@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR45_HUMAN: (2016-01-10 )
MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV
Atome Classification :
(20 SA)
-.........10.......----.20........-30........40........50........60........70........80........90.....-...100.......110.......120.......130.....---..140--.------.......150.......160..-....-.170...--....180..--..---.----.--.190........200.......210.......220.......230---------------.....-..----------------------------.-----------------------.---------------240--------------..-----------------------------------------------------------.-------------------------------------------------------------------------------------------.-----------------------------------------------------.--------------.--.---..250-----------.------------........260.......270.......280.......290.....-------..300-.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MACNSTSL
E
A
Y
T
Y
L
L
L
NT----SNASDSGSTQL-PA
P
L
R
I
S
L
A
I
V
M
L
L
M
T
V
V
G
FLGN
T
V
V
C
I
I
V
YQR
P
A
M
R
S
A
I
N
L
L
L
A
T
L
A
F
S
D
I
M
L
S
L
CCMPF
T
A
V
T
L
I
-
T
V
R
W
HFGD
H
F
C
R
L
S
A
T
L
Y
W
F
F
V
L
EG
V
A
I
L
L
I
I
SV
D
R
F
L
I
I
V
---QRQD---K------LNPR
R
A
K
V
I
I
A
V
S
W
V
L
S
F
C
IAG-PSLT-
G
W
T
L
V
EV--PARAP
Q
C
V
L--GY---T----E--LP-AD
R
A
Y
V
V
T
L
V
V
A
V
F
F
A
P
F
G
V
M
L
C
A
Y
M
C
I
L
N
T
V
R
K
N
A
V
R
VH-----------------NQSDS-
L
D
----------------------------
L
-----------------------
R
---------------
Q
----------------
L
T
-----------------------------------------------------------
R
-------------------------------------------------------------------------------------------
A
-----------------------------------------------------
G
--------------
L
--
R
---
R
L
Q
-------------
R
------------
Q
Q
Q
V
S
V
D
L
S
FKT
K
A
F
T
T
I
L
I
L
F
V
G
F
S
L
C
WL
P
H
S
V
Y
S
L
L
S
V
F
S
Q
RFY-------CGSSF-
Y
A
T
S
T
C
V
L
W
L
S
Y
L
K
S
V
F
N
P
I
V
Y
C
W
R
I
K
K
F
R
E
A
C
I
E
L
L
P
Q
T
F
Q
I
L
PK
V
P
E
R
I
R
R
RIQP
S
T
V
Y
V
CNENQSAV
25
HHSearch
92.13
23%
-157
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
---
S
P
F
K
YQS
L
------
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
H
--
Q
-
E
A
I
N
C
Y
A
--
E
E
---
T
CC--
D
--
F
F
-
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
-----------------
M
L
R
I
D
-
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
-----------------------
A
K
S
E
------------
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
-------------------------------------------------------------------------------------------
R
W
D
E
A
A
V
N
L
---------------------------------------------
A
K
S
R
-----------
W
--
Y
---
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
------------
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
-----------
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------
6
PsiBlast_PDB
90.58
28%
-159
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
8
PsiBlast_PDB
90.49
28%
-162
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[7-299]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
-------------------------
1
PsiBlast_PDB
90.33
28%
-162
- C4 -
2Y00
13
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
7
PsiBlast_PDB
90.08
28%
-159
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
23
HHSearch
89.84
22%
-146
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
---------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
---
K
P
L
T
YPV
K
------
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-
P
A
I
L
-
F
W
Q
F
I
V
G
VR
T
V
E
D
G
E
C
Y
I
--
Q
F
---
F
----
S
------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
-----------------
M
L
R
I
D
-
E
G
LRL
K
I
Y
K
D
--------------------
T
EG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
----------------
E
A
-----------------------------------------------------------
E
-------------------------------------------------------------------------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-------------
N
R
A
K
R
V
I
T
T
F
R
TG
T
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
--------
P
----
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------
3
PsiBlast_PDB
89.58
28%
-161
- C4 -
2Y02
13
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
27
HHSearch
89.24
24%
-149
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
---
I
P
L
R
Y
N
G
L
------
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
L
-
G
W
N
N
C
G
Q
-----
S
Q
G
C
G
E
--
G
Q
---
V
ACLF
E
--
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
-----------------
M
L
R
I
D
-
E
G
----------------------------
L
RL
K
I
-------------------
Y
K
D
TEGYYTIGIGHLL
T
KSPS
L
N
----------
A
A
-----------------------------------------------------------
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
------------
Q
KR
W
D
E
A
A
V
N
L
A
K
S----------------------------------------
R
W
Y
------------
N
--
Q
---
T
P
N
-------------
R
A
K
R
V
I
T
T
F
R
TGT
W
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---------
S
H
A
P
-
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------
5
PsiBlast_PDB
88.94
28%
-161
- C4 -
2Y04
13
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
2
PsiBlast_PDB
88.83
28%
-159
- C4 -
2Y01
12
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
D
P
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
14
PsiBlast_PDB
88.82
28%
-159
- C4 -
4BVN
11
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
R
---
K
T
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
