@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LPAR5_HUMAN: (2016-01-11 )
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
Atome Classification :
(20 SA)
-----------.........10....---...----.----20......--..30........40........50........60........70..-.-.....80.-.-...--...90........100.......110.......120.......130---.......140..--.....150...--....--160.------..--....170.......---180--....-...------------190......--.200.--...------------------...210----........---------.-----220-----------------.------.------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------..--...-----230.......240---------........250.----------......260..---.....270..-..-...280.......290-........300.......310--.-------......---.320.......---330.......340.......350.......360..-------.....370------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MLANSSSTNSSVLPC---PDY----R----P
T
H
R
L
H
L
V
--
V
Y
S
L
V
L
AAGL
P
L
N
A
L
A
L
W
V
F
L
R
A
L
R
V
H
S
V
V
S
V
Y
M
C
N
LAAS
D
L
L
F
T
L-S-LP
V
R
L
S
Y
Y
-
A
-LHH--WP
F
P
D
L
L
C
Q
TTG
A
I
F
Q
M
NMYG
S
C
I
F
L
M
L
INV
D
R
Y
A
A
I
V
H
P
L
R
L
R
H
L---R
R
P
R
V
A
R
L
L
C
L
G
--
V
W
A
L
I
L
V
F
AV
P
--
A
A
RV--HRPS------R
C
--
R
Y
R
D
L
E
V
R
L
C
F
E
S
F
---
S
D
E
--
L
WKG-R
L
L
------------
P
L
V
L
L
A
E
A
L
--
G
F
L
L
P
--
L
A
A
------------------
V
V
YS------SG
R
V
F
W
T
L---------A-----R-------------------P------D------------------------------A-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
--
Q
R
R
-----
R
K
T
V
R
L
L
L
A
N
L
V
----------
I
F
L
L
C
FVPYN
S
T
----------
L
A
V
Y
G
L
L
R
S
K
L
---
V
AASVP
A
R
D
R
-
V
R
-
G
V
L
M
V
M
V
L
L
AG
A
N
C
V
--
L
D
P
L
V
Y
Y
FS
A
E
G
F
R
N
T
L
R
GL---G-------TPHRAR---TSATNG
T
R
A
A
L
---
A
QSERSAVTTDATRPDAASQGLLRPSDSHS
L
S
S
F
T-------QCPQDSAL------------------------------------------------
27
HHSearch
91.59
22%
-138
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------
V
V
G
M
G
I
--
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-
A
V
V
P
F
G
A
A
H
I
-
L
-
M
K
M
--
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
--
H
W
Y
R
------
A
----
T
-
H
Q
E
A
I
N
C
Y
A
E
E
---
T
C
C
--
D
F
-
F
-
T
N
Q
------------
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
--
L
V
I
------------------
M
V
F
V
------
Y
S
R
V
F
Q
E
A
---------
K
-----
R
-------------------
Q
------
L
------------------------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
C
--
L
K
E
-----
H
K
A
L
K
T
L
G
I
I
M
G
----------
T
F
T
L
C
W
L
P
F
F
I
V
----------
N
I
V
H
V
I
Q
D
N
L
-------------
I
-
R
K
-
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
-------
C
L
-----------------------------------------------------------------------------------------------------------------------
46
Fugue
91.20
18%
-130
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
---
P
Q
Y
----
Y
LAE
P
W
Q
F
S
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
T
T
T
L
Y
-
T
-
S
L
H
GY
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
A
P
--
P
L
----
V
G
W
S
------
R
Y
--
I
P
E
G
M
Q
C
-
S
C
G
I
D
Y
---
Y
T
P
--
H
E
E
T
-
N
N
E
------------
S
F
V
I
Y
M
F
V
V
--
H
F
I
I
P
--
L
I
V
------------------
I
F
F
C
------
Y
G
Q
L
V
F
T
V
---------
K
-----
E
