@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LGR6_HUMAN: (2016-01-10 )
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
Atome Classification :
(20 SA)
.........10........20........30........40....-....50........60........70........80........90........100....--...110.......120.......130.......140.......150.......160.......170.......180.......190...-....200.......210.......220.......230-........240.......250.-.---------------------------------------------------.--.....260.......270.......280.......290.......300....---------------------------..--.310.......320--......----------------------------.330.......340.......350.......360..-----..-------------------------------------------------.---.-.370.......380.......390.......400.......410...--------....420.......430----.........---440.......450.......460........470.......480.......490.......500.......510.......520.......530..-.....540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSPP
G
L
R
A
L
W
L
C
A
A
L
C
A
SRRAGGAPQPGPGPTACPAPCHCQED
G
-
I
M
L
SA
D
C
S
ELGLSAVPGDL
D
P
L
T
A
Y
L
DLSM
N
N
L
T
EL
Q
P
G
L
F
H
H
L
R
F
L
E
E
L
RLSGNHLSHIP--
G
Q
A
F
S
G
L
Y
S
L
K
I
L
M
L
QNNQLGGI
P
A
E
A
L
WELPS
L
Q
S
L
RLD
A
N
L
I
S
LVPER
S
F
E
G
L
S
S
L
R
H
L
WLDDNA
L
T
E
I
P
V
R
A
LNNL
P
A
L
Q
A
M
T
L
A
L
-
N
R
I
SHI
P
D
Y
A
F
Q
N
L
T
S
L
V
V
L
HLHNN
R
I
Q
HLGTHSFE--GLHNL
E
T
LDL
N
Y
N
K
L
Q
E
F
P
V
-
A
-
I
---------------------------------------------------
R
--
T
L
G
R
L
Q
E
LGFHNNNIKAI
P
E
KAFMGN
P
L
L
Q
T
I
H
FYD
N
P
I
Q
F
V
G
R
S
A
F
Q
Y
LPK---------------------------
L
H
--
T
L
SLNGAM
D
I
Q
EFP--DLKGT
T
----------------------------
S
L
E
I
L
T
LTRA
G
I
R
LL
P
S
G
M
C
Q
QLPR
L
R
V
L
ELS
H
N
Q
I
-----
E
E
-------------------------------------------------
L
---
P
-
S
L
H
R
C
Q
K
L
E
E
IGLQHN
R
I
W
EI
G
A
D
T
F
S
Q
L
S
S
L
Q
A
LDL
S
W
N
A
I
R
SI
H
P
--------
E
A
F
S
T
L
H
S
L
V
KLDLT------DNQLTTLPL---AGLG
G
L
M
H
L
K
L
KG
N
L
A
L
S
QAF-SKDSFP
K
L
R
I
L
EVPYAYQCC
P
Y
G
M
C
A
S
F
F
K
ASGQWEAEDLHLDDEESSKR
P
L
G
L
L
A
R
Q
A
ENHYDQ
D
L
D
E
L
Q
L
EM-EDSKPHPS
V
Q
CSPTPGP
F
K
P
C
E
Y
L
F
E
SWG
I
R
L
A
V
W
A
I
V
L
L
S
V
L
CN
G
L
V
L
L
T
V
FAGGPVPL
P
P
V
K
F
V
V
G
A
IAGANTL
T
G
I
S
C
G
L
L
A
S
V
D
A
L
TFG
Q
F
S
E
YGARWETGLGCRA
T
G
F
L
A
V
LGSEA
S
V
L
L
L
T
L
A
A
V
Q
C
S
V
S
V
S
C
V
R
A
YGKSPSL
G
S
V
R
A
G
V
L
G
C
L
A
L
A
G
L
A
A
A
L
P
L
A
S
VGEYGAS
P
L
CLPYAPPEGQP
A
A
L
G
F
T
V
A
L
V
M
M
NS
F
C
F
L
VVAG
A
Y
I
K
L
Y
C
DLPR
G
D
F
E
A
V
W
D
C
A
M
V
R
H
V
A
W
L
I
FAD
G
L
L
Y
C
P
V
A
F
L
S
F
A
S
M
LGLFPV
T
P
E
A
V
K
S
V
L
L
V
VLP
L
P
A
C
L
N
P
L
L
Y
L
L
FNP
H
F
R
D
D
L
R
R
LRPRAGDSG
P
L
A
Y
AAAGELEKSSCDST
Q
A
L
V
A
FS
D
V
D
L
I
L
EASEAGRPPGLETYGFP
S
V
T
L
I
S
CQQPGAPRLEGSHCVEPEGNHFGNPQPSMD
G
E
L
L
L
R
AEGSTPAGGGLSGGGGFQPSGLAFASHV
3
PsiBlast_PDB
93.31
61%
-125
- C2 -
4BSS
2
LGR5_HUMAN
A:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
--------------------------------------------------E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.10
62%
-124
- C2 -
4KNG
2
LGR5_HUMAN
B:
[1-517]
------------------------------
G
P
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
-----------------------------------------------------------
H
S
V
Q
C
S
P
S
P
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
91.26
61%
-122
- C2 -
4BSS
3
LGR5_HUMAN
B:
[21-536]
----------------------------
G
V
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
----------------------------------------------------
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.89
62%
-120
- C2 -
4KNG
2
LGR5_HUMAN
A:
[1-514]
------------------------------
G
P
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
----------------------------------------------------------
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.41
61%
-121
- C2 -
4BSU
2
LGR5_HUMAN
A:
[24-536]
-------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
--------------------------------------------
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.50
61%
-123
- C2 -
4BSU
1
LGR5_HUMAN
B:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
---------------------------------------------
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
89.47
61%
-120
- C2 -
4BSS
1
LGR5_HUMAN
F:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
----------------------------------------------------
