@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM2_HUMAN: (2016-01-10 )
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Atome Classification :
(32 SA)
.........10........20........30........40..----......------50........60........70........80........90........100.......110........120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..-.....230.......240........250........260........270.......280....--..--.290.......300.......310.......320.......330.......340.......350......---------.360-.-----....-.-.--..370.......380.......390.......400.......410.....-.-.420.......430..-.-..--..-440........450.......460.......470.....-..480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
S
L
L
A
L
L
A
L
L
L
L
W
G
A
VAEGPA
K
K
V
L
T
LEG
D
L
V
L
GGLFPVHQK----GGPAED------CGP
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
RINRDPHLL
P
G
V
R
L
G
A
H
I
L
D
SCSK
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
-SRGADGSRHICPDGSYATHGDAPT
A
I
T
G
VIGGSYSD
V
S
I
Q
V
A
N
L
L
R
L
F
QIPQISYASTSAKLSDKSR
Y
D
Y
F
A
RTV
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
TVASEGDYGETG
I
E
A
F
-
E
L
EARAR
N
I
C
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
QK-PS
A
R
V
A
V
L
F
TRS
E
D
A
R
E
L
L
A
A
S
QRLN--
A
S
--
F
T
W
V
ASDG
W
G
A
L
E
S
V
VAGSEGAAE
G
A
I
T
I
E
LASY
P
I
S
D
F
A
S
Y
F
Q
SLDPWNNSR
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
SFR---------QR---D-----CAAH-S-L--RAVPFEQES
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
LCP
N
T
T
R
L
C
D
AMRPVNG
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
FDAPFRP-A-DT--HN-E-VR
F
D
RFGDGIGRY
N
I
F
T
Y
L
RAGSGR
Y
R
Y
Q
KVGYWAE
G
-
L
T
LDTSLIPWASPSAGPL
P
A
S
R
CSE
P
C
L
Q
N
E
V
KSVQPG
E
V
C
C
W
L
C
IPCQPY
E
Y
RLD
E
F
T
CADCGLGYWPNAS
L
T
G
C
F
E
L
P
Q
E
Y
I
RWGDAWAV
G
P
V
T
I
A
C
L
G
A
L
A
T
L
F
V
L
G
V
F
V
RHNAT
P
V
V
KASG
R
E
L
C
Y
I
L
L
G
G
V
F
L
C
Y
C
M
T
F
I
FIAKP
S
T
A
V
C
T
L
R
R
LGL
G
T
A
F
S
V
C
Y
S
A
L
L
T
K
T
N
R
I
A
R
I
FGGAREGAQRPRFIS
P
A
S
Q
V
A
I
C
L
A
L
ISGQ
L
L
I
V
V
A
W
L
V
V
EAPGTGKETAPER
R
E
V
V
T
L
R
CNH
R
D
A
S
M
L
G
S
L
A
Y
N
V
L
L
I
A
L
C
T
L
Y
A
F
K
TRKCPENFNE
A
K
F
I
G
F
T
M
Y
T
T
C
I
I
W
L
A
F
L
P
I
F
Y
VTSSD
Y
R
V
Q
T
T
T
M
C
V
S
V
SLSG
S
V
V
L
G
C
LFAP
K
L
H
I
I
L
FQPQ
K
N
V
V
SHRA
P
T
S
R
FG
S
A
A
A
RASSSLGQGSGS
Q
F
V
P
TVCNGR
E
V
V
D
STTSSL
1
PsiBlast_PDB
88.83
99%
-105
- C1 -
5CNJ
2
?
A:
[24-490]
---------------------
A
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
-----------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
---------
Q
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
-
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.48
99%
-105
- C1 -
4XAS
1
GRM2_HUMAN
B:
[25-489]
----------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
---------
Q
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
-
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
---
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.25
99%
-107
- C1 -
5CNI
5
?
A:
[25-489]
----------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
----------
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
-
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
--
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.65
99%
-105
- C1 -
5CNI
5
?
B:
[25-489]
----------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
---------
Q
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
---
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.52
99%
-105
- C1 -
4XAS
1
GRM2_HUMAN
A:
[25-489]
----------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
---------
Q
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
-
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.29
99%
-105
- C1 -
5CNJ
1
?
B:
[25-490]
----------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
----
G
G
P
A
E
D
------
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
-
S
---------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
-
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
---------
Q
R
---
D
-----
C
A
A
H
-
S
-
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
-
A
-
D
T
--
H
N
-
E
-
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
-
L
T
L
D
T
S
L
I
P
W
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.77
66%
-96
- C1 -
2E4X
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
N
H
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.14
66%
-100
- C1 -
2E4W
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.99
66%
-94
- C1 -
2E4Y
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
82.78
68%
-98
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-
I
---------------------
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
Q
V
---
C
-----
D
K
H
L
-
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
---
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
82.69
68%
-106
- C1 -
3SM9
8
GRM3_HUMAN
A:
[7-475]
------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
-
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
-
G
R
--
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
-HRR
V
-----
C
D
K
H
-
L
A
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
-
Y
L
L
K
I
N
F
T
A
--------
P
FN
D
S
-
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.59
66%
-98
- C1 -
2E4V
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.48
66%
-97
- C1 -
2E4W
2
GRM3_RAT
B:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.48
66%
-100
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------------QV---
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
82.43
67%
-99
- C1 -
2E4U
2
GRM3_RAT
A:
[7-543]
-----------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-----------Q--
V
-----
C
D
K
H
-
L
A
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
-
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
K
G
A
--
D
S
-
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
---
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.33
66%
-95
- C1 -
2E4V
2
GRM3_RAT
B:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.30
67%
-106
- C1 -
3SM9
8
GRM3_HUMAN
A:
[5-475]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
-
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
-
G
R
--
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
NH-------
R
R
---
V
-----
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
--------
D
S
-
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.05
66%
-95
- C1 -
2E4X
2
GRM3_RAT
B:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NH
R
Q
V
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.75
66%
-97
- C1 -
2E4U
2
GRM3_RAT
B:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------------QV---
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.51
67%
-105
- C1 -
5CNM
5
?
