@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LT4R1_HUMAN: (2016-01-11 )
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
Atome Classification :
(20 SA)
-------------.........10-----.........20........30---........40........50........60......-..-70-..-.......80..-.......90........100.......110.......120......---.130.......140.......-150--..-.....160-.--......---.170.--...--.---..180---..--......-------.--190.......200....--..--------.-------------------------------------------210----.------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------.-----..---------------------------------------------------...220...-----------....-230...--....240--.........250-----------.......260.......270-.---........280.......290.......300----.........310...----....320.......330.......340.......350-----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MNTTSSAAP
P
------
S
L
G
V
E
F
I
S
L
L
A
I
I
L
L
S
V
A
L
A
V---GLPGNS
F
V
V
W
S
I
L
K
R
M
Q
K
RS
V
T
A
L
M
V
L
N
L
A
L
A
D
L
A
V
-
L
L
-
T
--
A
P
-
F
F
L
H
F
L
AQ-GT-W
S
F
G
L
A
G
C
R
L
C
H
Y
V
C
G
V
S
M
Y
A
S
V
L
L
I
T
A
M
SLD
R
S
L
A
VA
R
P
F
V
S
Q
K
L
---
R
T
K
A
M
A
R
R
V
L
A
G
I
W
V
L
S
F
L
L
A-T
P
V
--
L
A
-
Y
R
TVVPW--K--TNM
S
L
C---FPRYP--SEG--
H
---
R
A
F
-----
H
L
--
I
F
E
A
V
T
-------
G
--
F
L
L
P
F
L
A
V
V
A
S
Y
S
D
I
G
R
--
R
L
--------
Q
-------------------------------------------
A
R
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
R
S---------------------------------------------------RRTG
R
L
V
V
L
-----------
I
I
L
T
-
F
A
A
F
W
L
--
P
Y
H
V
V
----
N
L
A
E
A
G
R
A
L
A
GQ-----------AA
G
L
G
L
V
G
K
R
L
S
L
A
R
N
V
L
---
I
---
A
L
A
F
L
SSSVN
P
V
L
Y
A
CAGG
G
L
L
R
SA
G
V
G
F
------
V
A
K
L
L
EGTGSEASST----RRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN-----------------------------------------------------------------------------------------
44
Fugue
96.43
28%
-142
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------
S
F
K
C
A
L
T
------
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
--
V
F
I
I
---
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
-
T
--
L
P
-
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
-
S
P
I
--
L
F
-
Y
S
G
T
G
V
R
--
K
--
N
K
T
I
T
C
---
Y
D
T
T
S
--
D
E
Y
--
L
---
R
S
Y
-----
F
I
--
Y
S
M
C
T
T
-------
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
--
A
L
--------
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG
K
D
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
EE
P
L
R
---------------------------------------------------
R
K
S
I
Y
L
V
I
I
-----------
V
L
T
V
-
F
A
V
S
Y
I
--
P
F
H
V
M
----
K
T
M
N
L
R
A
R
L
D
F
Q
-----------
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
---
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.03
24%
-146
- C3 -
4XNW
2
RUBR_CLOPA
A:
[47-381]
-------------------------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
--
V
F
I
I
---
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
-
T
D
-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
-
S
P
I
--
L
F
-
Y
S
G
T
G
V
R
--
K
--
N
K
T
I
T
C
---
Y
D
T
T
S
--
D
E
Y
--
L
---
R
S
Y
-----
F
I
Y
S
M
C
T
T
V
A
-------
M
--
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
--
A
L
--------
I
-------------------------------------------
Y
K
-----
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
-----------
I
V
L
T
V
F
A
V
S
Y
I
--
P
F
H
V
M
----
K
T
M
N
L
R
A
R
L
D
F
Q
-----------
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
---
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.53
24%
-148
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[47-381]
-------------------------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
--
V
F
I
I
---
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
-
T
D
-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
-
S
P
I
--
L
F
-
Y
S
G
T
G
V
R
--
K
--
N
K
T
I
T
C
---
Y
D
T
T
S
--
D
E
Y
--
L
---
R
S
Y
-----
F
I
Y
S
M
C
T
T
V
A
-------
M
--
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
--
A
L
--------
I
-------------------------------------------
Y
K
-----
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
----
R
R
K
S
I
Y
L
V
I
-----------
I
V
L
T
V
F
A
V
S
Y
I
--
P
F
H
V
M
----
K
T
M
N
L
R
A
R
L
D
F
Q
-----------
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
---
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
88.86
25%
-140
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-497]
-------------------------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
---
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
-
T
--
L
P
-
F
W
A
V
D
A
V
--
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
D
--
F
I
-
F
A
N
V
S
-
E
--
A
--
D
D
R
Y
I
C
---
D
