@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM6_HUMAN: (2016-01-10 )
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
Atome Classification :
(30 SA)
.........10........20........30........40.......----.50---.........60........70........80........90........100.......110..-.....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......--.260.......-.270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430...-....440-.-.-......450----.-------..--......460.......470...-....480.......490...-....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARPRRAREP
L
L
V
A
L
L
P
L
A
W
L
A
QA
G
L
A
RAAG
S
V
R
L
AG
G
L
T
LGGLFPVH----AR----GAA
G
R
A
C
G
Q
L
K
K
E
Q
G
V
H
R
L
E
A
M
L
Y
A
L
D
RVNADPELL
P
G
V
R
L
G
A
R
L
L
D
T
CSR
D
T
Y
A
L
E
Q
A
L
S
F
V
Q
-
A
L
I
RGRGDGDE
V
G
V
RCPGGVPPLRPAPPE
R
V
V
A
V
VGASASS
V
S
I
M
V
A
N
V
L
R
L
F
AIPQISYASTAPELSDST
R
Y
D
F
F
S
RVVPPD
S
Y
Q
A
Q
A
M
V
D
I
V
R
A
L
G
W
N
Y
V
S
T
L
ASEGNY
G
E
S
G
V
E
A
F
V
Q
I
S
REAG
G
V
C
I
A
QSIKIPREPKPG--
E
F
S
-
K
V
I
R
R
L
M
-ETPNA
R
G
I
I
I
F
AN
E
D
D
I
R
R
V
L
E
A
A
R
QANL
T
G
H
F
L
W
VGSDSWGAKTS
P
I
L
S
L
EDV
A
V
G
A
I
T
ILPKRASID
G
F
D
Q
Y
F
M
T
RSLENNR
R
N
I
W
F
A
E
F
W
EENF
N
C
K
L
TSSGTQSDDSTRKCTGEERIGRDSTYEQEG
K
V
Q
F
V
I
D
A
V
Y
A
I
A
H
A
L
H
S
M
H
Q
A
LCPGHTGLCPAMEP-T
D
G
R
M
-
L
-
L
-
Q
-
Y
I
R
A
VRF------N-------GS--AGT
P
V
M
FNENGDAPGR
Y
D
I
F
Q
Y
-QATNGSASSG
G
Y
Q
A
V
G
Q
W
A
E
-
T
L
R
L
D
V
E
ALQWSG
D
P
H
E
V
P
S
S
L
CSLPCG
P
G
E
R
K
K
M
VKGVP
C
C
W
HCEACDG
Y
R
F
Q
VD
E
F
TCEACPGDMRPTPNHTGCRPT
P
V
V
R
L
SWSSPWAA
P
P
L
L
L
A
V
L
G
I
V
A
T
T
T
V
V
A
T
F
V
RYNN
T
P
I
V
R
ASGR
E
L
S
Y
V
L
L
T
G
I
F
L
I
Y
A
I
T
F
L
M
VAEP
G
A
A
V
C
A
A
R
R
L
F
L
GLGT
T
L
S
Y
S
A
L
L
TK
T
N
R
I
Y
R
I
F
E
QGKRSVTPPPFISPT
S
Q
L
V
I
T
F
SL
T
S
L
Q
V
V
G
M
I
A
W
LGARPPHSVID
Y
E
E
QRTV
D
P
E
QA
R
G
V
L
K
CDM
S
D
L
S
L
I
G
C
L
G
Y
S
L
L
L
M
V
T
C
T
V
Y
A
I
KARGVPETFNEAKPI
G
F
T
M
Y
T
T
C
I
I
W
L
A
F
V
P
I
F
FGTAQSA
E
K
I
Y
I
Q
T
T
T
L
T
V
S
L
S
L
S
A
S
V
S
L
G
M
L
Y
VP
K
T
Y
V
I
L
FHPEQ
N
V
Q
K
R
K
R
S
LKATSTVAAPPKGEDAEAHK
1
PsiBlast_PDB
93.71
66%
-110
- C1 -
2E4Z
1
GRM7_RAT
A:
[8-479]
-----------------------------
P
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
----
A
K
----
G
P
S
G
V
P
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
-
A
L
I
Q
K
----------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------T
I
D
F
D
-
R
I
I
K
Q
L
L
-
D
T
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
W
V
G
S
D
S
W
G
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
-------------
K
C
T
G
Q
E
R
I
G
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
-
A
G
G
K
K
-
L
-
L
-
K
-
Y
I
R
H
V
N
F
------
N
-------
G
S
--
A
G
T
P
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
-
Q
T
T
N
--
T
T
N
P
G
Y
R
L
I
G
Q
W
T
D
-
E
L
Q
L
N
I
E
D
M
Q
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
87.12
48%
-94
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
-----------------------
S
L
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
-
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
-
Y
-
K
-
E
-
Y
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
---
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.13
46%
-105
- C1 -
3SM9
8
GRM3_HUMAN
A:
[8-475]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
-
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
--------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
---
H
R
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
-
K
D
Y
L
L
K
I
N
F
T
APFN--------------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
86.09
48%
-102
- C1 -
3SM9
8
GRM3_HUMAN
A:
[7-475]
-------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
-
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
--------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
I
-
S
I
A
T
A
E
K
V
G
R
--
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
L
Y
-
K
-
D
-
Y
L
L
K
I
N
F
------
T
-------
A
P
FN
D
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
---
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
85.85
47%
-97
- C1 -
2E4U
2
GRM3_RAT
A:
[8-543]
-------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
-
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
Y
K
-
E
-
Y
L
L
K
I
Q
F
------
T
APFNPNK
G
A
--
D
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
---
K
Y
S
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.58
45%
-93
- C1 -
2E4X
2
GRM3_RAT
B:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.32
45%
-95
- C1 -
2E4W
2
GRM3_RAT
A:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.25
45%
-97
- C1 -
2E4U
2
GRM3_RAT
A:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.22
45%
-92
- C1 -
2E4Y
2
GRM3_RAT
A:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.16
45%
-93
- C1 -
2E4V
2
GRM3_RAT
A:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.95
45%
-97
- C1 -
2E4U
2
GRM3_RAT
B:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.85
45%
-93
- C1 -
2E4V
2
GRM3_RAT
B:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.82
45%
-91
- C1 -
2E4X
2
GRM3_RAT
A:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.77
45%
-94
- C1 -
2E4W
2
GRM3_RAT
B:
[9-543]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.77
46%
-104
- C1 -
5CNM
5
?
