@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR39_HUMAN: (2016-01-10 )
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
Atome Classification :
(20 SA)
-----.........10.......-.-20........--30........40..-......50........60........70........80........90..-----......100.......110.......120.......130.......140-......---...150.......160.......170.......180.......190.......200.......210.......220.......230.......240..---...-.-.250.........-------------260-----------.---------------.---------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------.-----------------------------------------------------------.-----------------------.--.----------------.----------.----------------270.-......280-.......290.......300...---....310.......320.....--..330.......340.......350.......360.......370.......380.......390.......400.......410...-------------------....420.......430--.......440---.........450.----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MASPSL
P
G
S
D
C
S
Q
I
I
D
HS-H-VPE
F
E
V
A
T
W
I
--
K
I
T
L
I
L
V
Y
L
I
I
F
V
M
-
G
L
LGNSA
T
I
R
V
T
Q
V
L
Q
KKG
Y
L
Q
K
E
V
T
D
H
M
V
S
L
A
C
S
D
I
L
V
F
L
IGM
P
M
E
F
Y
S
-----
I
I
WNPLTTS
S
Y
T
L
S
C
K
L
H
T
F
L
F
E
A
C
S
Y
A
T
L
L
H
V
L
T
L
S
F
E
R
Y
I
A
ICH
P
---
F
R
YKAV---SGP
C
Q
V
K
L
L
I
G
F
V
W
V
T
S
A
L
V
A
L
P
L
L
F
AMGTEY
P
L
VNVPSHRGLTCNRSSTRHHEQPETSN
M
S
I
CTNLSS
R
W
T
V
F
Q
S
S
I
F
G
A
F
V
V
Y
L
V
V
L
L
S
V
A
F
M
C
W
N
---
M
M
Q
-
V
-
L
M
--
K
SQKGSLAG-------------G-------------T---------------R---------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------P-----------------------------------------------------------Q-----------------------L--R----------------K----------S----------------E
S
E
E
-
S
R
T
A
R
R
Q
T
I
-
I
F
L
R
L
I
V
V
T
L
A
V
CWM
P
N
Q
I
R
R
I
M
---
A
AAKP
K
H
D
W
T
R
S
Y
F
R
A
Y
M
I
L
L
P--F
S
E
T
F
F
Y
L
S
S
V
I
N
P
L
L
Y
TV
S
S
Q
Q
F
R
R
V
F
V
Q
V
L
C
C
R
L
S
L
Q
HANHE
K
R
L
R
V
H
A
HSTTD
S
A
R
F
V
Q
R
P
L
L
F
A
S
R
R
Q
SSAR
R
T
E
K
I
F
L
S
T
F
QS-------------------EAEPQSKSQSLS
L
E
SLE--PNSGAKPA-----N
S
A
A
ENGFQEHEV----------
2
PsiBlast_PDB
93.44
30%
-141
- C2 -
3ZEV
6
NTR1_RAT
A:
[9-325]
----------------------------
D
L
D
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
-
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
-----
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
---
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
G
L
V
C
T
-------
P
I
V
D
T
A
T
L
K
V
---------
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
---
K
L
T
-
V
-
M
V
HQ--------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------
R
-----------------------
V
--
Q
----------------------------------------------------
A
L
R
R
G
V
-
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
C
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
--
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
--------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.61
29%
-144
- C2 -
4BUO
10
NTR1_RAT
A:
[6-320]
----------------
N
S
D
L
D
--------
V
N
T
D
I
Y
S
--
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
-
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
-----
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
---
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
G
L
V
C
T
-------
P
I
V
D
T
A
T
L
K
V
---------
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
---
K
L
T
-
V
-
M
V
----
H
Q
----------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------
R
-----------------------
V
--
Q
----------------------------------------------------
A
L
R
R
G
V
-
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
C
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
--
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.91
30%
-133
- C2 -
4BWB
1
NTR1_RAT
A:
[7-325]
----------------
N
S
D
L
D
--------
V
N
T
D
I
Y
S
--
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
-
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
L
Y
N
-----
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
---
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
G
L
V
C
T
-------
P
I
V
D
T
A
T
L
R
V
V
I
Q
L
N
T
----
F
M
S
F
L
F
P
M
L
V
A
--
S
I
L
N
T
V
A
A
R
R
L
T
---
V
M
--
V
---------------------------------------------------------
E
---------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------
R
-----------------------
V
--
Q
----------------------------------------------------
A
L
R
R
G
V
-
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
V
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
--
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
87.24
22%
-118
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
-
I
V
F
G
N
G
L
V
C
M
A
V
--
L
K
E
R
A
-
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
-----
E
V
-
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
---
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
G
-----------
D
P
T
V
C
S
I
S
----------------
N
P
---
D
F
---
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
---
R
I
Y
-
V
V
L
K
--
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
-------------
D
---------------
T
EG
Y
Y
T
I
G
IGHL----------------------------------------------------------------------------
L
TKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------------------------------------------------
T
-----------------------
P
N
R
A
----------------
K
R
V
I
T
T
F
R
T
GT
W
----------------
D
A
Y
G
-
V
P
L
R
E
K
K
A
T
-
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
---
N
T
H
C
Q
T
C
H
-
V
------
S
P
E
L
Y
S
--
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.36
29%
-127
- C2 -
4BV0
1
NTR1_RAT
A:
[7-325]
----------------
N
S
D
L
D
--------
V
N
T
D
I
Y
S
--
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
-
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
-------
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
V
Y
N
-----
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
--------
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
V
G
L
Q
N
L
S
G
D
G
T
H
P
G
G
L
V
C
T
-------
P
I
V
D
T
A
T
L
K
V
V
I
Q
L
N
T
----
F
M
S
F
L
F
P
M
L
V
---
A
S
I
L
N
T
V
I
A
R
R
L
---
T
V
M
-
V
-
H
-----------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------
R
-----------------------
V
--
Q
----------------------------------------------------
A
L
R
R
G
V
-
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
V
Y
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
--
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
-------------------------------------------------------------------------------------------------------------------------------
41
Fugue
85.99
20%
-101
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
-
A
P
Q
Y
Y
L
A
E
----
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
-----
S
L
H
G
Y
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
---
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
-------
G
M
Q
C
-----------------
S
C
G
--
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
