@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR37_HUMAN: (2016-01-10 )
MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
Atome Classification :
(20 SA)
-----------.........10........20........30........40........50........60-----.........--70........80........90........100.......110.....----..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240........250..-.....260..------.....270..-------.....280.......290---------........300.......310..-.....320.-......330.......340.......350.......360.......370..--.....380.......390...-----....--400.......----------410....-...420.-.--.-....430.......440....----...450.......460.......470.....-----.---------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------------480.......490.......500.......510.......520-----..------......530.......540.......550.......560.......570.......580.......590.......600.......610.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MRA
P
G
A
L
L
A
R
M
S
R
L
L
L
L
L
L
L
KVSASSALGVAPASRNETCLGESC
A
P
T
V
I
Q
RRGRDAWGPG------
N
S
A
R
D
V
L
R
A--RAP
R
E
EQG
A
A
F
LAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPP----GPWRWKGARGQEP
S
E
TLGRG
N
P
T
A
L
Q
L
F
L
Q
ISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHK
P
L
S
K
TANGLAGHE
G
W
T
I
A
LPG
R
A
LAQNGSLGEGIHEPGGPRRGNST-N
R
R
V
R
LKNPFYPL-TQESY
G
A
Y
A
V
------
M
C
L
S
V
V
I
FGT-------
G
I
I
G
N
L
A
V
M
C
I
V
C
H
N
Y
Y
----------
M
R
S
I
S
N
S
L
L
A
N
L
A
F
W
D
F
L
I
I
F
F
C
-
L
P
L
V
I
F
H
E
L
-
T
K
K
W
L
L
E
DFS
C
K
I
V
P
Y
I
E
V
ASL
G
V
T
T
F
T
L
C
A
L
C
I
D
R
F
RAA
T
N
V
Q
M
Y
Y
E
M
I
E
--NCSST
T
A
K
L
A
V
I
W
V
G
A
L
L
L
A
L
-----
P
E
V
V
--
L
R
Q
L
S
K
E
DLG----------FSGRAPA-
E
R
C
I
I
K
I-S--P-DLPD
T
I
Y
V
L
A
L
T
YDS
A
R
L
W
W
Y
----
F
G
C
Y
F
C
L
P
T
L
F
T
I
T
C
S
L
V
T
A
R
K
I
R
K
A
E
K
A
CT-----R---------------------------------------------------------------------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------------------------------------------------------N
K
R
Q
I
Q
L
ESQMN
C
T
V
V
A
L
T
I
L
Y
G
F
CI
I
P
E
N
I
C
N
I
V
T
A
Y
M
ATG------V
S
------
Q
Q
T
M
D
L
L
N
I
I
S
Q
F
L
L
F
F
K
S
C
V
T
P
V
L
L
F
C
LC
K
P
F
S
R
A
F
M
E
C
C
C
C
C
C
E
E
C
I
Q
KSSTVTSDDNDN
E
Y
T
T
E
L
ELS
P
F
S
T
I
R
R
E
M
S
T
F
A
SVGTHC-
2
PsiBlast_PDB
86.80
22%
-107
- C6 -
3SN6
1
ENLYS_BPT4
R:
[121-490]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
G
V
A
G
F
T
N
S
L
R
---
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-
T
W
D
A
----
E
V
WVVGMG
I
V
M
S
L
I
V
L
A
I
--------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
----------
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
HW
Y
R
---
Q
E
A
I
N
CYAEETCCDF
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
--
V
-
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
KIDK
S
E
G
R
-------------------------
C
L
-----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
L
K
T
L
G
I
I
M
G
T
--------
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-------------------------------------------------
47
Fugue
85.24
17%
-113
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
-
S
P
---
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
------
Y
M
F
L
L
I
M
L
G
F
-------
P
I
--
N
F
L
T
L
Y
V
T
V
Q
H
K
K
----------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
L
-----------
V
G
----------
W
S
-
R
Y
I
P
-
E
G
M
Q
C
S
C
-
G
--
I
-
D
Y
----
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
--
V
F
T
V
K
E
A
A
A
-----
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
----
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
------
G
S
------
D
F
G
P
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------
13
PsiBlast_PDB
84.09
22%
-101
- C6 -
4QKX
2
ADRB2_HUMAN
A:
[121-462]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
G
V
A
G
F
T
N
S
L
R
---
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-
T
W
D
A
Y
A
A
D
E
V
------
W
-----
V
V
G
M
-------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FER
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
--
H
W
Y
R
A
T
H
Q
E
A
----------
I
N
C
Y
A
E
E
-
T
C
C
--------
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--------------
F
Y
V
P
L
V
I
M
V
---
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
32
HHSearch
83.53
18%
-131
- C6 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
------
A
L
S
Y
C
A
L
I
L
A
-------
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
----------
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-----
P
L
L
F
--
G
F
N
T
T
G
-------------------
D
P
-
T
V
C
S
I
S
N
-
P
--
D
-------
F
V
----------
I
Y
S
----
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
-----
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
---------------
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------
5
PsiBlast_PDB
82.69
22%
-100
- C6 -
4LDO
3
ENLYS_BPT4
A:
[121-462]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
G
V
A
G
F
T
N
S
L
R
---
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-
T
W
D
A
Y
A
A
D
E
V
------
W
-----
V
V
G
M
-------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FER
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
--
H
W
Y
R
A
T
H
Q
E
A
----------
I
N
C
Y
A
E
E
-
T
C
C
--------
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--------------
F
Y
V
P
L
V
I
M
V
---
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
4
PsiBlast_PDB
82.62
22%
-101
- C6 -
4LDL
3
ADRB2_HUMAN (first)
A:
[121-462]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
G
V
A
G
F
T
N
S
L
R
---
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-
T
W
D
A
Y
A
A
D
E
V
------
W
-----
V
V
G
M
-------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FER
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
--
H
W
Y
R
A
T
H
Q
E
A
----------
I
N
C
Y
A
E
E
-
T
C
C
--------
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--------------
F
Y
V
P
L
V
I
M
V
---
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
3
PsiBlast_PDB
81.88
22%
