@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HRH3_HUMAN: (2016-01-10 )
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
Atome Classification :
(20 SA)
........---.10........20........30.....-...40........50........60........70........80......-..90.....-...100.......110.......120.......130.......140.......150........160....-...170........180.-....---..190----...----.....200.......210-........220---------------.......---------230--------.........-------------240--------........250-----------.........260...-----------------------..----------..270.......280---....-----------------....--------------------.290.......300....--..--.310.-...--------------.-..320..--.....330-------.....---...340-------...----...--.--350...---....360-------------........370..-----------.....380------------.---------..--...---.390......-----.400.......410.....-..420.......430.......440...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MERAPPDG---PLNASGALAGEAAAAGGARG
F
S
A
A
W
T
A
V
-
L
A
A
L
M
A
L
L
I
V
A
T
V
L
G
N
A
L
V
M
L
A
F
VADSSLRTQN
N
F
F
L
L
N
L
A
I
S
D
F
L
V
G
A
F
C
-
I
P
L
Y
V
P
Y
VL-TGR
W
T
F
G
R
G
L
C
K
L
W
L
V
V
D
Y
L
L
CTSSA
F
N
I
V
L
I
S
Y
D
R
F
L
S
V
T
R
A
V
S
YRAQQG
D
T
R
-
R
A
V
R
K
M
L
L
V
W
V
L
A
F
L
L-YGP
A
-
I
L
S
W
E
Y
LSGGSSI-PE
G
H
---
C
Y
A
E
-----
F
F
Y
----
N
W
Y
F
L
I
T
A
S
T
L
E
F
F
T
P
F
--
L
S
V
T
F
F
N
L
S
I
Y
---------------
L
N
I
Q
R
R
T
---------
R
----------
L
RLDGAREA-------------AG---------PEPPPEAQP-------------SPPPPP
G
C
W
GCWQKG-----------------------HG----------EAM
P
L
H
RYGVGEA-----AVGA-----------------EAGE--------------------ATLGGGGGGGSVASPTSS--SG--SSSRG-TER--------------
P
-
R
S
LKRGS--KPSA
S
S
A
--------
S
L
E
K
R
---
M
K
M
V
S
Q
-------
S
F
T
----
Q
R
F--R--LS
R
D
R
K
---
V
A
K
S
L
A
--------------
V
I
V
S
I
F
G
L
C
W
A
P
Y
-----------
T
L
L
M
I
I
R
A
------------
A
---------CH--GHC---V
P
D
Y
WYE
T
S
F
-----
W
L
L
WANSAV
N
P
V
L
Y
P
L
C
H
H
-
S
F
R
R
A
F
T
K
LLCPQ
K
L
KIQPH
S
S
L
E
H
CWK---
1
PsiBlast_PDB
85.86
29%
-98
- C1 -
4U15
6
ACM3_RAT
A:
[8-398]
---------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
-
T
K
-
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
-
W
A
P
A
-
I
L
F
W
Q
Y
F
V
G
K
R
T
V
-
P
P
G
E
---
C
F
I
Q
-----
F
L
S
----
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
--
T
I
M
T
I
L
Y
W
R
I
Y
---------------
K
E
T
E
K
M
N
I
F
E
------
M
----------
L
R
I
D
E
G
G
G
S
-------------
G
G
---------
D
E
--
A
E
K
L
F
-------------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-----------------------
K
L
----------
K
P
V
----
Y
D
S
L
D
A
-----
V
R
R
A
-----------------
A
L
I
N
--------------------
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
--
M
L
--
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
----
W
D
A
--
Y
--
L
I
K
E
K
K
---
A
A
Q
T
L
S
--------------
A
I
L
L
A
F
I
I
T
W
T
P
Y
-----------
N
I
M
V
L
V
N
T
------------
F
---------
C
D
--
S
-
C
---
I
P
K
T
Y
W
N
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
-
T
F
R
T
T
F
K
T
L
----------------------
12
PsiBlast_PDB
85.70
24%
-166
- C1 -
3P0G
1
ENLYS_BPT4
A:
[37-480]
--------------------------------
D
E
V
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ET
C
C
D
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
-----------------
4
PsiBlast_PDB
83.77
28%
-104
- C1 -
4U14
1
ENLYS_BPT4
A:
[8-443]
---------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
-
T
T
K
-
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
-
W
A
P
A
-
I
L
F
W
Q
Y
F
V
G
K
R
T
V
-
P
P
G
E
---
C
F
I
Q
-----
F
