@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR75_HUMAN: (2016-01-10 )
MNSTGHLQDAPNATSLHVPHSQEGNSTSLQEGLQDLIHTATLVTCTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPCTVLLTLLLWATSFTLATLATLKTSKSHLCLPMSSLIAGKGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVVLSSNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQYIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSV
Atome Classification :
(20 SA)
----------------------------------------.........10........20....--....30......--..40.-------------.......50---------.........60--------.........70.-.......80..---......90.....-..-..100------.....----..110..------.....120....----...130-.....-------------...140.....--..150..-.----....160....-...170.....-..180.-------------.------.--------.------....190--...-----...---..200.......-..210...----....220--------.......230.......240......---.--250--------.-------------------------------------------.------------------------------------------------.---..---------.----.---------------.-----------.------------260.-.-----.---.----...-270-------------------------....----------------------------.---.--.-----------.--------.----------------------------------280---.----------.-------------------------------------...--.---.-----.-------------.290------------..---.---------.--------..---..------300----..--------.......310...-----------....320.......330.......340.......350------.........360.......370.........380....----...390..------------.....400......-------.410..-.....420.......430.......440.......450.......460.......470......---------.480.......490...-..-----..500.......510........520.......530...-------....540------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------MNSTGHLQDAPNA
T
S
L
HVPHSQEGN--
S
T
S
L
Q
E
G
L
Q
D
L
I
--
H
T
A
T
L
-------------
V
T
C
T
F
L
L
A
----------
V
I
F
C
L
GSYG
N
---------
F
I
V
F
L
SFF
D
P
A
F
-
R
K
FRTNF
D
F
M
I
---
L
N
L
S
F
C
D
-
L
F
I
CG-VT-
A
P
M
F
T
------
F
V
L
F
F----SSASSIP------
D
A
F
C
F
T
F
H
LTSS----
G
F
I
I
M
--
S
L
K
T
V
-------------
A
V
I
A
L
H
R
L
R
M
V
--LGKQPNR-T----ASF
P
C
T
V
L
L
T
L
-
L
L
W
A
T
S
F
T
L
A
T
-
L
A
TL-K-------------T------S--------K------S
H
L
CL
P
---
M
S
S
-----LIA---GKG--
K
A
I
L
S
L
Y
-
V
V
D
F
T
F
C
V
----
A
V
V
S
V
S
Y
--------
I
M
I
A
Q
T
L
R
KNAQVRKCP
P
V
I
T
VDASR---P--Q----------P-------------------------------------------F------------------------------------------------M---
G
V
---------P----V---------------Q-----------G------------GG
D
P
-
I
-----
Q
---
C
----
A
M
P
-
A
---------------------------
L
YRN----------------------------Q---N--Y-----------
N
--------
K
----------------------------------
L
-----
Q
----------
H
-------------------------------------
V
QT--R---G-----Y-------------TKS-------------PN---Q---------L--------VT---
P
A
------
A
------
S
R
--------
L
Q
L
V
S
A
INLSTAK-----------DS
K
A
V
V
T
C
V
I
I
V
L
S
V
L
V
C
C
L
P
L
G
I
S
L
V
Q
V
V
L
SSNG--------
S
F
I
L
Y
Q
F
E
LF
G
F
T
L
I
F
F
KSG--LN
P
F
I
YSRNSA
G
L
R
R
K
----
V
L
W
C
L
Q
Y
I------------
G
L
G
F
F
C
CKQ
K
T
R
L
R
-------AMGKGN-
L
E
V
NRNKSSHHETNS
A
Y
M
LSPK
P
Q
K
K
F
V
D
QACGPSHSKESMVSPKISA
G
H
QHCGQSSSTPIN
T
R
---------I
E
P
Y
Y
S
IYNSSPSQEES-SP-----CNLQPVNSFGFAN
S
-
Y
I
A
M
H
Y
H
T
T
N
D
L
V
Q
E
YDSTSAKQI-------PVPSV--------------------------------
57
HHSearch
69.28
16%
-127
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-474]
----------------------------------------------------------------------------------
E
V
W
V
-------------
V
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
---------
V
L
V
I
T
A
I
A
--
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
---
T
S
L
A
C
A
D
-
L
V
M
G
L
-
A
V
-
V
P
F
G
A
------
A
H
I
L
-----
M
K
M
W
T
F
G
------
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
--
S
I
E
T
L
-------------
C
V
I
A
V
D
R
Y
F
A
I
--
T
S
P
F
K
Y
Q
S
L
----
L
T
K
N
K
A
R
V
I
I
L
-
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
-------------
W
------
Y
RATH
Q
---