-99
- C6 -
4LDE
3
ENLYS_BPT4
A:
[121-462]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
G
V
A
G
F
T
N
S
L
R
---
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
-
T
W
D
A
Y
A
A
D
E
V
------
W
-----
V
V
G
M
-------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FER
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
--
H
W
Y
R
A
T
H
Q
E
A
----------
I
N
C
Y
A
E
E
-
T
C
C
--------
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--------------
F
Y
V
P
L
V
I
M
V
---
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
21
HHSearch
79.31
19%
-110
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-498]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
N
A
N
F
N
K
I
F
L
------
P
T
I
Y
S
I
I
F
L
T
-------
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
----------
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
--
L
-
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
-----
P
D
F
I
--
F
A
N
V
S
E
A
-----------------
D
D
R
-
Y
I
C
D
R
F
Y
-
P
--
N
-
D
L
W
V
V
V
----------
F
Q
F
Q
H
----
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
------
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------
22
HHSearch
78.88
17%
-122
- C6 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
I
------
V
L
V
A
G
S
L
S
L
V
-------
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
----------
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
--
T
-
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-----
P
A
I
L
--
F
W
Q
F
I
V
G
V
R
--------------
T
V
E
D
-
G
E
C
Y
I
Q
F
-
F
--
S
-
N
---
A
A
----------
V
T
F
G
T
----
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
-----
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----------------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------
6
PsiBlast_PDB
78.87
21%
-129
- C6 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
----------
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
-
L
T
-
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
-----
P
V
A
I
--
M
G
S
A
Q
V
E
D
-----------------
E
E
-
I
E
C
L
V
E
I
P
T
--
P
Q
D
Y
W
G
P
V
F
A
I
C
I
--------------
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
V
R
--
L
L
-----
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
------
S
S
------
E
T
A
V
A
I
L
R
F
C
T
A
-
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------------------
26
HHSearch
78.10
17%
-134
- C6 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
------
V
V
V
L
S
T
I
C
L
V
-------
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
----------
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
--
K
-
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-----
P
I
L
G
--
W
N
H
---------------------
R
R
E
-
D
K
C
E
T
D
F
-
Y
--
D
-
V
T
---
W
F
K
----------
V
M
T
----
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
-----
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
----------------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------
23
HHSearch
76.88
16%
-119
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
M
------
G
I
V
M
S
L
I
V
L
A
-------
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
----------
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
----------------
E
A
-
I
N
C
Y
A
E
E
-
T
CC
D
-
F
F
T
N
Q
A
----------
Y
A
I
A
S
----
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
-----
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----------------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
40
Fugue
76.42
17%
-101
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
-
S
P
---
F
E
A
P
Q
Y
Y
L
-
A
E
P
W
Q
F
S
M
L
A
------
A
Y
M
F
L
L
I
M
L
G
-------
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-----------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
L
-----------
V
G
----------
W
S
-
R
Y
I
P
-
E
G
M
Q
C
S
C
-
G
--
I
-
D
Y
----
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
I
F
T
H
------
Q
G
------
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------
14
PsiBlast_PDB
76.20
22%
-101
- C6 -
4GBR
1
ADRB2_HUMAN
A:
[3-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
W
V
V
G
M
-------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FER
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
EET
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
--
V
-
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
----------------------------
R
Q
L
Q
K
I
D
K
F
C
L
-----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
L
K
T
L
G
I
I
M
G
T
--------
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
------
I
R
------
K
E
V
Y
I
L
L
N
W
I
G
----
Y
V
N
S
G
F
N
P
-
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------
29
HHSearch
76.02
16%
-121
- C6 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
------
I
T
V
E
L
A
I
A
V
L
-------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
----------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-----
T
P
M
L
--
G
W
N
N
C
G
Q
-------------------
S
-
Q
G
C
G
E
G
Q
-
V
--
A
-
C
L
F
E
D
V
V
-----
P
M
N
Y
M
V
Y
F
N
----
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
-----
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--------------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------
27
HHSearch
74.61
20%
-118
- C6 -
2KS9
1
NK1R_HUMAN
A:
[33-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
W
------
A
A
A
Y
T
V
I
V
V
T
-------
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
----------
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
S
A
-----
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-----
P
Q
G
Y
--
Y
S
T
T
E
T
M
-----------------
P
S
R
-
V
V
C
M
I
E
W
-
P
--
E
-
H
P
N
K
-
I
------
Y
E
K
V
Y
H
I
C
V
----
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
-----
S
SD-------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
------
Y
L
------
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
------
48
Fugue
74.36
15%
-48
- C4 -
5A5T
-
?
