@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HRH4_HUMAN: (2016-01-10 )
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
Atome Classification :
(20 SA)
----------.........10------------........20........----30.---.......40........50........60.-....--..-.70......-.-.--80........90........100.......110.......120-.---......-..130.....-.-.140....-.-..150--------------..----.----.---------...--.----.---160.--.----..----.-----..-------..170----.----.....-...180-.......190..------------.....200--..-----------------------------------.....210-----.....------.---.220------------.---..--------.------..-----.------.---------------.---230---.--....--------.--...240----------..-------.....----------------------------.-------------250------------.-----------..------------------.-------.----------.----.--------------------260-----------.-.-..-------..--------...270...-----------.---------.-.--------.280------..-------.-------.....-.290-----.-----------------------...------------------------.----------....300.......310.......320.......330------...--...-..---------.340...-----.....350.......360.-......370.......380.......390--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MPDTN
S
T
I
N
L
S
------------LS
T
R
V
T
L
A
F
F
M
S
L
V
A
F
A
I
----
M
LG---N
A
L
V
I
L
A
F
V
VDKNLRHRS
S
Y
F
F
L
N
L
A
I
S
D
F
-
F
V
G
V
--
I
S-I
P
L
YIPHTL-F-E--WDFGK
E
I
C
V
F
W
LTTD
Y
L
L
C
T
A
S
V
Y
N
I
V
L
I
SYDRYLSVSNA
V
---
S
---YRTQH
T
-
G
V
L
K
I
V
T
L
M
V
-
A
-
V
W
V
L
A
F
L
V-N-G
P
M
----------------
I
L
----
V
----S---------ESW--K----D---E--G--S----EC----E-----PG-------F
F
S
------
E
----
W
Y
I
L
A
-
I
T
S
F
L
E
-
F
V
I
P
V
I
L
V
A
Y
FN------------
M
N
I
Y
W
S
L
W
--
K
R
-----------------------------------
D
H
L
S
R
C
Q
S-----HPGL
T
------
A
---
V
S
--------------
S
---NI--------C------G
H
-----
S
------
F
---------------
R
---
G
-----
R
--LSSR--------R--SLSAS-----------TE-------V
P
A
S
F
----------------------------
H
-------------
S
E
R
------------
Q
-----------
R
R
------------------
K
-------
S
----------S----L--------------------M-------------F-S-SR-------TK--------MN
S
N
T
I
A
S
K
-----------M---------G-S--------FS--------QS-------D-------
S
V
A
L
H
-
Q
R
-------
E
-----------------------
H
V
E
------------------------
L
----------
L
R
A
R
R
L
A
K
S
L
A
I
L
L
G
V
F
A
V
CWA
P
Y
S
L
F
T
I
V
L
S
F
Y
S--------SAT--G
P
K
-
S
V
---------
W
Y
R
-
I
A
F
-----
W
L
Q
W
F
N
S
F
V
N
P
L
L
Y
P
L
C
H
K
-
R
F
Q
K
A
F
L
K
I
F
C
I
KKQPL
P
S
Q
HSRSVSS----------
29
HHSearch
91.28
24%
-113
* C2 *
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
----
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
-
I
I
G
V
--
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
--
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
---
T
---
Y
P
V
K
R
T
--
T
K
M
A
G
M
M
I
A
-
A
-
A
W
V
L
S
F
I
L
-
W
-
A
P
A
----------------
I
L
----
F
----
W
---------
Q
F
I
--
V
GVRT
V
---
E
--
D
--
G
----
E
C
----
Y
-----
I
Q
-------
F
F
S
------
N
----
A
A
V
T
F
-
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
------------
W
H
I
S
R
A
S
K
--
S
R
-----------------------------------
I
N
I
F
E
M
L
R
-----
I
D
E
G
L
------
R
L
K
I
Y
K
--------------
D
---
T
E
--------
G
------
Y
Y
-----
T
I
GIGHL
L
---------------
T
---
K
SPS
L
N
A
A
K
S
E
L
D
K
-------
A
--
I
G
R
N
T
-----------
N
G
-------
V
I
T
K
D
E
A
--------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
------------
N
A----------
K
L
------------------
K
-------
P
V
---------
Y
----
D
--------------------
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
-
Q
-
M
G
E
------
T
G
--------
V
A
G
F
T
N
S
L
R
-----------
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
--------
P
N
R
A
K
R
V
I
T
T
-------
F
R
T
G
T
-
W
D
-------
A
-----------------------
Y
P
P
------------------------
P
----------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
--------
P
C
----
I
P
-
N
T
---------
V
W
T
-
I
G
Y
-----
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
M
--------------------------
1
PsiBlast_PDB
90.67
26%
-117
- C2 -
4U15
6
ACM3_RAT
A:
[13-395]
-------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
----
I
I