-------------------
A
------
A
------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
TQ
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
----------
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
T
H
Q
G
S
------------
D
F
-
G
P
-
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-------
K
N
P
S
T
T
---
V
S
K
T
E
T
S
Q
V
A
P
---
A
-------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.89
23%
-159
- C4 -
4MBS
8
CCR5_HUMAN (first)
A:
[38-366]
---------------------------------------------------
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
-
T
-
V
P
F
-
W
A
H
Y
-
A
-
A
A
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
--
T
W
V
V
A
V
F
A
S
L
P
--
N
I
I
F
--
T
R
S
Q
------
K
-----
E
G
L
H
Y
T
-
C
S
S
H
F
PYS
Q
Y
Q
--
F
W
K
N
F
Q
T
L
------------
K
I
V
I
----
L
--
G
L
V
L
P
--
L
L
V
------------------
M
V
I
C
------
Y
S
G
I
L
K
T
L
---------
L
-----
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGD
P
------
D
NGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
--
K
K
R
-----
H
R
D
V
R
L
I
F
T
I
M
I
----------
V
Y
F
L
F
W
A
P
Y
N
I
V
----------
L
L
L
-
N
T
F
Q
E
F
F
---
G
L
N
N
C
S
S
S
N
R
-
L
D
-
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
--
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
---
F
-------
Q
------------------------------------------------------------------------------------------------------------------------
32
HHSearch
90.02
21%
-148
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------
Y
A
L
--
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
-
L
V
M
P
W
V
V
Y
L
E
-
V
T
G
G
V
--
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
--
V
W
V
L
A
F
A
V
S
C
P
--
L
L
F
G
--
F
N
T
T
--------------
G
D
P
T
V
C
S
I
S
N
---
P
------------------------
D
F
V
I
Y
S
S
V
V
--
S
F
Y
L
P
--
F
G
V
------------------
T
V
L
V
------
Y
A
R
I
Y
V
V
L
---------
K
-----
Q
-------------------
R
------
R
------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
--
L
R
E
-----
K
K
A
T
Q
M
V
A
I
V
L
G
----------
A
F
I
V
C
W
L
P
F
F
L
T
----------
H
V
L
N
T
H
C
Q
T
C
------------
H
V
-
S
P
-
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
---
L
-------
S
C
-----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.65
25%
-142
- C4 -
4XNW
2
RUBR_CLOPA
A:
[37-382]
---------------------
S
S
F
K
C
---
A
L
T
----
K
----
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
--
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
--
L
K
S
L
---
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
-
L
I
V
V
V
A
I
S
--
P
I
L
F
--
Y
S
G
T
------
G
V
--
R
K
N
--
K
T
I
T
C
Y
D
T
T
---
S
D
E
--
Y
L
R
S
-
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
--
G
L
I
----
V
R
A
------------------
L
I
Y
K
------
M
K
K
Y
T
C
T
V
CG
Y
I
Y
N
PED
G
-----
D
-------------------
P
------
D
NGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
-
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
--
P
L
R
-----
R
K
S
I
Y
L
V
I
I
V
L
T
----------
V
F
A
V
S
Y
I
P
F
H
V
M
----------
K
T
M
N
--
L
R
A
R
L
DFQ
T
P
A
M
C
A
F
N
D
R
-
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
--
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.13
25%
-171
- C4 -
5C1M
7
?
