@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR26_HUMAN: (2016-01-10 )
MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE
Atome Classification :
(20 SA)
--------------------------------.........10......-..20........30........40..---......50........-60.......-.70........80........90........100.......110.....---..120.......130.......140....--------...--150--.-........160.--......170.......180.......190.......200.......210..--------------------------------.---------.---------------------.-------------------.---------------------------------------------.-----------------------------------------------------------------------220------------------------------------.----------.----------------------------------------------------------.-----------------------...--------------.-------------.-.230..--.....240.......250......-.260......-.--270--.........280.......290.......-300.......310.......320.......330.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------MNS
W
D
A
G
L
A
G
L
L
V
G
T
M
G
-
V
S
L
L
S
N
A
L
V
L
L
C
L
LHS
A
D
I
R
RQA
P
A
L
---
F
T
L
NLT
C
G
N
L
L
C
T
V
VN-M
P
L
T
L
A
G
V
V
-AQRQP
A
G
D
R
L
C
R
L
A
A
F
L
D
T
F
L
A
A
N
S
M
L
S
M
A
A
L
S
ID
R
W
V
A
V
V
FPLS
Y
R
A
K
---
M
RL
R
D
A
A
L
M
V
A
Y
T
W
L
H
A
L
T
F
P
A
A
A
L
A
L
S
W
--------
L
G
F
--
H
----
Q
-
L
Y
A
S
C
T
LCSRRP--DE
R
L
R
F
A
V
F
T
G
A
F
H
A
L
S
F
L
L
S
F
V
V
L
C
C
T
Y
L
K
V
L
K
V
A
R
F
H
C
KR
I
D
V
I
T
M
Q
T
L
--------------------------------
V
---------
L
---------------------L-------------------V---------------------------------------------D-----------------------------------------------------------------------L--------------------------------------
H
----------
P
----------------------------------------------------------
S
-----------------------
V
R
E
--------------
R
-------------
C
-
L
E
E
Q
K
R
--
R
R
Q
R
A
T
K
K
I
S
T
F
I
G
T
F
L
V
C
F
A
P
Y
V
-
I
T
R
L
V
E
L
F
ST-V--P----IG
S
H
W
G
V
L
S
K
C
L
A
Y
SKAAS
D
P
F
V
Y
S
L
L
R
H
-
Q
Y
R
K
S
C
K
E
I
L
N
R
L
L
H
R
RSIHSSGLTGDSHSQNILPVSE
39
Fugue
87.98
20%
-100
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
---
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
------------
V
G
W
--
S
----
R
-
Y
I
P
E
G
M
Q
C
S
C
G
I
--
D
----
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------------------------------
V
----------
F
----------------------------------------------------------
T
-----------------------
V
K
E
--------------
A
-------------
A
A
S
A
T
T
Q
K
--
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
--
D
----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
-----
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
31
HHSearch
86.06
18%
-117
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-334]
------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
-
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
-
T
P
A
N
M
---
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
--------
G
A
Y
T
L
E
----
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
--
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------------------------------------------------------------------------
K
E
L
--------------
R
-------------
K
-
A
Q
A
G
A
N
--
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
-
V
V
A
L
L
A
Q
F
G
P
-
L
E-
W
----
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
26
HHSearch
85.66
16%
-118
- C3 -
3EML
13
ENLYS_BPT4
A:
[24-472]
---------------------------------------
Y
I
T
V
E
L
A
I
A
V
-
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
T
N
Y
---
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
--------
N
N
C
--
G
Q------
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
--------------------------------
L
RL
K
I
Y
----
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN-----
G
VIT
K
-----------------------------------------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
-----
E
--------------------------------------
A
A
V
N
L
A
K
S
R
W
Y
N
----------------------------------------------------------
Q
-----------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-------------
A
-
Y
R
S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
-
D
CS
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------
28
HHSearch
84.95
20%
-119
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
-
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
-
T
T
T
N
Y
---
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
--------
N
T
T
-------
G
-
D
P
T
V
C
S
I
S
N
P
-----------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
----------------------
T
---------
E
---------------------
G
Y
Y
T
I
G
IGHL----------
L
TKSPS
L
N
A
A
K
S
E
L
D
K
A
I
G---------------------------
R
NTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
--------------------------------------
R
W
D
E
A
A
V
N
L
A
-
K
S
R
W
Y
N
-----------------------------------------------------
Q
-----------------------
T
P
N
--------------
R
A
K
R
V
I
T
T
F
R
T
GTW
D
-
A
Y
G
V
P
L
--
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
-
L
T
H
V
L
N
T
H
C
Q
T
C
--
H
----
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
-
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------
12
PsiBlast_PDB
84.59
19%
-132
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
23
HHSearch
84.24
16%
-117
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
-
T
V
T
N
Y
---
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
--------
Y
R
A
--
T
----
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
---