E
------
A
I
N
C
Y
A
---
E
E
T
CC---
D
F
F
---
T
N
Q
--
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
----
V
I
M
V
F
V
Y
--------
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TE
G
YYTIGIGHLL
T
-------------------------------------------
K
------------------------------------------------
S
PS
L
N
A
A
K
S
E
L
D
---
K
----
A
---------------
I
-----------
G
------------
R
N
T
N
-
G
-----
V
---
I
T
K
D
E
A
E
K
-
L
---------------------------
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
-----
V
R
R
A
A
L
I
N
-----------
M
V
F
------
Q
----------------------------------
M
G
E
T
G
V
A
----------
G
-------------------------------------
F
T
N
--
S
---
L
R
M
L
--
Q
-------------
Q
K
R
W
D
E
A
A
V
N
L
-----
A
K
S
R
W
Y
---------
N
--------
Q
T
---
P
N
------
R
A
K
R
V
I
T
T
F
--------
R
T
G
T
W
D
A
Y
K
F
C
L
K
-----------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
----
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
69.21
15%
-116
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-469]
-----------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
----------
A
L
I
L
A
I
V
F
G
N
---------
G
L
V
C
M
A
V
L
--
K
E
-
R
A
L
Q
T
T
T
N
Y
L
V
---
V
S
L
A
V
A
D
-
L
L
V
A
T
-
L
V
-
M
P
W
V
V
------
Y
L
E
V
T
----
G
G
V
W
N
F
S
------
R
I
C
C
D
V
F
V
T
L
D
V
----
M
M
C
T
A
--
S
I
W
N
L
-------------
C
A
I
S
I
D
R
Y
T
A
V
--
V
M
P
V
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
-
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
F
-
G
-------------
F
------
N
TTG-----
D
------
P
T
V
C
S
I
---
S
N
P
----------------
D
F
V
I
Y
S
S
-
V
V
S
F
Y
L
P
F
----
G
V
T
V
L
V
Y
--------
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
R
---
L
--
K
----------
I
-------------------------------------------
Y
------------------------------------------------
K
---
D
T
EG
Y
Y
T
I
G
IG
H
----
L
---------------
L
TKSPS
L
N
A
A
K
S
E
------------
L
D
K
A
-
I
GRNTN
G
VIT
K
D
E
--
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
----------------------------
A
---
L
--
I
N
M
V
F
Q
MG
E
---
T
G
V
A
G
F
T
N
S
L
----------------------------------
R
-----
M
----------
L
-------------------------------------
Q
Q
K
--
R
W
D
E
A
-----
A
-------------
V
N
L
-------------
A
K
---
S
R
W
Y
N
Q
T
P
N
R
A
--------
K
R
---
V
I
------
T
------
T
F
--------
R
T
G
T
W
D
A
Y
G
V
P
L
R
-----------
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
----
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
67.33
16%
-142
- C4 -
2Z73
5
OPSD_TODPA
A:
[29-331]
------------------------------------------------------------------------------
V
--
P
D
A
V
Y
-------------
Y
S
L
G
I
F
I
G
----------
I
C
G
I
I
G
C
G
G
N
---------
G
I
V
I
Y
L
F
T
--
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
---
I
N
L
A
F
S
D
-
F
T
F
S
L
-
V
N
G
F
P
L
M
T
------
I
S
C
F
-----
L
K
K
W
I
F
G
------
F
A
A
C
K
V
Y
G
F
I
G
G
----
I
F
G
F
M
--
S
I
M
T
M
-------------
A
M
I
S
I
D
R
Y
N
V
I
--
G
R
P
M
A
A
S
-
K
K
---
M
S
H
R
R
A
F
I
M
I
I
-
F
V
W
L
W
S
V
L
W
A
I
-
G
P
I
F
-
G
-------------
W
G
A
Y
T
L
E
G
--------
V
------
L
C
N
C
S
F
---
D
Y
I
-----
S
R
D
S
--
T
T
R
--
S
N
I
L
C
M
F
-
I
L
G
F
F
G
P
I
----
L
I
I
F
F
C
Y
--------
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
R
K
A
Q
A
G
A
N
A
-----------
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
----
I
S
Q
T
F
P
W
V
------------
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
-------
K
D
A
E
T
E
-
I
P
A
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
66.94
15%
-71
- C2 -
2OCC
-
COX1_BOVIN
A:
[1-514]
MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
G
Q
P
G
T
L
L
G
----------------------
D
D
Q
I
Y
N
V
V
--
V
T
A
H
A
-------------
F
V
M
I
F
F
M
V
----------
M
P
I
M
I
G
G
F
G
N
---------
W
L
V
P
L
M
I
G
A
P
D
M
A
F
P
R
M
N
N
M
S
F
W
L
---
L
P
P
S
F
L
L
-
L
L
A
S
S
M
V
E
------AGAGTG
W
T
V
Y
P
----
P
L
A
G
N
L
A
HAGA
S
V
D
L
T
I
F
S
L
H
L
A
G
V
----
S
S
I
L
G
--
A
I
N
F
I
-------------
T
T
I
I
N
