@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR32_HUMAN: (2016-01-10 )
MNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSSCPRGNAPRE
Atome Classification :
(20 SA)
.........10........20........30........-40....----....50.--..-.--..-..60.....-...-70..-.-...-..80........90..-.-..-...100..-..-...110.......120.......130.......140.......150---.......160.......170.......-------180--...--...-.190.......200.......210.......220.......230....-..--.-240---------------------------------...-------------------------------------------.----------------------------------..------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------.------------------250..-------..-----...260.......270.......280..--..----..----.290-------.......300---------.......310.......320.......330.......340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNGV
S
E
GTRGCSDRQPG
V
L
TRDRSCSRKMNSSGC
L
S
E
E
V-GSLR
P
L
----
T
V
V
I
L
S
A
--
S
I
-
V
--
V
G
-
V
LGN
G
L
V
L
W
-
M
T
V
-
F
R
M
A
-
R
-
T
V
S
-
T
V
C
F
F
H
L
A
L
A
D
F
M
L
S
L-S-
L
P
-
I
A
M
Y
Y
I
V
S-R
Q
-
W
L
L
G
E
W
A
C
K
L
Y
I
T
F
V
F
L
S
Y
F
ASN
C
L
L
V
F
I
S
V
D
R
C
I
S
V
L
Y
P
V
W
ALNH---
R
T
V
Q
R
A
S
W
L
A
F
G
V
W
L
L
A
A
A
L
C
S
A
H
L
K
F
-------
R
T
T--RKW--NG
C
-
T
H
C
Y
L
A
FNSDN
E
T
A
Q
I
W
I
EGVVEGH
I
I
G
T
I
G
H
F
L
L
G
F
L
G
P
L
A
I
I
G
T
C
A
-
H
L
--
I
-
R
A
----------------------------------
K
L
L
-------------------------------------------
R
----------------------------------EG------------------------------------------------------------------------------------------------------------------------------------------------------------------W--------------------------------------------------------------------------------------------------------------------------------------------------------------------V------------------HANR
P
-------
K
R
-----
L
L
L
V
L
V
S
A
F
F
I
F
W
S
P
F
N
V
V
L
L
V
H
L
W
R
R
V
--
M
L
----
K
E
----IYHP-------
R
M
L
L
I
L
QAS
F
---------
A
L
G
C
V
NSSLN
P
F
L
Y
V
F
VG
R
D
F
Q
E
K
F
F
Q
S
L
T
S
A
L
A
R
A
F
G
E
E
E
F
L
S
SCPRGNAPRE
45
Fugue
92.41
27%
-156
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------
S
F
K
C
A
L
T
K
T
-
G
F
Q
F
Y
Y
----
L
P
A
V
Y
I
L
--
V
F
-
I
--
I
G
-
F
L
G
N
S
V
A
I
W
-
M
F
V
-
F
H
M
K
-
P
W
S
G
I
-
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
-
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
------
G
T
G
--
V
R
K
--
N
K
T
-
I
T
C
Y
------
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
----
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
--
I
-
V
R
----------------------------------
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG
K
----------------------------------
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------
E
V
E
E
P
-------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
--
D
F
QTPA
M
C
----
A
F
N
D
-------
R
V
Y
A
T
Y
Q
V
T
R
---------
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------
1
PsiBlast_PDB
89.12
30%
-150
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[102-407]
-------------------
T
R
N
A
Y
I
Q
K
Y
L
G
S
P
G
A
R
S
A
S
S
-
L
A
L
A
I
A
----
I
T
A
L
Y
S
A
--
V
C
-
A
--
V
G
-
L
L
G
N
V
L
V
M
F
-
G
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------
A
V
T
--
R
P
R
--
D
G
A
-
V
V
C
M
L
Q
F
P
S
P
S
-----
W
Y
W
D
T
V
T
-----
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
-
G
L
--
M
-
L
L
----------------------------------
R
L
R
S
V
RLLSGS-----------------------------------
K
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
S
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
--
W
T
L
V
--
D
I
----
D
R
-----
R
D
P
-------
L
V
V
A
A
L
H
L
C
I
---------
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
--------------------
11
PsiBlast_PDB
85.56
24%
-163
- C3 -
4XNV
15
P2RY1_HUMAN
A:
[62-382]
--------------------------------------------------------------
I
--
I
G
-
F
L
G
N
S
V
A
I
W
-
M
F
V
-
F
H
M
K
-
P
W
S
G
I
-
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
K
-
T
D
-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-------
S
G
T
G
V
R
K
---
N
K
T
-
I
T
C
Y
------
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
----
P
L
V
L
I
L
G
C
Y
-
G
L
--
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDF
K
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
CPLCGVGKDQ
F
E
------
E
V
E
E
P
-------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
--
D
F
----
Q
T
PAM
C
A
F
N
D
-------
R
V
Y
A
T
Y
Q
V
T
R
---------
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------
21
PsiBlast_CBE
84.63
31%
-159
- C3 -
4RWD
5
OPRD_HUMAN
B:
[130-404]
-------------------------------------------------------
S
A
--
V
C
-
A
--
V
G
-
L
L
G
N
V
L
V
M
F
-
G
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------