G
---
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
-
I
I
G
V
--
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
-
N
R-
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
---
T
---
Y
R
A
K
R
T
-
T
K
R
A
G
V
M
I
G
L
-
A
--
W
V
I
S
F
V
L
-
W
-
A
P
A
----------------
I
L
----
F
----
W
---------
Q
Y
F
--
V
----
G
---
K
--
R
--
T
VPPG
E
C
----
F
-----
I
Q
-------
F
L
S
------
E
----
P
T
I
T
F
-
G
T
A
I
A
A
-
F
Y
M
P
V
T
I
M
T
I
----------------
L
Y
W
R
I
Y
--
K
E
T
EKMN
I
F
E
M
L
R
I
-----------------------
D
E
G
G
G
S
G
G
-----
D
E
A
E
K
------
L
---
F
N
--------------
Q
---
D
V
---------------
D
A
-----
A
------
V
---------------
R
---
G
-----
I
--
L
R
N
A
--------
K
------
L
-----------
K
P
-------
V
Y
D
S
L
----------------------------
D
-------------
A
V
R
------------
R
-----------
A
A
------------------
L
-------
I
----------
N
----
M
--------------------
V
-------------
F
-
Q
M
G
E
-------
T
G
--------
V
A
G
F
T
N
S
L
R
-----------
M
---------
L
-
Q
--------
Q
K
--------
R
W
-------
D
-------
E
A
A
V
N
-
L
A
-------
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
------------------------
L
----------
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
--------
S
C
I
---
P
K
-
T
Y
---------
W
-
N
-
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
-
T
F
R
T
T
F
K
T
L
----------------------------
2
PsiBlast_PDB
87.75
26%
-119
- C2 -
4U16
2
?
A:
[13-388]
-------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
----
I
I
G
---
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
-
I
I
G
V
--
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
-
N
R-
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
---
T
---
Y
R
A
K
R
T
-
T
K
R
A
G
V
M
I
G
L
-
A
--
W
V
I
S
F
V
L
-
W
-
A
P
A
----------------
I
L
----
F
----
W
---------
Q
Y
F
--
V
----
G
---
K
--
R
--
T
VPPG
E
C
----
F
-----
I
Q
-------
F
L
S
------
E
----
P
T
I
T
F
-
G
T
A
I
A
A
-
F
Y
M
P
V
T
I
M
T
I
----------------
L
Y
W
R
I
Y
--
K
E
T
EKMN
I
F
E
M
L
R
I
-----------------------
D
E
G
G
G
S
G
G
-----
D
E
A
E
K
------
L
---
F
N
--------------
Q
---
D
V
---------------
D
A
-----
A
------
V
---------------
R
---
G
-----
I
--
L
R
N
A
--------
K
------
L
-----------
K
P
-------
V
Y
D
S
L
----------------------------
D
-------------
A
V
R
------------
R
-----------
A
A
------------------
L
-------
I
----------
N
----
M
--------------------
V
-------------
F
-
Q
M
G
E
-------
T
G
--------
V
A
G
F
T
N
S
L
R
-----------
M
---------
L
-
Q
--------
Q
K
--------
R
W
-------
D
-------
E
A
A
V
N
-
L
A
-------
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
------------------------
L
----------
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
--------
S
C
I
---
P
K
-
T
Y
---------
W
-
N
-
L
G
Y
-----
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
---------------------------------------
14
PsiBlast_PDB
86.74
22%
-103
- C2 -
4EIY
25
AA2AR_HUMAN (first)
A:
[41-423]
----------------------------------------------
I
A
V
L
A
----
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
--
L
A
-
I
P
F
A
I
T
I
S
T
---
G
--
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
---
R
---
Y
N
G
L
V
T
-
G
T
-
R
A
K
G
I
I
A
-
I
-
C
W
V
L
S
F
A
I
-
G
L
T
P
M
----------------
L
---------------------
G
W
--
N
----
N
---
C
--
G
--
Q
----
P
K
----
E
-----
G
K
-------
N
H
S
------
Q
----
G
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------------------------------
R
Q
L
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
------
V
---
I
E
--------------
K
---
A
D
--------
N
------
A
A
-----
Q
------
V
---------------
K
---
D
-----
A
--
L
T
K
M
--------
R
A
A
A
L
D
A
Q
-----------
K
----------------------------------------------------------M
K
D
F
R
H
G
F
D
I
L
V
G
-----------
Q
I
------------------
D
-------
D
----------
A
----
L
--------------------
K
-------------
L
-
A
-
N
E
-------
G
K
--------
V
K
E
A
Q
A
A
A
E
-----------
Q
---------
L
-
K
--------
T
T
--------
R
N
-------
A
-------
Y
I
Q
K
Y
L
E
R
-------
A
-----------------------
R
S
T
------------------------
L
----------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-
C
F
T
F
F
C
--------
P
D
C
--
