@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR31_HUMAN: (2016-01-10 )
MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALHFLLDLSRSVGMAFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNSTRCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSVLNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS
Atome Classification :
(20 SA)
-----------------------.........10-........20........30........40........50........60....-....70........80.-.......90........100.......110.......120...---....130.......140.......150---.-----..-...--.---.-.-160.......170..---......180.......190.......200..--------------------------------------------.....----210---------.---------------------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------.......220.......230.......240....----.....250--........260.......------270.......280.......290.......300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MPFPNCSA
P
S
T
-
V
V
A
T
A
V
G
V
L
L
G
L
E
C
G
L
G
L
L
G
N
A
V
A
L
W
T
F
L
F
R
V
RVWK
P
Y
A
V
Y
L
L
N
L
A
L
A
D
L
L
L
A
A
-
C
L
P
F
L
A
A
F
Y
L
S
L
Q
A
W
HL-G
R
V
G
C
W
A
L
H
F
L
L
D
L
S
R
S
V
G
M
A
F
L
A
A
V
A
L
D
R
Y
L
R
V
VHP
R
L
K
V
N
L
---LS
P
Q
A
AL
G
V
S
G
L
V
W
L
L
M
V
A
L
TCP
G
L
-----
L
-----
I
S
-
E
AA--Q---N-S-
T
R
C
H
S
F
Y
SRAD-G
S
F
---
S
I
I
W
Q
E
A
L
S
C
L
Q
F
V
L
P
F
G
L
I
V
FCN
A
G
I
I
R
A
L
--------------------------------------------
Q
K
R
LR----E-----------P---------------------------------------------------------------------------------------------------------------------------------------------------------------E------------------------------------KQ
P
K
L
Q
R
A
Q
A
L
V
T
L
V
V
V
L
F
A
L
C
F
L
P
C
F
L
--
A
R
V
L
----
M
H
I
F
Q
N
L---
G
S
C
R
A
L
C
A
VAHTSDVT
G
S
------
L
T
Y
L
H
S
V
L
N
P
V
V
Y
CFSSP
T
F
R
S
S
Y
R
R
V
F
H
T
LRGKGQAAEPPDFNPRDSYS
40
Fugue
87.93
29%
-149
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
-
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
-----
F
-----
Y
S
-
G
T
G
--
V
R
KN
K
-
T
-
I
T
C
Y
D
T
T
S
D
E
Y
-
L
R
S
---
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG
K
D
Q
F
E
----
E
-----------
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
--
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
---
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
------
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------
1
PsiBlast_PDB
87.04
25%
-150
- C1 -
4XNV
15
P2RY1_HUMAN
A:
[63-382]
--------------------------------------------------
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
-
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
-----
F
-----
Y
S
-
G
T
G
--
V
---
R
-
K
-
N
K
T
I
T
C
Y
D
T
T
S
-
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
--------------------------------------------
I
Y
K
M
K
----
K
Y
T
C
TVCG
Y
I
Y
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
DGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
----
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
--
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
---
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
------
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
---
R
R
------------------------
8
PsiBlast_PDB
84.64
24%
-153
- C1 -
4N6H
23
C562_ECOLX (first)
A:
[118-408]
-----------------------------
S
A
S
S
L
-
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-----
V
M
A
---
V
T
-
R
P
R
--
D
---
G
-
A
-
V
V
C
M
L
Q
F
P
S
P
S
-
W
Y
W
---
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
--------------------------------------------
R
S
V
R
L
LSG-
S
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
----
W
T
L
V
D
I
D
---
R
R
D
P
L
V
V
A
A
L
H
---
L
C
I
A
------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-----------------
2
PsiBlast_PDB
83.74
25%
-153
- C1 -
4XNW
2
RUBR_CLOPA
A:
[63-382]
--------------------------------------------------
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
-
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
-----
F
-----
Y
S
-
G
T
G
--
V
---
R
-
K
-
N
K
T
I
T
C
Y
D
T
T
S
-
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
--------------------------------------------
I
Y
K
M
K
----
K
Y
T
C
TVCG
Y
I
Y
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
DGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
--
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
---
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
------
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
---
R
R
------------------------
6
PsiBlast_PDB
83.69
24%
-152
- C1 -
4RWA
2
C562_ECOLX (first)
A:
[115-405]
-----------------------------
S
A
S
S
L
-
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-----
V
M
A
---
V
T
-
R
P
R
--
D
---
G
-
A
-
V
V
C
M
L
Q
F
P
S
P
S
-
W
Y
W
---
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
---------------------------------------------------G---
S
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
----
W
T
L
V
D
I
D
---
R
R
D
P
L
V
V
A
A
L
H
---
L
C
I
A
------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------
7
PsiBlast_PDB
83.51
24%
-150
- C1 -
4RWD
7
C562_ECOLX (first)
A:
[115-405]
-----------------------------
S
A
S
S
L
-
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-----
V
M
A
---
V
T
-
R
P
R
--
D
---
G
-
A
-
V
V
C
M
L
Q
F
P
S
P
S
-
W
Y
W
---
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
--------------------------------------------
R
S
V
R
L
LSG-
S
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
----
W
T
L
V
D
I
D
---
R
R
D
P
L
V
V
A
A
L
H
---
L
C
I
A
------
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------
3
PsiBlast_PDB
83.34
26%
-157
- C1 -
5C1M
7
?
