@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LGR4_HUMAN: (2016-01-10 )
MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD
Atome Classification :
(20 SA)
.........10........20........30......-..40---.--........50........60........70........80........90........100.......110...-....120----------------------.----------------------..-....130.......140....------------------------...150.......160....-..--------.170-........180....-...190.......200.--------------------------.......210.......220.......230.......-----240.-......------.250.......260.......270.......280.......290.......300.--......310.-.-.....320.......330.......340.......350....--..-.-----------------------------------------------------------------------360.......370.......380.......390.......400---.......410.......420.......430--........440.......450.......460.......470.......480.......490.......500.......510.......--520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPG
P
L
G
L
L
C
F
L
A
L
G
L
LGSAGPSGAAPPLCAAPCSCDG-D
R
R
----V--DCSGKGLTAV
P
E
G
L
S
A
F
T
Q
A
L
DIS
M
N
N
I
TQL
P
E
D
A
FKNFP
F
L
E
E
L
Q
LAGNDL
S
F
I
H
P
K
A
LS
G
L
K
E
L
K
V
L
T
LQNN-QLKT
V
P
S
----------------------
E
----------------------
A
I
-
R
G
L
S
A
L
Q
S
LRLDANHITSVP
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
WLDDNSLT-EV--------PVH--PLSNL
P
T
L
Q
A
L
T
L
A
L
-
N
K
ISSIP
D
F
A
F
T
N
L
S
-
S
--------------------------
L
V
V
L
H
LHN
N
K
I
R
S
L
S
Q
H
C
FDGLDN
L
E
T
L
DLNY
N
N
L
G
E
-----
F
P
-
Q
-
A
I
K
A
L
P
------
S
L
K
E
LGFHSN
S
I
S
VIPDGAFDGNP
L
L
R
T
I
H
LYDN
P
L
S
F
VG
N
S
AFH
N
L
S
D
L
H
S
L
V
I
--
R
G
A
S
M
V
Q
QFP-N-L
T
G
T
V
H
L
E
S
L
T
LTG
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
LDLSYNNIR--DL-P-----------------------------------------------------------------------SFNG
C
H
A
L
E
E
I
S
LQRN
Q
I
Y
Q
IKEG
T
F
Q
G
L
I
S
L
R
I
L
D
L
S
R
N
L
I
H
---
E
I
H
S
R
A
F
ATLGPITNLDV
S
F
N
E
L
TSFPTE---GLNG
L
N
Q
L
K
L
V
GN
F
K
L
K
E
A
L
A
A
K
D
F
V
N
L
RSLSV
P
Y
A
Y
Q
C
C
A
FWGCDSYANLNTEDNSLQDH
S
V
A
Q
EKGTAD
A
A
N
V
T
S
TLENEEH
S
Q
I
I
--
I
H
C
TPSTGAF
K
P
C
E
Y
L
L
G
S
W
M
I
R
L
T
V
W
F
I
F
L
V
A
L
F
F
N
L
L
V
I
L
T
T
F
A
S
C
TSLPSS
K
L
F
I
G
L
I
S
V
S
N
L
F
M
G
I
Y
T
G
I
L
T
F
L
D
A
VSWGRFA
E
F
G
I
W
W
ETGSG
C
K
V
A
G
F
L
A
V
FSSES
A
I
F
L
L
M
L
A
T
V
E
RSL
S
A
K
D
I
M
KNG
K
S
N
H
L
K
Q
F
R
V
A
A
L
L
A
F
L
G
A
T
V
A
G
C
F
P
L
FHRGEYSAS
P
L
C
L
PFPTGETPSL
G
F
T
V
T
L
V
L
L
N
S
L
A
F
L
L
M
A
V
I
Y
T
K
L
YCNL
E
K
E
DLSEN
S
Q
S
S
M
I
K
H
V
A
W
L
I
F
T
N
C
I
F
F
C
P
V
A
F
F
S
F
A
P
L
I
T
AISI
S
P
E
I
M
K
S
V
T
L
I
F
FP
L
P
A
C
L
N
P
V
L
Y
V
F
FNP
K
F
K
E
D
W
K
L
L
K
R
R
VTKKSG
S
V
S
V
S
ISSQGGCLEQ
D
F
YYDCGM
Y
S
H
LQGNL
T
V
C
D
C
C
E
S
F
L
LTKP
V
S
C
K
H
L
I
K
SHSCP
A
L
A
VASCQRPEG
Y
W
SDCGTQSAHSDYADEEDSFVSDS
S
D
Q
V
Q
A
C
G
R
A
C
FYQSRG
F
P
L
V
R
Y
AYNLPRVKD
1
PsiBlast_PDB
92.19
100%
-127
- C4 -
4KT1
2
LGR4_HUMAN
A:
[1-502]
-------------------------
P
P
L
C
A
A
P
C
S
C
D
G
-
D
R
R
----
V
--
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
D
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
-
Q
L
K
T
V
P
S
----------------------
E
----------------------
A
I
-
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
-
E
V
--------
P
V
H
--
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
-
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
-----
F
P
-
Q
-
A
I
K
A
L
P
------
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
--
R
G
A
S
M
V
Q
Q
F
P
-
N
-