A
V
T
--
R
P
R
--
D
G
A
-
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
-------
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
-
G
L
--
M
-
L
L
----------------------------------
R
L
R
SVRLLSGS-----------------------------------
K
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
S
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
--
W
T
L
V
--
D
I
----
D
R
-----
R
D
P
-------
L
V
V
A
A
L
H
L
C
I
---------
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
--------------------------
12
PsiBlast_PDB
84.30
24%
-161
- C3 -
4XNW
2
RUBR_CLOPA
A:
[62-382]
--------------------------------------------------------------
I
--
I
G
-
F
L
G
N
S
V
A
I
W
-
M
F
V
-
F
H
M
K
-
P
W
S
G
I
-
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
K
-
T
D
-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-------
S
G
T
G
V
R
K
---
N
K
T
-
I
T
C
Y
------
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
----
P
L
V
L
I
L
G
C
Y
-
G
L
--
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDF
K
D
I
-------------------------------------------
P
----------------------------------
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
CPLCGVGKDQ
F
E
------
E
V
E
E
P
-------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
--
D
F
----
Q
T
PAM
C
A
F
N
D
-------
R
V
Y
A
T
Y
Q
V
T
R
---------
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------
22
PsiBlast_CBE
84.26
31%
-158
- C3 -
4RWA
1
OPRD_HUMAN
B:
[130-403]
-------------------------------------------------------
S
A
--
V
C
-
A
--
V
G
-
L
L
G
N
V
L
V
M
F
-
G
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------
A
V
T
--
R
P
R
--
D
G
A
-
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
-------
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
-
G
L
--
M
-
L
L
----------------------------------
R
--GS-----------------------------------------
K
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
S
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
--
W
T
L
V
--
D
I
----
D
R
-----
R
D
P
-------
L
V
V
A
A
L
H
L
C
I
---------
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
----------------------------
2
PsiBlast_PDB
83.99
31%
-158
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[130-404]
-------------------------------------------------------
S
A
--
V
C
-
A
--
V
G
-
L
L
G
N
V
L
V
M
F
-
G
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------
A
V
T
--
R
P
R
--
D
G
A
-
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
-------
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
-
G
L
--
M
-
L
L
-------------------------------------GS-----------------------------------------
K
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
S
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
--
W
T
L
V
--
D
I
----
D
R
-----
R
D
P
-------
L
V
V
A
A
L
H
L
C
I
---------
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------
3
PsiBlast_PDB
83.59
31%
-159
- C3 -
4RWD
6
C562_ECOLX (first)
A:
[130-404]
-------------------------------------------------------
S
A
--
V
C
-
A
--
V
G
-
L
L
G
N
V
L
V
M
F
-
G
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------
A
V
T
--
R
P
R
--
D
G
A
-
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
-------
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
-
G
L
--
M
-
L
L
----------------------------------
R
L
R
S
V
RLLSGS-----------------------------------
K
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
S
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
--
W
T
L
V
--
D
I
----
D
R
-----
R
D
P
-------
L
V
V
A
A
L
H
L
C
I
---------
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------
26
HHSearch
83.27
22%
-147
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-498]
------------------------------------
E
N
A
-
N
F
N
K
I
F
----
L
P
T
I
Y
S
I
--
I
F
-
L
--
T
G
-
I
V
G
N
G
L
V
I
L
-
V
M
G
-
Y
Q
K
K
-
L
R
S
M
T
-
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
-
F
W
A
V
D
A
V
--
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-------
A
N
V
--
S
E
A
--
D
D
R
-
Y
I
C
D
R
F
Y
P
N
D
L
------------
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
-
C
I
--
I
-
I
S
----------------------------------
K
L
S
-------------------------------------------
H
----------------------------------
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
------------------
Q
K
R
K
A
-------
L
K
-----
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
--
E
I
I
K
Q
-
G
C
----
E
F
E
N
-------
T
V
H
K
W
I
S
I
T
E
---------
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------
27
HHSearch
81.60
24%
-145
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------
V
F
----
I
V
L
V
A
G
S
--
L
S
-
L
--
V
T
-
I
I
G
N
I
L
V
M
V
-
S
I