A:
[7-296]
--------------------------
P
Q
T
G
S
P
S
M
-
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
-
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
-----
F
-----
M
A
-
T
T
K
Y
R
Q
---
G
-
S
-
I
D
C
T
L
T
F
S
H
P
T
-
W
Y
W
---
E
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
---------------------------------------------
K
S
V
R
MLSG
S
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------
K
D
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
-------------
I
H
I
Y
V
I
I
------
K
A
L
I
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------
32
HHSearch
83.21
26%
-145
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
-
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-----
F
-----
G
F
-
N
T
T
------
G
-
D
P
T
V
C
S
I
S
N
P
------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
--------------------------------------------
K
Q
R
R
R
----
K
-----------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
------------------------------------
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
--
T
H
V
L
----
N
T
H
C
Q
------
T
C
H
---
V
S
P
E
L
Y
S
A
T
T
W
------
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------
4
PsiBlast_PDB
81.92
26%
-156
- C1 -
4XT1
15
US28_HCMVA
A:
[38-309]
---------------------------
N
Q
S
K
P
V
T
-
L
F
------
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
L
P
L
W
M
Q
Y
L
L
D
--------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
R
Y
R
-------
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
-----
M
-----
V
V
-
T
K
K
--
D
---
N
----
Q
C
M
T
D
Y
D
Y
L
E
-
V
S
Y
---
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
--------------------------------------------
A
--
V
S
----
Q
-----------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------
H
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
--
V
D
T
L
----
K
L
L
K
W
I
S
---
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
------
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
------------------
23
HHSearch
80.24
22%
-146
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-498]
---------------------------------
N
-
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
-
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
-----
I
-----
F
A
-
N
V
S
--
E
A
--
D
-
D
R
Y
I
C
D
R
F
Y
P
N
D
---
L
W
---
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
--------------------------------------------
S
H
S
G
S
----
N
-----------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
------------------------------------
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
--
G
I
S
I
----
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
------
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------
24
HHSearch
80.19
21%
-148
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----
Q
-----
M
H
W
Y
R
A
--
T
H--
Q
-
E
A
I
N
C
Y
A
E
E
T
C
C
D
-
F
F
T
---
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--------------------------------------------
K
R
Q
L
N
----
I
-----------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
K
------------------------------------
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
----
H
V
I
Q
D
-----
N
-
L
----
I
R
K
E
V
Y
I
L
L
N
W
------
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------
5
PsiBlast_PDB
79.57
26%
-151
- C1 -
4XT3
2
US28_HCMVA
A:
[38-309]
---------------------------
N
Q
S
K
P
V
T
-
L
F
------
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
L
P
L
W
M
Q
Y
L
L
D
H
------
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
R
Y
R
-------
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
-----
M
-----
V
V
-
T
K
K
--
D
---
N
----
Q
C
M
T
D
Y
D
Y
L
E
-
V
S
Y
---
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
--------------------------------------------
A
--
V
S
----
Q
-----------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------
H
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
--
V
D
T
L
----
K
L
L
K
W
I
S
---
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
------
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
--------------------
17
PsiBlast_PDB
79.52
24%
-149
- C1 -
3C9L
13
OPSD_BOVIN
A:
[50-315]
--------------------------------------------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
GW
S
R
Y
I
P
-
E
G
M
--
Q
---
C
-
S
-
C
G
I
-
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----
Q
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
----
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
--------------
19
PsiBlast_PDB
79.48
24%
-150
- C1 -
3DQB
4
GNAT1_BOVIN (first)
A:
[50-315]
--------------------------------------------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
GW
S
R
Y
I
P
-
E
G
M
--
Q
---
C
-
S
-
C
G
I
-
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----
Q
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
----
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------
20
PsiBlast_PDB
78.99
24%
-154
- C1 -
3PQR
8
OPSD_BOVIN
A:
[50-315]
--------------------------------------------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
GW
S
R
Y
I
P
-
E
G
M
--
Q
---
C
-
S
-
C
G
I
-
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----
Q
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
----
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------
18
PsiBlast_PDB
78.51
24%
-152
- C1 -
1F88
7
OPSD_BOVIN
A:
[50-315]
--------------------------------------------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
GW
S
R
Y
I
P
-
E
G
M
--
Q
---
C
-
S
-
C
G
I
-
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
----
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
25
HHSearch
78.38
21%
-155
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
S
L
-
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-----
G
-----
W
N
-
H
---------R
R
E
D
K
C
E
T
D
F
Y
D
V
---------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
--------------------------------------------
R
Q
H
C
N
----
I
-----------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
L
------------------------------------
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
--
F
F
M
V
----
I
A
F
C
K
-----
N
-
C
C
----
N
E
H
L
H
M
F
T
I
W
------
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------
42
Fugue
77.74
20%
-132
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSP
F
E
A
P
Q
Y
Y
L
A
E
P
-
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
-
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
-----
I
P
-
E
G
M
--
Q
-----
C
-
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----
S
-----------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
--
Y
--
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
------
S
A
----
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
16
PsiBlast_PDB
77.69
24%
-150
- C1 -
3CAP
4
OPSD_BOVIN
A:
[50-315]
--------------------------------------------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
GW
S
R
Y
I
P
-
E
G
M
--
Q
---
C
-
S
-
C
G
I
-
D
Y
Y
T
P
H
E
-
E
T
N
---
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------------------------
K
E
A
A
A
----
Q
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
---
G
S
D
F
G
P
I
F
M
T
----
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------
29
HHSearch
76.25
21%
-135
- C1 -
2KS9
1
NK1R_HUMAN
A:
[33-327]
--------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
-
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-----
Y
-----
Y
S
-
T
T
E
--
T
---
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
N
K
I
Y
---
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
--------------------------------------------
W
A
S
E
I
----
P
-----------
G
DSSDRYH--------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
--
F
F
L
L
----
P
Y
I
N
P
D
L
---
Y
---
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
------
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L