S
H
A
-
P
L
---------
W
L
M
Y
L
A
I
-----
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-----------------------
47
Fugue
85.58
21%
-125
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------
D
------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
----
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-
V
M
G
L
--
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
--
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
---
K
---
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
-
M
-
V
W
I
V
S
G
L
T
-
S
-
F
L
P
----------------
I
Q
----
M
----
H
WYRATH
Q
E
A
I
N
C
--
Y
----
A
---
E
--
E
--
T
----
C
C
----
D
-----
F
F
-------
T
N
Q
------
A
----
Y
A
I
A
S
-
S
I
V
S
---
F
Y
V
P
L
V
I
M
V
F
V
Y
------------
S
R
V
F
Q
E
A
K
--
R
Q
LN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTK
S
P
S
L
N
A
A
K
-----
S
E
L
D
K
------
A
---
I
G
--------------
R
---
N
T
--------
N
------
G
V
-----
I
------
T
---------------
K
---
D
-----
E
--
A
E
K
L
--------
F
--
N
Q
D
V
D
-----------
A
A
-------
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
-------------
T
G
V
------------
A
-----------
G
F
------------------
T
-------
N
----------
S
----
L
--------------------
R
-------------
M
-
L
-
Q
Q
-------
K
R
--------
W
D
E
A
A
V
N
L
A
-----------
K
---------
S
-
R
--------
W
Y
--------
N
Q
-------
T
-------
P
N
R
A
K
-
R
V
-------
I
-----------------------
T
T
F
------------------------
R
TGTWDAYKFC
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--------
N
L
I
----
R
-
K
E
---------
V
Y
I
-
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
-
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------
4
PsiBlast_PDB
85.49
28%
-156
- C2 -
4MQT
2
ACM2_HUMAN
A:
[42-328]
------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
-
I
I
G
V
--
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
-
G
Y-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
---
T
---
Y
P
V
K
R
T
-
T
--
K
M
A
G
M
M
I
A
A
-
A
W
V
L
S
F
I
L
-
W
-
A
P
A
----------------
I
L
F
W
Q
F
I
----
V
---------
G
V
R
--
T
----
V
---
E
--
D
--
G
----
E
C
----
Y
-----
I
Q
-------
F
F
S
------
N
----
A
A
V
T
F
-
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
----------------
L
Y
W
-------------------------------------------
H
I
S
R
A
S
----------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
S
R
-------
E
K
--------
K
V
T
R
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
--------
P
C
I
---
P
N
-
T
V
---------
W
-
T
-
I
G
Y
-----
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
M
C
-------------------------
5
PsiBlast_PDB
85.05
23%
-121
- C2 -
4IAR
2
C562_ECOLX
A:
[14-398]
------------------
S
I
S
------------
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
----
T
L
S
---
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
-
L
V
S
I
--
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
--
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
---
E
---
Y
S
A
K
R
T
-
P
--
K
R
A
A
V
M
I
-
A
L
V
W
V
F
S
I
S
I
-
S
-
L
P
P
----------------
F
F
----
W
----
R
---------
Q
A
------------------
S
----
E
C
----
V
-----
V
N
-------
T
D
H
------
I
----
L
Y
T
V
--
Y
S
T
V
G
A
-
F
Y
F
P
T
L
L
L
I
A
L
Y
------------
G
R
I
Y
--
V
E
--
A
R
-----------------------------------
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
------
V
---
I
E
--------------
K
---
A
D
--------
N
------
A
A
-----
Q
------
V
---------------
K
---
D
-----
A
--
L
T
K
M
--------
R
--
A
A
A
L
D
-----------
A
Q
-------
K
A
T
P
P
----------------------------
K
-------------
L
E
D
------------
K
-----------
S
P
------------------
D
-------
S
----------
P
----
E
--------------------
M
-------------
K
-
D
-
F
R
H
G
F
D
I
L
V
G
Q
--------
I
D
D
A
L
K
L
A
N
-----------
E
---------
G
-
K
--------
V
K
--------
E
A
-------
Q
-------
A
A
A
E
Q
-
L
K
T
T
R
N
A
Y
I
Q
-----------------------
K
Y
L
------------------------
A
----------
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
------------------------------
W
F
H
-
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
-
D
F
K
Q
A
F
H
K
L
I
R
F
K
------------------------
3
PsiBlast_PDB
84.81
28%
-153
- C2 -
4MQS
1
?