------
H
F
I
---
I
P
L
-
I
-
V
I
--
F
F
C
Y
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
F
G
-------
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------
P
L
G
D
D
E
A
S
T
T
V
S
K
T
--
E
T
S
Q
V
A
P
A
----------------------------
26
HHSearch
83.68
19%
-119
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-471]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
-
A
I
L
G
N
V
L
V
C
W
A
V
--
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
-----
S
----
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-----------
S
Q
G
C
G
E
G
---------
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
---
R
I
F
L
A
-
A
R
--
R
Q
L
N
I
F
E
M
L
R
I
D
----------
E
GLRL
K
I
Y
------
K
D
TEGYYTIGIGHLLT
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------------------------------------------------------------------------------
T
-----------------------------------------------------------
P
-----------------------
N
--
R
A
K
R
V
I
T
T
F
R
TGT----
W
----------
D
----------------
A
Y
R
S
-
T
L
Q
K
E
V
H
A
A
-
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
---
T
F
F
C
P
D
C
S
H
------
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.79
22%
-104
- C2 -
3C9L
13
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
--------------------------------------------------------------------------------------------------------------------------
47
Fugue
81.25
14%
-86
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--------------
P
C
F
R
E
E
N
A
N
-
F
-
N
K
I
F
L
P
T
I
Y
S
--
I
I
F
L
T
G
I
V
G
N
G
L
V
I
-
L
V
M
G
Y
Q
K
K
------------
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
---
L
P
F
W
A
-----
V
D
A
V
A
N
W
Y
F
G
-
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
---
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
------
D
D
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
-
K
-
I
Y
--
K
D
T
E
G
Y
Y
T
I
-------------
G
IGHLL--------
T
---------------
K
---------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------
S
-----------------------
L
--
N
----------------
A
----------
A
----------------
K
S
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N-
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
--
F
Q
M
G
E
T
G
V
A
G
-
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
--
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
AFL
G
A
K
F
K
T
S
A
Q
H
A
L
T
SGRPLEVLFQ
44
Fugue
81.25
22%
-113
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------
S
F
K
C
A
L
T
K
T
G
------------
F
Q
--
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
-
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
---
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
-----
F
N
K
T
D
W
I
F
G
--
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---
K
S
L
G
R
L
---
K
K
K
-
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
-----
K
N
K
T
I
T
C
Y
D
T
T
S
D
E
Y
-------------
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
---
A
L
I
-
Y
-
K
M
--
K
K
Y
T
C
T
V
C
G
-------------
Y
-------------
I
---------------
Y
---------------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------
E
DGDPDNGVNPGTDFKDIVCPLCG
V
--
G
----------------
K
----------
D
----------------
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
-
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
--
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.19
22%
-108
- C2 -
2I35
4
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
--------------------------------------------------------------------------------------------------------------------------
42
Fugue
81.18
18%
-101
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
-
F
E
A
P
Q
Y
Y
L
A
E
----
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
-----
S
L
H
G
Y
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
---
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
-------
G
M
Q
C
----------------
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
---
Y
G
Q
-
L
-
V
F
--
T
V
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
A
----------------
A
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
F
G
-------
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-------------------------------------------------------------------------
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
--
P
A
----------------------------------
6
PsiBlast_PDB
80.44
22%
-111
- C2 -
3CAP
7
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MS
N
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.13
22%
-109
- C2 -
4PXF
8
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.08
22%
-108
- C2 -
3PQR
10
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.80
22%
-107
- C2 -
1F88
7
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MS
N
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
------------------------------------------------
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------
22
HHSearch
79.46
18%
-112
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
-
T
V
G
L
N
L
L
V
L
Y
A
V
--
R
S
E
R
K
-
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
-----
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
---
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
-------------
R
R
E
D
K
C
E
T
D
----------------
F
Y
D
V
--
T
W
-
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
---
K
I
Y
-
K
A
V
R
--
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
EG
Y
Y
T
I
G
IGHLLT
K
SPS
L
-----------
N
---------------------------------------------------------------------------------------
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
---------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
-----------------------
Q
--
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
----------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
-
H
M
N
R
E
R
K
A
A
-
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
---
I
A
F
C
K
N
C
C
-
N
-------
E
H
L
H
M
--
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.28
22%
-105
- C2 -
3DQB
7
GNAT1_BOVIN (first)
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.24
22%
-107
- C2 -
3PXO
5
OPSD_BOVIN
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.18
22%
-108
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[27-323]
---------------------------
P
Q
Y
Y
L
A
E
P
W
--
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GY
F
V
F
G
P
T
-------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSN
F
R
F
-------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
--------------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
------------------
G
Q
L
V
F
-------------
T
-------------
V
---------------
K
---------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------
A
-----------------------
A
--
Q
----------------
Q
----------
Q
----------------
E
S
A
T
-
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
D
-----
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
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