@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR61_HUMAN: (2016-01-10 )
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70....--.--.--..80........90..-......100.......110.......120.......130.......140.......150.---......160.......170.......180.......-.190----...----..---...---200---..-.---......-----210.......220.......230.......240.......250--------------------------.----------------------------.----.----------------------------------------------.-.---------------------------------.-------------------------------------------------------------------------------------------------.--.--------------.--------------------------------------------260---------------------------------------------------.------.--------------------------------------------------.-----------------.---------.------------------.----------.-----------.--------------------.----------270.......280.......290.......300.......310...-.---------...320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEV
G
L
R
D
V
A
S
E
S
V
A
L
F
F
M
L
L
L
D
L
T
A
VAGN
A
A
V
M
A
V
IAK
T
P
A
L
R
K
--
F
--
V
--
F
V
F
H
L
C
L
V
D
L
L
A
A
L
T
L
-
M
P
L
A
M
LS
S
S
A
L
F
D
H
A
L
F
G
E
V
A
C
R
L
Y
L
F
L
S
V
C
F
V
S
L
A
I
L
S
V
S
A
I
N
V
E
R
Y
Y
Y
V
V
H
P
M
R
Y
E
V
R
---
M
T
L
G
L
V
A
S
V
L
V
G
V
W
V
K
A
L
A
M
ASV
P
V
L
G
-
R
V
SWEEGA-PSV-----PPG----C
S
---
L
Q
W---S-----
H
S
-
A
---
Y
C
Q
L
F
V
-----
V
V
F
A
V
L
Y
F
L
L
P
L
L
L
I
L
V
V
Y
C
S
M
F
R
V
A
R
V
A
A
MQHGPL
P
T
W
M
E----------------------------T----------------------------
P
----
R
----------------------------------------------
Q
-
R
---------------------------------
S
-------------------------------------------------------------------------------------------------
E
--S--------------L--------------------------------------------S-----------------------------------------------------S------R--------------------------------------------------S-----------------
T
---------
M
------------------
V
----------T-----------S--------------------S----------GAPQTTPHRTFGGG
K
A
A
V
V
L
L
A
VG
G
Q
F
L
L
C
W
L
P
Y
F
S
F
H
L
Y
V
A
L
SAQ-P---------IST
G
Q
V
E
S
V
V
T
W
I
G
Y
F
C
FTSN
P
F
F
Y
G
C
L
N
R
Q
I
R
G
E
L
SK
Q
F
V
C
F
FKPA
P
E
E
ELRLPSREGS
I
E
E
N
F
L
Q
F
L
QGTGCPS
E
S
W
VSRPLPSPKQEPPAV
D
F
RIP
G
Q
I
A
E
E
T
S
E
F
L
E
Q
Q
L
T
S
D
I
IMSDSYLRPAASPRLES
30
HHSearch
93.55
24%
-166
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
--
Y
--
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
-
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
-
N
T
T
G
-----
D
-----
P
T
V
----
C
S
---
I
S
N
---
P
---------------
D
F
V
-----
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
----------------------------
E
----------------------------
G
LRL
K
I
----------------------------------------------
Y
-
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
-------------------------------------------------------------------------------------------------
T
--
N
--------------
G
--------------------------------------------
V
IT---------------------------------------------------
K
D
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
---------
S
------------------
R
W
Y
N
-------
Q
T
P
N
R
A
K
R
V
I
T
T
F
--------------------
R
----------
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
-
C
---------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------------------------------------------------
31
HHSearch
90.76
20%
-157
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-472]
----------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
VT
N
--
Y
--
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
----
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
N
C
G
Q
----------
S
Q
G
----
C
G
---
E
G
Q
---
V
ACLFE
D
V
-
V
---
P
M
N
Y
M
V
-----
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
----------------------------
L
RL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
----
K
----------------------------------------------
S
-
E
---------------------------------
L
D
K
A
I
G--------------------------------------------------------------------------------------------
R
NT
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
-------------------------------------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
----
Q
------
Q
--------------------------------------------------
K
R
W
D
E
A
A
V
----------
N
---------
L
------------------
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
---
R
--------------------
T
----------
G
T
W
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------
22
HHSearch
90.59
20%
-158
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-----------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
--
Y
--
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
--
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
-
Q
F
I
V
G
V
R
T
V
E
-----
D
G
E
----
C
Y
---
I
Q
F
---
F
-----
S
-------
N
A
A
V
T
-----
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
----------------------------
L
----------------------------
R
----
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
---------------------------------
K
-------------------------------------------------------------------------------------------------
L
--
F
--------------
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
-
A
G
F
---------------------------------------------------
T
N
S
L
R
M
L
Q
--------------------------------------------------
Q
-----------------
K
---------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
---
T
-----------
F
--------------------
R
----------
T
G
T
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-
C
----------
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------------------------------------------------------------
23
HHSearch
90.26
20%
-150
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