R
F
Y
P
--
N
D
L
--
W
---
V
V
V
-----
F
Q
--
F
Q
H
I
M
V
-------
G
--
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
--
K
L
--------
S
-------------------------------------------
H
S
-----
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-----
Q
K
---------------------------------------------------
R
K
A
L
K
T
T
V
I
-----------
L
I
L
A
-
F
F
A
C
W
L
--
P
Y
Y
I
G
----
I
S
I
D
S
F
I
L
L
E
I
I
-----------
K
Q
-
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
---
E
---
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
------
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
87.15
24%
-129
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
-----------------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
---
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
V
F
S
--
M
N
-
L
Y
T
L
Y
T
V
I
-
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
--
I
L
-
F
W
Q
F
I
V
G
VR
T
--
V
E
D
G
E
C
---
Y
I
Q
F
F
--
S
N
--------
A
A
-----
V
T
--
F
G
T
A
I
A
-------
A
--
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
--
A
S
--------
K
-------------------------------------------
S
R
-----
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
R
E
---------------------------------------------------
K
K
V
T
R
T
I
L
A
-----------
I
L
L
A
-
F
I
I
T
W
A
--
P
Y
N
V
M
----
V
L
I
N
T
F
C
A
P
----------------------
C
I
P
N
T
V
W
T
I
G
---
Y
---
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
------
M
------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
86.31
21%
-114
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------------
P
C
F
R
------
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
---
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
-
T
--
L
P
-
F
W
A
V
D
A
V
A
-
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
D
--
F
I
-
F
A
N
V
S
E
---
A
--
D
D
R
Y
I
C
---
D
R
F
Y
P
--
N
D
L
--
W
---
V
V
V
-----
F
Q
--
F
Q
H
I
M
V
-------
G
--
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
--
K
L
--------
S
-------------------------------------------
H
S
GSN--
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
M
L
---------------------------------------------------
R
I
D
E
G
L
R
L
K
-----------
I
Y
K
D
-
T
E
G
Y
Y
T
I
G
I
G
H
L
L
TKSP
S
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
---
L
R
NA
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
2
PsiBlast_PDB
85.07
27%
-149
- C3 -
5C1M
7
?
A:
[12-286]
----------------------
P
------
S
M
-
V
T
A
I
T
I
M
A
--
L
Y
S
I
V
C
V
V
---
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
--
L
P
-
F
Q
S
V
N
Y
L
M
-
G
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
-
L
P
V
--
M
F
-
M
A
T
T
K
Y
R
--
Q
GS
I
D
C
T
L
T
---
F
-
S
H
P
--
T
W
Y
--
W
---
E
N
L
-----
L
K
--
I
C
V
F
I
F
-------
A
--
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
--
R
L
--------
K
-------------------------------------------
S
V
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
LSGS
K
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
N
L
---------------------------------------------------
R
R
I
T
R
M
V
L
V
-----------
V
V
A
V
-
F
I
V
C
W
T
--
P
I
H
I
Y
----
V
I
I
K
A
L
I
T
I
P
E
T
-----------
T
F
Q
--------
T
V
S
W
H
F
C
---
I
---
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
84.62
22%
-130
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
---
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
-
G
A
V
V
--
M
P
-
M
N
I
L
Y
L
L
M
-
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
--
L
G
-
W
N
H
---------
R
R
E
D
K
C
---
E
T
D
F
Y
--
D
V
T
--------
W
-----
F
K
--
V
M
T
A
I
I
-------
N
--
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
--
A
V
--------
R
-------------------------------------------
Q
H
-----
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
-----
R
E
---------------------------------------------------
R
K
A
A
K
Q
L
G
F
-----------
I
M
A
A
-
F
I
L
C
W
I
--
P
Y
F
I
F
----
F
M
V
I
A
F
C
K
N
----------------------
C
C
N
E
H
L
H
M
F
T
---
I
---
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
------
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
83.55
19%
-128
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
FEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
---
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
-
G
G-
F
T
-
T
T
L
Y
T
S
L
H
-
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
--
L
V
G
W
S
R
Y
I
P
E
--
G
--
M
Q
C
S
C
G
I
DY
Y
T
P
H
E
--
E
T
N
--
N
---
E
S
F
-----
V
I
--
Y
M
F
V
V
H
----------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--
T
V
--------
K
-------------------------------------------
E
A
AASAT
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
A
E
---------------------------------------------------
