@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MTLR_HUMAN: (2016-01-11 )
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70---.---.......80.......-.-90.......-..100.......110.......120.......130.......140.......---150.......160.......170.......180.......190.......200.......210.......220.......230.......----240-.......250......-.260.......270..----.---....280..--------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------------------------------------..-..290.......300.......310.......320....------..----.330.......340..-----.....350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLG
A
L
V
P
V
T
A
V
C
L
C
L
F
V
VGVSG
N
V
V
T
V
M
L
I
GRYRDMRT---T---T
N
L
Y
L
G
S
M
A
V
S
D
L
L
I
L
-L-G-L
P
F
D
L
Y
R
-
L
W
RSRPW
V
F
G
P
L
L
C
R
L
S
L
Y
VGEG
C
T
Y
A
T
L
L
H
M
T
A
L
S
V
E
R
Y
L
A
I
C
R
P
L
R
A
R
V
L
---
V
T
R
R
R
V
R
A
L
I
A
V
L
W
A
V
A
L
LSAG
P
F
L
F
L
V
GVEQDPG
I
S
V
VPGLNGTARIASSPLASSPP
L
W
LSRAPPPSPPSGP
E
T
A
E
A
A
A
L
F
SRECRPSP----
A
Q
L
-
G
A
L
R
V
M
L
W
V
T
T
A
Y
F
F
L
-
P
F
L
C
L
S
I
L
Y
G
L
I
G
R
E
L
----
W
---SSRRPLRGP--------------------------------------------------------------------------------------------------------------------------------------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------AS-GRER
G
H
R
Q
T
V
R
V
L
L
V
V
V
L
A
F
I
I
C
W
L
P
FHVG
R
I
I
Y
I
NTED------S
R
----
M
M
Y
F
S
Q
Y
F
N
I
V
A
L
Q
L
F
-----
Y
L
SAS
I
N
P
I
L
Y
N
L
I
S
K
K
Y
R
A
A
A
F
K
L
L
L
ARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
52
HHSearch
89.73
26%
-150
- C11 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
---
T
---
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
-
T
L
V
-
M
P
W
V
V
Y
L
-
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
G
D
P
-------------------------------------------------
T
V
C
S
I
S
N
----
P
------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
-
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
----
K
---
Q
R
R
R
K
N
I
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
-
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
------
C
H
-------
V
S
P
E
L
Y
S
A
T
T
W
L
G
-----
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------
3
PsiBlast_PDB
89.24
35%
-161
- C11 -
3ZEV
6
NTR1_RAT
A:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
---
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
H
---
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
----------------------------------------
6
PsiBlast_PDB
89.09
33%
-163
- C11 -
4XES
5
?
A:
[33-345]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
S
L
Q
S
L
Q
S
T
---
V
H
Y
H
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
A
S
L
S
V
A
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
------------------------------
N
R
S
A
D
G
T
H
P
G
G
L
-----------
V
C
T
P
-
I
----
V
D
T
-
A
T
V
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
I
S
I
L
N
T
V
I
A
N
K
L
T
V
--
M
---
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
G
R
V
Q
A
L
R
H
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
F
-----
Y
A
S
S
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
23
PsiBlast_CBE
88.99
35%
-161
- C11 -
3ZEV
2
NTR1_RAT
B:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
------
S
L
Q
S
T
---
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
----------------------------------------
4
PsiBlast_PDB
88.86
33%
-169
- C11 -
4XEE
4
?