K
-
V
N
R
H
-
L
Q
T
V
N
-
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
-
L
Y
T
L
Y
T
V
I
-
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-------
W
Q
F
--
I
V
G
VR
T
V
E
D
G
E
C
Y
I
Q
F
F
---------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
-
W
H
--
I
-
S
R
----------------------------------
A
S
K
-------------------------------------------
S
----------------------------------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------
R
E
K
K
V
-------
T
R
-----
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
----------------------
I
P
N
T
V
W
T
I
G
Y
---------
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------
28
HHSearch
81.49
23%
-140
- C3 -
2Z73
5
OPSD_TODPA
A:
[29-335]
-------------------------------------
V
P
-
D
A
V
Y
Y
S
----
L
G
I
F
I
G
I
--
C
G
-
I
--
I
G
-
C
G
G
N
G
I
V
I
Y
-
L
F
T
-
K
T
K
S
-
L
Q
T
P
A
-
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
-
L
M
T
I
S
C
F
L
-
K
K
-
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-------
W
G
A
--
Y
T
L
--
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
-----------
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
--
I
-
V
M
----------------------------------
S
V
S
-------------------------------------------
N
----------------------------------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------------------
A
E
M
R
L
-------
A
K
-----
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
--
E
W
---------------------
V
T
P
Y
A
A
Q
L
P
V
---------
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
6
PsiBlast_PDB
81.36
28%
-162
- C3 -
5C1M
7
?
A:
[2-296]
-------------------------------
S
H
S
L
-
P
Q
T
-
G
S
P
S
M
V
----
T
A
I
T
I
M
A
L
Y
S
I
-
V
C
V
V
G
-
L
F
G
N
F
L
V
M
Y
-
V
I
V
R
Y
T
K
M
-
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
-
F
Q
S
V
N
Y
L
M
-
G
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-------
A
T
T
--
K
Y
R
--
Q
G
S
-
I
D
C
T
L
T
F
---
S
H
P
T
W
Y
W
-
E
N
L
L
K
------
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
-
G
L
M
I
L
-
R
L
----------------------------------
K
S
V
-------------------------------------------
R
MLSGS
K
----------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
N
L
R
R
I
-------
T
R
-----
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
------------------------------
A
L
I
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-----------------------------
7
PsiBlast_PDB
80.86
28%
-171
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
--------------------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
--
A
V
-
C
--
V
G
G
L
L
G
N
C
L
V
M
Y
-
V
I
L
-
R
H
T
K
M
K
-
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
-
L
P
-
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-------
G
S
A
--
Q
V
E
--
D
E
E
-
I
E
C
L
V
E
I
P
T
P
Q
D
---
Y
W
------
G
P
V
F
A
-
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
-
S
L
--
M
-
I
R
----------------------------------
R
L
R
GVRLLSGS-----------------------------------
R
----------------------------------
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
N
L
R
R
I
-------
T
R
-----
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
--
P
S
----
S
E
----
T
-----------
A
V
A
I
L
R
F
C
T
---------
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
----------------------------
14
PsiBlast_PDB
79.85
20%
-162
- C3 -
4MBS
8
CCR5_HUMAN (first)
A:
[38-366]
-----------------------------------------------------
L
Y
S
L
--
V
F
-
I
--
F
G
-
F
V
G
N
M
L
V
I
L
-
I
L
I
N
Y
K
R
L
-
K
-
S
M
T
-
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
-
T
-
V
P
-
F
W
A
H
Y
-
A
A
-
A
Q
-
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
-------
T
R
S
--
Q
K
E
--
G
L
H
-
Y
T
C
S
S
H
F
P
Y
S
Q
--
Y
Q
F
W
K
N
-------
F
Q
T
L
K
I
V
I
L
G
L
V
L
P
L
L
V
M
V
I
C
Y
-
S
G
--
I
-
L
K
----------------------------------
T
L
L
-------------------------------------------
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIP
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
CPLCGVGKDQ
F
E
E
V
E
E
EK
K
R
H
R
D
-------
V
R
-----
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
L
L
L
N
T
F
Q
E
F
FG
L
N
----
N
C
----
S
S
S
N
-------
R
L
D
Q
A
M
Q
V
T
E
---------
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
------------------------
37
HHSearch
79.13
24%
-156
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------
Y
A
L
S
Y
C
A
--
L
I
-
L
--
A
I
-
V
F
G
N
G
L
V
C
M
-
A
V
L
-
K
E
R
A
-
L
Q
T
T
T
-
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
-
W
V
V
Y
L
E
V
T
G
G
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-------
F
N
T
--
T
G
D
----
P
-
T
V
C
S
I
S
N
P
---------------
D
---
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
--
I
-