K
E
V
T
R
M
V
I
I
-----------
M
V
I
A
-
F
L
I
C
W
L
--
P
Y
--
A
----
G
V
A
F
Y
I
F
T
H
Q
G
S
-----------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
---
V
-----------
Y
N
P
V
I
Y
I
M
M
------
N
K
Q
F
R
N
------
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
----
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------------------
27
HHSearch
83.24
21%
-126
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
---
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
L
A
V
--
V
P
-
F
G
A
A
H
I
L
M
-
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
--
I
Q
-
M
H
W
Y
R
A
T
--
H
--
Q
E
A
I
N
C
---
Y
A
E
E
T
CC
D
F
F
--
T
---
N
Q
A
-----
Y
A
--
I
A
S
S
I
V
-------
S
--
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
--
E
A
--------
K
-------------------------------------------
R
Q
-----
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
-----
K
E
---------------------------------------------------
H
K
A
L
K
T
L
G
I
-----------
I
M
G
T
-
F
T
L
C
W
L
--
P
F
F
I
V
----
N
I
V
H
V
I
Q
D
N
----------------------
L
I
R
K
E
V
Y
I
L
L
---
N
---
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
------
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.12
31%
-149
- C3 -
4EA3
3
C562_ECOLX (first)
B:
[124-394]
--------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
L
-
T
--
L
P
-
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
---
R
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
M
G
-
S
A
-------
E
--
I
E
C
L
V
E
---
I
P
T
-
P
--
Q
D
Y
--
W
---
G
P
V
-----
F
A
--
I
C
I
F
L
F
-------
S
--
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
--
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKD-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
N
L
---------------------------------------------------
R
R
I
T
R
L
V
L
V
-----------
V
V
A
V
-
F
V
G
C
W
T
--
P
V
Q
V
F
----
V
L
A
Q
---------------------
G
L
G
-
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
---
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
82.08
22%
-136
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
---
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
-
A
T
L
V
--
M
P
-
W
V
V
Y
L
E
V
T
G
G
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
--
L
F
-
G
F
N
T
T
-------
G
D
P
T
V
C
---
S
I
S
N
P
--
D
----------------
F
V
--
I
Y
S
S
V
V
-------
S
--
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
--
V
L
--------
K
-------------------------------------------
Q
R
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
-----
R
E
---------------------------------------------------
K
K
A
T
Q
M
V
A
I
-----------
V
L
G
A
-
F
I
V
C
W
L
--
P
F
F
L
T
----
H
V
L
N
T
H
C
Q
T
C
---------------------
H
V
S
P
E
L
Y
S
A
T
---
T
---
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
------
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.60
28%
-147
- C3 -
4RWD
6
C562_ECOLX (first)
A:
[128-392]
------------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
--
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
--
M
V
-
M
A
V
T
R
P
---
R
--
D
G
A
V
V
C
---
M
L
Q
F
P
--
S
P
S
---------------
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
--
R
L
R
S
V
RLLSG
S
-------------------------------------------
K
E
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
S
L
---------------------------------------------------
R
R
I
T
R
M
V
L
V
-----------
V
V
G
A
-
F
V
V
C
W
A
--
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------
V
A
A
L
H
L
C
--------------
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
81.51
24%
-138
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
-------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
---
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
-
A
A
F
N
--
T
V
-
V
N
F
T
Y
A
V
H
-
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
--
G
Y
-
Y
S
T
T
E
-
T
--
M
--
P
S
R
V
V
C
---
M
I
E
W
P
--
E
H
P
--
N
KIY
E
K
V
-----
Y
H
--
I
C
V
T
V
L
-------
I
--
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
--
T
L
--------
W
-------------------------------------------
A
S
-----
E
IPGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
A
K
---------------------------------------------------
R
K
V
V
K
M
M
I
V
-----------
V
V
C
T
-
F
A
I
C
W
L
--
P
F
H
I
F
----
F
L
L
P
Y
I
N
P
D
L
Y
------------------
L
K
K
F
I
Q
Q
V
Y
L
A
I
---
M
---
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
------
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
----
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.27
31%
-151
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[124-394]
--------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
L
-
T
--
L
P
-