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
--
D
L
-
P
-----------------------------------------------------------------------
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
S
R
N
L
I
H
---
E
I
H
S
R
A
F
A
T
L
G
P
I
T
N
L
D
V
S
F
N
E
L
T
S
F
P
T
E
---
G
L
N
G
L
N
Q
L
K
L
V
G
N
F
K
L
K
E
A
L
A
A
K
D
F
V
N
L
R
S
L
S
V
P
Y
A
Y
Q
C
C
A
F
W
G
C
---------------------------------------------
I
H
C
T
P
S
T
G
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.04
96%
-124
- C4 -
4QXE
7
LGR4_HUMAN
A:
[3-388]
--------------------------
P
L
C
A
A
P
C
S
C
D
G
-
D
R
R
----
V
--
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
-
Q
L
K
T
V
P
S
----------------------
E
----------------------
A
I
-
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
-
E
V
--------
P
V
H
--
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
-
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
-----
F
P
-
Q
-
A
I
K
A
L
P
------
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
--
R
G
A
S
M
V
Q
Q
F
P
-
N
-
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
--
D
L
-
P
-----------------------------------------------------------------------
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
A
S
N
Q
L
K
---
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
---
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
P
V
R
S
I
I
C
P
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.75
76%
-113
- C4 -
4LI1
2
LGR4_XENTR
B:
[16-431]
-----------------------------------
D
L
-
D
G
G
----
A
--
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
-
Q
L
K
T
V
P
S
----------------------
E
----------------------
S
L
-
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
-
E
V
--------
P
I
R
--
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
-
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
C
F
H
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
-----
F
P
-
D
-
S
I
R
S
L
P
------
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
L
H
F
L
I
I
--
R
G
A
S
N
V
Q
W
F
P
-
N
-
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
--
A
L
-
V
-----------------------------------------------------------------------
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
---
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
F
N
D
L
T
A
F
P
T
A
---
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.34
53%
-112
- C4 -
4KNG
2
LGR5_HUMAN
B:
[1-517]
-------------------
G
P
R
G
-----
C
P
T
H
C
H
C
E
P
-
D
G
R
MLLR
V
--
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
-
Q
L
R
H
V
P
T
----------------------
E
----------------------
A
L
-
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
------------------------
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
-
E
I
--------
P
V
Q
--
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
-----
F
P
-
T
-
A
I
R
T
L
S
------
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
-
D
-
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
--
D
L
-
P
-----------------------------------------------------------------------
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
---
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
---
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
----------------------------------------------HS
V
Q
C
S
P
S
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.89
76%
-108
- C4 -
4LI2
-
LGR4_XENTR
A:
[16-429]
-----------------------------------