M
K
P
P
A
---
M
S
Q
Y
Q
T
P
-
L
----
F
V
W
S
V
M
I
T
A
V
L
-
L
L
L
S
L
P
V
L
A
A
G
-
I
T
M
L
-
L
-------------
T
------
D
--------
R
------
N
L
N
T
T
F
---
F
D
P
-----
A
G
G
---
G
D
P
--
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
----
I
L
I
L
P
G
F
--------
G
M
I
S
H
I
V
T
Y
Y
S
-------------
G
K
---
K
--
E
----------
P
-------------------------------------------
F
-------------------------------------------------------------------------------------------------------------
G
Y
M
G
-
M
-----
V
---
W
----
A
M
M
-
S
---------------------------
I
G
F
L
----------------------------
G
---
F
--
I
-----------
V
--------
W
----------------------------------
A
-----
H
----------
H
-------------------------------------
M
F
T
--
V
---
G
-----
M
-------------
D
V
D
-------------
T
R
---
A
---------
Y
--------
F
T
---
S
A
------
T
------
M
I
--------
I
A
I
P
T
G
V
K
V
F
S
W
L
-----------
A
T
L
H
---------------------------
G
G
N
I
--------
K
W
S
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
--
L
T
G
I
V
L
A
N
S
S
L
D
I
V
L
H
DTY
Y
V
V
A
H
F
H
Y
V
L
S
M---------
G
A
V
F
A
I
M
G
G
F
V
H
W
F
-------
P
L
F
S
G
Y
T
L
N
D
T
W
A
K
I
H
F
A
I
M
F
V
G
V
N
M
T
F
F
P
Q
H
F
L
G
L
S
G
M
P
R
R
Y
S
D
Y
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
A
V
M
L
M
---------
V
F
I
I
W
E
A
F
A
S
K
R
E
V
L
----
T
-----
V
D
L
T
T
T
N
L
E
W
L
N
G
C
-
P
P
P
Y
H
T
F
E
E
P
T
Y
V
N
L
K
----------------------------------------------------
54
HHSearch
66.51
16%
-124
* C4 *
3V2Y
1
ENLYS_BPT4
A:
[60-490]
----------------------------------------------------------------------------------
E
N
S
I
-------------
K
L
T
S
V
V
F
I
----------
L
I
C
C
F
I
I
L
E
N
---------
I
F
V
L
L
T
I
W
--
K
T
-
K
K
F
H
R
P
M
Y
Y
F
I
---
G
N
L
A
L
S
D
-
L
L
A
G
V
-
A
Y
-
T
A
N
L
L
------
L
S
G
A
------
T
T
Y
K
L
T
------
P
A
Q
W
F
L
R
E
G
S
M
F
----
V
A
L
S
A
--
S
V
F
S
L
-------------
L
A
I
A
I
E
R
Y
I
T
M
--
L
K
------------
N
N
F
R
L
F
L
L
I
S
-
A
C
W
V
I
S
L
I
L
G
G
-
L
P
I
M
-
G
-------------
W
NCI---
S
--------
A
------
L
S
S
C
S
T
---
V
L
P
-----
L
Y
H
--------
K
H
Y
I
L
F
C
-
T
T
V
F
T
L
L
L
----
L
S
I
V
I
L
Y
--------
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
---
Y
--
K
----------
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
------------------------------------------------
K
---
L
F
---------
N
----
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
-----------
P
------------
V
Y
D
S
L
D
-----
A
---
V
R
---
R
A
A
-
L
---------------------------
I
N
M
V
----------------------------
F
---
Q
--
M
G
E
T
G
V
A
G
F
T
N
S
L
--------
R
M
L
Q
Q
KR
W
D
E
A
------------------------
A
-----
V
----------
N
-------------------------------------
L
A
K
S
R
W
---
Y
-----
N
-------------
Q
T
P
-------------
N
R
---
A
---------
K
--------
R
V
---
I
T
------
T
------
F
R
--------
T
G
T
W
D
A
Y
A
S
R
S
S
E
-----------
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
--------
T
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
--
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
----
F
I
R
I
M
G
R
P
------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
66.43
16%
-117
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-490]
-----------------------------------------------------------------------------
E
N
--
A
N
F
N
K
-------------
I
F
L
P
T
I
Y
S
----------
I
I
F
L
T
G
I
V
G
N
---------
G
L
V
I
L
V
M
G
--
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
---
L
H
L
S
V
A
D
-
L
L
F
V
--
I
T
-
L
P
F
W
A
------
V
D
A
V
------
A
N
W
Y
F
G
------
N
F
L
C
K
A
V
H
V
I
Y
T
----
V
N
L
Y
S
--
S
V
W
I
L
-------------
A
F
I
S
L
D
R
Y
L
A
I
--
V
H
A
T
N
S
Q
-
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
-
G
V
W
I
P
A
L
L
L
T
I
-
P
D
F
I
-
F
-------------
A
N
V
S
E
A
-
D
--------
D
------
R
Y
I
C
D
R
---
F
Y
P
-----
N
D
L
---
W
V
V
--
V
F
Q
F
Q
H
I
-
M
V
G
L
I
L
P
G
----
I
V
I
L
S
C
Y
--------
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
---
K
--
I
----------
Y