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
89.21
61%
-122
- C2 -
4BSR
2
LGR5_HUMAN
B:
[24-536]
-------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
--------------------------------------
R
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.20
61%
-121
- C2 -
4BSU
2
LGR5_HUMAN
F:
[23-536]
------------------------------
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
--------------------------------------------------------
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.80
61%
-123
- C2 -
4BST
2
LGR5_HUMAN
B:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
----------------------------------------------------------
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.51
61%
-121
- C2 -
4BSR
3
LGR5_HUMAN
A:
[21-536]
----------------------------
G
V
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
--------------------------------------
R
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.40
61%
-120
- C2 -
4BSU
1
LGR5_HUMAN
E:
[24-536]
-------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
N
---------------------------------------------------------
Q
C
S
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
87.90
61%
-117
- C2 -
4BSS
2
LGR5_HUMAN
E:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
------------------------------------------------E
E
D
L
K
A
L
H
S
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.39
61%
-119
- C2 -
4BST
3
LGR5_HUMAN
A:
[26-536]
---------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
--
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
-
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
--
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
-
A
-
I
---------------------------------------------------
R
--
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
---------------------------
L
R
--
T
L
T
L
N
G
A
S
Q
I
T
E
F
P
--
D
L
T
G
T
A
----------------------------
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
-----
E
D
-------------------------------------------------
L
---
P
-
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
--------
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
------
S
N
L
L
S
S
F
P
I
---
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
-
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
-----------------------------------------------------------
V
Q
C
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.02
57%
-120
- C2 -
4QXE
7
LGR4_HUMAN
A:
[5-399]
----------------------------------
C
A
A
P
C
S
C
D
G
D
R
----
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
--
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
-
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
--
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
P
Q
-
A
-
I
---------------------------------------------------
K
--
A
L
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
---------------------------
L
H
--
S
L
V
I
R
G
A
S
M
V
Q
Q
F
P
--
N
L
T
G
T
V
----------------------------
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
-----
R
D
-------------------------------------------------
L
---
P
-
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
A
S
N
Q
L
K
S
V
P
D
--------
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
------
T
N
P
W
D
C
S
C
P
---
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
-
C
S
G
S
G
K
P
V
R
S
I
I
C
P
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.56
59%
-122
- C2 -
4LI1
2
LGR4_XENTR
B:
[21-424]
--------------------------------------------------
A
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
--
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
I
R
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
-
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
C
F
H
--
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
P
D
-
S
-
I
---------------------------------------------------
R
--
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
---------------------------
L
H
--
F
L
I
I
R
G
A
S
N
V
Q
W
F
P
--
N
L
T
G
T
N
----------------------------
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
-----
S
A
-------------------------------------------------
L
---
V
-
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
--------
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
------
F
N
D