D
L
-
D
G
G
----
A
--
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
-
Q
L
K
T
V
P
S
----------------------
E
----------------------
S
L
-
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
-
E
V
--------
P
I
R
--
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
-
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
S
F
H
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
-----
F
P
-
D
-
S
I
R
S
L
P
------
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
L
H
F
L
I
I
--
R
G
A
S
N
V
Q
W
F
P
-
N
-
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
--
A
L
-
V
-----------------------------------------------------------------------
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
---
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
F
N
D
L
T
A
F
P
T
A
---
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.84
53%
-110
- C4 -
4KNG
2
LGR5_HUMAN
A:
[1-514]
-------------------
G
P
R
G
-----
C
P
T
H
C
H
C
E
P
-
D
G
R
M
L
L
R
V
--
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
-
Q
L
R
H
V
P
T
----------------------
E
----------------------
A
L
-
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
------------------------
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
-
E
I
--------
P
V
Q
--
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
-----
F
P
-
T
-
A
I
R
T
L
S
------
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
-
D
-
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
--
D
L
-
P
-----------------------------------------------------------------------
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
---
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
---
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
---------------------------------------------H
S
V
Q
C
S
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.21
35%
-118
- C4 -
4R5C
2
?
A:
[61-304]
--------------------------------------------------------------------------------------
L
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
--
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
-
Q
L
E
T
L
P
Q
----------------------
G
----------------------
V
F
-
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
------------------------
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
-
S
L
--------
P
Q
G
--
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
-
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
-
N
--------------------------
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
-----
I
S
---
A
L
K
N
L
D
------
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
--
S
A
L
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
--
S
A
L
K
N
L
T
S
L
H
T
L
D
L
SN
N
G
I
T
D
I
S
A
L
K
-
N
-
L
D
---
N
L
E
T
L
D
L
R
N
N
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.55
92%
-107
- C4 -
4QXF
-
LGR4_HUMAN
A:
[3-259]
--------------------------
P
L
C
A
A
P
C
S
C
D
G
-
D
R
R
----
V
--
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
-
Q
L
K
T
V
P
S
----------------------
E
----------------------
A
I
-
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
------------------------
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
-
E
V
--------
P
V
H
--
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
-
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
-
S
--------------------------
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
-----
F
P
-
Q
-
A
I
K
A
L
P
------
