@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM4_HUMAN: (2016-01-10 )
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
Atome Classification :
(28 SA)
.........10........20........30........40-........50........60....----.----...70........80........90........100.......110.......120..-...---..130.......140....-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.--......270..-..-...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440...-.-..-.-450....-------.------.------.460.......470.......480...-....-.490-........500......-.510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPGKRG
L
G
W
W
W
A
R
L
P
L
C
L
L
L
S
L
YGPWMPSSLGKPKGHPHM
N
-
S
I
R
IDG
D
I
T
L
G
G
L
F
PVHGRGSEGK----P----
C
G
E
L
K
K
E
KG
I
H
R
L
E
A
M
L
F
A
L
D
RINNDPDLLPNI
T
L
G
A
R
I
L
D
T
CSR
D
T
H
A
L
E
Q
S
L
T
F
V
Q
-
A
L
I
---EKDG
T
E
V
RCGSGGPPIITK-PE
R
V
V
G
V
IGASG
S
S
V
S
I
M
V
A
N
I
L
R
L
FKIPQISYASTAPDLSDNS
R
Y
D
F
F
S
RVVPSDT
Y
Q
A
Q
A
M
V
D
I
V
R
A
L
K
W
N
Y
V
S
T
VASEGSY
G
E
S
G
V
E
A
F
I
Q
K
SREDG
G
V
C
I
A
QSVKIPREPKAG--
E
F
D
K
I
I
R
R
L
L
E-TS-NA
R
A
V
I
I
FAN
E
D
D
I
R
R
V
L
E
A
A
R
RANQT
G
H
F
F
W
MGSDSWGSK
I
A
P
V
L
H
L
E
E
VAEG
A
V
T
I
LPKRMSV
R
G
F
D
R
Y
F
SSRTLDNNR
R
N
I
W
F
A
EFWEDN
F
H
C
K
L
S
R
H
A
L
KKG
S
H
V
K
K
CT
N
R
E
RIGQDSAYEQEG
K
V
Q
F
V
I
D
A
V
Y
A
M
G
H
A
L
H
A
M
H
R
DLCPGRVGLCPRMDPV
D
G
T
Q
-
L
-
L
K
-
Y
-
I
RNVNFS-------G------I------AGNP
V
T
FNENGDAPGRY
D
I
Y
Q
Y
Q
-LRN-DSA
E
-
Y
K
V
--
I
GSWT
D
H
L
H
L
R
I
E
R
MHW-PGS
G
Q
Q
L
P
R
S
I
CSLPCQPGERKKTVKGM
P
C
C
W
HCEPCTG
Y
Q
Y
Q
V
D
R
Y
T
CKTCPYDMRPTENRTGCRPI
P
I
I
K
L
EWGSP
W
A
V
L
P
L
F
L
A
V
V
G
I
A
A
T
L
F
V
V
I
T
F
V
RYNDT
P
I
V
KASGR
E
L
S
Y
V
L
L
A
G
I
F
L
C
Y
A
T
T
F
L
M
I
AEPDL
G
T
C
S
L
R
R
I
F
L
GLGM
S
I
S
Y
A
A
L
L
TK
T
N
R
I
Y
R
I
F
E
QGKRSVSAPRFISP
A
S
Q
L
A
I
T
F
S
L
I
S
L
Q
L
L
G
I
C
V
W
F
V
VDPSH
S
V
VDFQDQRTL
D
P
R
F
A
R
G
V
L
K
CDIS
D
L
S
L
I
C
L
L
G
Y
S
M
L
L
M
V
T
C
T
V
Y
A
I
KTRGVPETFNEAKPI
G
F
T
M
Y
T
T
C
I
V
W
L
A
F
I
P
I
FFGTSQSA
D
K
L
Y
I
Q
T
T
T
L
T
V
S
V
S
L
S
A
S
V
S
L
G
M
L
YM
P
K
V
Y
I
I
L
F
HPEQN
V
P
K
R
K
R
S
L
K
A
V
V
T
A
A
TMSNKFTQKGNFRPNG
E
A
K
S
E
L
C
E
NLEAPALAT
K
Q
T
Y
V
T
YTNHAI
1
PsiBlast_PDB
93.08
68%
-99
- C1 -
2E4Z
1
GRM7_RAT
A:
[8-479]
-------------------------------------
P
H
---
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
G
P
S
G
V
----
P
----
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
-
A
L
I
---
Q
K
------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------T
I
D
F
D
R
I
I
K
Q
L
L
D
-
T
P
-
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
W
V
G
S
D
S
W
G
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
-------------
K
C
T
G
Q
E
R
I
G
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
-
I
R
H
V
N
F
N
-------
G
------
S
------
A
G
T
P
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
-
T
T
N
-
T
T
N
P
G
Y
R
L
--
I
G
Q
W
T
D
E
L
Q
L
N
I
E
D
M
Q
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
83.92
48%
-96
- C1 -
3SM9
8
GRM3_HUMAN
A:
[7-475]
------------------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
-
Y
-
L
L
K
I
N
F
T
-------
A
------
P
FN----
D
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.82
47%
-97
- C1 -
3SM9
8
GRM3_HUMAN
A:
[8-474]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
---
H
R
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
-------
A
PFN-----------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
83.77
48%
-81
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
---------------------------------------
R
R
-
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
---------------------
L
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
-
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
-
E
Y
L
L
K
I
Q
F
T
APFNPN-
K
------
G
------
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
-
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.34
46%
-85
- C1 -
2E4U
2
GRM3_RAT
A:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.27
46%
-85
- C1 -
2E4W
2
GRM3_RAT
A:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.15
46%
-86
- C1 -
2E4U
2
GRM3_RAT
B:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.76
46%
-84
- C1 -
2E4V
2
GRM3_RAT
B:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.67
46%
-84
- C1 -
2E4W
2
GRM3_RAT
B:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.59
46%
-83
- C1 -
2E4X
2
GRM3_RAT
B:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.59
46%
-80
- C1 -
2E4Y
2
GRM3_RAT
A:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.51
46%
-82
- C1 -
2E4V
2
GRM3_RAT
A:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
82.46
47%
-84
- C1 -
2E4U
2
GRM3_RAT
A:
[7-543]
----------------------------------------
R
-
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
---------------------
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
-
Y
-
L
L
K
I
Q
F
T
APFNPNK
G
------
A
------
D
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
-
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.30
46%
-80
- C1 -
2E4X
2
GRM3_RAT
A:
[9-543]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
81.69
45%
-91
- C1 -
1EWT
3
GRM1_RAT
B:
[8-470]
--------------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