-------------------------------------------
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
---
Q
D
---------
V
D
A
A
V
R
---------------
G
-----------
I
------------
L
R
N
A
-
K
-----
L
---
K
----
P
V
Y
-
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M----------
G
E
T
G
----------------------------
V
---
A
--
G
F
T
N
--------
S
--------
L
----------------------------------
R
-----
M
----------
L
-------------------------------------
Q
Q
K
--
R
---
W
-----
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-------------
N
R
---
A
---------
K
--------
R
V
---
I
T
------
T
------
F
R
--------
T
G
T
W
D
A
Y
G
S
K
G
H
Q
-----------
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
--
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
----
A
Q
H
A
L
T
S
G
------------
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
66.41
15%
-122
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-440]
---------------------------------------------------------------------------------------------------
M
P
L
V
V
V
L
S
----------
T
I
C
L
V
T
V
G
L
N
---------
L
L
V
L
Y
A
V
R
--
S
E
-
R
K
L
H
T
V
G
N
L
Y
I
---
V
S
L
S
V
A
D
-
L
I
V
G
A
-
V
V
-
M
P
M
N
I
------
L
Y
L
L
M
-----
S
K
W
S
L
G
------
R
P
L
C
L
F
W
L
S
M
D
Y
----
V
A
S
T
A
--
S
I
F
S
V
-------------
F
I
L
C
I
D
R
Y
R
S
V
--
Q
Q
P
L
R
Y
L
K
Y
----
R
T
K
T
R
A
S
A
T
I
L
-
G
A
W
F
L
S
F
L
W
V
I
-
P
I
L
G
-
W
-------------
N
------
H
R-------
R
------
E
D
K
C
E
T
---
D
F
Y
-----
D
V
------
T
--
W
F
K
V
M
T
A
-
I
I
N
F
Y
L
P
T
----
L
L
M
L
W
F
Y
--------
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
-
K
----------
D
-------------------------------------------
T
EG
Y
Y
T
I
G
IGHLLT-----------------------------------
K
S--
P
S
---------
L
----
N
---------------
A
-----------
A
K
S
E
L
D
K
A
I
GRNT
N
G
V
I
-
T
-----
K
---
D
----
E
A
E
-
K
---------------------------
L
F
N
Q
----------------------------
D
---
V
--
D
-----------
A
--------
A
----------------------------------
V
-----
R
----------
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
--
L
---
R
-----
M
-------------
L
Q
Q
-------------
K
R
---
W
---------
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
------
P
------
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
-----------
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
----------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
--
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
----
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
65.57
14%
-108
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-455]
---------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
----------
S
L
S
L
V
T
I
I
G
N
---------
I
L
V
M
V
S
I
K
--
V
N
-
R
H
L
Q
T
V
N
N
Y
F
L
---
F
S
L
A
C
A
D
-
L
I
I
G
V
-
F
S
-
M
N
L
Y
T
------
L
Y
T
V
-----
I
G
Y
W
P
L
G
------
P
V
V
C
D
L
W
L
A
L
D
Y
----
V
V
S
N
A
--
S
V
M
N
L
-------------
L
I
I
S
F
D
R
Y
F
C
V
--
T
K
P
L
T
Y
P
V
K
----
R
T
T
K
M
A
G
M
M
I
A
-
A
A
W
V
L
S
F
I
L
W
A
-
P
A
I
L
-
F
-------------
W
------
Q
F
I
V
GVRTV
E
------
D
G
E
C
Y
I
---
Q
F
F
-----
S
------
N
A
--
A
V
T
F
G
T
A
-
I
A
A
F
Y
L
P
V
----
I
I
M
T
V
L
Y
--------
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
--
Y
----------
K
D
TE----------------------------------------
G
Y
Y
T
I
GIGHLLT-------------------------------------
K
---
S
P
---------
S
----
L
---------------
N
A
A
K
S
-------
E
L
D
K
A
I
GRN----
T
N
G
V
-
I
-----
T
---
K
----
D
E
A
-
E
---------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
---
A
--
L
-----------
I
N
M
V
F
----
Q
----------------------------------
M
-----
G
----------
E
-------------------------------------
T
G
V
--
A
---
G
F
T
N
--
S
-------------
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
---
S
R
W
-------
Y
N
-------
Q
T
---
P
N
R
A
K
R
V
I
T
------
T
F
--------
R
T
G
T
W
D
A
Y
P
P
P
S
R
-----------
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
----
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