A:
[7-605]
RP
E
N
A
L
K
R
A
N
E
F
L
E
V
G
K
K
Q
P
A
L
D
V
L
Y
D
V
M
K
S
K
K
H
R
T
W
Q
K
I
H
E
P
I
M
L
K
Y
L
E
L
C
V
D
L
R
K
S
H
L
A
K
E
G
L
Y
Q
Y
K
N
I
CQQV
N
I
K
S
L
E
D
V
V
R
A
Y
L
K
L
A
E
E
K
T
E
A
A
K
E
E
S
Q
Q
M
V
L
D
I
E
D
L
D
N
I
Q
T
P
E
S
V
L
L
S
A
V
S
G
E
D
T
Q
D
R
T
D
R
L
L
L
T
P
W
V
K
F
L
W
E
S
Y
R
Q
C
L
D
L
L
R
N
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
F
K
F
C
L
Q
------------
Y
T
R
K
A
E
F
R
K
L
C
D
N
L
R
M
H
L
S
Q
I
Q
R
H
H
N
Q
S
-
T
A
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
R
L
V
Q
L
D
S
A
I
S
M
E
L
W
Q
E
A
F
K
A
V
E
D
I
H
-
G
L
F
S
L
S
K
K
P
--
P
K
-
P
Q
L
M
A
N
Y
Y
N
K
------
V
S
T
V
F
W
K
S
G
N
-------
A
L
F
H
A
S
T
L
H
R
L
Y
H
L
S
R
E
----------
M
R
K
N
L
T
Q
D
E
M
Q
R
M
S
T
R
V
L
L
A
T
L
S
-
I
P
--
I
T
P
E
R
-
T
D
I
A
R
L
L
D
M
----------
D
G
I
I
V
E
K
Q
R
R
L
A
T
L
L
G
L
Q
A
P
P
T
R
I
G
L
I
N
D
M
V
R
--
F
---
N
V
L
Q
Y
V
V
P
E
V
K
D
L
Y
N
W
L
EVEFN
P
L
K
L
--
C
E
R
V
T
K
V
L
N
W
----------
V
R
E
Q
P
E
K
-
E
P
E
L
Q
Q
Y
-
V
--
P
-
Q
L
Q
S
N
T
I
L
R
L
L
Q
Q
V
A
Q
I
--
Y
Q
----
S
I
E
F
S
R
L
T
S
L
V
P
F
V
D
A
F
Q
L
E
R
A
I
V
D
A
A
R
H
C
D
LQVRI
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
H
----------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
R
T
L
S
F
G
S
D
L
N
--------------
Y
A
T
R
E
D
A
P
I
G
P
H
L
Q
S
M
------
P
S
------
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
K
A
L
E
V
I
K
P
A
--
H
I
L
Q
E
K
E
E
Q
H
Q
L
A
V
T
A
Y
L
K
N
S
R
K
E
H
Q
R
I
L
A
R
R
Q
T
I
E
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
E
E
L
E
Q
R
E
A
E
L
Q
K
V
R
33
HHSearch
72.32
20%
-107
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[39-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
V
V
------
I
I
A
Y
A
L
V
F
L
L
-------
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
----------
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
-
K
--
R
-
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
-----
P
F
F
L
--
F
R
Q
A
Y
H
P
----------------
N
N
S
S
-
P
V
C
Y
E
V
L
-
G
--
N
-
D
T
A
K
--
W
------
R
M
V
L
R
I
L
P
----
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
Q
------
V
I
QE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------
31
HHSearch
71.71
15%
-121
- C6 -
1U19
14
OPSD_BOVIN
A:
[37-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
Q
F
S
M
L
------
A
A
Y
M
F
L
L
I
M
L
-------
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
----------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
--
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
L
V
--
G
W
S
R
Y
I
P
E
----------------
G
M
Q
-
C
S
C
G
I
D
Y
-
Y
--
T
-
P
H
E
E
T
N
-------
N
E
S
F
V
I
Y
M
----
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
-----
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---------------
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------
24
HHSearch
68.79
14%
-117
* C6 *
2Z73
5
OPSD_TODPA
A:
[32-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Y
Y
S
L
------
G
I
F
I
G
I
C
G
I
I
-------
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
----------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
--
H
-
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-----
G
P
I
F
--
G
W
G
A
Y
T
L
E
----------------
G
V
L
-
C
N
C
S
F
D
Y
-
I
--
S
-
R
D
S
T
T
---------
R
S
N
I
L
C
M
----
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
-----
A
M
A
K
RLNAKE
L
R
----------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
---------------
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------