A:
[42-328]
------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
-
I
I
G
V
--
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
-
G
Y-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
---
T
---
Y
P
V
K
R
T
-
T
--
K
M
A
G
M
M
I
A
A
-
A
W
V
L
S
F
I
L
-
W
-
A
P
A
----------------
I
L
F
W
Q
F
I
----
V
---------
G
V
R
--
T
----
V
---
E
--
D
--
G
----
E
C
----
Y
-----
I
Q
-------
F
F
S
------
N
----
A
A
V
T
F
-
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
----------------
L
Y
W
-------------------------------------------
H
I
S
R
A
S
----------------------------------------------------------------------------------------
K
---
S
------------------------------------------------------------------------------------------------------------------------------------------------------
P
----------
P
-----------------------------------------
P
-
S
R
-------
E
K
--------
K
V
T
R
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
--------
P
C
I
---
P
N
-
T
V
---------
W
-
T
-
I
G
Y
-----
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
K
K
T
F
K
H
L
L
M
--------------------------
11
PsiBlast_PDB
82.10
22%
-129
- C2 -
4NC3
12
C562_ECOLX
A:
[33-407]
----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
----
I
G
G
---
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
-
L
V
G
L
--
F
V
-
M
P
I
A
L
L
T
I
M
-
F
-
E
AM
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
QAN
Q
---
Y
N
S
R
A
T
-
A
F
I
K
I
T
V
------
V
W
L
I
S
I
G
I
-
A
-
I
P
V
P
I
K
GIETVDNPNNITC
V
L
----
T
----
K
---------
E
R
F
--
G
----
D
F
M
L
F
--
G
--
S
----
L
A
-----------
A
-------
F
F
T
------
P
----
L
A
I
M
I
-
V
T
Y
F
L
---
T
I
H
A
L
Q
K
K
A
A
D
------------
L
E
D
N
W
E
T
L
---
N
-----------------------------------
D
N
L
K
V
I
E
K
-----
A
D
N
A
A
------
Q
---
V
K
--------------
D
---
A
L
--------
T
------
K
M
-----
R
----------------------
A
------------------------------------------------------------------------------------------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
------------------
D
-------
D
----------
A
----
L
--------------------
K
-------------
L
-
A
-
N
E
-------
G
K
--------
V
K
E
A
Q
A
A
A
E
-----------
Q
---------
L
-
K
--------
T
T
--------
R
N
-----------------
A
Y
I
-
Q
K
-------
Y
-----------------------
L
Q
T
------------------------
I
----------
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
--------
S
C
N
--
Q
T
T
L
Q
M
---------
L
L
E
-
I
F
V
-----
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
-
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------------
53
Fugue
81.02
21%
-130
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------
S
F
K
C
A
L
T
K
T
------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
----
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
-
A
L
I
F
Y
Y
F
N
K
-
T
-
D
--
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
---
S
---
L
--
G
R
L
-
K
K
K
N
A
I
C
I
S
V
-
L
-
V
W
L
I
V
V
V
A
-
I
-
S
P
I
----------------
L
F
----
Y
----
S
---------
G
T
G
V
R
K
----
N
---
K
--
T
--
I
----
T
C
YDTT
S
-----
D
E
-------
Y
L
R
------
S
----
Y
F
I
Y
S
-
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
------------
G
L
I
V
R
A
L
I
--
Y
K
---------------------------------------------------
M
K
------
K
---
Y
T
--------------
C
---
T
V
--------
C
------
G
Y
-----
I
------
Y
---------------
N
-----------------------------------------------------
P
E
D
G
----------------------------
D
-------------
P
D
N
------------
G
-----------
V
N
------------------
P
-------
G
----------
T
----
D
----------------------------------------------------------
F
K
D
I
V
C
P
L
-----------
C
---------
G
--------------------------------------
V
G
K
D
-
Q
F
-------
E
-----------------------
E
V
E
------------------------
E
----------
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
--------
L
D
F
--
Q
T
P
-
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
-
V
T
R
-----
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
-
T
F
R
R
R
--------------------------------
10
PsiBlast_PDB
80.83
22%
-127
- C2 -
4IB4
10