L
S
----
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
--
T
I
M
T
I
L
Y
W
R
I
Y
---------------
K
E
T
E
K
M
N
C
F
E
M
L
R
I
D
E
G
----------
L
R
L
K
I
Y
K
D
C
-------------
E
G
Y
Y
T
I
G
IGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
L
D
A
V
R
R
C
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
--
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
C
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
----
W
D
A
--
Y
--
L
I
K
E
K
K
---
A
A
Q
T
L
S
--------------
A
I
L
L
A
F
I
I
T
W
T
P
Y
-----------
N
I
M
V
L
V
N
T
------------
F
---------
C
D
--
S
-
C
---
I
P
K
T
Y
W
N
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
-
T
F
R
T
T
F
K
T
L
L
L
--------------------
13
PsiBlast_PDB
83.66
24%
-99
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
I
F
E
M
L
---------
R
I
D
E
G
------
L
R
L
K
I
Y
K
D
T
-------------
E
G
YYTIGIGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
11
PsiBlast_PDB
82.03
24%
-104
- C1 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-478]
-----------------------------------
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
I
F
E
M
L
---------
R
I
D
E
G------
L
R
L
K
I
Y
K
D
T
-------------
E
G
Y
Y
T
I
G
IGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
2
PsiBlast_PDB
81.62
29%
-99
- C1 -
4U16
2
?
A:
[8-388]
---------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
-
T
K
-
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
-
W
A
P
A
-
I
L
F
W
Q
Y
F
V
G
K
R
T
V
-
P
P
G
E
---
C
F
I
Q
-----
F
L
S
----
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
--
T
I
M
T
I
L
Y
W
R
I
Y
---------------
K
E
T
E
K
M
N
I
F
E
------
M
----------
L
R
I
D
E
G
G
G
S
-------------
G
G
---------
D
E
--
A
E
K
L
F
-------------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-----------------------
K
L
----------
K
P
V
----
Y
D
S
L
D
A
-----
V
R
R
A
-----------------
A
L
I
N
--------------------
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
--
M
L
--
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
----
W
D
A
--
Y
--
L
I
K
E
K
K
---
A
A
Q
T
L
S
--------------
A
I
L
L
A
F
I
I
T
W
T
P
Y
-----------
N
I
M
V
L
V
N
T
------------
F
---------
C
D
--
S
-
C
---
I
P
K
T
Y
W
N
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
---------------------------------
9
PsiBlast_PDB
81.42
24%
-98
- C1 -
3NY8
7
ENLYS_BPT4
A:
[40-478]
-----------------------------------
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
I
F
E
M
L
---------
R
I
D
E
G------
L
R
L
K
I
Y
K
D
T
-------------
E
G
Y
Y
T
I
G
IGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
14
PsiBlast_PDB
81.18
24%
-101
- C1 -
3PDS
8
ADRB2_HUMAN (first)
A:
[5-446]
--------------------------------
D
E
V
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
I
F
E
M
L
---------
R
I
D
EG------
L
R
L
K
I
Y
K
D
T
-------------
E
G
YYTIGIGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
V
------------
I
----------
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
10
PsiBlast_PDB
81.16
24%
-102
- C1 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-478]
-----------------------------------
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
I
F
E
M
L
---------
R
I
D
E
G------
L
R
L
K
I
Y
K
D
T
-------------
E
G
YYTIGIGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
3
PsiBlast_PDB
80.90
29%
-104
- C1 -
4DAJ
5
ACM3_RAT (first)
A:
[9-440]
----------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
-
T
T
K
-
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
-
W
A
P
A
-
I
L
F
W
Q
Y
F
V
G
K
R
T
V
-
