..------..90........100.......110.......120.......130.......140..---.....150.......160.......170-.-...-..-.---..-180----.....----...-.190-.---..----..----....200----........210.......220-----------...-------.-------------------------------.------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------230------------------------------------------------------------------------------------------------------------------------------------------------------------....------..---------------------------------...240.......250.....------..260..-.....270-.--...-----.....-----280........290.....--..300......--.310--....-....320.......330-------.......340.......350.......360------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDPE
E
T
S
V
Y
L
D
Y
Y
Y
ATSPNS
D
I
R
E
------
T
HSHVP
Y
T
S
V
F
L
P
V
--------
F
Y
T
A
V
F
L
T
G
V
L
G
N
L
V
L
--
M
G
A
L
HFKPGS
R
R
L
---
I
D
I
F
I
I
NLAAS
D
F
I
F
L
V
-
T
--L
P
------
L
W
VDKEASLGLWRTG
S
F
L
CKG
S
S
Y
M
I
S
V
NM
H
C
S
V
L
L
L
T
C
M
S
V
D
R
Y
L
A
I
V
W
P
V
V
S
R
K
F---RRTD
C
A
Y
V
V
C
A
S
I
W
F
I
S
C
L
L
G
L
P
T
L
L
---S-R
E
L
-
T
L-I---DD-K------PYCAE----KKA-
T
P
---
I
---
K
L
----
I
W
----
S
L
V
A
L
I
-----
F
T
F
F
V
P
L
L
S
I
V
T
C
Y
C
C
I
A
R
K
L
-----------
C
A
H
-------
Y
-------------------------------
Q
------------------------------------
Q
S--------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------------------------------------------------------------------------------------------------------------------------------------------------------KH
N
K
------
K
L
---------------------------------
K
K
S
I
K
I
I
F
I
V
V
A
A
F
L
V
S
WLPF------
N
T
F
K
F
L
A
-
I
V
S
G
L
R
---Q--EHY-----
L
P
S
A
I
-----
L
Q
-
L
G
MEVSG
P
L
A
F
A
N
S
C
V
--
N
P
F
I
Y
Y
I
F
D
S
Y
--
I
R
R
---
A
I
V
H
-
C
L
C
P
C
L
KNYDFGSSTET-------
S
D
S
H
L
T
K
A
L
S
T
F
I
H
A
E
D
F
A
R
R
R
K
RSVSL--------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.04
29%
-134
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[122-406]
--------------------------------------
A
I
A
I
T
A
--------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
V
R
Y
T
K
M
K
T
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
------
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
---
M
-
A
V
T
-
R
P
-
R
---
D
G
-
A
------
V
V
C
M
L
----
Q
F
P
-
S
P
-------
S
W
----
Y
W
----
D
T
V
T
K
I
C
V
F
L
-
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
-----------
R
S
V
-------
R
-------------------------------
L
------------------------------------
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
------
S
L
---------------------------------
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
------
H
I
F
V
I
V
W
-
T
L
V
D
I
D
---
R
--
R
D
P
-----
L
V
V
A
A
-----
L
H
-
L
C
I
A
----
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
--
F
K
R
---
C
F
R
Q
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
86.92
26%
-130
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-495]
--------------------------------------
K
I
F
L
P
T
--------
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
--
I
L
V
M
G
Y
Q
K
K
L
R
S
M
---
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
P
------
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
---
F
-
A
N
V
-
S
E
-
A
---
D
D
-
R
------
Y
I
C
D
R
----
F
Y
P
-
N
D
L
--
W
---
V
V
----
V
F
----
Q
F
Q
H
I
M
-----
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-----------
S
H
S
-------
G
-------------------------------
S
------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
G
H
------
Q
K
---------------------------------
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
------
Y
I
G
I
S
I
D
-
S
F
I
L
L
E
---
I
I
K
Q
G
C
-----
E
F
E
N
T
-----
V
H
-
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
--
N
P
I
L
Y
A
F
L
G
A
K
--
F
K
T
---
S
A
Q
H
-
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
86.34
29%
-119
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------
S
F
K
C
------
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
--------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
--
I
W
M
F
V
F
H
M
K
P
W
S
G
---
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
------
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
--
S
-
G
T
G
-
V
R
-
K
---
N
K
-
T
------
I
T
C
Y
D
----
T
T
S
-
D
E
Y
L
R
S
---
Y
F
----
I
Y
----
S
M
C
T
T
V
-----
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TV
C
G
Y
-------
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKD
Q
------------------------------------
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
E
P
------
L
R
---------------------------------
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
------
H
V
M
K
T
M
N
-
L
R
A
R
L
D
FQT
P
--
A
M
C
-----
A
F
N
D
R
-----
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
-------------------------------------------------------
A
G
D
T
F
R
R
R
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.12
30%
-140
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[121-401]
------------------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
--
M
Y
V
I
L
R
H
T
K
M
K
T
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
--
L
P
-------
F
Q
G
T
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
---
M
-
G
S
A
-
Q
V
-
E
---
D
E
-
E
------
I
E
C
L
V
----
E
I
P
-
T
P
---
Q
---
D
Y
W
G
P