S
L
K
E
L
A
L
D
T
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
--
K
E
Q
G
S
A
K
C
S
G
-
S
-
G
K
P
V
R
S
I
I
C
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
52.00
36%
-82
- C4 -
4PQ8
1
?
A:
[87-248]
----------------------------------------------------------------------------------
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
-
Q
L
T
S
L
P
Q
----------------------
G
----------------------
V
F
-
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
------------------------
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
-
S
L
--------
P
Q
G
--
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
-
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
-
S
--------------------------
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
51.16
29%
-102
- C4 -
4U7L
6
LRIG1_HUMAN
A:
[2-377]
----------------------------
C
P
S
R
C
T
C
S
G
-
D
S
-----
L
--
D
C
G
G
R
G
L
A
A
L
P
G
D
L
P
S
S
T
R
S
L
N
L
S
Y
N
K
L
S
E
I
D
P
A
G
F
E
D
L
P
N
L
Q
E
V
Y
L
N
N
N
E
L
T
A
V
-
P
S
L
G
A
A
S
S
H
V
V
S
L
F
L
Q
H
N
-
K
I
R
S
V
E
G
----------------------
S
----------------------
Q
L
-
K
A
Y
L
S
L
E
V
L
D
L
S
L
N
N
I
T
E
V
R
N
------------------------
T
C
F
P
H
G
P
P
I
K
E
L
N
L
A
G
N
R
I
G
-
T
L
--------
E
L
G
--
A
F
D
G
L
S
R
S
L
L
T
L
R
L
S
K
N
R
I
T
Q
L
P
V
R
A
F
K
-
L
P
-
R
--------------------------
L
T
Q
L
D
L
N
R
N
R
I
R
L
I
E
G
L
T
F
Q
G
L
N
S
L
E
V
L
K
L
Q
R
N
N
------------------------------------
I
S
K
L
T
D
G
A
F
W
G
L
S
K
M
H
V
L
H
L
E
Y
N
S
L
V
E
V
N
S
G
S
L
Y
G
L
T
A
L
H
Q
L
H
L
--
S
N
N
S
I
A
R
----------
I
H
R
K
G
W
S
------------
F
C
Q
K
---
L
H
E
L
V
L
S
F
N
N
L
T
RL
D
E
-
E
-----------------------------------------------------------------------
S
L
A
E
L
S
S
L
S
V
L
R
L
S
H
N
S
I
S
H
I
A
E
G
A
F
K
G
L
R
S
L
R
V
L
D
L
D
H
N
E
I
S
GTI
E
D
T
S
G
A
F
S
G
L
D
S
L
S
K
L
T
L
F
G
N
K
I
K
S
V
A
K
R
AFS
G
L
E
G
L
E
H
L
N
L
G
G
N
A
I
R
S
V
Q
F
D
A
F
V
K
M
K
N
L
K
E
L
H
I
S
S
D
S
F
L
C
D
C
Q
L
K
W
L
P
P
W
L
I
G
R
M
L
Q
A
F
V
T
A
T
C
A
H
P
E
S
L
K
G
Q
S
I
F
S
V
P
P
E
S
F
V
C
D
D
--
F
L
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
49.06
24%
-64
- C1 -
3RGZ
7
BRI1_ARATH
A:
[203-716]
------------------------------------------------------------------
E
F
L
D
V
S
S
N
N
F
S
T
G
I
P
-
F
L
G
D
C
S
A
L
Q
H
L
D
I
S
G
N
K
L
S
G
D
F
S
R
A
I
S
T
C
T
E
L
K
L
L
N
I
S
S
N
-
Q
F
V
G
P
I
P
PLPLKSLQ
Y
L
S
LAENK
F
T
G
EIP
D
----------------------
F
L
S
G
A
C
D
T
L
T
G
L
D
L
S
G
N
H
F
Y
G
A
V
P
------------------------
P
F
F
G
S
C
S
L
L
E
S
L
A
L
S
S
N
N
F
S
G
E
L
--------
P
M
D
--
T
L
L
K
M
R
G
L
K
V
L
D
L
S
F
-
N
E
F
S
G
E
L
P
E
S
L
T
N
L
S
A
S
LLTLDLSSNNFSGPILPNLCQNPKNT
L
Q
E
L
Y
L
Q
N
N
G
F
T
G
K
I
P
P
T
L
S
N
C
S
E
L
V
S
L
H
L
S
F
N
Y
L
S
G
T----
I
P
-
S
-
S
L
G
S
L
S
------
K
L
R
D
L
K
L
W
L
N
M
L
E
G
E
I
P
Q
E
L
M
Y
V
K
T
L
E
T
L
I
L
D
F
N
D
L
T
G
E
I
P
S
G
L
S
N
C
T
N
L
N
W
I
S
L
--
S
N
N
R
L
T
G
E
I
P
-
K
W
I
G
R
L
E
N
L
A
I
L
K
L
S
N
N
S
F
S
G
N
I
P
A
E
L
G
D
C
R
S
L
I
W
L
D
L
N
T
N
L
F
N
--
G
T
I
P
AAMFKQSGKIAANFIAG
K
R
Y
V
Y
I
K
N
DGMKKECHGA
G
N
L
L
E
F
Q
GIRSEQLNRLSTRNPCNIT
S
R
V
Y
G
G
H
TSP
T
F
D
N
N
G
S
M
M
F
L
D
M
S
Y
N
M
L
S
G
Y
I
P
K
E
I
G
S
M
P
Y
L
F
I
L
N
L
G
H
N
D
I
S
---
G
S
I
P
D
E
V
G
D
L
R
G
L
N
I
L
D
L
S
S
N
K
L
D
G
R
I
P
Q
AMS
A
L
T
M
L
T
E
I
D
L
S
N
N
N
L
S
G
P
I
P
E
M
G
Q
F
E
T
F
P
P
A
K
F
L
N
N
P
G
L
C
G
Y
P
L
P
R
C
D
P
S
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
48.77
31%
-80
- C4 -
4U08
3
?