5HT2B_HUMAN (first)
A:
[33-407]
----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
----
I
G
G
---
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
-
L
V
G
L
--
F
V
-
M
P
I
A
L
L
T
I
M
-
F
-
E
AM
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
QAN
Q
---
Y
N
S
R
A
T
-
A
F
I
K
I
T
V
------
V
W
L
I
S
I
G
I
-
A
-
I
P
V
P
I
K
GIETNPNNITC--
V
L
----
T
----
K
---------
E
R
F
--
G
----
D
F
M
L
F
--
G
--
S
----
L
A
-----------
A
-------
F
F
T
------
P
----
L
A
I
M
I
-
V
T
Y
F
L
---
T
I
H
A
L
Q
K
K
A
A
D
------------
L
E
D
N
W
E
T
L
---
N
-----------------------------------
D
N
L
K
V
I
E
K
-----
A
D
N
A
A
------
Q
---
V
K
--------------
D
---
A
L
--------
T
------
K
M
-----
R
----------------------
A
---
A
-----
A
--
L
D
A
Q
--------
K
-----------------------------------------------------------------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
------------------
D
-------
D
----------
A
----
L
--------------------
K
-------------
L
-
A
-
N
E
-------
G
K
--------
V
K
E
A
Q
A
A
A
E
-----------
Q
---------
L
-
K
--------
T
T
--------
R
N
-----------------
A
Y
I
-
Q
K
-------
Y
-----------------------
L
Q
T
------------------------
I
----------
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
--------
S
C
N
--
Q
T
T
L
Q
M
---------
L
L
E
-
I
F
V
-----
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
-
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------------
9
PsiBlast_PDB
79.89
23%
-154
- C2 -
3SN6
1
R:
[183-490]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
----
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-
V
M
G
L
--
A
V
-
V
P
F
G
A
A
H
I
L
-
T
-
K
T-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
---
K
---
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
----
V
W
I
V
S
G
L
T
-
S
-
F
L
P
----------------
I
Q
----
M
HWYR
Q
---------
E
A
I
--
N
----
C
---
Y
--
A
--
E
----
E
T
----
C
-----
C
D
-------
F
F
T
------
N
----
Q
A
Y
A
I
-
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
------------
S
R
V
F
Q
E
----
A
K
-----------------------------------
R
Q
L
Q
K
I
D
K
-----
S
E
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----
L
------------------------------------------------------------------------------------------------------------------------------------
K
-------
E
-----------------------
H
K
A
------------------------
L
-----------------
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--------
N
L
I
---
R
K
-
E
V
----------
Y
I
-
L
L
N
-----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
--
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------------------------
48
Fugue
77.99
21%
-115
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------
P
C
F
R
E
E
N
A
N
F
---------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
----
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
--
L
F
V
--
I
T
-
L
P
F
W
A
V
D
A
V
-
A
-
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
---
N
---
S
Q
R
P
R
K
-
L
L
A
E
-
K
V
V
Y
V
-
G
-
V
W
I
P
A
L
L
L
T
I
-
P
D
F
----------------
I
F
----
A
----
N
---------
V
S
E
--
A
----
D
---
D
--
R
--
Y
----
I
C
----
D
R
F
Y
PN
D
L
-------
W
V
V
------
V
----
F
Q
F
Q
H
-
I
M
V
G
L
I
-
L
P
G
I
V
I
L
S
C
Y
C
I
------------
I
I
S
K
L
S
H
S
--
G
S
-----------------------------------
N
I
F
E
M
L
R
I
-----
D
E
G
L
R
------
L
---
K
I
--------------
Y
---
K
D
TEG
Y
Y
T
I
G
I
------
G
H
-----
L
------
L
---------------
T
KSP
S
-----
L
--
N
A
A
K
--------
S
--
E
L
D
K
A
IGRNTNGVIT
K
D
E
-------
A
E
K
L
F
----------------------------
N
-------------
Q
D
V
------------
D
-----------
A
A
------------------
V
-------
R
----------
G
----
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
-------------
I
-
N
-
M
V
-------
F
Q
--------
M
G
E
T
G
V
A
G
F
-----------
T
---------
N
-
S
--------
L
R
--------
M
L
-------
Q
Q
KRW
D
E
A
A
V
N
L
A
-
K
S
-------
R
-----------------------
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
----------
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
--
N
T
V
-
H
K
---------
W
I
S
-
I
T
E
-----
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
