@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM3_HUMAN: (2016-01-10 )
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
Atome Classification :
(35 SA)
.........10........20........30........40........50.----...----.----...60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...-....240.......250...--..-..260....-...270.......280.......290--..--.....300.......310.......320.......330.......340.......350.......360.--..----....370.....-..-380.......390.......400.......410.......420.......-430........440.....-..450........460.......470-..-.-...-.480....-..-.490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
M
L
T
R
L
Q
V
L
T
L
A
L
FSK
G
F
L
L
SLGD
H
N
F
L
R
R
E
I
K
IEG
D
L
V
L
GGLFPINEKGT----
G
T
E
----
E
----CGRI
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
EINKDDYLLP
G
V
K
L
G
V
H
I
L
DTCSR
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
TKVDEA
E
Y
MCPDGS
Y
A
I
QENI
P
L
L
I
A
GVIGGSY
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
QIPQISYASTSAKLSDKSR
Y
D
Y
F
A
RTV
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
TVASEGDYG
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
QK-PN
A
R
V
V
V
L
F
M
RSDDS
R
E
L
I
A
A
ASRAN--
A
S
--
F
T
W
V
ASDGWG
A
Q
E
S
I
IKGSE
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
SLNPYNNHRN
P
W
F
R
D
F
W
E
Q
K
F
Q
C
SL--QN----KR
N
H
R
R
V
C
D
K
HL-AI-DSSNYEQE
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
TLCP
N
T
T
K
L
C
D
A
M
K
IL
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
TAPFNPN-KDA-D
S
I
V
K
FDTFGDGMGRY
N
V
F
N
F
Q-NV-G-GK
Y
-
S
Y
L
K
VG
H
W
-
A
E
-
T
L
S
L
DV
N
S
I
HWSRNSVPTSQCSDPCAPNEMKNMQPG
D
V
C
C
W
I
C
IPC
E
P
Y
E
Y
L
A
D
E
F
T
C
MDCGSGQWPTADLTGCYDL
P
E
D
Y
I
R
WEDAWAI
G
P
V
T
I
A
C
L
G
F
M
C
T
C
M
V
V
T
V
F
I
KHNNT
P
L
V
KASGR
E
L
C
Y
I
L
L
F
GV
G
L
S
Y
C
M
T
F
F
FIAKP
S
P
V
I
C
A
L
R
R
LGLG
S
S
F
A
I
C
Y
S
A
L
L
TK
T
N
C
I
A
R
I
F
D
G
V
KNGAQRPKFISPS
S
Q
V
F
I
C
L
G
L
I
L
V
Q
I
V
M
V
S
V
W
L
I
L
EAPGTR
R
Y
T
LAEKR
E
T
V
I
L
K
C
NVKDS
S
M
L
I
S
L
T
Y
D
V
I
L
V
I
L
C
T
V
Y
A
F
KTRKCPENFNE
A
K
F
I
G
F
T
M
Y
T
T
C
I
I
W
L
A
F
L
P
I
F
Y
VTSSD
Y
R
V
Q
T
T
T
M
C
I
S
V
SLS
G
F
V
V
L
G
CLFAP
K
V
H
I
I
L
FQPQKN
V
V
T
H
R
L
H
L
N
R
F
S
VSGTGTTYSQSSASTYVPTVCN
G
R
E
V
L
D
S
TTSSL
3
PsiBlast_PDB
90.40
96%
-95
- C1 -
2E4W
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
90.15
96%
-96
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
I
--------------------
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
Q
----
V
------
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.01
96%
-94
- C1 -
2E4V
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
89.81
96%
-94
- C1 -
2E4U
2
GRM3_RAT
B:
[4-543]
---------------------------
F
M
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
----------
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.79
96%
-97
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
----------
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.56
96%
-92
- C1 -
2E4V
2
GRM3_RAT
B:
[4-543]
---------------------------
F
M
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.53
96%
-92
- C1 -
2E4X
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.34
96%
-93
- C1 -
2E4W
2
GRM3_RAT
B:
[4-543]
---------------------------
F
M
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.84
96%
-93
- C1 -
2E4X
2
GRM3_RAT
B:
[4-543]
---------------------------
F
M
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.66
96%
-93
- C1 -
2E4Y
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
88.30
95%
-96
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
----------
Q
V
C
D
K
H
L
A
I
D
-
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
-
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.18
99%
-104
- C1 -
3SM9
8
GRM3_HUMAN
A:
[5-475]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-----
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
-----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
-------
H
R
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
-------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
86.43
99%
-102
- C1 -
3SM9
8
GRM3_HUMAN
A:
[6-475]
------------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-----
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
-----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
-------
H
R
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
-
Y
L
L
K
I
N
F
T
A
-------
P
F
N
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.37
99%
-103
- C1 -
5CNM
5
?
A:
[32-497]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
-------
H
R
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
P
N
-
K
D
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
----------
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.97
99%
-95
- C1 -
5CNK
5
?
A:
[32-505]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
----------
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
P
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.78
99%
-94
- C1 -
4XAR
9
GRM3_HUMAN
A:
[32-510]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-------------
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
------
D
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.63
99%
-93
- C1 -
5CNK
3
?