64.88
21%
-130
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-319]
------------------------------------------------------------------------------------
N
K
-------------
Y
V
V
I
I
A
Y
A
----------
L
V
F
L
L
S
L
L
G
N
---------
S
L
V
M
L
V
I
L
--
Y
S
-
R
V
G
R
S
V
T
D
V
Y
L
---
L
N
L
A
L
A
D
-
L
L
F
A
L
--
T
-
L
P
I
W
A
------
A
S
K
V
------
N
G
W
I
F
G
------
T
F
L
C
K
V
V
S
L
L
K
E
----
V
N
F
Y
S
--
G
I
L
L
L
-------------
A
C
I
S
V
D
R
Y
L
A
I
--
V
H
A
T
R
T
L
-
T
----
Q
K
R
H
L
V
K
F
V
C
L
-
G
C
W
G
L
S
M
N
L
S
L
-
P
F
F
L
-
F
-------------
R
------
Q
AYHPNN--
S
------
S
P
V
C
Y
E
---
V
L
G
-----
N
D
T
AK-
W
R
M
--
V
L
R
I
L
P
H
-
T
F
G
F
I
V
P
L
----
F
V
M
L
F
C
Y
--------
G
F
T
L
R
T
L
F
K
A
H
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
-----------
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
Q
VIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
--
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
----
F
L
K
I
L
A
M
H
------------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
64.79
16%
-145
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-319]
---------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
----------
V
I
V
V
T
S
V
V
G
N
---------
V
V
V
M
W
I
I
L
--
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
---
V
N
L
A
F
A
E
-
A
S
M
A
A
-
F
N
-
T
V
V
N
F
------
T
Y
A
V
-----
H
N
E
W
Y
Y
G
------
L
F
Y
C
K
F
H
N
F
F
P
I
----
A
A
V
F
A
--
S
I
Y
S
M
-------------
T
A
V
A
F
D
R
Y
M
A
I
--
I
H
P
L
Q
P
R
-
L
-----
S
A
T
A
T
K
V
V
I
C
-
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
-
Y
-------------
S
TTETM-
P
--------
S
------
R
V
V
C
M
I
---
E
W
P
-----
E
H
P
NKI
Y
E
K
--
V
Y
H
I
C
V
T
-
V
L
I
Y
F
L
P
L
----
L
V
I
G
Y
A
Y
--------
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
-----------
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
YL------
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
--
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
----
F
K
H
A
F
R
C
C
------------
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
-------
S
T
R
Y
L
Q
-
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
64.66
13%
-113
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-464]
---------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
----------
A
I
A
V
L
A
I
L
G
N
---------
V
L
V
C
W
A
V
W
--
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
---
V
S
L
A
A
A
D
-
I
A
V
G
V
-
L
A
-
I
P
F
A
I
------
T
I
S
T
-------
G
F
C
A
A
------
C
H
G
C
L
F
I
A
C
F
V
L
----
V
L
T
Q
S
--
S
I
F
S
L
-------------
L
A
I
A
I
D
R
Y
I
A
I
--
R
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
L
-
G
-------------
W
------
N
--------
N
CGQ---
S
Q
G
C
G
E
---
G
Q
V
ACLFE
D
V
V
---
P
M
N
--
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
----
L
L
M
L
G
V
Y
--------
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
-
K
----------
D
-------------------------------------------
T
EGYYTIGIGHL-------------------------------------
L
---
T
K
SPS
L
-----
N
----
A
---------------
A
K
S
E
L
D
K
A
I
---
G
------------
R
N
T
N
-
G
-----
V
---
I
----
T
K
D
E
A
---------------------------
E
K
L
F
----------------------------
N
---
Q
--
D
-----------
V
--------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
-----
E
T
G
V
A
G
F
T
N
S
L
R
-------------------------------------
M
L
Q
--
Q
---
K
R
W
D
E
A
A
-------------
V
N
L
-------------
A
K
---
S
---------
R
W
Y
N
Q
----
T
P
---
N
R
A
K
R
V
I
T
T
------
F
R
--------
T
G
T
W
D
A
Y
R
S
T
L
Q
K
-----------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
----
F
R
K
I
I
R
S
H
------------
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Fugue
63.06
14%
-98
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
VV
R
S
P
F
E
A
P
Q
Y
Y
L
A
--
E
P
W
Q
F
-------------
S
M
L
A
A
Y
M
F
----------
L
L
I
M
L
G
F
P
I
N
---------
F
L
T
L
Y
V
T
V
Q
--
H
-
K
K
L
R
T
P
L
N
Y
I
L
---
L
N
L
A
V
A
D
-
L
F
M
V
F
-
G
--
G
F
T
T
T
------