Y
V
----------------------------------
V
L
K
-------------------------------------------
Q
----------------------------------
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
------------------
R
E
K
K
A
-------
T
Q
-----
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
--
C
H
---------------------
V
S
P
E
L
Y
S
A
T
T
---------
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------
5
PsiBlast_PDB
78.36
26%
-155
- C3 -
4XT3
2
US28_HCMVA
A:
[27-316]
-----------------------------
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
V
----
T
L
F
L
Y
G
V
--
V
F
-
L
--
F
G
-
S
I
G
N
F
L
V
I
F
-
T
I
T
-
W
R
R
R
-
I
-
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
-
L
P
-
L
W
M
Q
Y
L
L
D
-
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
--------
V
T
--
K
K
D
--
N
Q
C
-
M
-------
T
D
Y
D
Y
L
E
------
V
S
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
-
Y
R
--
I
-
S
R
----------------------------------
I
V
A
-------------------------------------------
V
----------------------------------
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
H
K
G
R
I
-------
V
R
-----
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
----
L
L
----
K
W
----
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
---------
A
F
C
--
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
-----------------------
20
PsiBlast_PDB
77.93
24%
-177
- C3 -
4MQT
2
ACM2_HUMAN
A:
[43-328]
---------------------------------------------------
I
V
L
V
A
G
--
S
L
S
L
--
V
T
-
I
I
G
N
I
L
V
M
V
S
I
K
V
-
N
R
H
L
-
Q
-
T
V
N
-
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
-
L
Y
T
L
Y
T
V
I
-
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
GV
R
T
V
--
E
D
-------
G
E
C
Y
I
Q
F
F
S
N
A
A
V
---------------
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
--
S
-
R
A
S
K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSRE
K
K
V
T
R
-----
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
I
----
P
N
----
T
--------------
V
W
T
I
G
Y
---------
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
C
-----------------------
30
HHSearch
77.64
21%
-134
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
-----------------------------------------
V
W
V
V
G
----
M
G
I
V
M
S
L
--
I
V
-
L
--
A
I
-
V
F
G
N
V
L
V
I
T
-
A
I
A
-
K
F
E
R
-
L
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
M
-
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H------
W
Y
R
--
A
T
H
--
Q
E
A
-
I
N
C
Y
A
E
E
T
C
C
D
F
---
F
-------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
--
V
-
F
Q
----------------------------------
E
A
K
-------------------------------------------
R
----------------------------------
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
------------------
K
E
H
K
A
-------
L
K
-----
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
----------------------
I
R
K
E
V
Y
I
L
L
N
---------
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------
4
PsiBlast_PDB
76.85
26%
-157
- C3 -
4XT1
15
US28_HCMVA
A:
[27-318]
-----------------------------
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
V
----
T
L
F
L
Y
G
V
--
V
F
-
L
--
F
G
-
S
I
G
N
F
L
V
I
F
-
T
I
T
-
W
R
R
R
-
I
-
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
-
L
P
-
L
W
M
Q
Y
L
L
D
--------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
--------
V
T
--
K
K
D
--
N
Q
C
-
M
-------
T
D
Y
D
Y
L
E
------
V
S
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
-
Y
R
--
I
-
S
R
----------------------------------
I
V
A
-------------------------------------------
V
----------------------------------
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------
H
K
G
R
I
-------
V
R
-----
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
----
L
L
----
K
W
----
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
---------
A
F
C
--
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
---------------------
31
HHSearch
76.43
22%
-154
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------
P
----
L
V
V
V
L
S
T
--
I
C
-
L
--
V
T
-
V
G
L
N
L
L
V
L
Y
-
A
V
R
-
S
E
R
K
-
L
H
T
V
G
-
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
-
M
N
I
L
Y
L
L
M
-
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-------
N
H
---------
R
R
E
D
K
C
E
T
D
F
Y
D
---------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
--
I
-
Y
K
----------------------------------
A
V
R
-------------------------------------------
Q
----------------------------------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------------------
R
E
R
K
A
-------
A
K
-----
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
----------------------
C
N
E
H
L
H
M
F
T
I
---------
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------