A:
[32-497]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
-
G
---
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
NH-------
R
R
---
V
-----
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
P
N
K
-
D
A
--
D
S
-
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-------
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.93
67%
-96
- C1 -
4XAR
9
GRM3_HUMAN
A:
[32-505]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
S
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----------
R
---
V
-----
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
------
D
A
--
D
S
-
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.19
66%
-92
- C1 -
2E4Y
1
GRM3_RAT
B:
[6-484]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
----
G
T
G
T
E
E
------
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
Q
E
A
R
L
R
N
I
C
I
A
T
A
E
K
V
-
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
---------
N
K
---
R
NHRQV
C
D
K
H
L
A
-
I
--
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
-
N
-
K
G
--
A
D
-
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
S
R
N
S
---
V
P
T
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.38
42%
-96
- C1 -
1EWK
7
GRM1_RAT
B:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
-----
V
-
G
-
V
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.32
42%
-93
- C1 -
1ISS
1
GRM1_RAT
B:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I-----------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
-----
V
-
G
-
V
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.95
42%
-97
- C1 -
2E4Z
1
GRM7_RAT
A:
[8-479]
----------------------
P
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
----
G
P
S
G
V
P
------
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
I
-
Q
K
--------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P-----
T
I
D
F
D
-
R
I
I
K
Q
L
L
D
T
-
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
QV
G
H
--
F
L
W
V
G
S
D
S
W
G
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
----------------
K
-----
C
T
G
Q
-
E
-
R
IG
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
I
R
H
V
N
F
N
------
G
-
S
A
--
G
T
-
P
-
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
T
N
T
T
N
P
G
Y
R
L
I
G
Q
W
T
D
E
-
L
Q
L
N
I
E
D
M
Q
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
70.58
41%
-93
- C1 -
3KS9
2
GRM1_HUMAN
B:
[8-482]
------------------
Q
---
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
S
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
NF-------
K
R
---
I
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
-
D
F
L
I
K
S
S
F
I
G
V
-------
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.45
42%
-93
- C1 -
1ISS
1
GRM1_RAT
A:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I-----------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
-----
V
-
G
-
V
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
69.56
44%
-81
* C1 *
1EWK
5
GRM1_RAT
A:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
K
P
---------------------------
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
-
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
--
V
V
GE
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
L
I
-
K
S
S
F
V
G
V
-------
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
-
V
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.37
42%
-86
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
-----
V
-
G
-
V
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.88
42%
-88
- C1 -
1ISR
3
GRM1_RAT
A:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE
K
V
P
E
R
K
------
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
-
K
E
L
A
A
Q
E
G
L
C
I
A
H
S
D
K
I
-
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
GHLLENPNF
K
K
---
V
-----
C
T
G
N
-
E
-
S
--
L
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
-----
V
-
G
-
V
S
--
G
E
-
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.79
39%
-88
- C1 -
3LMK
4
GRM5_HUMAN
A:
[12-482]
---------------------
R
R
V
V
A
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
------
P
T
V
D
KVHERK
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
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T
L
L
P
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L
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D
S
C
W
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A
V
A
L
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Q
S
I
E
F
I
R
D
--------------------------
K
P
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
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D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
-
K
D
M
S
A
K
E
G
I
S
I
A
H
S
Y
K
I
-
Y
S
N
A
G
E
Q
S
F
D
-
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
LA
G
E
--
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
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A
V
G
G
I
T
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L
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P
D
V
K
W
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D
D
Y
Y
L
K
L
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T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
E
G--------
N
K
---
T
-----
C
N
S
S
-
L
-
T
--
L
K
T
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
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M
Q
M
S
L
C
P
G
Y
A
G
L
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D
A
M
K
P
I
D
G
R
K
-
L
-
L
E
S
L
---
M
K
T
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F
T
G
V
S
-
G
-
D
T
-------
I
L
F
D
E
N
G
D
S
P
G
R
Y
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F
K
E
M
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K
D
Y
F
D
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
68.35
39%
-86
- C1 -
3LMK
3
GRM5_HUMAN
B:
[13-482]
----------------------
R
V
V
A
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
------
P
T
V
D
KVHERK
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
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L
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C
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I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
--------------------------
K
P
I
V
G
V
I
G
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G
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S
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V
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Q
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N
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-
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--
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W
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N
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---
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-----
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---
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K
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V
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G
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T
-------
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L
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N
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D
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K
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Y
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S
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D
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G
E
L
K
M
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------