P
P
G
E
---
C
F
I
Q
-----
F
L
S
----
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
--
T
I
M
T
I
L
Y
W
R
I
Y
K
E
TE
K
----------
M
N
I
F
E
M
L
---------
R
I
D
E
G------
L
R
L
K
I
Y
K
D
T
-------------
E
G
YYTIGIGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
--
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
----
W
D
A
--
Y
--
L
I
K
E
------
A
Q
T
L
S
--------------
A
I
L
L
A
F
I
I
T
W
T
P
Y
-----------
N
I
M
V
L
V
N
T
------------
F
---------
C
D
--
S
-
C
---
I
P
K
T
Y
W
N
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
-
T
F
R
T
T
F
K
T
-----------------------
8
PsiBlast_PDB
80.79
24%
-101
- C1 -
3D4S
6
ENLYS_BPT4
A:
[40-478]
-----------------------------------
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
-
A
R
V
-
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
----
N
---
C
Y
A
E
ETCCD
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q---------
L
N
I
F
E
M
L
---------
R
I
D
EG------
L
R
L
K
I
Y
K
D
T
-------------
E
G
YYTIGIGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WDA-
Y
K
F
--
C
--
L
-
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
-------------
V
---------
I
Q
--
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
5
PsiBlast_PDB
79.11
25%
-101
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-441]
----------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
--
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
-
V
I
P
--
I
L
G
W
N
H
-------R
R
E
D
K
---
C
E
T
D
-----
F
Y
D
----
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
--
L
L
M
L
W
F
Y
A
K
I
Y
---------------
K
A
V
R
Q
H
C
---------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
-------------
E
G
Y
Y
T
I
G
IGHL
L
T
K
S
P
S
L
N
A
-------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
VIT--------------------
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
--------------------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
R
M
L
Q
Q
K
R
W
-
D
E
A
--------------
A
-
V
N
L
A
K
-
S
--
R
W
Y
N
Q
T
P
--------
N
R
A
K
R
---
V
I
T
T
F
R
-------
T
G
T
WD--
A
Y
L
--
H
--
M
N
R
E
R
K
---
A
A
K
Q
L
G
--------------
F
I
M
A
A
F
I
L
C
W
I
P
Y
-----------
F
I
F
F
M
V
I
A
------------
F
---------
C
K
---
N
C
---
C
N
E
H
L
H
M
F
T
I
-----
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
-
N
F
K
K
T
F
K
R
I
L
H
I
-------------------
46
Fugue
77.60
22%
-98
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
-
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
-
S
F
L
P
-
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
-
I
N
C
Y
A
EE
T
C
C
D
-----
F
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
---------------
Q
E
A
K
R
Q
L
---------
N
-----------
I
F
E
M
L
R
I
D
-------------
E
G
---------
L
R
L
K
I
Y
K
D
T
-------------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
-----------------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
--
L
Q
--
Q
K
R
W
D
-
E
A
A
--------------
V
-
N
L
A
K
S
R
W
--
Y
N
Q
T
P
N
R
--------
A
K
R
V
I
---
T
T
F
R
T
G
-------
T
W
D
----
A
Y
K
--
F
--
C
L
K
E
H
K
---
A
L
K
T
L
G
--------------
I
I
M
G
T
F
T
L
C
W
L
P
F
-----------
F
I
V
N
I
V
H
V
------------
I
---------
Q
D
--
N
-
L
---
I
R
K
E
V
Y
I
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
-
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
7
PsiBlast_PDB
74.88
23%
-117
- C1 -
4IAR
2
C562_ECOLX
A:
[14-395]
------------------------------
S
I
S
L
P
W
K
V
L
-
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
R
T
P
K
R
-
A
A
V
M
-
I
A
L
V
W
V
F
S
I
S
I
-
S
L
P
P
-
F
