@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM1_HUMAN: (2016-01-10 )
MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.-.......410.......420.......430.......440.......-450-........460-----.------.--.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
G
L
L
L
F
F
F
P
A
I
F
L
E
V
S
LLPRSPG
R
K
V
L
L
AGASSQR
S
V
A
RMDG
D
V
I
I
G
A
L
F
S
VHHQP
P
A
E
KV
P
E
R
K
C
G
E
I
R
E
Q
YG
I
Q
R
V
E
A
M
F
H
T
L
D
KINAD
P
V
L
L
PNITL
G
S
E
I
R
D
S
CWH
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
S
IRDEKD
G
I
N
R
CLPDGQSLPPGRTKKP
I
A
G
V
IGPGS
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
FDIPQIAYSATSIDLS
D
K
T
L
Y
K
Y
F
L
R
VVPS
D
T
L
Q
A
R
A
M
L
D
I
V
K
RYN
W
T
Y
V
S
A
V
HTEGNYG
E
S
G
M
D
A
F
K
E
L
A
A
QE
G
L
C
I
AHSDKIYSNAG
E
K
S
F
D
R
L
L
R
K
L
R
E
RLPK
A
R
V
V
V
C
FCEG
M
T
V
R
G
L
L
S
A
M
R
RLGVV
G
E
F
S
L
IGSDGWA
D
R
D
E
VIE
G
Y
E
V
EANG
G
I
T
I
K
LQSPEVRSF
D
D
Y
F
L
K
L
R
L
DTNTRNPW
F
P
E
F
W
Q
H
R
FQCRLPGHLLENPN
F
K
R
ICTGN
E
S
L
E
-
E
-
N
Y
VQDSKM
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
ALCPGHV
G
L
C
DAMKPI
D
G
S
K
-
L
-
L
-
D
F
L
I
K
S
SFI-------G------V--SGE
E
V
W
FDEKGDAPGR
Y
D
I
M
N
L
Q
YTEANRY
D
Y
V
H
VGTWHEG
V
L
NID
D
Y
K
I
Q
MNKS
G
V
V
R
S
V
C
SEPCLKG
Q
I
K
V
I
RKGE
V
S
C
C
W
I
CTACKENEYVQDEFTCKACDLGWWPNADLTGCEPI
P
V
R
Y
LEWS
N
I
E
S
I
I
A
I
A
F
S
C
L
G
I
L
V
T
L
F
V
T
L
I
F
V
L
YRDTPVVKSSSR
E
L
C
Y
I
I
L
A
G
I
F
L
G
Y
VC
P
F
T
L
IAKPT
T
T
S
C
Y
L
Q
R
L
L
V
G
L
S
S
A
M
C
Y
S
A
L
V
T
K
T
N
R
I
A
R
I
LAGSKKKICTRK
P
R
F
M
S
A
W
A
Q
V
I
I
A
S
I
L
I
S
V
Q
L
T
L
V
V
T
L
I
I
MEPPMPILSYPS
I
K
E
V
Y
L
I
C
NTSN
L
G
V
V
A
PLGYN
G
L
L
I
M
S
C
T
Y
Y
A
F
KTRNVPANFNE
A
K
Y
I
A
F
T
M
Y
T
T
C
I
I
W
L
A
F
V
P
I
YFGSN
Y
K
I
I
T
T
C
F
A
V
S
L
S
V
T
V
A
L
G
C
MFTP
K
M
Y
I
I
I
AKPER
N
V
R
SAFTTS
D
V
V
R
M
H
VGDGKLPCRS
N
T
F
L
N
I
F
R
R
KKAGAGNANSNGKSVSWSEPGGGQVPKGQH
M
W
H
R
L
S
V
H
V
KTNETACNQ
T
A
V
IKP
L
T
K
SYQGSG
K
S
L
T
FSDTST
K
T
L
YNVEEEEDAQ
P
I
RFSPPGSP
S
M
V
V
H
RRVPSAATTPPLPSHLTAEET
P
L
F
L
AEPALPKGLPPP
L
Q
QQQQPP
P
Q
Q
K
S
L
M
D
Q
L
Q
G
V
V
S
N
F
S
TAIP
D
F
H
A
V
LAGPGGPGNGLRSLYPPPP
P
P
Q
H
L
Q
M
L
P
L
Q
L
S
T
F
G
E
E
LVSPPADDD
D
D
S
E
R
F
K
L
L
Q
E
Y
V
Y
E
H
EREGNT
E
E
D
E
L
E
E
E
E
E
D
L
Q
A
A
SKLTPDDSPALTPPS
P
F
R
D
SVASGSSVPSSPVSESVLCTPPN
V
S
Y
A
S
V
I
L
R
D
Y
K
Q
SSSTL
24
PsiBlast_CBE
93.70
98%
-104
- C1 -
1EWK
7
GRM1_RAT
B:
[3-480]
----------------------------------
Q
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Fugue
92.85
99%
-97
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.64
98%
-97
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
92.62
98%
-103
- C1 -
1EWT
3
GRM1_RAT
B:
[3-480]
----------------------------------
Q
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
S
I
R
----------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.55
99%
-105
- C1 -
3KS9
2
GRM1_HUMAN
B:
[8-482]
----------------------------------
Q
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
--------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
-------
N
F
K
R
I
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
-
D
F
L
I
K
S
S
F
I
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.45
98%
-101
- C1 -
1ISS
1
GRM1_RAT
B:
[4-480]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.09
98%
-97
- C1 -
1ISR
3
GRM1_RAT
A:
[4-480]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.67
98%
-102
- C1 -
1ISS
1
GRM1_RAT
A:
[4-480]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.53
98%
-100
- C1 -
1EWT
2
GRM1_RAT
A:
[3-480]
----------------------------------
Q
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
S
I
R
----------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.69
98%
-96
- C1 -
1EWV
-
GRM1_RAT
A:
[36-512]
-----------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
-
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
-------
G
------
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.42
70%
-92
- C1 -
3LMK
3
GRM5_HUMAN
B:
[13-482]
-----------------------------------
R
V
V
A
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
P
T
V
D
K
V
H
E
R
K
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
----------------------------
K
P
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
K
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
F
D
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
E
G
------
K
Y
N
K
T
C
N
S
S
L
T
L
K
-
T
-
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
E
S
L
M
K
T
N
F
T
-------
G
------
V
--
S
G
D
T
I