A:
[33-345]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
-----S--
T
---
V
H
Y
H
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
A
S
L
S
V
E
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
------------------------------
N
R
S
A
D
G
T
H
P
G
G
L
-----------
V
C
T
P
-
I
----
V
D
T
-
A
T
V
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
I
S
I
L
N
T
V
I
A
N
K
L
----
T
V
M
V-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
G
R
V
Q
A
L
R
H
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
F
-----
Y
A
S
S
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
21
PsiBlast_CBE
88.64
35%
-164
- C11 -
4BWB
1
NTR1_RAT
B:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
K
--------S
R
-
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
-
A
-
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
--
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
R
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V
H
---
Q
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
D
------
E
Q
WT
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
------------------------------------------
1
PsiBlast_PDB
88.54
35%
-165
- C11 -
4BWB
1
NTR1_RAT
A:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
---
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
-
A
-
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
R
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
D
------
E
Q
WT
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
--------------------------------------
2
PsiBlast_PDB
87.46
35%
-162
- C11 -
4BUO
10
NTR1_RAT
A:
[19-313]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
---
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
--
M
---
V
H
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
------------------------------------------
5
PsiBlast_PDB
87.37
34%
-167
- C11 -
4BV0
1
NTR1_RAT
A:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
---------SR-
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
-
A
-
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
-----
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
V
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
D
------
E
Q
WT
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
---------------------------------------
22
PsiBlast_CBE
87.33
35%
-158
- C11 -
4BUO
5
NTR1_RAT
B:
[19-313]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
------LQ
S
T
---
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
-
L
-
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
--
M
---
V
H
Q
A
A
F
N
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
-
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
D
------
E
Q
WT
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
----------------------------------------
24
PsiBlast_CBE
86.67
34%
-162
- C11 -
4BV0
1
NTR1_RAT
B:
[20-316]
--------------------------------------
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
---------
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
-
A
-
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
F
K
H
K
T
----
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
V
G
L
Q
N
L
S
G
D
G
T
H
P
G
-----
G
L
V
C
T
P
I
V
D
T
------------------------------------------
A
T
L
K
V
V
I
Q
L
N
T
F
M
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
D
------
E
Q
WT
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
-----
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
P
-------------------------------------
47
HHSearch
84.86
24%
-145
- C11 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
----------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
---
V
---
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-
V
F
S
-
M
N
L
Y
T
L
Y
-
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
--
V
----
E
--------------------------------------
D
G
E
C
Y
I
Q
F
----
F
S
---
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
-
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
----
K
---
S
R
I
N
I
F
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
------
C
--------
I
P
N
T
V
W
T
I
G
Y
W
L
C
-----
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------
45
HHSearch
84.57
21%
-139
* C11 *
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
---------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
---
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
-
V
P
F
G
A
A
H
-
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----
I
N
C
Y
------------------------------------
A
E
E
T
C
C
D
F
F
----
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
-
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
----
K
---
R
Q
L
N
I
F
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
------
L
--------
I
R
K
E
V
Y
I
L
L
N
W
I
G
-----
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------
48
HHSearch
83.00
21%
-143
- C11 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
---
V
---
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
-
A
V
V
-
M
P
M
N
I
L
Y
-
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
--------------
R
-------------------------------------
R
E
D
K
C
E
T
D
F
----
Y
D
V
---
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
-
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
----
R
---
Q
H
C
N
I
F
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
------
C
C
--------
N
E
H
L
H
M
F
T
I
W
L
G
-----
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------
49
HHSearch
82.16
19%
-133
- C11 -
3EML
13
ENLYS_BPT4
A:
[23-472]
---------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
---
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
-
V
L
A
-
I
P
F
A
I
T
I
-
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
------------
S
Q
-
G
C
G
E
-----------------------------
G
Q
V
A
C
L
F
E
D
----
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
----
R
---
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
-
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
------
C
S
------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
-----
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------------
11
PsiBlast_PDB
80.14
24%
-145
- C11 -
4RWA
2
C562_ECOLX (first)
A:
[115-399]
------------------------------
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
---
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
-
L
P
F
Q
S
A
K
--
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
D
G
A
V
V
C
---------------------
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
----------------------------
F
V
V
-
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
-
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
------
D
R
----
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
-----
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------
53
HHSearch
80.07
26%
-135
- C11 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
---
V
---
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
-
A
F
N
-
T
V
V
N
F
T
Y
-
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
M
P
S
R
V
-----------------------------------------------
V
C
M
I
E
W
PEHP
N
K
I
-
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
-
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
----
W
---
A
S
E
I
P
G
D
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
R--------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
-
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
------
L
Y
----
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
-----
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
46
HHSearch
80.04
20%
-133
- C11 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-498]
-------------------------------------
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
---
M
---
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
-
T
-
L
P
F
W
A
V
D
-
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
D
D
R
-----------------------------------------------
Y
I
C
D
R
F
Y
----
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
-
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
----
S
---
H
S
G
S
N
I
F
E
M
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
G
-
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
----
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
-----
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------------
12
PsiBlast_PDB
78.77
24%
-135
- C11 -
4RWD
7
C562_ECOLX (first)
A:
[115-399]
------------------------------
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
---
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
-
L
P
F
Q
S
A
K
--
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
D
G
A
V
V
C
---------------------
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
----------------------------
F
V
V
-
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
----------
R
L
R
S
V
R
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
-
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
------
D
R
----
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
-----
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------
8
PsiBlast_PDB
77.19
27%
-136
- C11 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
---------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
---
A
---
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
-
L
-
T
-
L
P
F
Q
G
T
D
-
I
L
L
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
----------------
G
S
A
Q
V
E
D
E
E
I
E
C
-----
L
V
E
I
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
----------------------------
F
I
V
-
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
--------
R
G
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-
E
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
----
F
V
L
A
Q
G
------
L
G
----
V
Q
P
S
S
E
--
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
---------------------------------------------