@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRM8_HUMAN: (2016-01-10 )
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
Atome Classification :
(32 SA)
.........10........20........30........40........50......------.-.60..---......70........80........90........100.......110.......120...---.....130.......140.-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.-......270-........280.......290.......300.......310..--.....320.......330.......340.......350.......360.......370.......380..-......390...-....400.......410.......420.......430.......440.-.-.-.-....450-----.-------...--....460.......470....-...480-.-.-.....490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVCEGKRSASC
P
C
F
F
L
L
T
A
K
F
Y
W
I
L
T
M
M
Q
R
T
H
S
Q
E
Y
A
H
S
IRVDG
D
I
I
L
GGL
F
P
VHAK------G-ERGVP---C
G
E
L
K
K
E
KG
I
H
R
L
E
A
M
L
Y
A
I
D
QINKD
P
D
L
L
S
N
I
T
L
G
V
R
I
L
D
TCSR
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
-
A
L
I
---EKDASDVKCANGDPPIFTK-P
D
K
I
S
G
V
I
GAA
A
S
S
V
S
I
M
V
A
N
I
L
R
L
FKIPQISYASTAPELSDNT
R
Y
D
F
F
S
RVVPPDS
Y
Q
A
Q
A
M
V
D
I
V
T
A
L
G
W
N
Y
V
S
T
L
ASEGNYG
E
S
G
V
E
A
F
T
Q
I
S
R
EIG
G
V
C
I
AQSQKIPREPRP
G
E
F
E
-
K
I
I
K
R
L
L-E-TPNA
R
A
V
I
M
FA
N
E
D
D
I
R
R
I
L
E
A
A
K
K
LNQSG
H
F
L
W
IGSDSWGSK--IA
P
V
Y
Q
Q
E
E
IAEG
A
V
T
I
LPKRASI
D
G
F
D
R
Y
F
R
S
RTLANNRR
N
V
W
F
A
E
F
W
EENFGCKLGSHGKRNS
H
-
I
K
K
-CT
G
L
E
R
I
ARDSS-YEQEG
K
V
Q
F
V
I
D
A
V
Y
S
M
A
Y
A
L
H
N
M
H
K
D
LCP
G
Y
I
GLCPRMSTI
D
G
K
E
-
L
-
L
-
G
-
Y
-
I
R
A
V
NF------N-------GSA--GT
P
V
T
FNENGDAPGR
Y
D
I
F
Q
Y
-
Q
ITNKS-T-
E
-
Y
K
V
I
G
H
WT
N
Q
L
H
L
K
V
E
D
M
Q
W
A
H
REHTHP
A
S
V
CSLPCKPGERKKTVKGVPC
C
W
H
C
E
RCEGYNY
Q
V
DELSCELCPLDQRPNMNRTG
C
Q
L
I
P
I
I
K
L
EWHSP
W
A
V
V
P
V
F
V
A
I
L
G
I
I
A
T
T
F
V
I
V
T
F
V
RYNDT
P
I
V
R
ASGR
E
L
S
Y
V
L
L
T
G
I
F
L
C
Y
S
I
T
F
L
M
IAAP
D
T
I
I
C
S
F
R
R
V
F
L
G
L
G
M
C
F
S
Y
A
A
L
L
TK
T
N
R
I
H
R
I
F
E
QGKKSVTAPKFISPA
S
Q
L
V
I
T
F
S
L
I
S
V
Q
L
L
G
V
F
V
W
F
V
VDP
P
H
I
I
I
DYGEQRTL
D
P
E
KA
R
G
V
L
K
CDI
S
D
L
S
L
I
C
S
L
G
Y
S
I
L
L
M
V
T
C
T
V
Y
A
I
KTRGVPETFNEAKPI
G
F
T
M
Y
T
T
C
I
I
W
L
A
F
I
P
I
F
FGTAQSA
E
K
M
Y
I
Q
T
T
T
L
T
V
S
M
S
LS
A
S
V
S
L
G
M
L
YM
P
K
V
Y
I
I
I
FHPEQ
N
V
Q
K
R
K
R
S
F
K
A
V
V
T
A
A
T
M
Q
S
K
L
I
QKGNDRPN
G
E
V
K
S
E
L
C
E
S
L
ETNTSS
T
K
T
T
Y
I
SYSNHSI
1
PsiBlast_PDB
94.52
71%
-98
- C2 -
2E4Z
1
GRM7_RAT
A:
[9-479]
-------------------------------------
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
------
G
-
P
S
G
V
P
---
C
G
D
I
K
R
E
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
-
A
L
I
---
Q
K
------------------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
----
T
I
D
F
D
-
R
I
I
K
Q
L
L
-
D
-
T
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
W
V
G
S
D
S
W
G
S
K
--
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
-------------
K
-
C
T
G
Q
E
R
I
G
K
D
S
N
-
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
--
Y
R
G
V
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
-
K
-
Y
-
I
R
H
V
N
F
------
N
-------
G
S
A
--
G
T
P
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
-
Q
T
T
N
T
T
-
N
-
P
G
Y
R
L
I
G
Q
W
T
D
E
L
Q
L
N
I
E
D
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.15
46%
-78
- C2 -
2E4V
2
GRM3_RAT
A:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.06
46%
-81
- C2 -
2E4W
2
GRM3_RAT
A:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.78
46%
-76
- C2 -
2E4X
2
GRM3_RAT
A:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.77
46%
-78
- C2 -
2E4W
2
GRM3_RAT
B:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
87.65
48%
-76
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
---------------------
L
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
-
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
-
C
D
K
H
L
A
I
-
D
S
S
N
-
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
-
E
Y
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
V
--
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.63
46%
-78
- C2 -
2E4X
2
GRM3_RAT
B:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
87.14
46%
-78
- C2 -
2E4V
2
GRM3_RAT
B:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
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Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
86.95
46%
-80
- C2 -
2E4U
2
GRM3_RAT
B:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
--------