F
-
W
R
Q
A
-------
S
E
C
V
---
V
N
T
D
H----
I
L
Y
----
T
V
Y
S
T
V
G
A
----
F
Y
F
P
------
T
L
L
L
I
A
L
Y
---------------
G
R
I
Y
V
E
A
---------
R
----------
S
R
I
A
D
L
E
D
N
---------------------------------------------------------
W
E
T
L
-----------------------
N
D
----------
N
L
K
V
I
E
K
---
A
D
N
-----
A
A
Q
V
-----------------
K
D
A
L
--------------------
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
--
E
D
--
K
S
P
D
S
-
P
E
M
KD
F
R
H
G
F
D
I
L
V
G
Q
I
D
-
D
A
L
K
L
A
N
--
E
G
K
V
K
E
A
Q
-------
A
A
A
E
Q
---
L
K
T
T
R
N
-------
A
Y
I
----
Q
K
Y
--
L
--
A
A
R
E
R
K
---
A
T
K
T
L
G
--------------
I
I
L
G
A
F
I
V
C
W
L
P
F
-----------
F
I
I
S
L
V
M
P
------------
I
-----------------------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
-
D
F
K
Q
A
F
H
K
L
I
R
F
K
------------------
47
Fugue
74.73
20%
-89
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----
P
C
F
R
---
E
E
N
A
N
------------------
F
N
K
I
F
-
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
-
L
L
F
V
I
T
-
L
P
F
W
A
V
D
A
V
-
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
-
T
I
P
D
-
F
I
F
A
N
V
S
E
A
D
D
R
Y
-
I
C
D
R
---
F
Y
P
N
-----
D
L
W
----
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
--
I
V
I
L
S
C
Y
C
I
I
I
---------------
S
K
L
S
H
S
G
---------
S
----------
N
I
F
E
M
L
R
I
D
-------------
E
G
---------
L
R
L
K
I
Y
K
D
T
EG
Y
Y
T
I
GIGHLLT
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
-----------------------
I
G
RNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
NAKL-----------
K
P
V
Y
--------------------
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
--
G
E
--
T
G
V
A
G
F
T
N
S
--------------
L
-
R
M
L
Q
Q
K
R
--
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
---
A
K
R
V
I
T
-------
T
F
R
TGTW
D
A
Y
--
G
SK
G
H
Q
K
R
K
---
A
L
K
T
T
V
--------------
I
L
I
L
A
F
F
A
C
W
L
P
Y
-----------
Y
I
G
I
S
I
D
S
------------
F
I
L
L
EI
I
K
Q
G
C
E
--
F
E
N
---
T
V
H
K
W
I
S
I
T
E
-----
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
-
K
F
K
T
S
A
Q
H
A
L
T
S
G
-------
R
P
L
E
V
L
F
Q
---
6
PsiBlast_PDB
73.80
24%
-105
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[20-456]
------------------------------
T
F
E
V
V
F
I
V
L
-
V
A
G
S
L
S
L
V
---
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
-
T
T
K
-
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
-
W
A
P
A
-
I
L
F
W
Q
F
I
V
G
V
R
T
V
-
E
D
G
E
---
C
Y
I
Q
-----
F
F
S
----
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
--
I
I
M
T
V
----
L
Y
---------------
W
H
I
S
R
A
S
---------
K
----------
S
R
I
N
I
F
E
M
L
-------------
R
I
---------
D
E
-----------------------------
G
L
R
L
K
I
-----------------------
Y
K
----------
D
T
E
G
Y
Y
T
I
G
I
G
H
L
LTKSP
S
L
N
A
-----------------
A
K
S
E
--------------------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
--
E
K
--
L
F
N
Q
D
-
V
D
A
--------------
A
V
R
G
I
L
R
N
A
KL
K
P
V
Y
D
S
L
--------
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
----
N
S
L
--
R
--
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
PPPSREK
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
---------
I
N
--
T
F
C
APC
I
P
N
T
V
W
T
I
G
Y
-----
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
M
--------------------
50
Fugue
72.07
21%
-113
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
FYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
--
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
-
A
A
P
P
-
L
V
G
W
-----
S
R
Y
I
-
P
E
G
----
M
Q
C
S
-----
C
G
I
----