K
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
31
HHSearch
88.79
23%
-157
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
---
M
P
V
H
---
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
F
-
G
F
N
T
T
G
-----
D
P
T
V
C
S
I
--
S
N
---
P
-------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
-----------------
F
E
M
L
R
I
D
E
GLRL
K
I
----------------------
Y
-----------------------
K
---------------
D
----------------
T
E
G
Y
Y
T
I
G
IGHL-------------------------------------------------
L
TKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
--------------------------------------------
K
S
R
W
Y
----------
N
--
Q
---
T
P
N
-------------
R
A
K
R
V
I
T
T
F
R
T
G-
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
----------
H
V
S
-
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------
4
PsiBlast_PDB
88.79
28%
-160
- C4 -
2Y03
9
ADRB1_MELGA
A:
[7-300]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------
R
-----------------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
10
PsiBlast_PDB
88.63
27%
-153
- C4 -
2YCW
7
ADRB1_MELGA
A:
[7-299]
------------------------------
S
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
SPF
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
D
P
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
---------------
K
----------------
I
D
-----------------------------------------------------------
R
-------------------------------------------------------------------------------------------
A
-----------------------------------------------------
S
--------------
K
--
R
---
K
--------------------------------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
F
-----------------------
12
PsiBlast_PDB
88.26
27%
-159
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
--------------------------------
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
---------------
K
----------------
I
D
-----------------------------------------------------------
R
-------------------------------------------------------------------------------------------
A
-----------------------------------------------------
S
--------------
K
--
R
---
K
--------------------------------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
F
-----------------------
9
PsiBlast_PDB
87.71
27%
-158
- C4 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
---------------------------------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
------------------------
11
PsiBlast_PDB
86.64
27%
-154
- C4 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
---------------
K
----------------
I
D
-----------------------------------------------------------
R
-------------------------------------------------------------------------------------------
A
-----------------------------------------------------
S
--------------
K
--
R
---
K
--------------------------------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
----------------------------
13
PsiBlast_PDB
84.76
27%
-151
- C4 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
---------------------------------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
----
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
------
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
D
--
P
-
Q
A
L
K
C
Y
Q
DP
G
C
---
C
----
D
--
F
V
-
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-----------
A
L
R
V
Y
-----------------
R
E
A
K
E
--
Q
----------------------------
I
-----------------------
R
---------------------------------
D
-----------------------------------------------------------
R
-------------------------------------------------------------------------------------------
A
-----------------------------------------------------
S
--------------
K
--
R
---
K
--------------------------------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
-------
P
D
W
L
F
-
V
A
F
N
----
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
--------
F
K
R
L
L
A
F
-----------------------
45
Fugue
84.24
20%
-149
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
S
F
K
C
A
L
T
K
---------------------------
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
YP-
K
S
L
G
---
R
------
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-
P
I
L
F
-
Y
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
D
--
T
T
---
S
----
D
EY
L
R
-
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDN
G
V
N
P
G
-
T
D
----------------------------
F
-----------------------
K
---------------
D
----------------
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
C
-----------------------------------------------------
P
--------------
L
--
C
---
G
V
G
-------------
K
------------
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
QTPAM
C
A
F
N
D
R
V
-
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
--------------------------------------
42
Fugue
84.23
21%
-132
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVV
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
---
K
P
M
S
N
F
-
R
------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
-
G
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
G
I
--
D
Y
YTP
H
----
E
--
E
T
-
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
-----------------
T
Q
K
A
E
-
K
E
----------------------------
V
-----------------------
T
---------------
R
----------------
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----------
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------