@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR17_HUMAN: (2016-01-10 )
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
Atome Classification :
(20 SA)
.........10........20........30........40......--------..50.-...--....60........70........80........90........100......-.110-........120.......130.......140.......150.......160.......170-.........180.......190....-.-----..200..---.-..------...210---.-------.----.--...----..---.-220...-..---..230.....----..240---.......-------------------------------------------------.-----.250-----..-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------.--.....------260.--......270.......280.....---..290---...----.....300.......310....--...320.......330.---......340.---.......350.......360.....---------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKRSWWAGSRK
P
P
R
E
M
L
KLSGSDSSQSMN
G
L
EVAPPG
L
I
TNFS
L
A
T
--------
A
E
QCG-QET--P
L
E
N
M
L
F
A
S
F
Y
L
L
D
F
I
L
A
L
VGN
T
L
A
L
W
L
F
I
R
DHKSGTP
A
N
V
F
L
M
H
L
A
V
AD
L
S
C
-
V
L
V
--LP
T
R
L
V
Y
H
FSGNHW
P
F
G
E
I
A
C
R
L
T
G
F
L
F
Y
L
N
M
Y
A
S
I
Y
F
L
T
CISAD
R
F
L
A
IVH
P
V
K
SLKL---R
R
P
L
Y
A
H
L
A
C
A
F
L
W
V
V
V
A
V
A
M
A
P
LLV-S-----PQT-VQT---N-
H
T
------
V
V
C
L
-----
Q
-------
L
----
Y
--
R
E
K----AS---
H
-
H
A
L
V
S
L
-
A
V
---
A
F
T
F
P
F
I
T
T
V
----
T
C
Y
-----
L
L
I
I
R
S
L
-------------------------------------------------
R
-----
Q
G
-------
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
K
R
L
K
T
------
K
A
V
R
--
M
I
A
I
V
L
A
I
F
L
V
C
F
V
P
YHVNR
S
V
Y
V
---
L
H
YR----SHG----
A
S
C
A
T
Q
R
I
L
A
L
A
N
R
I
T
S
C
L
T
S
L--NG
A
L
D
P
I
M
Y
F
F
V
A
E
K
F
R
---
H
A
L
C
N
L
L
-CG---KRLKGPPPSFEGKTNESSLSAKSEL---------------------------------------------------------------------------------------------------------------------------------
40
Fugue
92.68
32%
-156
* C2 *
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------------------------------
S
F
K
C
A
L
T
K
T
--
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
-----
G
T
G
-
V
R
K
---
N
-
K
T
------
I
T
C
Y
-----
D
-------
T
----
T
--
S
D
E
Y
L
R
S
Y
F
---
I
-
Y
S
M
C
T
T
-
V
A
---
M
F
C
V
P
L
V
L
I
L
----
G
C
Y
-----
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGK----
D
-----
Q
F
-------
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
E
P
L
R
R
------
K
S
I
Y
--
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
---
R
A
R
L
----
D
F
Q
TP--
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
--
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
---
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
91.48
29%
-163
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
-----
F
N
T
-
T
G
------
D
P
------
T
V
C
S
-----
I
-------
S
----
N
--
P
-----------
D
-
F
V
I
Y
S
S
-
V
V
---
S
F
Y
L
P
F
G
V
T
V
----
L
V
Y
-----
A
R
I
Y
V
V
L
-------------------------------------------------
K
-----
Q
R
-------
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
--
P
L
R
E
K
------
K
A
T
Q
--
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
---
T
H
V
---
L
N
T
H
----
C
Q
T
---------
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
--
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
---
K
A
F
L
K
I
L
-
S
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.83
27%
-156
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------------------------------
S
F
K
C
A
L
T
K
T
--
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
-
Y
-----
S
G
T
G
V
R
K
---
N
-
K
T
------
I
T
C
Y
-----
D
-------
T
TSDE
Y
--
L
R
S
----
Y
F
---
I
-
Y
S
M
C
T
T
-
V
A
---
M
F
C
V
P
L
V
L
I
L
----
G
C
Y
-----
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGK----
D
-----
Q
F
-------
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
E
P
L
R
R
------
K
S
I
Y
--
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
----
T
P
A
----
M
C
A
F
N
D
R
V
Y
A
-
T
Y
Q
V
T
R
G
L
A
S
L
--
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
---
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.01
27%
-151
- C2 -
4XNW
2
RUBR_CLOPA
A:
[37-382]
----------------------------------------------
S
--------
S
F
K
C
A
L
T
K
T
--
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
-
Y
-----
S
G
T
G
V
R
K
---
N
-
K
T
------
I
T
C
Y
-----
D
-------
T
TSDE
Y
--
L
R
S
----
Y
F
---
I
-
Y
S
M
C
T
T
-
V
A
---
M
F
C
V
P
L
V
L
I
L
----
G
C
Y
-----
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGK
D
-----
Q
F
-------
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
E
P
L
R
R
------
K
S
I
Y
--
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
----
T
P
A
----
M
C
A
F
N
D
R
V
Y
A
-
T
Y
Q
V
T
R
G
L
A
S
L
--
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
---
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
86.68
24%
-155
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-498]
-----------------------------------------------------------
E
-
E
N
A
--
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
-----
A
N
V
-
S
E
A
---
D
-
D
R
------
Y
I
C
D
-----
R
-------
F
----
Y
--
P
N
D
----
L
W
V
V
-
V
-
F
Q
F
Q
H
I
-
M
V
---
G
L
I
L
P
G
I
V
I
L
----
S
C
Y
-----
C
I
I
I
S
K
L
-------------------------------------------------
S
-----
H
S