A:
[21-293]
-----------------------------------------------
M
A
--
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
V
N
Y
-
L
-
M
G
T
--
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
--
N
W
I
L
S
S
A
I
G
L
P
-----
V
--
M
F
M
A
------
T
T
--
K
Y
R
Q
G
S
I
D
-
C
T
L
T
F
---
S
H
P
--
T
W
Y
W
-
E
N
L
-------------
L
K
I
C
V
F
I
F
--
A
F
I
M
P
--
V
L
I
------------------
I
T
V
C
------
Y
G
L
M
I
L
R
L
---------
K
S
VRML
S
-------------------
G
------
S
------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
--
R
N
L
-----
R
R
I
T
R
M
V
L
V
V
V
A
----------
V
F
I
V
C
W
T
P
--------------
I
H
I
Y
V
I
I
K
A
L
I
------
T
I
P
E
T
T
F
-
Q
T
-
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
---------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.07
29%
-169
- C4 -
4XT1
14
US28_HCMVA
A:
[45-318]
-----------------------------------------------
L
F
--
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
-
L
P
L
W
M
Q
Y
--
L
-
L
D
-------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
-
M
R
Y
R
P
V
---
K
Q
---
A
C
L
F
S
I
F
--
W
W
I
F
A
V
I
I
A
I
P
--
H
F
M
V
V
T
K
K
D
N
------
Q
C
M
T
D
Y
D
Y
L
E
V
S
Y
---------------------------------
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
--
L
S
V
------------------
I
S
Y
C
------
Y
Y
R
I
S
R
I
V
---------
A
---------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
--
R
H
K
-----
G
R
I
V
R
V
L
I
A
V
V
L
----------
V
F
I
I
F
W
L
P
Y
H
L
T
----------
L
F
V
D
T
L
K
L
L
K
W
---
I
S
S
S
C
E
F
E
R
S
-
L
K
-
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
--
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
---
L
-------
A
E
F
R
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.70
25%
-149
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
---
A
L
T
----
K
----
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
--
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---
K
S
L
---
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
-
L
I
V
V
V
A
I
S
--
P
I
L
F
--
Y
S
G
T
------
G
V
--
R
K
N
--
K
T
I
T
C
Y
D
T
T
---
S
D
E
--
Y
L
R
S
-
Y
F
I
Y
S
M
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
G
C
Y
--
G
L
I
----
V
R
A
------------------
L
I
Y
K
------
M
K
K
Y
T
C
T
V
CG
Y
I
Y
N
PED
G
-----
D
-------------------
P
------
D
NGVNPGTDFKDIVCPLCGVGKDQ
F
E
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
--
P
L
R
-----
R
K
S
I
Y
L
V
I
I
V
L
T
----------
V
F
A
V
S
Y
I
P
F
H
V
M
----------
K
T
M
N
--
L
R
A
R
L
DFQ
T
P
A
M
C
A
F
N
D
R
-
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
--
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.67
29%
-159
- C4 -
4XT3
2
US28_HCMVA
A:
[45-316]
-----------------------------------------------
L
F
--
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
-
L
P
L
W
M
Q
Y
--
L
-
L
D
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
-
M
R
Y
R
P
V
---
K
Q
---
A
C
L
F
S
I
F
--
W
W
I
F
A
V
I
I
A
I
P
--
H
F
M
V
V
T
K
K
D
N
------
Q
C
M
T
D
Y
D
Y
L
E
V
S
Y
---------------------------------
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
--
L
S
V
------------------
I
S
Y
C
------
Y
Y
R
I
S
R
I
V
---------
A
---------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
--
R
H
K
-----
G
R
I
V
R
V
L
I
A
V
V
L
----------
V
F
I
I
F
W
L
P
Y
H
L
T
----------
L
F
V
D
T
L
K
L
L
K
W
---
I
S
S
S
C
E
F
E
R
S
-
L
K
-
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
--
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
---
L
-------
A
E
-----------------------------------------------------------------------------------------------------------------------
26
HHSearch
88.45
21%
-150
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------
P
L
V
V
--
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
-
V
V
M
P
M
N
I
L
Y
L
-
L
-
M
S
K
--
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
--
A
W
F
L
S
F
L
W
V
I
P
--
I
L
G
W
--
N
H
----------------
R
R
E
D
K
C
E
T
D
F
---
Y
D
V
--
T
-------------------
W
F
K
V
M
T
A
I
I
--
N
F
Y
L
P
--
T
L
L
------------------
M
L
W
F
------
Y
A
K
I
Y
K
A
V
---------
R
-----
Q
-------------------
H
------
C
------------------------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
M
--
N
R
E
-----
R
K
A
A
K
Q
L
G
F
I
M
A
----------
A
F
I
L
C
W
I
P
Y
F
I
F
----------
F
M
V
I
A
F
C
K
N
C
C
--------------
N
E
-
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
--
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
---
L
-------
H
I