C:
[32-510]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
----------
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
---
P
N
-
K
D
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
--
S
V
P
T
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.76
99%
-96
- C1 -
5CNK
4
?
B:
[32-501]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-------------
R
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
L
L
K
I
N
F
T
A
P
F
N
P
----
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
N
S
I
H
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.19
96%
-90
- C1 -
2E4Y
1
GRM3_RAT
B:
[6-484]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
--------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
--
Y
D
-
S
V
I
R
E
L
L
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
K
R
N
H
R
Q
V
C
D
K
H
L
-
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
A
P
F
N
P
N
-
K
G
A
-
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
-
G
-
G
K
Y
-
S
Y
L
K
V
G
H
W
-
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
P
T
S
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.39
67%
-90
- C1 -
5CNJ
1
?
B:
[25-490]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
S
--------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
---------
Q
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
--
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
A
-
G
S
G
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.34
67%
-91
- C1 -
5CNJ
2
?
A:
[25-490]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
---------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
---------
Q
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
--
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
A
-
G
S
G
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.09
66%
-92
- C1 -
5CNI
5
?
A:
[25-489]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
----------
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
--
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
A
-
G
--
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.88
66%
-93
- C1 -
4XAS
1
GRM2_HUMAN
A:
[25-489]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
---------
Q
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
--
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
A
-
G
-
G
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
76.72
66%
-92
- C1 -
4XAS
1
GRM2_HUMAN
B:
[25-489]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
---------
Q
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
R
P
--
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
----
G
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
76.10
66%
-91
- C1 -
5CNI
5
?
B:
[25-489]
-----------------------------
K
K
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
----
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
-----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
--
F
E
-
G
V
V
R
A
L
L
Q
K
-
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--
R
---------
Q
R
D
C
A
A
H
--
S
L
-
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
D
A
P
F
----
A
D
T
-
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
-
R
A
-
G
-
G
R
Y
-
R
Y
Q
K
V
G
Y
W
-
A
E
-
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.24
45%
-89
- C1 -
2E4Z
1
GRM7_RAT
A:
[8-479]
-----------------------------
P
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
G
P
----
S
G
V
----
P
----
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
I
Q
K
-------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------
T
I
D
F
D
-
R
I
I
K
Q
L
L
D
T
-
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
QV
G
H
--
F
L
W
V
G
S
D
S
W
G
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
---------------
K
C
T
G
Q
E
-
R
I
G
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
I
R
H
V
N
F
------
N
-
G
S
A
-
G
T
P
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
-
T
T
-
N
T
T
N
P
-
G
Y
R
L
I
G
Q
W
-
T
D
-
E
L
Q
L
N
I
E
D
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
69.35
45%
-81
* C1 *
1EWK
5
GRM1_RAT
A:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
----
V
PERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
K
P
-------------------------
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
-
R
L
L
R
K
L
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
--
V
V
GE
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
E
-
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
L
I
K
S
S
F
V
G
V
S
G
--------
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
H
E
G
-
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
68.58
41%
-85
- C1 -
1ISS
1
GRM1_RAT
B:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
---------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.43
41%
-86
- C1 -
1ISS
1
GRM1_RAT
A:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
---------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
68.22
41%
-88
- C1 -
3KS9
2
GRM1_HUMAN
B:
[9-482]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
----------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
-------
N
F
K
R
I
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
-
D
F
L
I
K
S
S
F
I
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.78
42%
-81
- C1 -
3LMK
3
GRM5_HUMAN
B:
[20-482]
------------------------------------
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
P
T
VDKV
H
E
R
----
K
----
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
----------------------
K
P
--
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
-
K
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
--
F
D
-
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
LA
G
E
--
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
EG--------
K
Y
N
K
T
C
N
S
S
L
-
T
L
--
K
T
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
E
S
-
L
M
K
T
N
F
T
G
V
------
S
G
-
D
T
I
L
-
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
-
E
M
-
G
-
K
D
Y
F
D
Y
I
N
V
G
S
W
-
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.32
41%
-88
- C1 -
1EWK
7
GRM1_RAT
B:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.15
41%
-79
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.97
41%
-79
- C1 -
1ISR
3
GRM1_RAT
A:
[4-480]
-----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
----
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
--
F
D
R
L
L
R
K
L
R
E
R
L
-
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
VV
G
E
--
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
--
P
G
HLLE
N
P
N
F
K
K
V
C
T
G
N
E
-
S
L
-
E
-
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
F
L
I
K
S
S
F
V
G
V
-------
S
-
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
-
A
-
N
R
Y
-
D
Y
V
H
V
G
T
W
-
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.82
42%
-83
- C1 -
3LMK
4
GRM5_HUMAN
A:
[20-482]
------------------------------------
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
P
T
VDKV
H
E
R
----
K
----
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D
----------------------
K
P
--
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
-
K
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
--
F
D
-
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
LA
G
E
--
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
EG----------
N
K
T
C
N
S
S
L
-
T
L
--
K
T
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
E
S
-
L
M
K
T
N
F
T
G
V
------
S
G
-
D
T
I
L
-
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
-
E
M
-
G
-
K
D
Y
F
D
Y
I
N
V
G
S
W
-
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------