-
V
F
----
A
I
C
I
F
L
-----
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-----------
R
G
V
-------
R
-------------------------------
L
------------------------------------
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
SR------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
------
N
L
---------------------------------
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
------
Q
V
F
-
V
L
A
-
Q
G
L
G
V
Q
---
P
--
S
S
E
-----
T
A
V
A
I
-----
L
R
-
F
----
C
T
A
L
G
Y
V
N
S
C
L
--
N
P
I
L
Y
A
F
L
D
E
N
--
F
K
A
---
C
F
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
85.56
22%
-115
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------------
P
C
F
R
E
------
E
N
A
N
--
F
N
K
I
F
L
P
T
--------
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
--
I
L
V
M
G
Y
Q
K
K
L
R
S
M
---
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
P
------
F
W
A
V
D
A
V
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
---
F
-
A
N
V
-
S
E
-
A
---
D
D
-
R
------
Y
I
C
D
R
----
F
Y
P
N
D
L
---
W
---
V
V
----
V
F
----
Q
F
Q
H
I
M
-----
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-----------
S
H
S
GSN
I
F
E
M
L
-------------------------------
R
------------------------------------
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
------
K
I
---------------------------------
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
------
L
N
A
A
K
S
E
-
L
D
K
A
I
G
---
R
--
N
T
N
GV---
I
T
K
D
E
-----
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
--
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
---
A
A
L
I
-
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
10
PsiBlast_PDB
85.38
29%
-135
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[125-413]
--------------------------------------
A
I
A
I
T
A
--------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
V
R
Y
T
K
M
K
T
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
------
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
---
M
-
A
V
T
-
R
P
-
R
---
D
G
-
A
------
V
V
C
M
L
----
Q
F
P
-
S
P
-------
S
W
----
Y
W
----
D
T
V
T
K
I
C
V
F
L
-
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
-----------
R
S
V
-------
R
-------------------------------
L
------------------------------------
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
------
S
L
---------------------------------
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
------
H
I
F
V
I
V
W
-
T
L
V
D
I
D
---
R
--
R
D
P
-----
L
V
V
A
A
-----
L
H
-
L
C
I
A
----
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
--
F
K
R
---
C
F
R
Q
L
C
R
K
P
C
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.95
29%
-137
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[122-406]
--------------------------------------
A
I
A
I
T
A
--------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
V
R
Y
T
K
M
K
T
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
------
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
---
M
-
A
V
T
-
R
P
-
R
---
D
G
-
A
------
V
V
C
M
L
----
Q
F
P
-
S
P
-------
S
W
----
Y
W
----
D
T
V
T
K
I
C
V
F
L
-
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
------
S
L
---------------------------------
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
------
H
I
F
V
I
V
W
-
T
L
V
D
I
D
---
R
--
R
D
P
-----
L
V
V
A
A
-----
L
H
-
L
C
I
A
----
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
--
F
K
R
---
C
F
R
Q
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.35
27%
-140
- C2 -
5C1M
7
?
A:
[8-294]
-----------------------
Q
------
T
G
S
P
S
M
V
T
A
I
T
I
M
A
--------
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
--
M
Y
V
I
V
R
Y
T
K
M
K
T
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
-------
F
Q
S
V
N
Y
L
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
---
M
-
A
T
T
-
K
Y
-
R
---
Q
G
-
S
------
I
D
C
T
L
----
T
F
S
-
H
P
---
T
W
Y
W
E
N
----
L
L
----
K
I
C
V
F
I
-----
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
-----------
K
S
V
-------
R
-------------------------------
M
------------------------------------
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
------
N
L
---------------------------------
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
------
H
I
Y
---
V
-
I
I
K
A
L
I
---
T
----------
I
P
E
T
T
-----
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
--
N
P
V
L
Y
A
F
L
D
E
N
--
F
K
R
---
C
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.51
26%
-132
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[52-381]
----------------------------------------
Y
L
P
A
--------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
-----
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
------
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
---
Y
-
S
G
T
-
G
V
-
R
---
K
N
-
K
------
T
I
T
C
Y
----
D
T
T
-
S
D
---
E
---
Y
L
R
S
Y
F
I
Y
----
S
M
C
T
T
V
-----
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TV
C
G
Y
-------
I
Y
N
-----------------------------
P
------------------------------------
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
N
------
G
V
NPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
----
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
------
H
V
M
K
T
M
N
-
L
R
A
--
R
---
L
--
D
F
Q
-----
T
P
A
M
C
A
F
N
D
R
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
--