-----------------------------------------------------------------------------------------------------------------------
24
HHSearch
87.77
19%
-144
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------
V
F
I
V
L
--
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
-
F
S
M
N
L
Y
T
L
Y
T
-
V
-
I
G
Y
--
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
--
A
W
V
L
S
F
I
L
W
A
P
--
A
I
L
F
--
W
Q
F
I
------
V
G
---
V
R
T
V
E
D
G
E
C
Y
I
Q
F
---
F
S
N
---------
A
------------
A
V
T
F
G
T
A
I
A
--
A
F
Y
L
P
--
V
I
I
------------------
M
T
V
L
------
Y
W
H
I
S
R
A
S
---------
K
-----
S
-------------------
R
------
I
------------------------------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
--
S
R
E
-----
K
K
V
T
R
T
I
L
A
I
L
L
----------
A
F
I
I
T
W
A
P
Y
N
V
M
----------
V
L
I
N
T
F
C
A
P
C
-------------
I
-
P
N
-
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
---
L
-------
M
------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.52
27%
-166
- C4 -
4RWD
6
C562_ECOLX (first)
A:
[128-405]
---------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
-
L
-
M
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
--
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
--
T
R
P
-------------
R
D
G
A
V
-
V
C
M
L
Q
F
---
P
S
P
--
S
W
Y
W
-
D
T
V
------------
T
K
I
C
V
F
-
L
F
--
A
F
V
V
P
--
I
L
I
------------------
I
T
V
C
------
Y
G
L
M
L
L
R
L
---------
R
-----
S
-------------------
V
------
R
------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
--
S
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
W
A
P
I
H
I
F
----------
V
I
V
W
T
L
V
----------
D
I
D
R
R
D
P
L
V
V
-
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
--------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.94
27%
-166
- C4 -
4RWA
2
C562_ECOLX (first)
A:
[128-405]
---------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
-
L
-
M
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
--
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
--
T
R
P
-------------
R
D
G
A
V
-
V
C
M
L
Q
F
---
P
S
P
--
S
W
Y
W
-
D
T
V
------------
T
K
I
C
V
F
-
L
F
--
A
F
V
V
P
--
I
L
I
------------------
I
T
V
C
------
Y
G
L
M
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
S
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
W
A
P
I
H
I
F
----------
V
I
V
W
T
L
V
----------
D
I
D
R
R
D
P
L
V
V
-
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
--------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.34
27%
-155
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[131-405]
---------------------------------------------------
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
-
L
P
F
Q
G
T
D
I
-
L
-
L
G
F
--
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
--
I
W
A
L
A
S
V
V
G
V
P
--
V
A
I
M
-----
G
------
S
A
--
Q
V
E
D
E
E
I
E
C
L
V
E
I
P
---
T
P
Q
--
D
Y
W
G
-
P
V
F
------------
A
I
C
I
F
--
L
F
--
S
F
I
V
P
V
L
V
I
S
------------------
V
C
Y
S
L
M
I
R
R
L
R
G
V
R
L
L
S
G
---------
S
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
--
R
N
L
-----
R
R
I
T
R
L
V
L
V
V
V
A
----------
V
F
V
G
C
W
T
P
V
Q
V
F
----------
V
L
A
Q
G
L
----------
G
V
Q
P
S
S
E
T
-
A
V
-
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
--
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
--------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
85.89
17%
-107
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
---
P
Q
Y
YLAE
P
----
W
Q
F
S
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
T
T
T
L
Y
-
T
-
S
L
H
GY
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
A
P
--
P
L
----
V
G
W
S
------
R
Y
--
I
P
E
G
M
Q
C
-
S
C
G
I
D
Y
---
Y
T
P
--
H
E
E
T
-
N
N
E
------------
S
F
V
I
Y
M
F
V
V
--
H
F
I
I
P
--
L
I
V
------------------
I
F
F
C
------
Y
G
Q
L
V
F
T
V
---------
K
-----
E
-------------------
A
AAQQQE
S
------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
--
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
----------
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
T
H
Q
G
S
D
---
F
G
----------
P
-
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---
L
----------------------------------------------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
-------
E
T
S
Q
V
A
P
A
------------------------------------------------
22
HHSearch
85.87
21%
-144
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-498]
------------------------------------
N
----
F
N
K
I
F
L
P
T
--
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