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
---------
L
---------------------
D
-------------------
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
-----------------------------------------------------------------------
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
----------
K
----------------------------------------------------------
S
R
W
Y
N
Q
------------------
T
P
N
--------------
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
K
F
C
L
--
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
-
I
V
N
I
V
H
V
I
Q
D
-
N
--
L
----
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
-
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------
21
HHSearch
83.31
20%
-112
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------
F
I
V
L
V
A
G
S
L
S
L
-
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
-
T
V
N
N
Y
---
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
--------
Q
F
I
--
V
GVRT
V
-
E
D
G
E
C
Y
I
Q
F
F
S
--------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
--------------------------------
L
RL
K
I
Y
K
D
TE
G
Y
Y
T
I
GIGHLLTK---------
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
VIT
K
-----------------------------------------
D
-----------------------------------------------------------------------
E
--------------------------------------
A
----------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
-----
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
--------------
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
P
P
P
S
--
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
-
V
M
V
L
I
N
T
F
C
A
-
P
--
C
----
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
M
---------------------------
6
PsiBlast_PDB
83.29
19%
-133
- C3 -
2Y00
13
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
17
PsiBlast_PDB
83.22
19%
-129
- C3 -
4BVN
11
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
--------------
K
-------------
T
-
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
--
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------
11
PsiBlast_PDB
82.85
19%
-129
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
27
HHSearch
82.75
18%
-116
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
-
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
-
T
V
T
N
Y
---
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
--------
T
E
T
--
M
----
P
-
S
R
V
V
C
M
I
E
W
P
E
H
--
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------
R
-
Y
H
E
Q
V
S
--
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
-
I
F
F
L
L
P
Y
I
N
P
-
D
--
L
YLKK
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
8
PsiBlast_PDB
82.66
19%
-132
- C3 -
2Y02
13
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
13
PsiBlast_PDB
82.35
19%
-132
- C3 -
3ZPR
11
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
----------------------------
7
PsiBlast_PDB
82.24
19%
-131
- C3 -
2Y01
12
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
10
PsiBlast_PDB
81.94
19%
-131
- C3 -
2Y04
13
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
15
PsiBlast_PDB
81.55
21%
-126
- C3 -
4MQT
2
ACM2_HUMAN
A:
[45-334]
------------------------------------------
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
----
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-
L
F
W
Q
F
I
-----
V
G
V
--
R
----
T
-
V
E
D
G
E
C
Y
I
Q
F
F
S
--
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
-----
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PS
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
-
V
M
V
L
I
N
T
F
C
A
-
P
--
C
----
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
--
M
C
------------------------
1
PsiBlast_PDB
81.41
20%
-128
- C3 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
-----------------------------------
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------
22
HHSearch
81.34
21%
-113
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------
P
L
V
V
V
L
S
T
I
C
L
-
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
-
T
V
G
N
L
---
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
--
G
W
--------
N
H
--------
R
-
R
E
D
K
C
E
T
D
F
Y
D
V
--------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
-----
N
---------
A
A
K
S
E
L
D
K
A
-------------
I
-------------------
G
RNTNGVIT
K
------------------------------------
D
-----------------------------------------------------------------------
E
--------------------------------------
A
----------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----
T
P
N
--------------
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
L
H
M
N
--
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
-
I
F
F
M
V
I
A
F
C
K
-
N
--
C
----
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
-
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------
2
PsiBlast_PDB
80.92
20%
-130
- C3 -
2YCW
7
ADRB1_MELGA
A:
[8-297]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
K
R
--------------------------------
V
---------
M
---------------------
L
-------------------
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------
9
PsiBlast_PDB
80.73
19%
-131
- C3 -
2Y03
9
ADRB1_MELGA
A:
[8-299]
---------------------------------
Q
Q
W
E
A
G
M
S
-
L
L
M
A
L
V
V
-
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
WRDED
P
Q
A
L
K
C
--
Y
----
Q
-
D
P
G
C
C
D
F
V
T
N
R
----------
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
V
N
I
V
N
V
F
N
R
-
D
--
L
----
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
-
D
F
R
K
A
F
K
R
L
L
A
---------------------------