@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MC4R_HUMAN: (2016-01-11 )
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90---........100.......110.-..---....120.......130.......140.......150.......160-.........170.......180...-----------------------..-----------------------..----------------------190--------------------..-.......--------200....-------...210.......------------220.......230------------------------------------------------------------------------------------------------------------------------------------------------------.......--.240---------------------------------------------------------------------------------------------------------------------------------------------------..---.......250.......260....--...270.......280.......290---.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVNSTHRGMH
T
S
L
H
L
WNRS
S
Y
R
LHSNA
S
E
S
LGKGYSDG
G
C
Y
E
Q
LFVS
P
E
V
F
V
T
L
G
V
I
S
L
L
E
N
I
L
V
I
V
A
I
AKNKNLHS
P
M
Y
F
F
I
C
S
L
A
V
A
D
M
---
L
VSVSNGS
E
T
I
V
I
T
L
LNSTDTD-A
Q
---
S
F
T
V
N
I
D
N
V
I
D
S
V
I
C
S
S
L
L
A
S
I
C
S
L
L
S
I
A
V
D
R
Y
F
T
I
F
Y
A
L
Q
YH
N
I
---
M
T
V
K
R
V
G
I
I
I
S
C
I
W
A
A
C
T
VS
G
I
L
F
I
-----------------------
I
Y-----------------------SD----------------------S----------------------
S
A
-
V
I
I
C
L
I
T
--------
M
F
F
T
M
L
A
-------
L
M
A
S
L
Y
V
H
M
F
L
M
A
------------
R
L
H
I
K
R
I
A
VLPG-------------------------------------------------------------------------------------------------------------------------------------------------------T
G
A
IRQG--AN-----------------------------------------------------------------------------------------------------------------------------------------------------MK---
G
A
I
T
L
T
I
L
I
G
V
F
V
V
C
W
A
P
F
F
L
H
L
I
--
F
YISCPQN
P
Y
C
V
C
F
MSHF
N
L
Y
L
I
L
I
M
---
C
N
S
I
I
D
P
L
I
Y
A
L
R
S
Q
E
L
R
K
T
F
K
E
I
I
CCYPLG
G
L
CDLSSRY
44
HHSearch
91.99
28%
-164
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-477]
------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
---
V
M
G
L
A
V
V
P
F
G
A
A
H
I
---
L
M
K
M
W
T
F
G
---
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
---
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----------------------
Q
M
H----------------------
W
Y
RATH
Q
E
A
I
N
C
Y
A
EETCCDFFTN
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
--------
S
F
Y
V
P
L
V
-------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------------
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
K
F
C
L
--
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
K
---
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
--
V
H
V
I
Q
D
N
L
----
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
---
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------
63
Fugue
86.01
27%
-185
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
---
V
M
G
L
A
------
V
V
P
F
G
A
A
H
I
L
M
-
K
M
W--
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----------------------
Q
M
HWYRATH
Q
E
A
I
N
C
Y
A
EETCCDFF
T
N
----------------------
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
--------
S
F
Y
V
P
L
V
-------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------------
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
--
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
---
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
--
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
---
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------
51
HHSearch
85.27
29%
-173
- C7 -
3EML
13
ENLYS_BPT4
A:
[23-472]
---------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
-
G
F
C
-
A
A
---
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQSQGCGEGQVACLFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
--------
C
V
L
V
P
L
L
-------
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
R
S
T
L
Q
--
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
H
---
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
--
F
T
F
F
C
P
D
C
S
--
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------
43
HHSearch
82.56
24%
-159
- C7 -
3UON
4
ACM2_HUMAN (first)
A:
[28-457]
------------------------------------------------
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
---
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
---
V
I
G
Y
W
P
L
G
---
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
---
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-----------------------
L
F
-----------------------
W
Q
F
I
V
GVRTVEDGECYIQFFSN--
A
----------------------
A
V
-
T
F
G
T
A
I
A
--------
A
F
Y
L
P
V
I
-------
I
M
T
V
L
Y
W
H
I
S
R
A
S
------------
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
P
P
P
S
--
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
K
---
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
--
I
N
T
F
C
A
P
C
I
----
P
N
T
V
W
T
I
G
Y
W
L
C
Y
---
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------
45
HHSearch
81.81
28%
-164
- C7 -
3V2Y
1
ENLYS_BPT4
A:
[67-495]
-----------------------------------------------
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
---
L
A
G
V
A
Y
T
A
N
L
L
L
S
G
A
----
T
T
Y
K
L
T
---
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
---
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
-----------------------
M
G
-----------------------
W
N
CISALSSCSTVLPLY-------
H
----------------------
K
H
-
Y
I
L
F
C
T
T
--------
V
F
T
L
L
L
L
-------
S
I
V
I
L
Y
C
R
I
Y
S
L
V
------------
R
T
R
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
A
S
R
S
S
--
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
--
L
D
V
G
C
K
V
K
T
--
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
---
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------
49
HHSearch
80.78
24%
-160
- C7 -
3RZE
5
ENLYS_BPT4 (first)
A:
[13-443]
------------------------------------------------
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
---
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
---
M
S
K
W
S
L
G
---
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
---
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-----------------------