-------
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
H
Q
K
R
------
K
A
L
K
--
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
---
G
I
S
---
I
D
S
F
----
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
--
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
---
T
S
A
Q
H
A
L
-
T
S
---
G
R
P
L
E
V
L
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
83.82
22%
-157
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------
D
--
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
--
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
H----
W
Y
R
-
A
T
H
---
Q
-
E
A
I
N
C
Y
A
E
E
T
C
C
-----
D
-------
F
----
F
--
T
------
N
Q
---
A
-
Y
A
I
A
S
S
-
I
V
---
S
F
Y
V
P
L
V
I
M
V
----
F
V
Y
-----
S
R
V
F
Q
E
A
-------------------------------------------------
K
-----
R
Q
-------
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
--
C
L
K
E
H
------
K
A
L
K
--
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
---
V
N
I
---
V
H
V
I
----
Q
D
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
--
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
---
I
A
F
Q
E
L
L
-
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.52
23%
-143
- C2 -
3PQR
11
OPSD_BOVIN
A:
[1-326]
----------------------------
M
N
G
T
E
--
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFE
A
P
Q
Y
Y
-
L
A
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
---
S
-
C
G
------
I
D
Y
Y
-----
T
-------
P
----
H
--
E
E
T
----
N
N
---
E
-
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
T
H
Q
----
G
S
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
---
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
82.93
23%
-141
- C2 -
3PXO
6
OPSD_BOVIN
A:
[1-326]
----------------------------
M
N
G
T
E
--
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFE
A
P
Q
Y
Y
-
L
A
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
---
S
-
C
G
------
I
D
Y
Y
-----
T
-------
P
----
H
--
E
E
T
----
N
N
---
E
-
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
T
H
Q
----
G
S
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
---
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
82.55
23%
-162
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
-----
W
Q
F
-
I
V
G
VRT
V
-
E
D
------
G
E
C
Y
-----
I
-------
Q
----
F
--
F
S
N
----
A
----
A
-
V
T
F
G
T
A
-
I
A
---
A
F
Y
L
P
V
I
I
M
T
----
V
L
Y
-----
W
H
I
S
R
A
S
-------------------------------------------------
K
-----
S
R
-------
I
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
--
P
S
R
E
K
------
K
V
T
R
--
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
---
M
V
L
---
I
N
T
F
----
C
A
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
--
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
---
K
T
F
K
H
L
L
-
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
82.13
22%
-145
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------------------------------
P
C
F
-
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
-----
A
N
V
-
S
E
A
---
D
-
D
R
------
Y
I
C
D
-----
R
-------
F
----
Y
PN
D
L
W
----
V
V
---
V
-
F
Q
F
Q
H
I
-
M
V
---
G
L
I
L
P
G
I
V
I
L
----
S
C
Y
-----
C
I
I
I
S
K
L
-------------------------------------------------
S
-----
H
S
GSN
I
F
E
M
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
E
G
L
R
L
------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
---
L
D
K
A
IGRN
T
N
G
----
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
-
Y
D
S
L
D
A
V
R
R
---
A
A
L
I
N
M
V
-
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
17
PsiBlast_PDB
81.93
23%
-144
- C2 -
3CAP
8
OPSD_BOVIN
A:
[1-326]
----------------------------
M
N
G
T
E
--
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFE
A
P
Q
Y
Y
-
L
A
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
---
S
-
C
G
------
I
D
Y
Y
-----
T
-------
P
----
H
--
E
E
T
----
N
N
---
E
-
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
T
H
Q
----
G
S
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
---
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.85
23%
-142
- C2 -
3DQB
8
GNAT1_BOVIN (first)
A:
[1-326]
----------------------------
M
N
G
T
E
--
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFE
A
P
Q
Y
Y
-
L
A
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
---
S
-
C
G
------
I
D
Y
Y
-----
T
-------
P
----
H
--
E
E
T
----
N
N
---
E
-
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
T
H
Q
----
G
S
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
---
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
81.53
22%
-123
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
------
G
T
E
G
P
N
---
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
----------------------
A
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
--------------
S
C
G
I
DYYT
P
-------
H
----
E
--
E
T
N
----
N
E
---
S
-
F
V
I
Y
M
F
-
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
TT
Q
K
A
E
K
------
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
T
H
Q
----
G
S
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
-
C
C
---
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
80.90
22%
-146
- C2 -
2Z73
5
OPSD_TODPA
A:
[28-334]