B:
[161-377]
------------------------------------------------------------------
E
S
L
G
L
D
H
N
Q
L
N
V
L
P
K
E
I
G
Q
-
L
R
N
L
E
S
L
G
L
D
H
N
Q
L
N
V
L
-
P
K
E
I
G
Q
L
Q
N
L
Q
I
L
H
L
R
N
N
-
Q
L
T
T
L
P
K
----------------------
E
IGQLQNLQKLLLNKNKLTTLPK
E
I
-
G
Q
L
Q
N
L
Q
K
L
K
L
Y
E
N
Q
L
T
T
L
P
K
------------------------
E
I
G
Q
-
L
Q
N
L
Q
E
L
D
L
D
G
N
Q
L
T
-
T
L
--------
P
E
N
---
I
G
Q
L
Q
R
L
Q
T
L
Y
L
G
N
-
N
Q
L
N
F
L
P
K
-
E
I
G
Q
L
R
-
N
--------------------------
L
E
S
L
D
L
E
H
N
Q
L
N
A
L
P
K
E
-
I
G
K
L
Q
K
L
Q
T
L
N
L
K
Y
N
Q
L
A
T
-----
L
P
-
E
-
E
I
K
Q
L
K
------
N
L
K
K
L
Y
L
H
N
N
P
L
P
S
E
K
I
A
R
I
R
K
L
L
P
Q
C
I
I
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.70
30%
-104
- C4 -
2ID5
6
LIGO1_HUMAN
A:
[3-330]
----------------------------
C
P
P
R
C
E
C
S
A
Q
D
R
A
----
V
--
L
C
H
R
K
R
F
V
A
V
P
E
G
I
P
T
E
T
R
L
L
D
L
G
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
-
R
L
K
L
I
P
L
----------------------
G
----------------------
V
F
-
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
V
I
L
L
D
------------------------
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
V
-
Y
I
--------
S
H
R
--
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
-
C
N
L
T
S
I
P
T
E
A
L
S
H
L
H
-
G
--------------------------
L
I
V
L
R
L
R
H
L
N
I
N
A
I
R
D
Y
S
F
K
R
L
Y
R
L
K
V
L
E
I
S
H
----------
W
P
-
Y
-
L
D
T
M
T
P
NCLYGL
N
L
T
S
L
S
I
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
H
E
L
L
R
L
Q
E
I
Q
L
--
V
G
G
Q
L
A
V
V
E
P
Y
A
-
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
--
C
D
-
C
-----------------------------------------------------------------------
R
L
L
W
V
F
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
P
N
Y
---
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
---
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
48.61
31%
-83
- C4 -
4U08
6
?
A:
[161-377]
------------------------------------------------------------------
E
S
L
G
L
D
H
N
Q
L
N
V
L
P
K
E
I
G
Q
-
L
R
N
L
E
S
L
G
L
D
H
N
Q
L
N
V
L
-
P
K
E
I
G
Q
L
Q
N
L
Q
I
L
H
L
R
N
N
-
Q
L
T
T
L
P
K
----------------------
E
IGQLQNLQKLLLNKNKLTTLPK
E
I
-
G
Q
L
Q
N
L
Q
K
L
K
L
Y
E
N
Q
L
T
T
L
P
K
------------------------
E
I
G
Q
-
L
Q
N
L
Q
E
L
D
L
D
G
N
Q
L
T
-
T
L
--------
P
E
N
---
I
G
Q
L
Q
R
L
Q
T
L
Y
L
G
N
-
N
Q
L
N
F
L
P
K
-
E
I
G
Q
L
R
-
N
--------------------------
L
E
S
L
D
L
E
H
N
Q
L
N
A
L
P
K
E
-
I
G
K
L
Q
K
L
Q
T
L
N
L
K
Y
N
Q
L
A
T
-----
L
P
-
E
-
E
I
K
Q
L
K
------
N
L
K
K
L
Y
L
H
N
N
P
L
P
S
E
K
I
A
R
I
R
K
L
L
P
Q
C
I
I
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
48.60
33%
-84
- C4 -
4R6J
1
?