-
V
--
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
I
P
--
D
F
I
F
--
A
N
V
S
------------
E
A
D
D
R
Y
I
C
D
R
F
Y
---
P
N
D
--
L
----
W
V
V
------------
V
F
Q
F
Q
H
I
M
V
--
G
L
I
L
P
--
G
I
V
------------------
I
L
S
C
------
Y
C
I
I
I
S
K
L
---------
S
-----
H
-------------------
S
------
G
------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
--
H
Q
K
-----
R
K
A
L
K
T
T
V
I
L
I
L
----------
A
F
F
A
C
W
L
P
Y
Y
I
G
----------
I
S
I
D
S
F
I
L
L
E
I
---
I
K
Q
G
C
E
F
E
N
T
-
V
H
-
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
--
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
---
L
-------
T
S
G
R
P
L
---
E
V
L
F
Q
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.86
27%
-166
- C4 -
4N6H
22
OPRD_HUMAN
A:
[131-408]
---------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
-
L
P
F
Q
S
A
K
Y
-
L
-
M
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
--
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
--
T
R
P
-------------
R
D
G
A
V
-
V
C
M
L
Q
F
---
P
S
P
--
S
W
Y
W
-
D
T
V
------------
T
K
I
C
V
F
-
L
F
--
A
F
V
V
P
--
I
L
I
------------------
I
T
V
C
------
Y
G
L
M
L
L
R
L
---------
R
-----
S
-------------------
V
------
R
------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
--
S
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
W
A
P
I
H
I
F
----------
V
I
V
W
T
L
V
----------
D
I
D
R
R
D
P
L
V
V
-
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
-------
R
K
P
C
G
--------------------------------------------------------------------------------------------------------------------
48
Fugue
85.21
22%
-119
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
------------------------
P
C
F
R
E
E
N
A
----
N
----
F
N
K
I
F
L
P
T
--
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
-
V
-
A
N
---
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
I
P
--
D
F
I
F
--
A
N
V
S
E
A
DD
R
Y
I
C
--
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
---
F
Q
H
--
I
M
V
G
-
L
I
L
------------
P
G
I
V
I
L
S
C
Y
--
C
I
I
I
S
--
K
L
S
HSGSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
------
D
T
E
G
Y
Y
T
I
---------
G
-----
I
-------------------
G
------
H
------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
--
S
P
S
-----
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
----------
A
A
V
R
G
I
L
R
N
A
K
---
L
K
P
V
Y
D
S
L
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
---
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
GSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
33
HHSearch
85.14
18%
-132
* C4 *
3EML
13
ENLYS_BPT4
A:
[21-472]
-------------------------------------------
S
S
V
Y
I
T
--
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
----
T
G
--
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
--
P
M
L
G
--
W
N
N
C
------
G
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
LF
E
D
V
V
-
P
M
N
------------
Y
M
V
Y
F
N
F
F
A
--
C
V
L
V
P
--
L
L
L
------------------
M
L
G
V
------
Y
L
R
I
F
L
A
A
---------
R
-----
R
-------------------
Q
------
L
------------------------------
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
-
T
L
--
Q
K
E
-----
V
H
A
A
K
S
L
A
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
C
-----------
S
H
A
-
P
L
-
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---
I
-------
R
S
H
V
L
R
---
Q
---------------------------------------------------------------------------------------------------------------
44
Fugue
84.41
23%
-118
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
---
A
L
T
----
K
----
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
-
F
-
N
K
T
D-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
-
A
I
C
I
S
V
L
--
V
W
L
I
V
V
V
A
I
S
P
--
I
L
F
Y
-----
S
------
G
T
--
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
---
S
D
E
--
Y
L
R
S
-
Y
F
I
------------
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
--
L
V
L
------------------
I
L
G
C
------
Y
G
L
I
V
R
A
L
---------
I
-----
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
M
K
K
Y
T
C
T
V
C
G
Y
I
----------
Y
N
P
E
D
G
D
P
D
N
G
V
NPGTDFKDIV
C
P
L
C
G
V
G
K
D
Q
F
---
E
E
V
E
E
P
L
R
R
K
-
S
I
-
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
--
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
-----------------------------
F
Q
T
P
A
M
C
---
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
-------
R
R
R
-----------------------------------------------------