--
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
---
E
-----
A
I
N
----
C
Y
---
A
E
E
---
T
CC---
D
F
-
F
---
T
N
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
----------------------------
A
----
K
----------------------------------------------
S
-
E
---------------------------------
L
-------------------------------------------------------------------------------------------------
D
--
K
--------------
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
------------------------------------------
M
------
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
------------------------
A
-----------------
K
---------
S
R
W
Y
N
Q
T------------
P
N
R
A
K
R
V
I
T
--
T
-----------
F
--------------------
R
----------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-
L
----------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------------------------------------------------
43
Fugue
88.22
20%
-122
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
-----
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
--
L
--
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
----
W
---
S
-
R
Y
I
-----
P
E
G
MQC
S
C
G
I
DY
Y
T
P
---
H
-----
E
E
-
T
---
N
N
E
S
F
V
-----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
---------------------------------------------
T
----------------------------
V
----
K
----------------------------------------------
E
-
A
---------------------------------
A
-------------------------------------------------------------------------------------------------
A
--
S
--------------
A
--------------------------------------------
T
-----------------------------------------------------
T
------
Q
--------------------------------------------------
K
----------------------------------------------------------------------------------------------------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
-------------------------------
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------
28
HHSearch
84.89
19%
-157
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
--
L
--
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
--
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
-
N
H
------
R
R
-----
E
D
K
----
C
E
---
T
D
F
---
Y
-----
D
V
-------
T
W
F
K
-----
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
----------------------------
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLT-------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
G-----------------------------------
R
-
N
---------------------------------
T
-------------------------------------------------------------------------------------------------
N
--
G
--------------
V
I-------------------------------------------
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
------
F
--------------------------------------------------
T
-----------------
N
---------
S
------------------
L
R
M
L
-------
Q
-----------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
-
C
----------
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.90
23%
-161
- C2 -
2YCX
3
ADRB1_MELGA
A:
[16-283]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
-------------
E
----------------------------
Q
----------------------------
I
----
R
----------------------------------------------
K
-
I
---------------------------------
D
-------------------------------------------------------------------------------------------------
R
--
A
--------------
S
--------------------------------------------
K
-----------------------------------------------------
R
------
K
--------------------------------------------------
R
-----------------
V
---------
M
------------------
L
----------
M
-----------
R
--------------------
E
-----------------------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.89
23%
-163
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[16-283]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
-------------
E
----------------------------
Q
----------------------------
I
----
R
----------------------------------------------
K
-
I
---------------------------------
D
-------------------------------------------------------------------------------------------------
R
--
A
--------------
S
--------------------------------------------
K
-----------------------------------------------------
R
------
K
--------------------------------------------------
R
-----------------
V
---------
M
------------------
L
----------
M
-----------
R
--------------------
E
-----------------------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------
44
Fugue
83.47
21%
-123
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
--
L
--
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
-------
I
-----
P
E
G
MQC
S
C
G
---
I
D
Y
YTP
H
-----
E
E
-
T
---
N
N
E
S
F
V
-----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
-------------------
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------
11
PsiBlast_PDB
82.96
23%
-165
- C2 -
2YCW
7
ADRB1_MELGA
A:
[16-283]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
-------------
E
----------------------------
Q
----------------------------
I
----
R
----------------------------------------------
K
-
I
---------------------------------
D
-------------------------------------------------------------------------------------------------
R
--
A
--------------
S
--------------------------------------------
K
-----------------------------------------------------
R
------
K
--------------------------------------------------
R
-----------------
V
---------
M
------------------
L
----------
M
-----------
R
--------------------
E
-----------------------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------
19
PsiBlast_PDB
82.34
24%
-164
- C2 -
4BVN
11
ADRB1_MELGA
A:
[16-282]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