B:
[61-253]
--------------------------------------------------------------------------------------
L
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
S
--
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
-
Q
L
E
T
L
P
Q
----------------------
G
----------------------
V
F
-
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
GVFERLASLTTLNLSNNNLANLND
K
V
F
E
G
L
T
N
L
T
T
L
N
L
S
N
N
N
L
A
-
R
L
WKHANPGG
P
I
Y
--
F
L
K
G
L
T
N
L
T
T
L
N
L
S
N
-
N
G
F
D
E
F
P
K
E
V
F
K
D
L
T
-
S
--------------------------
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
L
Q
S
-----
L
P
-
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
48.34
35%
-91
- C4 -
4R5D
3
?
A:
[80-276]
----------------------------------------------------------------------------------
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
-
Q
L
T
S
L
P
Q
----------------------
G
----------------------
V
F
-
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
------------------------
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
-
S
L
--------
P
Q
G
--
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
-
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
-
S
--------------------------
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
D
G
V
F
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
L
T
K
EA
C
R
A
V
A
-
N
-
A
L
K
Q
A
A
------
S
L
H
E
L
H
L
S
N
N
N
I
G
--
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
A
C
R
E
I
A
R
A
L
--
K
Q
A
T
T
L
H
E
L
H
-
L
-
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
A
C
R
E
I
--
A
R
-
A
-----------------------------------------------------------------------
L
K
Q
A
T
T
L
H
E
L
H
L
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
---
C
N
L
T
K
E
A
C
R
E
I
A
R
A
L
K
Q
A
T
S
L
H
E
L
H
L
S
N
N
---
N
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.27
32%
-93
- C4 -
1XEC
3
PGS2_BOVIN
A:
[23-283]
--------------------------
P
V
C
P
F
R
C
Q
C
H
L
--
R
V
----
V
--
Q
C
S
D
L
G
L
E
K
V
P
K
D
L
P
P
D
T
A
L
L
D
L
Q
N
N
K
I
T
E
I
K
D
G
D
F
K
N
L
K
N
L
H
T
L
I
L
I
N
N
K
I
S
K
I
S
P
G
A
F
A
P
L
V
K
L
E
R
L
Y
L
S
K
N
-
Q
L
K
E
L
P
E
----------------------
K
----------------------
M
P
-
K
---
T
L
Q
E
L
R
V
H
E
N
E
I
T
K
V
R
K
------------------------
S
V
F
N
G
L
N
Q
M
I
V
V
E
L
G
T
N
P
L
K
-
S
S
--------
G
I
E
NG
A
F
Q
G
M
K
K
L
S
Y
I
R
I
A
D
-
T
N
I
T
T
I
P
Q
G
L
---
P
P
-
S
--------------------------
L
T
E
L
H
L
D
G
N
K
I
T
K
V
D
A
A
S
L
K
G
L
N
N
L
A
K
L
G
L
S
F
N
S
I
S
A
-----
V
D
-
N
G
S
L
A
N
T
P
------
H
L
R
E
L
H
L
N
N
N
K
L
V
K
V
P
G
G
L
A
D
-
H
K
Y
I
Q
V
V
Y
L
H
N
N
N
I
S
A