SIR---------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
--
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
V
-------
G
------
V
------
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
-
Y
V
H
--
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.88
44%
-90
- C1 -
3KS9
2
GRM1_HUMAN
B:
[13-475]
--------------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
-------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
-------
N
F
K
R
I
C
T
G
N
E
S
L
E
E
N
--
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
I
-------
G
------
V
------
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
-
Y
V
H
--
V
G
T
W
H
E
G
V
L
N
I
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
80.66
45%
-82
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
---------------------------------------
R
S
-
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
----
V
PERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
-
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
R
L
P
-
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
V
-------
G
------
V
------
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
-
N
R
Y
D
-
Y
V
H
--
V
G
T
W
H
E
G
-
V
L
N
I
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.57
45%
-89
- C1 -
1EWK
7
GRM1_RAT
B:
[8-470]
--------------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
--
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
V
-------
G
------
V
------
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
-
Y
V
H
--
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.13
45%
-80
- C1 -
1EWK
5
GRM1_RAT
A:
[8-470]
--------------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
VPER
K
----
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
--
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
V
-------
G
------
V
------
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
-
Y
V
H
--
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.01
44%
-96
- C1 -
5CNJ
2
?
A:
[24-490]
--------------------------------------
A
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
-----------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APFRP--
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
A
-
G
S
G
R
-
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.67
46%
-96
- C1 -
5CNM
5
?
A:
[32-497]
----------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
---
H
R
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
-------
A
PFNPNK
D
------
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
--------
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.83
46%
-88
- C1 -
4XAR
9
GRM3_HUMAN
A:
[32-501]
----------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----------
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
-------
A
P-----
D
------
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
V
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
-
S
R
N
S
V
P
T
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.99
44%
-90
- C1 -
5CNI
5
?
A:
[25-489]
---------------------------------------
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
-
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APFRP--
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
A
-
G
--
R
-
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.65
46%
-82
- C1 -
2E4Y
1
GRM3_RAT
B:
[9-484]
-------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
----
E
----
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
-
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
------
P
FNPNKG
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
T
G
-
G
K
Y
S
-
Y
L
K
--
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
---
S
R
N
S
V
P
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.55
44%
-89
- C1 -
5CNI
5
?
B:
[25-489]
---------------------------------------
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APF----
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
A
-
G
-
G
R
-
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.85
44%
-91
- C1 -
4XAS
1
GRM2_HUMAN
A:
[25-489]
---------------------------------------
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APFRP--
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
A
-
G
-
G
R
-
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.62
44%
-93
- C1 -
5CNJ
1
?
B:
[25-490]
---------------------------------------
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
---
S
-------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APFRP--
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
A
-
G
S
G
R
-
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
76.18
44%
-91
- C1 -
4XAS
1
GRM2_HUMAN
B:
[25-489]
---------------------------------------
K
K
-
V
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
----
D
----
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
G
V
V
R
A
L
L
Q
-
K
P
-
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
R
D
C
--
A
A
H
S
L
R
A
V
---------
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
D
APFRP--
A
------
D
------
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
--
L
R
----
G
R
-
Y
R
Y
QK
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------