L
T
A
F
P
T
---
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.85
60%
-111
- C2 -
4LI2
-
LGR4_XENTR
A:
[21-424]
--------------------------------------------------
A
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
--
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
I
R
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
-
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
S
F
H
--
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
P
D
-
S
-
I
---------------------------------------------------
R
--
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
---------------------------
L
H
--
F
L
I
I
R
G
A
S
N
V
Q
W
F
P
--
N
L
T
G
T
N
----------------------------
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
-----
S
A
-------------------------------------------------
L
---
V
-
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
--------
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
------
F
N
D
L
T
A
F
P
T
---
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
66.68
25%
-101
- C4 -
1ZIW
15
TLR3_HUMAN
A:
[8-594]
----------------------------------------------------------------------
V
A
D
C
S
H
L
K
L
T
Q
V
P
D
D
L
---
P
T
N
I
T
V
L
N
L
T
H
N
Q
L
R
R
L
P
--
A
A
N
F
T
R
Y
S
Q
L
T
S
L
D
V
G
F
N
T
I
S
K
L
E
P
E
L
C
Q
K
L
P
M
L
K
V
L
N
L
Q
H
N
E
L
S
Q
L
S
D
K
T
F
A
F
C
T
N
L
T
E
L
H
L
M
S
N
S
I
Q
K
I
K
N
N
P
F
V
K
Q
K
N
L
I
T
L
D
L
S
H
-
N
G
L
S
S
T
K
L
G
T
Q
V
Q
L
E
N
L
Q
E
L
L
L
S
N
N
K
I
Q
A
L
K
S
E
E
L
D
IF
A
N
S
S
L
K
K
L
E
L
S
S
N
Q
I
K
E
F
S
P
-
G
C
F
HAIGRLF
G
L
F
LNNVQLG
P
S
L
T
E
K
L
C
L
E
L
ANTSIR
N
L
S
LSNSQLSTTSNTTF
L
GL
K
W
T
N
L
T
M
L
D
L
S
Y
N
N
L
N
V
V
G
N
D
S
F
A
W
L
P
Q
L
E
Y
F
F
L
E
Y
N
N
I
Q
H
L
F
S
H
S
L
H
G
L
F
N
VRYLNLKRSFTKQL
P
K
I
D
D
FSFQWLKC
L
E
--
H
L
N
M
E
D
N
D
I
-
P
G
I
K
SN
M
F
T
G
L
I
NLKYLSLSNSFTSLRTLTNETFVSLAHS
P
L
H
I
L
N
L
T
K
N
K
I
S
K
I
E
S
D
A
F
S
W
L
G
H
L
E
V
L
D
L
G
L
N
E
I
-----
G
Q
E
LTGQEWRGLENIFEIYLSYNK
Y
L
Q
L
T
RNSFALVPSLQRLMLRRVALKN
V
DSS
P
S
P
F
Q
P
L
R
N
L
T
I
L
D
L
S
N
N
N
I
A
N
I
N
D
D
M
L
E
G
L
E
K
L
E
I
L
D
L
Q
H
N
N
L
A
R
L
W
K
HANPGGPI
Y
F
L
K
G
L
S
H
L
H
I
L
N
L
E
------
S
N
G
F
D
E
I
P
V
EVF
K
D
L
F
E
L
K
I
I
D
L
G
L
N
N
L
N
T
L
P
A
S
V
F
N
N
Q
V
S
L
K
S
L
N
L
Q
K
N
L
I
T
S
V
E
K
K
V
F
G
P
A
F
R
N
L
T
E
L
D
M
R
F
N
P
F
D
C
T
C
E
S
I
A
W
F
V
N
W
I
N
E
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.96
58%
-109
- C2 -
4QXF
-
LGR4_HUMAN
A:
[5-259]
----------------------------------
C
A
A
P
C
S
C
D
G
D
R
----
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
--
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
-
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
--
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
P
Q
-
A
-
I
---------------------------------------------------
K
--
A
L
P
S
L
K
E
L
A
L
D
T
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
---------------------------
L
N
--
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
--
S
G
K
P
V
R
----------------------------
S
I
I
C
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.71
31%
-100
- C2 -
4U7L
6
LRIG1_HUMAN
A:
[2-413]
----------------------------------
C
P
S
R
C
T
C
S
G
D
-----
S
L
D
C
G
G
R
G
L
A
A
L
P
G
D
L
P
S
S
T
R
S
L
N
L
S
Y
N
K
L
S
E
I
D
P
A
G
F
E
D
L
P
N
L
Q
E
V
Y
L
N
N
N
E
L
T
A
V
P
SL
G
A
A
S
S
H
V
V
S
---
L
F
L
Q
H
N
K
I
R
S
V
E
G
S
Q
L
K
A
Y
L
S
L
E
V
L
D
L
S
L
N
N
I
T
E
V
R
N
T
C
F
P
H
G
P
P
I
K
E
L
N
L
A
G
N
R
I
G
T
L
E
L
G
A
F
D
G
L
S
R
S
L
L
T
L
R
L
S
K
N
R
I
T
Q
L
P
V
R
A
F
K
-
L
P
R
L
T
Q
L
D
L
N
R
N
R
I
R
L
I
E
G
L
T
F
Q
--
G
L
N
S
L
E
V
L
K
L
Q
R
N
N
I
S
K
L
T
D
G
A
-
F
---------------------------------------------------
W
--
G
L
S
K
M
H
V
L
H
L
E
Y
N
S
L
V
E
V
N
S
G
S
L
Y
G
L
T
A
L
H
Q
L
H
L
S
N
N
S
I
A
R
I
H
R
K
G
W
S
F
C
Q
K
---------------------------
L
H
E
L
V
L
S
F
N
N
L
T
R
L
D
E
-
E
--
S
L
A
E
L
S
----------------------------
S
L
S
V
L
R
L
S
H
N
S
I
S
H
I
A
E
G
A
F
K
G
L
R
S
L
R
V
L
D
L
D
H
N
E
I
SGTIE
D
T
-------------------------------------------------
S
---
G
-
A
F
S
G
L
D
S
L
S
K
L
T
L
F
G
N
K
I
K
S
V
A
K
R
A
F
S
G
L
E
G
L
E
H
L
N
L
G
G
N
A
I
R
S
V
Q
F
--------
D
A
F
V
K
M
K
N
L
K
E
L
H
I
S
S
DSFLC
D
C
Q
L
K
W
L
P
P
---
W
L
I
G
R
M
L
Q
A
F
V
T
A
T
C
A
H
P
E
S
L
-
K
G
Q
S
I
F
S
V
P
P
E
S
F
V
C
D
D
F
L
K
A
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