E
A
K
E
Q
-------
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
R
--------------
K
--------------------------------------------
T
-----------------------------------------------------
S
------
R
--------------------------------------------------
V
-----------------
M
---------
L
------------------
M
----------
R
-----------
E
--------------------
H
----------
K
A
L
K
T
--------------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------
33
HHSearch
81.99
26%
-149
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-322]
--------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
VT
D
--
V
--
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
V
---
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
-
Q
A
Y
H
P
N
--
N
S
-----
S
P
V
----
C
Y
---
E
V
L
---
G
-----
N
D
-
T
AK-
W
R
M
V
L
R
-----
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
-
Q
VIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.77
23%
-175
- C2 -
2VT4
8
ADRB1_MELGA
A:
[16-283]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
-------------
E
----------------------------
Q
----------------------------
I
----
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------
29
HHSearch
81.35
21%
-155
- C2 -
2KS9
1
NK1R_HUMAN
A:
[27-326]
------------------------------------
Q
P
A
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
--
Y
--
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
--
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
--
T
T
E
T
M
-
P
-
S
-----
R
V
V
----
C
M
---
I
E
W
---
P
-----
E
H
-
P
NKI
Y
E
K
V
Y
H
-----
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
-
L
YLK------
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
---------------------------------------------------
27
HHSearch
81.12
17%
-149
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[54-495]
--------------------------------
N
I
S
A
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
--
Y
--
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
---
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
-
N
C
I
S
-----
A
-----
L
S
S
----
C
S
---
T
V
L
---
P
-----
L
Y
------
H
K
H
Y
------
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
E
G
L
----------------------------
R
----------------------------
L
----
K
----------------------------------------------
I
-
Y
---------------------------------
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
--
L
--------------
R
M
L
Q
Q
KR
W
D
E
A
A
V
--------------------------------
N
-----------------------------------------------------
L
------
A
--------------------------------------------------
K
S
R
W
Y
N
------------
Q
T
P
N
R
A
K
R
V
I
T
------------------
T
----------
F
-----------
R
--------------------
T
----------
G
T
W
D
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
-
K
T--------
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.12
24%
-178
- C2 -
2Y00
13
ADRB1_MELGA
A:
[16-285]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------
R
--------------------------------------------------
V
-----------------
M
---------
L
------------------
M
----------
R
-----------
E
--------------------
H
----------
K
A
L
K
T
--------------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------
24
HHSearch
81.02
19%
-150
* C2 *
2Z73
5
OPSD_TODPA
A:
[25-338]
--------------------------------
E
F
D
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
PA
N
--
M
--
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
--
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
-
G
A
Y
T
L
E
-
G
-
V
-----
L
C
N
----
C
S
---
F
D
Y
---
I
-----
S
R
D
S
---
T
T
R
S
N
I
-----
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
K
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
-
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------------------------------------------------------------------
4
PsiBlast_PDB
80.99
24%
-175
- C2 -
2Y02
13
ADRB1_MELGA
A:
[16-285]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------
R
--------------------------------------------------
V
-----------------
M
---------
L
------------------
M
----------
R
-----------
E
--------------------
H
----------
K
A
L
K
T
--------------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.89
24%
-173
- C2 -
2Y04
13
ADRB1_MELGA
A:
[16-285]
----------------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
--
L
T
N
L
--
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
--
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
-
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
Q
D
P
G
----
C
C
---
D
F
V
---
T
-----
N
R
-
A
---
Y
----
A
-----
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
---
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------
R
--------------------------------------------------
V
-----------------
M
---------
L
------------------
M
----------
R
-----------
E
--------------------
H
----------
K
A
L
K
T
--------------
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
-
V
N
V
F
N
R
-
D
---------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.79
22%
-173
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[12-270]
------------------------------------------------
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
--
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
--
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
---
Q
M
H
W
Y
R
A
T
-
H
Q
E
-----
A
I
N
----
C
------
Y
---
A
-----
E
E
-
T
---
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
----------------
E
----------------------------
A
----------------------------
K
----
R
----------------------------------------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
I
D
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
V
I
Q
D
-
N
---------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------