-
K
F
K
T
S
A
Q
H
A
L
T
-
S
G
R
P
L
E
V
L
F
Q
---------------
50
Fugue
77.93
19%
-106
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
----
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
--
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-----
P
---
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
-
F
-
T
W
V
M
A
L
A
C
-
A
-
A
P
P
----------------
L
V
----
G
----
W
---------
S
R
Y
--
I
----
P
---
E
--
G
MQ
C
----
S
C
----
G
-----
I
D
-------
Y
Y
T
------
P
----
H
E
E
T
N
-
N
E
S
F
V
I
-
Y
M
F
V
V
H
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
I
P
L
I
V
----------------------------
I
-------------
F
F
C
------------
Y
-----------
G
Q
---------------------------------------------------------------------------------------------------------
L
V
F
T
-----------
V
---------
K
-
E
--------
A
A
--------
A
S
-------
A
-------
T
T
Q
K
A
-
E
K
-------
E
-----------------------
V
T
R
------------------------
M
----------
V
I
---------
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
S
D
--
F
G
P
-
I
F
---------
M
T
I
-
P
A
F
-----
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A------
32
HHSearch
76.24
20%
-118
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-472]
-----------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
----
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
--
L
A
-
I
P
F
A
I
T
I
S
--
T
-
G
--
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
---
R
---
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
-
I
-
C
W
V
L
S
F
A
I
-
G
-
L
T
P
----------------
M
L
----
G
----
W
---------
N
N
C
--
G
----
Q
------
S
--
Q
----
G
C
----
G
-----
E
G
QVACLFE
D
V
V
------
P
M
---
N
Y
M
V
Y
-
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
------------
L
R
I
F
L
A
A
R
--
R
Q
-----------------------------------
L
N
I
F
E
M
L
R
-----
I
D
E
G
L
------
R
---
L
K
--------------
I
Y
K
D
T
E
--------
G
YYTIGI
G
H
LLTKS
P
S
L
----
N
---------------
A
---
A
-----
K
--
S
E
L
D
K
A
I
GRNTN
G
--
V
I
T
K
D
------------
E
-------
A
E
K
L
F
----------------------------
N
-------------
Q
D
V
------------
D
-----------
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
----------
M
V
F
Q
M
G
--------------------
E
-------------
T
G
V
-
A
G
F
T
N
S
L
--
R
M
--------
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------
T
-
P
--------
N
R
--------
A
K
R
V
I
T
T
--
F
-------
R
T
G
T
W
-
D
A
-------
Y
-----------------------
R
S
T
------------------------
L
----------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
--------
D
C
S
--
H
A
P
-
L
W
---------
L
M
Y
-
L
A
I
-----
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------
41
HHSearch
75.04
20%
-130
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-----------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
----
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-
T
F
S
L
--
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-
K
--
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
---
A
S
K
K
M
S
--
H
R
R
A
F
I
M
I
I
-
F
-
V
W
L
W
S
V
L
W
-
A
-
I
G
P
----------------
I
F
----
G
----
W
---------
G
A
Y
--
T
----
L
---
E
GV
L
--
C
----
N
C
----
S
-----
F
D
-------
Y
I
S
------
R
D
S
T
T
R
S
N
I
L
-
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
------------
F
N
I
V
M
S
V
S
--
N
H
-----------------------------------
E
K
E
M
A
A
M
A
-----
K
R
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
-
R
K
-------
A
-----------------------
Q
A
G
------------------------
A
----------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
--------
L
E
---
W
V
T
-
P
Y
---------
A
A
Q
-
L
P
V
-----
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
----------
49
Fugue
74.96
20%
-92
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYY---
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
GG
F
T
-
T
T
L
Y
T
S
L
H
G
-
Y
----
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
N
F
R
F
G
E
N
H
A
-
I
M
G
V
A
F
T
W
V
M
-
A
-
L
A
C
A
A
P
P
L
-
V
-
G
W
S
----------------
R
Y
----
I
----
P
---------
E
G
M
--
Q
--------------
C
----
S
C