L
Y
T
S
L
----
H
G
Y
F
V
F
G
------
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
--
A
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
--
C
K
P
M
S
N
F
-
R
----
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
-
G
-------------
W
------
S
--------
R
Y
I
P
E
GM
Q
C
S
C
G
I
DYY
T
P
H
-----
E
E
T
---
N
N
E
--
S
F
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
----
I
V
I
F
F
C
Y
--------
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
-
T
Q
K
A
E
K
E
V
T
R
---
M
--
V
----------
I
-------------------------------------------
I
------------------------------------------------
M
---
V
I
---------
A
----
F
---------------
L
-----------
I
------------
C
W
L
P
-
Y
-----
A
---
G
----
V
A
F
-
Y
---------------------------
I
F
T
H
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---
G
-----
S
-------------
D
F
G
-------------
P
I
---
F
---------
M
--------
T
I
---
P
A
------
F
------
F
A
--------
K
T
S
A
V
Y
N
P
V
I
Y
I
M
-----------
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-------
C
G
K
N
P
S
T
T
V
S
K
T
E
T
--------
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
61.23
11%
-67
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------------------------
D
E
V
W
V
-------------
V
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
---------
V
L
V
I
T
A
I
A
K
F
---
E
R
L
Q
T
V
T
N
Y
F
I
---
T
S
L
A
C
A
D
-
L
V
M
G
L
-
A
V
-
V
P
F
G
A
------
A
H
I
L
M
----
K
M
W
T
-
F
G
------
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
--
S
I
E
T
L
-------------
C
V
I
A
V
D
R
Y
F
A
I
--
T
S
P
F
K
Y
Q
-
S
----
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
-
M
HWYRATH
Q
E
A
I
N
C
Y
------
A
--------
E
------
E
T
C
C
D
F
---
F
T
N
-----
Q
A
Y
---
A
I
A
--
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
--------
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
---
E
--
G
----------
Y
-------------------------------------------
Y
------------------------------------------------
T
---
I
G
---------
I
----
G
---------------
H
-----------
L
------------
L
T
K
S
-
P
-----
S
---
L
----
N
A
A
-
K
---------------------------
S
E
L
D
----------------------------
K
---
A
--
I
-----------
G
--------
R
----------------------------------
N
-----
T
NG--------
V
-------------------------------------
I
T
K
--
D
---
E
-----
A
-------------
E
K
L
-------------
F
N
---
Q
---------
D
--------
V
D
---
A
A
------
V
------
R
G
--------
I
L
R
N
A
K
L
K
P
V
Y
D
S
-----------
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
----------------------------------------------------------------------------------------------
E
T
G
V
A
G
F
T
-------
N
S
L
R
M
L
-
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
-
F
T
L
C
---------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
-----
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------
79
Fugue
60.13
11%
-91
* C3 *
2EUD
2
RIR1_YEAST
A:
[90-746]
------------------------------------------
T
T
K
Q
F
S
K
V
V
E
D
L
Y
R
Y
V
N
A
A
T
G
K
P
--
A
P
M
I
S
D
D
V
Y
N
I
V
M
E
N
K
D
K
L
N
S
A
IVYDRDFQYS
Y
F
G
F
K
T
L
E
----------
R
S
Y
L
L
R
I
N
G
Q
VAER
P
Q
H
L
I
M
R
V
A
L
G
I
H
G
R
D
I
-
E
A
A
L
E
T
Y
N
L
M
S
L
KY
F
T
H
A
S
P
T
-
L
F
N
A
G
-
T
P
-
K
P
Q
M
S
------
S
C
F
L
V
A
MKE
D
S
I
E
G
I
Y
------
D
T
L
K
E
C
A
L
I
S
K
T
A
G
G
I
G
L
H
I
H
--
N
I
R
S
T
GSYIAGTNGTSNG
L
I
P
M
I
R
V
F
N
N
T
--
A
R
Y
V
D
Q
G
-
G
----
N
K
R
P
G
A
F
A
L
Y
L
-
E
P
W
H
A
D
--
I
F
D
-
F
I
D
I
-
R
-------------
K
------
N
--------
H
------
G
K
E
E
I
R
---
A
R
D
-----
L
F
P
---
A
L
W
IP
D
L
F
M
K
R
V
-
E
E
N
G
T
W
T
L
F
SPT
S
A
P
G
L
S
D
--------
C
Y
G
D
E
F
E
A
L
Y
T
R
Y
E
K
E
G
R
G
K
T
I
K
A
Q
K
---
L
--
W
----------
Y
-------------------------------------------
S
------------------------------------------------
I
---
L
E
---------
A
----
Q
---------------
T
-----------
E
------------
T
G
T
P
-
F
-----
V
---
V
----
Y
K
D
-
A
---------------------------
C
N
R
K
----------------------------
S
---
N
--
Q