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.95
46%
-77
- C2 -
2E4Y
2
GRM3_RAT
A:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.93
46%
-80
- C2 -
2E4U
2
GRM3_RAT
A:
[9-543]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
--------
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
T
APFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
85.98
46%
-79
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
------------------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
---------------------
I
-
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
-
A
R
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
----------
Q
V
-
C
D
K
H
L
A
I
D
S
-
S
N
-
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
-
E
-
Y
-
L
L
K
I
Q
F
------
T
APFNPNK
G
A
D
--
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
85.69
44%
-80
- C2 -
1EWK
5
GRM1_RAT
A:
[4-480]
------------------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
PPAE--
K
-
V
P
E
R
K
---
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
----------------------------
K
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
G
-
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
-
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
-
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
R
Y
-
D
-
Y
V
H
V
G
T
W
H
E
G
-
V
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.09
47%
-94
- C2 -
3SM9
8
GRM3_HUMAN
A:
[8-475]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
-
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
H
-
R
R
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
-
Y
-
L
L
K
I
N
F
T
APFN--------------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.50
47%
-98
- C2 -
5CNM
5
?
A:
[35-497]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
----
H
-
R
R
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
-
Y
-
L
L
K
I
N
F
T
APFNP
N
-------
K
D
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
--------
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
84.38
47%
-92
- C2 -
3SM9
8
GRM3_HUMAN
A:
[6-475]
-------------------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
-
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
-------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
-
A
R
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
--
S
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
------
H
-
R
R
V
-
C
D
K
H
L
A
I
D
S
-
S
N
-
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
-
D
-
Y
-
L
L
K
I
N
F
------
T
-------
A
P
F
ND
S
-
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
84.27
43%
-83
- C2 -
1EWK
7
GRM1_RAT
B:
[8-479]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
-
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.83
43%
-86
- C2 -
1EWT
3
GRM1_RAT
B:
[8-479]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
SIR--------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
-
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.69
47%
-88
- C2 -
5CNK
4
?
B:
[35-501]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----------
R
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
-
Y
-
L
L
K
I
N
F
TAPFNP----------
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
83.43
43%
-75
- C2 -
1EWK
5
GRM1_RAT
A:
[8-479]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
---------------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
-
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.36
42%
-87
- C2 -
3KS9
2
GRM1_HUMAN
B:
[13-482]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
------------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
-------
N
-
F
K
R
I
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
I
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.14
47%
-87
- C2 -
4XAR
9
GRM3_HUMAN
A:
[35-502]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
------------------------
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
-----------
R
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
-
Y
-
L
L
K
I
N
F
T
AP------------
D
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
-
Q
N
V
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.81
43%
-87
- C2 -
4XAS
1
GRM2_HUMAN
A:
[28-489]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
-
Q
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
82.75
43%
-86
- C2 -
5CNJ
1
?