----
G
-----
I
D
-------
Y
Y
T
------
P
----
H
E
E
T
N
-
N
E
S
F
V
I
-
Y
M
F
V
V
-----------------------------------------------------------------------
H
F
I
-----
I
P
L
I
V
------
I
---
F
F
--------------
C
---
Y
--------------------------------------------------
G
-----
Q
--
L
V
F
T
--------
V
--
K
E
A
A
A
-----------
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
-------
S
-----------------------
A
T
T
------------------------
Q
----------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
S
D
--
F
G
P
-
I
F
---------
M
T
I
-
P
A
F
-----
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
39
HHSearch
74.73
20%
-130
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-326]
---------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
----
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-
S
M
A
A
--
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
-
E
--
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
---
Q
---
P
R
L
S
A
----
T
A
T
K
V
V
I
C
-
V
-
I
W
V
L
A
L
L
L
-
A
-
F
P
Q
----------------
G
Y
----
Y
----
S
---------
T
T
E
--
T
M---
P
---
S
--
R
--
V
----
V
C
----
M
-----
I
E
-------
W
P
E
HPNKIY
E
----
K
V
Y
H
I
-
C
V
T
V
L
I
-
Y
F
L
P
L
L
V
I
G
Y
A
Y
------------
T
V
V
G
I
T
L
W
--
A
S
-----------------------------------
E
I
P
G
D
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-------
Y
-----------------------
H
E
Q
------------------------
V
----------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
--------
D
L
Y
LK
K
F
I
-
Q
Q
---------
V
Y
L
-
A
I
M
-----
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
----------
35
HHSearch
72.71
17%
-109
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
-----------------------------------
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
----
I
L
E
---
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
-
L
A
G
V
--
A
Y
-
T
A
N
L
L
L
S
G
A
-
T
-
T
--
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------------
N
--
N
F
R
L
F
L
L
I
S
-
A
-
C
W
V
I
S
L
I
L
-
G
-
G
L
P
----------------
I
M
----
G
----
W
---------
N
C
I
--
S
--------
A
--
L
--
S
----
S
C
----
S
-----
T
V
-------
L
P
L
------
Y
H---
K
H
Y
-
I
-
L
F
C
T
T
V
-
F
T
L
L
L
L
S
I
V
I
L
Y
------------
C
R
I
Y
S
L
V
R
--
T
R
-----------------------------------
N
I
F
E
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
K
D
T
---
E
G
Y
Y
T
I
G
IGHLLTKSP
S
---
L
N
--------
A
------
A
K
-----
S
------
E
L
D
K
A
I
GRNTNGVIT
K
D
---
E
A
E
K
--
L
--
F
N
Q
D
--------
V
--
D
A
A
V
R
-----------
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
----------------------------
L
-------------
D
A
V
R
-----------
R
-----------
A
A
------------------
L
I
------
N
M
V
F
Q
MG
E
T
G
V
A
----
G
--------------------
F
-------------
T
-
N
-
S
L
-------
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
-----------
W
---------
Y
-
N
--------
Q
T
P
N
R
A
K
R
V
I
T
T
-------
F
-------
R
T
G
T
W
-
D
A
-------
Y
-----------------------
A
S
R
------------------------
S
----------
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
--------
V
K
T
--
C
D
I
-
L
F
---------
R
A
E
-
Y
F
L
-----
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
-
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------
38
HHSearch
69.77
19%
-117
- C2 -
1U19
14
OPSD_BOVIN
A:
[42-329]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
----
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
--
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
---
N
F
R
F
-
G
--
E
N
H
A
I
M
G
V
A
-
F
-
T
W
V
M
A
L
A
C
-
A
-
A
P
P
----------------
L
V
----
G
----
W
---------
S
R
Y
--
I
----
P
---
E
--
G
--
M
QC--
S
C
----
G
-----
I
D
-------
Y
Y
T
PHEETN
N
----
E
S
F
V
I
-
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
------------
G
Q
L
V
F
T
V
K
--
E
A
-----------------------------------
A
A
Q
Q
Q
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
------------------------
Q
----------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
S
---
D
F
G
-
P
I
---------
F
M
T
-
I
P
A
-----
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
----------