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
M
G
-
S
A
Q
V
E
D
E
--
E
--
I
E
C
L
V
E
---
I
P
T
-
P
--
Q
D
Y
--
W
---
G
P
V
-----
F
A
--
I
C
I
F
L
F
-------
S
--
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
--
R
L
--------
R
-------------------------------------------
G
V
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
LSGSREK
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
N
L
---------------------------------------------------
R
R
I
T
R
L
V
L
V
-----------
V
V
A
V
-
F
V
G
C
W
T
--
P
V
Q
V
F
----
V
L
A
Q
---------------------
G
L
G
-
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
---
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.06
28%
-149
- C3 -
4N6H
22
OPRD_HUMAN
A:
[131-395]
------------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
--
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
--
M
V
-
M
A
V
T
R
P
---
R
--
D
G
A
V
V
C
---
M
L
Q
F
P
--
S
P
S
---------------
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
--
R
L
R
S
V
RLLSG
S
-------------------------------------------
K
E
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
S
L
---------------------------------------------------
R
R
I
T
R
M
V
L
V
-----------
V
V
G
A
-
F
V
V
C
W
A
--
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------
V
A
A
L
H
L
C
--------------
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------
R
K
P
C
G
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.91
28%
-147
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[128-392]
------------------------------------------
L
Y
S
A
V
C
A
V
---
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
--
L
P
-
F
Q
S
A
K
Y
L
M
-
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
--
M
V
-
M
A
V
T
R
P
---
R
--
D
G
A
V
V
C
---
M
L
Q
F
P
--
S
P
S
---------------
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
----G-------
S
-------------------------------------------
K
E
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
S
L
---------------------------------------------------
R
R
I
T
R
M
V
L
V
-----------
V
V
G
A
-
F
V
V
C
W
A
--
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------
V
A
A
L
H
L
C
--------------
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
79.91
20%
-129
- C3 -
2Z73
5
OPSD_TODPA
A:
[31-334]
---------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
---
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
L
-
V
N
G
F
P
-
L
M
T
I
S
C
F
L
-
K
K
-
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
--
I
F
-
G
W
G
A
Y
T
L
--
E
--
G
V
L
C
N
C
---
S
F
D
Y
I
--
S
R
D
S
-
T
---
T
R
S
-----
N
I
--
L
C
M
F
I
L
-------
G
--
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
--
S
V
--------
S
-------------------------------------------
N
H
-----
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
A
E
---------------------------------------------------
M
R
L
A
K
I
S
I
V
-----------
I
V
S
Q
-
F
L
L
S
W
S
--
P
Y
A
V
V
----
A
L
L
A
Q
F
G
P
L
---------------------
E
W
V
T
P
Y
A
A
Q
L
P
---
V
---
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
------
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
----
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.67
25%
-146
- C3 -
2Y00
13
ADRB1_MELGA
A:
[16-286]
-----------------------------------------
L
L
M
A
L
V
V
L
L
---
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
--
V
P
-
F
G
A
T
L
V
V
R
-
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
-
H
W
----
W
--
R
--
D
E
D
P
Q
A
---
L
K
C
Y
Q
--
D
P
G
--
C
---
C
D
F
VTN
R
A
Y
A
--
I
A
S
S
I
I
-------
S
--
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
-
F
T
L
C
W
L
--
P
F
F
L
V
----
N
I
V
N
V
F
N
R
-------------------
D
L
V
P
D
W
L
F
V
A
F
N
---------
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.03
26%
-125
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
----------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
---
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
-
A
L
-
T
--
L
P
-
I
W
A
A
S
K
-
V
-
N
G
-
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
-
L
P
F
--
F
L
-
F
R
Q
A
Y
H
P
--
N
--
N
S
S
P
V
C
---
Y
E
V
L
G
--
N
D
T
AK
W
---
R
M
V
-----
L
R
--
I
L
P
H
T
F
-------
G
--
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
--
T
L
--------
F
-------------------------------------------
K
A
-----
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
Q
K
---------------------------------------------------
H
R
A
M
R
V
I
F
A
-----------
V
V
L
I
-
F
L
L
C
W
L
--
P
Y
N
L
V
----
L
L
A
D
T
L
M
R
T
Q
V
I
-----------
Q
E
-
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
---
E
---
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
------
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------