I
G
S
N
D
F
C
P
P
G
Y
N
T
K
K
A
S
--
Y
S
G
V
S
L
F
S
N
P
-
V
-
Q
Y
W
E
I
Q
P
S
T
F
R
C
V
Y
V
R
A
A
V
Q
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.08
35%
-99
- C4 -
1P8T
2
RTN4R_HUMAN
A:
[1-234]
----------------------------
C
P
G
A
C
V
C
Y
N
-
E
P
K
----
V
TT
S
C
P
Q
Q
G
L
Q
A
V
P
V
G
I
P
A
A
S
Q
R
I
F
L
H
G
N
R
I
S
H
V
P
A
A
S
F
R
A
C
R
N
L
T
I
L
W
L
H
S
N
V
L
A
R
I
D
A
A
A
F
T
G
L
A
L
L
E
Q
L
D
L
S
D
N
A
Q
L
R
S
V
D
P
----------------------
A
----------------------
T
F
-
H
G
L
G
R
L
H
T
L
H
L
D
R
C
G
L
Q
E
L
G
P
------------------------
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
N
A
L
Q
-
A
L
--------
P
D
D
--
T
F
R
D
L
G
N
L
T
H
L
F
L
H
G
-
N
R
I
S
S
V
P
E
R
A
F
R
G
L
H
-
S
--------------------------
L
D
R
L
L
L
H
Q
N
R
V
A
H
V
H
P
H
A
F
R
D
L
G
R
L
M
T
L
Y
L
F
A
N
N
L
S
A
-----
L
P
T
E
-
A
L
A
P
L
R
------
A
L
Q
Y
L
R
L
N
D
N
P
W
V
C
D
C
R
A
R
P
L
W
A
W
L
Q
K
F
R
G
S
S
S
E
V
P
C
S
L
P
Q
R
L
A
G
R
D
L
K
R
L
A
A
N
D
--
L
Q
G
C
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
47.98
33%
-85
- C4 -
4R6J
1
?
A:
[61-253]
--------------------------------------------------------------------------------------
L
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
S
--
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
-
Q
L
E
T
L
P
Q
----------------------
G
----------------------
V
F
-
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
GVFERLASLT
T
L
N
LSNNNLANLND
K
V
F
E
G
L
T
N
L
T
T
L
N
L
S
N
N
N
L
A
-
R
L
WKHANPGG
P
I
Y
--
F
L
K
G
L
T
N
L
T
T
L
N
L
S
N
-
N
G
F
D
E
F
P
K
E
V
F
K
D
L
T
-
S
--------------------------
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
L
Q
S
-----
L
P
-
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
47.90
35%
-97
- C4 -
1OZN
3
RTN4R_HUMAN
A:
[2-235]
----------------------------
C
P
G
A
C
V
C
Y
N
-
E
P
K
----
V
T
T
S
C
P
Q
Q
G
L
Q
A
V
P
V
G
I
P
A
A
S
Q
R
I
F
L
H
G
N
R
I
S
H
V
P
A
A
S
F
R
A
C
R
N
L
T
I
L
W
L
H
S
N
V
L
A
R
I
D
A
A
A
F
T
G
L
A
L
L
E
Q
L
D
L
S
D
N
A
Q
L
R
S
V
D
P
----------------------
A
----------------------
T
F
-
H
G
L
G
R
L
H
T
L
H
L
D
R
C
G
L
Q
E
L
G
P
------------------------
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
N
A
L
Q
-
A
L
--------
P
D
D
--
T
F
R
D
L
G
N
L
T
H
L
F
L
H
G
-
N
R
I
S
S
V
P
E
R
A
F
R
G
L
H
-
S
--------------------------
L
D
R
L
L
L
H
Q
N
R
V
A
H
V
H
P
H
A
F
R
D
L
G
R
L
M
T
L
Y
L
F
A
N
N
L
S
A
-----
L
P
T
E
-
A
L
A
P
L
R
------
A
L
Q
Y
L
R
L
N
D
N
P
W
V
C
D
C
R
A
R
P
L
W
A
W
L
Q
K
F
R
G
S
S
S
E
V
P
C
S
L
P
Q
R
L
A
G
R
D
L
K
R
L
A
A
N
D
--
L
Q
G
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------