-----------
K
--------
N
----------------------------------
L
-----
G
----------
V
-------------------------------------
I
K
S
--
S
---
N
-----
L
-------------
C
C
E
-------------
I
V
---
E
---------
Y
--------
S
A
---
P
D
------
E
------
T
A
--------
V
C
N
L
A
S
V
A
L
P
A
F
I
ETSEDGK
T
S
T
Y
N
F
K
K
L
H
E
I
A
K
V
V
T
R
N
L
N
R
V
I
D
R
N
Y
Y
P
V
E
E
A
R
K
S
N
M
--------
R
H
R
P
I
A
L
G
V
Q
G
L
A
D
T
F
M
L
L
R
--
L
P
F
--
D
S
E
E
A
R
L
L
N
I
Q
----
I
F
E
T
I
Y
H
A
------------
S
M
E
A
S
C
E
L
A
Q
K
D
G
P
YETFQGS
P
A
S
Q
G
I
-
L
Q
F
D
M
W
D
Q
K
P
Y
G
M
W
D
W
D
T
L
R
K
D
I
M
K
H
------
G
V
R
N
S
L
T
M
A
P
M
P
T
A
S
T
S
Q
I
L
G
Y
N
E
C
F
E
P
V
T
S
N
MFQVVN
P
Y
L
L
R
D
L
V
D
L
G
I
W
D
E
G
M
K
Q
Y
-
L
I
-----
T
Q
N
G
S
I
Q
G
L
P
N
V
P
Q
-
E
L
K
D
L
Y
K
T
V
W
E
I
S
Q
K
T
I
I
N
M
A
A
D
R
SVYIDQS
H
S
L
N
L
F
L
RAPT
M
G
K
L
T
S
M
H
F
Y
G
W
K
K
GLKTGMY
Y
L
R
T
Q
74
Fugue
59.40
16%
-87
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
VV
R
S
P
F
E
A
P
Q
Y
Y
L
A
--
E
P
W
Q
F
-------------
S
M
L
A
A
Y
M
F
----------
L
L
I
M
L
G
F
P
I
N
---------
F
L
T
L
Y
V
T
V
Q
--
H
-
K
K
L
R
T
P
L
N
Y
I
L
---
L
N
L
A
V
A
D
-
L
F
M
V
F
-
G
--
G
F
T
T
T
------
L
Y
T
S
L
----
H
G
Y
F
V
F
G
------
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
--
A
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
--
C
K
P
M
S
N
F
-
R
----
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
-
G
-------------
W
------
S
--------
R
Y
I
P
E
GM
Q
C
S
C
G
I
DYY
T
P
H
-----
E
E
T
---
N
N
E
--
S
F
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
----
I
V
I
F
F
C
Y
--------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
K
A
-----------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--------
D
F
---
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
-------------------------------
K
Q
F
R
N
C
M
V
T
T
L
C
C
-------
G
K
N
P
L
G
-
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
---
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
58.32
12%
-77
- C3 -
3GF3
2
?
A:
[3-587]
-------MYSMPGYFQN
M
P
T
I
G
K
ELVNPN
P
E
N
E
Q
E
I
K
A
V
E
S
D
I
H
E
S
I
K
K
A
L
D
A
G
I
T
S
E
E
K
L
N
E
R
G
--
Q
L
S
A
M
Q
R
I
N
A
L
I
--
D
P
G
T
W
-------------
C
P
L
N
S
L
F
N
PENNKFGTTN
I
V
N
G
L
G
R
V
D
G
---------
K
W
V
Y
I
V
A
S
D
N
----
K
K
M
A
G
A
W
V
P
G
---
Q
A
E
N
L
I
R
-
C
S
D
A
A
-
K
M
-
M
H
L
P
L
------
I
Y
L
L
N
----
C
S
G
V
E
F
P
------
N
Q
D
K
V
Y
P
N
R
R
G
G
----
G
T
P
F
F
--
R
N
S
E
L
-------------
N
Q
L
G
I
P
V
I
V
G
I
--
Y
G
T
N
P
A
--
G
----
G
G
Y
H
S
I
S
P
T
I
L
-
I
A
H
Q
D
A
N
M
A
V
G
-
G
A
G
A
-
E
-------------
Q
------
I
--------
I
------
A
A
Q
I
E
N
---
S
K
L
-----
K
V
P
---
A
P
G
--
S
V
P
I
H
Y
----
D
E
T
G
F
F
----
R
E
V
Y
Q
N
D
--------
L
G
V
I
D
G
I
K
K
Y
I
S
Y
L
P
A
Y
N
L
E
F
F
R
V
D
T
---
P
--
K
----------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
Q
---------------------------
L
P
A
E
----------------------------
D
---
L
--
Y
-----------
S
--------
I
----------------------------------
I
-----
P
----------
M
-------------------------------------
N
Q
K
--
R
---
P
-----
Y
-------------
D
---------------------------------------
I
Y
---
E
V
------
I
------
A
R
--------
L
F
D
N
S
E
F
S
E
Y
K
K
G
-----------
Y
G
P
E
M
V
T
G
L
A
K
V
N
G
L
L
V
G
V
I
A
N
V
Q
G
L
L
M
---------------
N
Y
P
E
Y
K
Q
N
S
V
G
I
G
G
K
L
Y
R
Q
G
--
L
I
K
M
N
E
F
V
T
L
C
A
R
D
R
I
----
P
L
I
W
L
Q
D
T
TGIDVG
D
E
A
E
K
A
E
L
L
G
L
G
Q
S
L
I
Y
S
I
E
-------
N
S
K
L
P
S
-
L
E
I
T
I
R
K
A
S
--
A
A
A
H
Y
V
L
G
G
P
Q
G
N
N
T
N
V
F
S
I
G
T
G
A
C
E
Y
Y
V
M
P
G
E
T
A
A
N
A
M
Y
S
R
K
L
V
K
A
Q
P
I
I
G
K
---------
M
N
D
M
I
Q
M
Y
T
D
K
S
R
P
K
Y
C
-
T
E
K
GMVD
E
I
V
D
M
T
E
V
R
P
Y
I
Q
A
-
F
T
E
A
A
Y
Q
N
P
Q
S
I
C
P
M
H
Q
M
L
T
P
R
S
T
-------
R
E
F
E
T
F
G------------------------------
62
HHSearch
57.01
15%
-111
- C4 -
1U19
13
OPSD_BOVIN
A:
[34-321]
-----------------------------------------------------------------------------
L
A
--
E
P
W
Q
F
-------------
S
M
L
A
A
Y
M
F
----------
L
L
I
M
L
G
F
P
I
N
