@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM7_HUMAN: (2016-01-10 )
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140....-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....-.-.450-......------.-------.460-........470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
Q
L
R
K
L
L
R
V
L
T
L
MKF
P
C
C
V
L
E
V
L
L
C
A
L
A
A
AARGQEMYAP
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
HAKGPSGVPCGDIKRENG
I
H
R
L
E
A
M
L
Y
A
L
D
QINSDPNLLPNV
T
L
G
A
R
I
L
D
T
CSR
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
I
QKDTSDVRCTNGEP
P
V
F
V
K
-
P
E
K
V
V
G
V
IGASG
S
S
V
S
I
M
V
A
N
I
L
R
L
FQIPQISYASTAPELSDDR
R
Y
D
F
F
S
RVVPPD
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
ASEGSY
G
E
K
G
V
E
S
F
T
Q
I
S
K
EAG
G
L
C
I
A
QSVRI
P
Q
ERKDRTI
D
F
D
R
I
I
K
Q
L
LDTPNS
R
A
V
V
I
F
AN
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
DQV
G
H
F
L
W
VGSDSWGSKINP
L
H
Q
H
EDIAE
G
A
I
T
I
QPKRATVE
G
F
D
A
Y
F
T
SRTLENNRR
N
V
W
F
A
E
Y
W
EENF
N
C
K
L
T
ISGSKKEDTDRKCTG
Q
E
RIGKDSNYEQEG
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
HM
N
K
D
L
C
A
D
Y
R
GVC
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
-
I
RNVNF------N-------GSA--GT
P
V
M
F
NKNGDAPGR
Y
D
I
F
Q
Y
QTTNTSNP
G
Y
R
L
I
GQWTD
E
L
Q
L
NI
E
D
M
Q
WG
K
G
V
R
E
IPASVCTLPCKPGQRKKTQKGT
P
C
C
W
TCEPCDG
Y
Q
Y
Q
FDEM
T
C
QHCPYDQRPNENRTGCQDI
P
I
I
K
L
EWHSPW
A
V
I
P
V
F
L
A
M
L
G
I
I
A
T
I
F
V
M
A
T
F
I
RYNDT
P
I
V
R
ASGR
E
L
S
Y
V
L
L
T
G
I
F
L
C
Y
I
I
T
F
L
M
IAKP
D
V
A
V
C
S
F
R
R
V
F
L
G
L
G
M
C
I
S
Y
A
A
L
L
TK
T
N
R
I
Y
R
I
F
E
QGKKSVTAPRLISPT
S
Q
L
A
I
T
S
S
L
I
S
V
Q
L
L
G
V
F
I
W
FGVDPP
N
I
I
I
DYDEHKTM
N
P
E
Q
AR
G
V
L
K
CDI
T
D
L
Q
I
I
C
S
L
G
Y
S
I
L
L
M
V
T
C
T
V
Y
A
I
K
TRGVPENFNEAKPI
G
F
T
M
Y
T
T
C
I
V
W
L
A
F
I
P
I
F
FGTAQSA
E
K
L
Y
I
Q
T
T
T
L
T
I
S
M
NL
S
A
S
V
A
L
G
M
L
YM
P
K
V
Y
I
I
I
FHPEL
N
V
Q
K
R
K
R
S
F
K
A
V
V
T
A
A
T
M
S
S
R
LSHKPSDRPNG
E
A
K
T
E
L
CENVDPNSP
A
A
K
K
K
Y
VSYNNLVI
1
PsiBlast_PDB
92.64
99%
-95
- C1 -
2E4Z
1
GRM7_RAT
A:
[8-479]
---------------------------------------
P
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
G
P
S
G
V
P
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
I
Q
K
------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------
T
I
D
F
D
R
I
I
K
Q
L
L
D
T
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
W
V
G
S
D
S
W
G
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
-------------
K
C
T
G
Q
E
R
I
G
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
-
I
R
H
V
N
F
------
N
-------
G
S
A
--
G
T
P
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
T
N
T
T
N
P
G
Y
R
L
I
G
Q
W
T
D
E
L
Q
L
N
I
E
D
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.47
46%
-92
- C1 -
3SM9
8
GRM3_HUMAN
A:
[8-475]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
--
R
--
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
----
Q
N
---
H
R
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFN--------------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
77.29
47%
-87
- C1 -
3SM9
8
GRM3_HUMAN
A:
[6-475]
----------------------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
----------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
-
A
R
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
--
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-------
H
R
R
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
-
Y
-
L
L
K
I
N
F
------
T
-------
A
P
F
ND
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
G
K
-
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
76.59
47%
-75
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
------------------
L
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
N
-
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
----------
Q
Q
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
-
E
Y
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.84
44%
-73
- C1 -
2E4V
2
GRM3_RAT
A:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.81
44%
-75
- C1 -
2E4U
2
GRM3_RAT
A:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.70
44%
-74
- C1 -
2E4W
2
GRM3_RAT
A:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.19
44%
-76
- C1 -
2E4U
2
GRM3_RAT
B:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.14
44%
-70
- C1 -
2E4X
2
GRM3_RAT
A:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.05
44%
-73
- C1 -
2E4X
2
GRM3_RAT
B:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.98
44%
-73
- C1 -
2E4W
2
GRM3_RAT
B:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.71
44%
-73
- C1 -
2E4V
2
GRM3_RAT
B:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.50
44%
-91
- C1 -
5CNM
5
?
A:
[32-497]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
-----
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
----
Q
N
---
H
R
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFNP
N
-------
K
D
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
-------
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.45
44%
-84
- C1 -
4XAR
9
GRM3_HUMAN
A:
[32-509]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
---------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----------
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
AP------------
D
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
--
S
V
P
T
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.42
45%
-73
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
------------------
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
-
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
--
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
C
D
K
H
L
A
I
D
S
-
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
-
Y
-
L
L
K
I
Q
F
------
T
APFNPNK
G
A
D
--
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
-
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.94
43%
-78
- C1 -
4XAS
1
GRM2_HUMAN
A:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
--
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
Q
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.87
44%
-70
- C1 -
2E4Y
2
GRM3_RAT
A:
[9-543]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.73
44%
-82
- C1 -
5CNK
5
?
A:
[32-505]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
----
Q
------
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
TAPFNP-------------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
--
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.42
43%
-82
- C1 -
5CNJ
2
?
A:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
--------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
--
G
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
Q
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.20
44%
-82
- C1 -
5CNK
3
?
C:
[32-509]
---------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
----
Q
------
R
V
C
D
K
H
L
A
I
-
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
TAP---
N
-------
K
D
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
----
S
V
P
T
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.00
43%
-78
- C1 -
5CNI
5
?
A:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
--
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
-
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
--
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.92
43%
-77
- C1 -
5CNI
5
?
B:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
--
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
Q
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APF----
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.53
43%
-80
- C1 -
5CNJ
1
?
B:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L
S
-------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
--
G
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
Q
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.87
43%
-78
- C1 -
4XAS
1
GRM2_HUMAN
B:
[28-489]
------------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
G
G
P
A
E
D
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
----------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
--
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
---------
R
Q
R
D
C
A
A
H
S
L
--
R
A
V
P
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
---
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.47
44%
-72
- C1 -
2E4Y
1
GRM3_RAT
B:
[9-484]
------------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
--
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
--
A
S
F
T
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----
Q
N
K
R
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
-
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------