A:
[35-497]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
---
H
R
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
-
K
D
Y
L
L
K
I
N
F
T
APFNP
N
-------
K
D
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
------
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.85
46%
-96
- C1 -
5CNK
5
?
A:
[35-505]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
-
K
D
Y
L
L
K
I
N
F
TAPFNP-------------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.52
46%
-94
- C1 -
5CNI
5
?
B:
[30-489]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
--------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
---------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APF----
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.52
46%
-97
- C1 -
4XAS
1
GRM2_HUMAN
A:
[30-489]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
--------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
---------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APFRP--
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.51
46%
-97
- C1 -
5CNJ
2
?
A:
[30-490]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
------------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
---------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APFRP--
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
80.47
46%
-97
- C1 -
5CNK
3
?
C:
[35-509]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
-
K
D
Y
L
L
K
I
N
F
TAP---
N
-------
K
D
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
--
S
--
V
P
T
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.99
46%
-94
- C1 -
5CNI
5
?
A:
[30-489]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
--------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
----------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APFRP--
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
--
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.54
46%
-96
- C1 -
5CNJ
1
?
B:
[30-490]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
S
-----------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
---------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APFRP--
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.28
45%
-92
- C1 -
2E4Y
1
GRM3_RAT
B:
[9-484]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-----------------------
I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.18
46%
-96
- C1 -
4XAR
9
GRM3_HUMAN
A:
[35-509]
--------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
----
E
K
----
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
--
S
Y
D
-
S
V
I
R
E
L
L
-
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
------------
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
-
K
D
Y
L
L
K
I
N
F
T
AP------------
D
--
A
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
Y
S
---
Y
L
K
V
G
H
W
A
E
-
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
--
V
P
T
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
78.65
41%
-95
- C1 -
1EWK
7
GRM1_RAT
B:
[8-480]
---------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
HQPP
A
E
----
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
P
--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
-
I
D
G
R
K
-
L
-
L
-
D
-
F
L
I
K
S
S
F
------
V
-------
G
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
--
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
78.31
46%
-95
- C1 -
4XAS
1
GRM2_HUMAN
B:
[30-489]
----------------------------------
L
E
G
D
L
V
L
G
G
L
F
P
V
H
----
Q
K
----
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
--------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
--
A
F
E
-
G
V
V
R
A
L
L
-
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
R
Q
---------
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
-
V
N
G
R
R
-
L
-
Y
-
K
D
F
V
L
N
V
K
F
------
D
APFRP--
A
D
--
T
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
---
G
R
Y
R
---
Y
Q
K
V
G
Y
W
A
E
-
G
L
T
L
D
T
S
L
I
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.58
40%
-98
- C1 -
3KS9
2
GRM1_HUMAN
B:
[8-482]
----------------------------
Q
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
HQPP
A
E
----
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
------------------------
K
P
--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
-------
N
F
K
R
I
C
T
G
N
E
S
L
--
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
-
I
D
G
S
K
-
L
-
L
-
D
-
F
L
I
K
S
S
F
------
I
-------
G
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
--
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.37
41%
-97
- C1 -
1ISS
1
GRM1_RAT
B:
[8-480]
---------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
HQPP
A
E
----
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-----------------------
K
P
--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
-
I
D
G
R
K
-
L
-
L
-
D
-
F
L
I
K
S
S
F
------
V
-------
G
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
--
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.98
41%
-97
- C1 -
1ISS
1
GRM1_RAT
A:
[8-480]
---------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
HQPP
A
E
----
K
V
P
E
R
K
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-----------------------
K
P
--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
--
S
F
D
R
L
L
R
K
L
R
E
-
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
-
I
D
G
R
K
-
L
-
L
-
D
-
F
L
I
K
S
S
F
------
V
-------
G
V
--
S
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
--
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.80
39%
-91
- C1 -
3LMK
3
GRM5_HUMAN
B:
[17-482]
---------------------------------
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
----
H
Q
PTVD
K
V
H
E
R
K
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D--------------------------
K
P
--
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
K
E
-
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
--
S
F
D
-
K
L
L
K
K
L
T
S
H
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
--
E
G
------
K
Y
N
K
T
C
N
S
S
L
T
L
K
T
H
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
-
I
D
G
R
K
-
L
-
L
-
E
-
S
L
M
K
T
N
F
------
T
-------
G
V
--
S
G
D
T
I
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
-
K
E
M
G
K
D
Y
F
D
--
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------