B:
[28-490]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
---
S
-------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
-
Q
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.52
43%
-85
- C2 -
5CNI
5
?
A:
[28-489]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
--
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
--
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.40
46%
-80
- C2 -
2E4Y
1
GRM3_RAT
B:
[9-484]
---------------------------------------
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
------
G
-
T
G
T
E
E
---
C
G
R
I
N
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
-
A
S
L
----------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
-
S
V
I
R
E
L
L
-
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
Q
--
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--
Q
N
K
R
N
-
H
-
R
Q
V
-
C
D
--
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
P
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
-
K
E
Y
-
L
L
K
I
Q
F
TAPFNP
N
-------
K
G
A
--
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
-
Q
Q
T
G
G
K
-
Y
-
S
-
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.11
43%
-88
- C2 -
5CNJ
2
?
A:
[28-490]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
L
-----------------------
P
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
S
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
-
Q
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
81.72
43%
-87
- C2 -
4XAS
1
GRM2_HUMAN
B:
[28-489]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
-
Q
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APFRP--
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
---
G
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
81.58
43%
-83
- C2 -
1ISS
1
GRM1_RAT
B:
[8-479]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-----------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
-
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.57
43%
-84
- C2 -
1ISS
1
GRM1_RAT
A:
[8-479]
----------------------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
------
P
P
A
E
K
V
P
ERK
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
-----------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
-
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
A
D
R
--
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
L
L
E
N
P
N
-
F
K
K
V
C
T
G
N
E
S
L
--
E
E
N
-
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
P
G
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
D
-
F
-
L
I
K
S
S
F
------
V
-------
G
V
S
--
G
E
E
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
-
Q
Y
T
E
A
N
-
R
Y
D
-
Y
V
H
V
G
T
W
H
E
G
V
-
L
N
I
D
D
Y
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.46
43%
-84
- C2 -
5CNI
5
?
B:
[28-489]
---------------------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
H
Q
K
------
G
-
G
P
A
E
D
---
C
G
P
V
N
E
H
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
-
A
S
-------------------------
T
A
I
T
G
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
-
E
L
E
A
R
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
-
G
V
V
R
A
L
L
-
Q
-
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
--
F
T
W
V
A
S
D
G
W
G
A
L
--
E
E
V
V
A
G
S
E
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
S
F
--------
R
-
Q
R
D
-
C
A
A
--
H
S
L
R
A
V
P
-
F
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
A
L
C
P
N
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
-
F
-
V
L
N
V
K
F
------
D
APF----
A
D
T
--
H
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
A
G
-
G
R
-
Y
-
R
-
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
81.25
42%
-77
- C2 -
3LMK
3
GRM5_HUMAN
B:
[20-482]
-------------------------------------------
G
D
I
I
I
G
A
L
F
S
V
H
H
Q
PTVDKV
H
-
E
R
--
K
---
C
G
A
V
R
E
Q
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
R
D---------------------------
K
P
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
K
-
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
F
D
-
K
L
L
K
K
L
T
S
H
-
L
P
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
L
L
G
S
D
G
W
A
D
R
YD
V
T
D
G
Y
Q
R
E
A
V
--
G
G
I
T
I
K
L
Q
S
P
D
V
K
W
F
D
D
Y
Y
L
K
L
R
P
E
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N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
Q
C
R
L
E
G
------
K
-
Y
N
K
--
T
C
N
S
S
L
T
L
K
T
H
-
H
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
S
M
A
Y
G
L
H
N
M
Q
M
S
L
C
P
G
Y
A
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
-
E
-
S
-
L
M
K
T
N
F
------
T
-------
G
V
S
--
G
D
T
I
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
-
K
E
M
G
K
D
-
Y
F
D
-
Y
I
N
V
G
S
W
D
N
G
-
E
L
K
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------