F
R
R
---
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.78
21%
-139
- C2 -
4MBS
8
CCR5_HUMAN (first)
A:
[21-350]
-----------------
P
C
Q
K
I
N
V
------
K
Q
----
I
A
A
R
L
L
P
P
--------
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
--
I
L
I
L
I
N
Y
K
R
L
K
S
M
---
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
-
T
--
V
P
------
F
W
A
H
Y
A
A
A
--
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
---
F
-
T
R
S
-
Q
K
-
E
---
G
L
-
H
------
Y
T
C
S
S
----
H
F
P
-
Y
S
---
Q
---
Y
Q
----
F
W
K
N
F
Q
T
L
K
I
V
I
-----
L
G
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
I
L
K
T
L
L
R
M
K
K
Y
T
C
TV-
C
G
Y
-------
I
-------------------------------
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
K
------
K
R
---------------------------------
H
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
------
N
----
I
V
-
L
L
L
N
T
F
---
Q
--
E
F
F
GLNN
C
S
S
S
N
R
-----
L
D
-
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
--
N
P
I
I
Y
A
F
V
G
E
E
--
F
R
N
---
Y
L
L
V
-
F
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
81.30
21%
-134
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
-----------------------------------------
L
V
V
--------
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
--
L
Y
A
V
R
S
E
R
K
L
H
T
V
---
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
-
V
V
-
M
P
------
M
N
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
---
W
-
N
H
---------
R
R
-
E
------
D
K
C
E
T
----
D
F
Y
-
D
V
--------
T
----
W
F
----
K
V
M
T
A
I
-----
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-----------
R
Q
H
-------
C
-------------------------------
N
------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
M
N
------
R
E
---------------------------------
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
------
F
I
F
F
M
V
I
-
A
F
C
K
N
---------
C
-----
C
N
---------
E
-
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
--
N
P
L
I
Y
P
L
C
N
E
N
--
F
K
K
---
T
F
K
R
-
I
L
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
80.82
21%
-136
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
----------------------------------------
G
M
G
I
--------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
--
I
T
A
I
A
K
F
E
R
L
Q
T
V
---
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-
A
V-
V
P
------
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
-
H
---
Q
E
-
A
I
N
C
Y
A
E
E
T
C
C
D
----
F
F
-------
T
---
N
Q
----
A
Y
----
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
-------------------------------
N
------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
C
L
------
K
E
---------------------------------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
------
F
I
V
N
I
V
H
-
V
I
Q
D
N
---------
L
-----
I
---------
R
K
-
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
--
N
P
L
I
Y
C
-
R
S
P
D
--
F
R
I
---
A
F
Q
E
-
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
80.04
21%
-131
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
-----------------------------------------
I
V
L
--------
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
--
M
V
S
I
K
V
N
R
H
L
Q
T
V
---
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
N
------
L
Y
T
L
Y
T
-
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
---
F
-
W
Q
F
-
I
V
-
G
VRT
V
E
-
D
------
G
E
C
Y
I
----
Q
F
F
-
S
--------
N
A
----
A
V
----
T
F
G
T
A
I
-----
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-----------
K
S
R
-------
I
-------------------------------
N
------------------------------------
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
P
P
S
------
R
E
---------------------------------
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
------
N
V
M
V
L
I
N
-
T
F
C
A
P
---------
C
-----
I
P
---------
N
-
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
--
N
P
A
C
Y
A
L
C
N
A
T
--
F
K
K
---
T
F
K
H
-
L
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
79.37
18%
-104
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
--
Y
V
P
F
S
N
K
T
G
V
V
R
S
PFEAPQ
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
--------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
--
L
Y
V
T
V
Q
H
K
K
L
R
T
P
---
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
------
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---
G
-
W
S
R
-
Y
I
-
P
---
E
G
M
Q
------
C
S
C
G
I
DYYT
P
H
E
-
E
T
---
N
---
N
E
----
S
F
----
V
I
Y
M
F
V
-----
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
-------
A
-------------------------------
A
-------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
------
A
E
---------------------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
------
A
G
V
A
F
Y
I
-
F
T
H
Q
G
S
---
D
--
F
G
--------------------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
VY
N
P
V
I
Y
I
M
M
N
K
Q
--
F
R
N
---
C
M
V
T
-
T
L
C
--
C
G
K
N
P
S
T
T
V
S
K
T
-------
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.05
23%
-140
- C2 -
4BWB
1
NTR1_RAT
A:
[7-327]
------------------
N
S
D
L
-
D
------
V
N
T
D
I
-
Y
S
K
V
L
V
T
A
--------
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
--
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
--
L
P
V
D
L
Y
NF
I
W
V
H
H
P
-----
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
---
T
-
M
G
L
Q
N
L
-
S
---
G
D
-
G