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
E
M
G
K
D
Y
F
D
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.74
70%
-94
- C1 -
3LMK
4
GRM5_HUMAN
A:
[12-482]
----------------------------------
R
R
V
V
A
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
P
T
V
D
K
V
H
E
R
K
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
----------------------------
K
P
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
K
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
F
D
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
E
G
--------
N
K
T
C
N
S
S
L
T
L
K
-
T
-
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
E
S
L
M
K
T
N
F
T
-------
G
------
V
--
S
G
D
T
I
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
E
M
G
K
D
Y
F
D
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Fugue
81.43
45%
-94
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
------------------------
L
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
Q
V
----------
C
D
K
H
L
A
I
D
-
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
L
L
K
I
Q
F
T
APFNPN
K
------
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.87
42%
-93
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
79.42
44%
-94
- C1 -
2E4U
2
GRM3_RAT
A:
[7-543]
------------------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
-
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
-
E
Y
L
L
K
I
Q
F
T
APFNPNK
G
------
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
-
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.41
42%
-92
- C1 -
2E4W
2
GRM3_RAT
A:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.08
42%
-90
- C1 -
2E4V
2
GRM3_RAT
B:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.93
42%
-91
- C1 -
2E4V
2
GRM3_RAT
A:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.92
42%
-89
- C1 -
2E4X
2
GRM3_RAT
A:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.90
42%
-90
- C1 -
2E4X
2
GRM3_RAT
B:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
78.81
42%
-90
- C1 -
2E4W
2
GRM3_RAT
B:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.65
42%
-92
- C1 -
2E4U
2
GRM3_RAT
B:
[6-543]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
-
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
75.39
44%
-96
- C1 -
3SM9
8
GRM3_HUMAN
A:
[8-475]
--------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-----
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
---------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
-
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
-
D
Y
L
L
K
I
N
F
T
-------
A
------
P
FN
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
-
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.14
42%
-94
- C1 -
3SM9
8
GRM3_HUMAN
A:
[5-475]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
---------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
-------
A
PFN-------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.33
41%
-93
- C1 -
5CNM
5
?
A:
[32-497]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
-------
A
PFNPNK
D
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-------
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.13
42%
-82
- C1 -
2E4Y
1
GRM3_RAT
B:
[6-484]
-----------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
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T
S
A
K
L
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D
K
S
R
Y
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Y
F
A
R
T
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P
P
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Y
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A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
--
V
N
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
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H
V
A
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G
A
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T
L
E
L
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H
P
V
R
Q
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D
R
Y
F
Q
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L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
-
N
Y
E
Q
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S
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I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
PFNPNK
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
-
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------