G
W
-----------------------
N
H
RREDKCETDFYDV---------
T
----------------------
W
F
-
K
V
M
T
A
I
I
--------
N
F
Y
L
P
T
L
-------
L
M
L
W
F
Y
A
K
I
Y
K
A
V
------------
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
L
H
M
N
--
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
K
---
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
--
V
I
A
F
C
K
N
C
C
----
N
E
H
L
H
M
F
T
I
W
L
G
Y
---
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------
53
HHSearch
78.55
22%
-163
- C7 -
3PBL
2
DRD3_HUMAN (first)
A:
[43-472]
------------------------------------------------
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
---
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
--
T
G
G
V
W
N
F
S
---
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
---
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-----------------------
F
G
-----------------------
F
N
TTGDPTVCSISN----------
P
----------------------
D
F
-
V
I
Y
S
S
V
V
--------
S
F
Y
L
P
F
G
-------
V
T
V
L
V
Y
A
R
I
Y
V
V
L
------------
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
G
V
P
L
--
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
K
---
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
--
L
N
T
H
C
Q
T
C
H
---
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
---
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------
6
PsiBlast_PDB
76.87
28%
-154
- C7 -
3VGA
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQSQGCG--------------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------
1
PsiBlast_PDB
76.59
28%
-160
- C7 -
2YDO
3
?
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
A
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPK
E
G
K
A
H
S
Q
GCG-------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
K
Q
M
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
17
PsiBlast_PDB
76.48
27%
-207
- C7 -
3SN6
1
R:
[200-490]
-------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
VMG
L
A
V
V
P
F
G
A
A
H
I
----
L
T
K
T
W
T
F
-
G
N
FWC
E
F
W
T
S
I
D
-----
V
L
C
--
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
QMHWYRQEAINCYAEETCCD---
F
F
-----------------------
T
N
----------------------
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
--------
S
F
Y
V
P
L
V
-------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
KRQLQKIDKSEG
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------CL
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
K
---
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
--
V
H
V
I
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
IGY
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------------
3
PsiBlast_PDB
76.41
28%
-161
- C7 -
4UG2
3
?
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
A
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPK
E
G
K
A
H
S
Q
GCG-------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------
5
PsiBlast_PDB
76.36
28%
-150
- C7 -
3VG9
8
?
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQSQGCG--------------
E
G
-
Q
V
A
C
L
F
E
DVVPMNYM
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------
2
PsiBlast_PDB
75.72
28%
-160
- C7 -
2YDV
6
?
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
A
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPK
E
G
K
A
H
S
Q
GCG-------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
9
PsiBlast_PDB
75.06
27%
-145
- C7 -
3RFM
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
A
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPGCG---------------
E
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
A
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
4
PsiBlast_PDB
74.74
28%
-152
- C7 -
4UHR
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
T
A
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPKEGKAGCG----------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
16
PsiBlast_PDB
74.31
28%
-178
- C7 -
4GBR
1
ADRB2_HUMAN
A:
[23-285]
-------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
----
L
T
K
T
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
-----
V
L
C
V
T
--
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HWYRATH
Q
E
A
I
N
C
Y
A
EET
C
C
D
F
F
-----------------------
T
N
----------------------
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
--------
S
F
Y
V
P
L
V
-------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------------
K
R
Q
L
Q
K
I
D
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
K
E
H
--
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
K
------
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
--
V
H
V
I
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------
11
PsiBlast_PDB
74.25
27%
-148
- C7 -
3UZC
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
A
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPGCG---------------
E
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
A
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
8
PsiBlast_PDB
74.10
27%
-147
- C7 -
3REY
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
A
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPGCG---------------
E
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
A
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
7
PsiBlast_PDB
74.08
27%
-147
- C7 -
3PWH
1
?
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
A
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPGCG---------------
E
G
-
Q
V
A
C
L
F
E
DVVP
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
A
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
10
PsiBlast_PDB
74.06
27%
-149
- C7 -
3UZA
1
AA2AR_HUMAN
A:
[12-303]
-------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
---
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
---
L
F
I
A
C
F
V
L
V
L
A
Q
-------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----------------------
L
G
-----------------------
W
N
----------------------
N
CGQPGCG---------------
E
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
--
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
A
H
---
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------