------
T
H
P
G
G
----
L
V
C
-
T
P
---
I
---
V
D
----
T
A
----
T
L
R
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
-----------
T
V
M
-------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E
P
G
R
V
Q
A
L
---------------------------------
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
------
H
V
R
R
L
M
F
-
V
Y
I
S
D
E
---
Q
--
W
T
T
-----
A
L
F
D
F
-----
Y
H
-
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
I
--
N
P
I
L
Y
N
L
V
S
A
N
--
F
R
Q
V
F
L
S
T
L
A
-
C
L
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.94
26%
-130
- C2 -
4XNW
2
RUBR_CLOPA
A:
[52-381]
----------------------------------------
Y
L
P
A
--------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
-----
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
------
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
---
Y
-
S
G
T
-
G
V
-
R
---
K
N
-
K
------
T
I
T
C
Y
----
D
T
T
-
S
D
---
E
---
Y
L
R
S
Y
F
I
Y
----
S
M
C
T
T
V
-----
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TV
C
G
Y
-------
I
Y
N
-----------------------------
P
------------------------------------
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
N
------
G
V
NPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
------
H
V
M
K
T
M
N
-
L
R
A
--
R
---
L
--
D
F
Q
-----
T
P
A
M
C
A
F
N
D
R
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
--
F
R
R
---
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
77.95
24%
-129
- C2 -
2Z73
5
OPSD_TODPA
A:
[35-332]
---------------------------------------
Y
S
L
G
I
--------
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
--
I
Y
L
F
T
K
T
K
S
L
Q
T
P
---
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-
V
N
G
F
P
------
L
M
T
I
-
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
---
G
-
W
G
A
-
Y
T
L
E
---
G
V
-
L
------
C
N
C
S
F
----
D
Y
I
-
S
R
D
S
-
T
---
T
R
----
S
N
----
I
L
C
M
F
I
-----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
H
-------
E
-------------------------------
K
------------------------------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
N
------
A
E
---------------------------------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
------
A
V
V
A
L
L
A
-
Q
F
G
P
L
E
-----------------
W
V
-----
T
P
-
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
--
N
P
M
I
Y
S
V
S
H
P
K
--
F
R
E
---
A
I
S
Q
-
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
-------
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.85
26%
-163
- C2 -
4XT3
2
US28_HCMVA
A:
[48-313]
-----------------------------------------------------
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
--
I
F
T
I
T
W
R
R
R
I
Q
C
S
---
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
--
L
P
------
L
W
M
--
Q
Y
L
L
D
H
---
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
V
T
K
-
K
D
N
-
Q
C
-
M
---
T
D
-
Y
------
D
Y
L
------
E
V
S
-
Y
P
---
I
---
I
L
----------
N
V
E
L
M
L
-----
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
-----------
A
V
-----------------------------------------------------------------------------
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
K
G
------
R
I
------------------------------------
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
S
S
S
C
E
---
F
--
E
R
S
-----
L
K
R
A
L
-----
I
------
L
T
E
S
L
A
F
C
H
C
C
L
--
N
P
L
L
Y
V
F
V
G
T
K
--
F
R
Q
---
E
L
-
H
-
C
L
L
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
76.36
23%
-136
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------
Y
A
L
--------
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
--
C
M
A
V
L
K
E
R
A
L
Q
T
T
---
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
P
------
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
---
G
-
F
N
T
-
T
G
------
D
-
P
------
T
V
C
S
I
----
S
N
P
----------------
D
F
----
V
I
Y
S
S
V
-----
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
-----------
K
Q
R
-------
R
-------------------------------
R
------------------------------------
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
V
P
L
------
R
E
---------------------------------
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
------
F
L
T
H
V
L
N
-
T
H
C
Q
T
---------
C
-----
H
---
V
-----
S
P
-
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
--
N
P
V
I
Y
T
T
F
N
I
E
--
F
R
K
---
A
F
L
K
-
I
L
S
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.15
26%
-171
- C2 -
4XT1
13
US28_HCMVA
A:
[48-313]
-----------------------------------------------------
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
--
I
F
T
I
T
W
R
R
R
I
Q
C
S
---
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
--
L
P
------
L
W
M
--
Q
Y
L
L
D
-----
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
V
T
K
-
K
D
N
-
Q
C
-
M
---
T
D
-
Y
------
D
Y
L
------
E
V
S
-
Y
P
---
I
---
I
L
----------
N
V
E
L
M
L
-----
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
-----------
A
V
-----------------------------------------------------------------------------
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
K
G
------
R
I
------------------------------------
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
S
S
S
C
E
---
F
--
E
R
S
-----
L
K
R
A
L
-----
I
------
L
T
E
S
L
A
F
C
H
C
C
L
--
N
P
L
L
Y
V
F
V
G
T
K
--
F
R
Q
---
E
L
-
H
-
C
L
L
A
E
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------