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
--
M
F
V
V
H
F
I
I
P
L
I
---------------
V
I
F
F
C
Y
G
---------
Q
----------
L
V
F
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
K
E
A
A
A
S
A
--------
T
T
Q
K
----------------------------------
A
E
K
E
---
V
T
R
M
V
I
--------------
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----------
A
G
V
A
F
Y
I
F
------------
T
---------
H
Q
--
G
S
D
---
F
G
P
I
F
M
T
I
P
A
-----
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
19
PsiBlast_PDB
71.24
23%
-128
- C1 -
4NC3
12
C562_ECOLX
A:
[33-407]
-----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
--
Q
A
N
Q
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
-
A
I
P
V
P
I
K
G
I
E
T
-
V
D
N
P
N
N
-
I
T
C
V
---
L
T
K
E
-----
R
F
G
----
D
--
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
-
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
---------
I
----------
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
RA------------------------------------------------------------------------------------------
K
D
F
R
H
G
F
-
D
I
-----
L
V
G
Q
-----------------
I
D
D
A
--------------------
L
K
L
A
N
E
G
---------------------------------------------------
K
V
K
E
A
Q
A
--------
A
A
E
-
Q
---
L
K
T
T
R
N
-------
A
Y
I
----
Q
K
Y
L
Q
T
--
I
S
N
E
Q
R
---
A
S
K
V
L
G
--------------
I
V
F
F
L
F
L
L
M
W
C
P
F
-----------
F
I
T
N
I
T
L
V
------------
L
---------
C
D
SC
N
Q
T
---
T
L
Q
M
L
L
E
I
F
V
-----
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
-
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------
38
HHSearch
70.16
22%
-139
- C1 -
2Z73
5
OPSD_TODPA
A:
[21-333]
-----------------------
P
H
W
R
E
F
D
Q
V
P
D
A
V
Y
Y
S
-
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
-
S
H
R
-
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
-
A
I
G
P
-
I
F
G
W
G
A
Y
T
L
--
E
G
-
V
L
C
N
---
C
S
F
D
-----
Y
I
S
RD
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
--
L
I
I
F
F
C
Y
F
N
I
V
---------------
M
S
V
S
N
H
E
---------
K
----------
E
M
A
A
M
A
K
R
L
-------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
------------------------------------------------------
E
-------
L
R
K
----
A
Q
A
--
G
--
A
N
A
E
M
R
---
L
A
K
I
S
I
--------------
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-----------
A
V
V
A
L
L
A
Q
------------
F
---------
G
P
--
L
E
W
---
V
T
P
Y
A
A
Q
L
P
V
-----
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
---
18
PsiBlast_PDB
70.02
23%
-129
- C1 -
4IB4
10
5HT2B_HUMAN (first)
A:
[33-407]
-----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
--
Q
A
N
Q
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
-
A
I
P
V
P
I
K
G
I
E
T
---
N
P
N
N
-
I
T
C
V
---
L
T
K
E
-----
R
F
G
----
D
--
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
-
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
---------
I
----------
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
LD
A
Q
---------
K
--------------------------------------------------------------------------
K
D
F
R
H
G
F
-
D
I
-----
L
V
G
Q
-----------------
I
D
D
A
--------------------
L
K
L
A
N
E
G
---------------------------------------------------
K
V
K
E
A
Q
A
--------
A
A
E
-
Q
---
L
K
T
T
R
N
-------
A
Y
I
----
Q
K
Y
L
Q
T
--
I
S
N
E
Q
R
---
A
S
K
V
L
G
--------------
I
V
F
F
L
F
L
L
M
W
C
P
F
-----------
F
I
T
N
I
T
L
V
------------
L
---------
C
D
SC
N
Q
T
---
T
L
Q
M
L
L
E
I
F
V
-----
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
-
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------