-------------------------------------------------------------
Q
V
P
--
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
-----
W
G
A
-
Y
T
L
---
E
G
V
L
------
C
N
C
S
-----
F
-------
D
----
Y
--
I
S
R
----
D
S
T
T
R
S
-
N
I
L
C
M
F
-
I
L
---
G
F
F
G
P
I
L
I
I
F
----
F
C
Y
-----
F
N
I
V
M
S
V
-------------------------------------------------
S
-----
N
H
-------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
A
N
A
E
M
------
R
L
A
K
--
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
---
V
A
L
---
L
A
Q
F
----
G
P
L
---------
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
---
E
A
I
S
Q
T
F
-
P
W
---
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.24
28%
-168
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[130-405]
--------------------------------------------------------------------------
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
L
T
--
L
P
F
Q
G
T
D
I
L
L
G
-
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
-
M
-----
G
S
A
-
Q
V
E
---
D
-
E
E
------
I
E
C
L
-----
V
-------
E
----
I
--
P
T
P
----
Q
D
---
Y
-
W
G
P
V
F
A
-
I
C
---
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
-----
S
L
M
I
R
R
L
-------------------------------------------------
R
GVRLL
S
G
-------
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
R
N
L
R
------
R
I
T
R
--
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
----
V
F
V
---
L
A
-
Q
----
G
L
G
----
V
Q
P
S
S
E
T
A
V
A
I
L
-
R
F
C
T
A
L
G
Y
V
--
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
---
A
C
F
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
79.17
20%
-161
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
--
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
-----
N
H
--------
R
-
R
E
------
D
K
C
E
-----
T
-------
D
----
F
--
Y
D
V
----
T
----
W
-
F
K
V
M
T
A
-
I
I
---
N
F
Y
L
P
T
L
L
M
L
----
W
F
Y
-----
A
K
I
Y
K
A
V
-------------------------------------------------
R
-----
Q
H
-------
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
--
M
N
R
E
R
------
K
A
A
K
--
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
---
F
F
M
---
V
I
A
F
----
C
K
N
----------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
--
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
---
K
T
F
K
R
I
L
-
H
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.01
23%
-167
- C- -
3C9M
1
OPSD_BOVIN
A:
[34-327]
------------------------------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
---
S
-
C
G
------
I
D
Y
Y
-----
T
-------
P
----
H
--
E
E
T
----
N
N
---
E
-
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
-----
G
Q
L
V
F
T
V
-------------------------------------------------
K
-----
E
A
-------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
Q
E
S
A
T
TQK
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
---
F
-------
T
H
Q
----
G
S
C
F
G
P
I
F
M
T
----
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
---
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.21
28%
-148
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[135-406]
----------------------------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
-
M
-----
A
V
T
-
R
P
R
---
D
-
G
A
------
V
V
C
M
-----
L
-------
Q
----
F
--
P
S
P
----
S
W
---
Y
-
W
D
T
V
T
K
-
I
C
---
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
LL---------------------------------------------------------------
G
-------
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
R
S
L
R
------
R
I
T
R
--
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
---
L
V
D
I
----
D
R
---------
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.06
19%
-152
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
--
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-----
W
N
N
-
C
G
Q
------
S
------
Q
G
C
G
-----
E
GQVACLF
E
----
D
--
V
V
P
----
M
N
---
Y
-
M
V
Y
F
N
F
-
F
A
---
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
-----
L
R
I
F
L
A
A
-------------------------------------------------
R
-----
R
Q
-------
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
-
T
--
L
Q
K
E
V
------
H
A
A
K
--
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
---
I
N
C
---
F
T
F
F
----
C
P
D
----
C
----
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
---
Q
T
F
R
K
I
I
-
R
S
---
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.17
26%
-157
- C2 -
5C1M
7
?
A:
[8-294]
---------------------------------------------------------
Q
T
G
-
S
P
S
--
M
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
T
--
L
P
F
Q
S
V
N
Y
L
M
G
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
-
M
-----
A
T
T
-
K
Y
R
---
Q
-
G
S
------
I
D
C
T
-----
L
-------
T
----
F
--
S
H
P
----
T
W
---
Y
W
E
N
L
L
K
I
-
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
----
V
C
Y
-----
G
L
M
I
L
R
L
-------------------------------------------------
K
S
VRML
S
G
-------
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
R
N
L
R
------
R
I
T
R
--
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
---
L
--------------
I
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
--
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
---
R
C
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------