---------
F
L
T
L
Y
V
T
V
--
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
---
L
N
L
A
V
A
D
-
L
F
M
V
F
-
G
G
-
F
T
T
T
L
------
Y
T
S
L
-----
H
G
Y
F
V
F
G
------
P
T
G
C
N
L
E
G
F
F
A
T
----
L
G
G
E
I
--
A
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
--
C
K
P
M
S
N
F
-
R
----
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
-
G
-------------
W
S
R
Y
I
--
P
E
G------
M
------
Q
C
S
C
G
I
---
D
Y
Y
-----
T
P
H
EET
N
N
E
--
S
F
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
----
I
V
I
F
F
C
Y
--------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
-----------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
----
M
V
T
T
L
C
C
G
------------
K
N
P
L
G
D
D
E
A
S
T
T
V
S
-------
K
T
E
T
S
Q
-
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.51
24%
-121
- C4 -
4XT3
2
US28_HCMVA
A:
[46-244]
-------------------------------------------------------------------------------------------------------
F
L
Y
G
----------
V
V
F
L
F
G
S
I
G
N
---------
F
L
V
I
F
T
I
--
T
W
R
-
R
R
I
Q
C
S
G
D
V
Y
F
---
I
N
L
A
A
A
D
L
L
F
V
C
---
T
-
L
P
L
W
M
Q
-----
Y
L
L
D
H
-------
A
S
V
P
------
C
T
L
-----
L
T
A
C
----
F
Y
V
A
M
F
A
S
L
C
F
I
-------------
T
E
I
A
L
D
R
Y
Y
A
I
VY
M
R
Y
R
P
V
K
-
Q
----
A
C
-----
L
F
S
I
-
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
-
V
-------------
T
------
K
--------
K
------
D
N
Q
C
M
T
---
D
Y
D
-----
Y
L
E
---
V
S
Y
--
P
I
I
L
N
V
E
-
L
M
L
G
A
F
V
I
----
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
V
S
Q
S
R
H
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
---
W
--
L
----------
P
-------------------------------------------
Y
------------------------------------------------
H
---
L
T
---------
L
----
F
---------------
V
-----------
D
------------
T
L
K
L
-
L
-----
K
---
W
----
I
S
S
-
S
---------------------------
C
E
F
E
----------------------------
R
---
S
--
L
-----------
K
--------
R
----------------------------------
A
-----
L
----------
I
-------------------------------------
L
T
E
--
S
---
L
-----
A
-------------
F
C
H
-------------
C
C
---
L
---------
N
--------
P
L
---
L
Y
------
V
------
F
V
--------
G
T
K
F
R
Q
E
L
H
C
L
L
A
-----------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
52.95
24%
-115
- C4 -
4XT1
12
US28_HCMVA
A:
[46-244]
-------------------------------------------------------------------------------------------------------
F
L
Y
G
----------
V
V
F
L
F
G
S
I
G
N
---------
F
L
V
I
F
T
I
--
T
W
R
-
R
R
I
Q
C
S
G
D
V
Y
F
---
I
N
L
A
A
A
D
L
L
F
V
C
---
T
-
L
P
L
W
M
Q
-----
Y
L
L
D
---------
S
V
P
------
C
T
L
-----
L
T
A
C
----
F
Y
V
A
M
F
A
S
L
C
F
I
-------------
T
E
I
A
L
D
R
Y
Y
A
I
VY
M
R
Y
R
P
V
K
-
Q
----
A
C
-----
L
F
S
I
-
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
-
V
-------------
T
------
K
--------
K
------
D
N
Q
C
M
T
---
D
Y
D
-----
Y
L
E
---
V
S
Y
--
P
I
I
L
N
V
E
-
L
M
L
G
A
F
V
I
----
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
V
S
Q
S
R
H
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
---
W
--
L
----------
P
-------------------------------------------
Y
------------------------------------------------
H
---
L
T
---------
L
----
F
---------------
V
-----------
D
------------
T
L
K
L
-
L
-----
K
---
W
----
I
S
S
-
S
---------------------------
C
E
F
E
----------------------------
R
---
S
--
L
-----------
K
--------
R
----------------------------------
A
-----
L
----------
I
-------------------------------------
L
T
E
--
S
---
L
-----
A
-------------
F
C
H
-------------
C
C
---
L
---------
N
--------
P
L
---
L
Y
------
V
------
F
V
--------
G
T
K
F
R
Q
E
L
H
C
L
L
A
-----------
E
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
52.72
28%
-42
- C4 -
3KJ6
-
A:
[268-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
-------------------------
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
-------------
I
------------
A
F
Q
E
L
L
C
L
R
R
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------