@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10A3_HUMAN: (2016-01-11 )
MKRQNQSCVVEFILLGFSNFPELQVQLFGVFLVIYVVTLMGNAIITVIISLNQSLHVPMYLFLLNLSVVEVSFSAVITPEMLVVLSTEKTMISFVGCFAQMYFILLFGGTECFLLGAMAYDRFAAICHPLNYPVIMNRGVFMKLVIFSWISGIMVATVQTTWVFSFPFCGPNEINHLFCETPPVLELVCADTFLFEIYAFTGTILIVMVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCASHLTSVTLFYGTANMTYLQPKSGYSPETKKLISLAYTLLTPLLNPLIYSLRNSEMKRTLIKLWRRKVILHTF
Atome Classification :
(20 SA)
----------------.........10........20--.........30...--.....40........50........60........70-......-..80........90...-------------.....100.......110.......120.......130.......140.......150....-...160---------.....-----..170-........180....-----------...190..--.....200.......210.....-..220...---------------..---------..230----------.--------------------..---.....240-------........250------....------....260.--..--.---.-..---270-----------.......280.-......290-.......300.......310..------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MKR
Q
N
Q
S
C
V
V
E
F
I
L
L
GFSNF---
P
E
L
Q
V
Q
L
F
G
V
F
L
V
I
--
Y
V
V
T
L
MGN
A
I
I
T
V
I
I
SLNQSLH
V
P
M
Y
L
F
L
L
N
L
S
V
V
E
V
-
S
F
S
A
VI-TP
E
M
L
V
V
LST
E
K
T
M
I
S
F
-------------
V
G
C
F
A
Q
M
Y
F
I
L
L
FGG
T
E
C
F
L
L
G
A
M
A
Y
D
R
F
A
A
I
CHPLNY
P
V
IMNR
G
V
F
M
K
L
V
I
F
S
W
I
S
G
I
M
V
A
-
T
V
Q
T
T
W
---------
V
F
SFP-----FCGP--
N
E
I
N
H
LFCETP
P
V
L
E
-----------
L
VCA
D
T
F
L
--
F
E
I
Y
A
FT
G
T
I
L
I
V
M
V
P
F
L
L
I
L
L
S
-
Y
I
R
V
L
F
A
I
---------------LK---------MPST-----------T--------------------G
R
---
Q
K
A
F
S
T
C
--------
A
S
H
L
T
S
V
T
L
F
-------
Y
GTA------
N
M
T
Y
LQPK--SG--Y---S-
P
E
---
T
K
K
-----------
L
I
S
L
A
Y
T
L
L
T
P
-
L
L
N
P
L
I
Y
S
L
-
R
N
S
E
M
K
R
T
L
I
K
L
W
R
R
K
V
ILHTF------------------
1
PsiBlast_PDB
94.27
22%
-157
- C4 -
3VG9
8
?
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQ-------
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
2
PsiBlast_PDB
94.16
22%
-156
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQ-------
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
9
PsiBlast_PDB
92.78
22%
-152
- C4 -
2YDV
6
?
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L
K
Q
M
ESQ---------------------------------------S
T
L
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
4
PsiBlast_PDB
91.34
22%
-156
- C4 -
3REY
1
AA2AR_HUMAN
A:
[12-305]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQP-------------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
3
PsiBlast_PDB
91.01
22%
-153
- C4 -
3PWH
1
?
A:
[12-305]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQP-------------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
8
PsiBlast_PDB
90.76
22%
-148
- C4 -
2YDO
3
?
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L
K
Q
M
E
S----------------------------------------T
L
-
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
5
PsiBlast_PDB
90.63
22%
-155
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[12-305]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQP-------------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
6
PsiBlast_PDB
90.56
22%
-156
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[12-305]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQP-------------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
7
PsiBlast_PDB
90.41
22%
-155
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[12-305]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQP-------------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
90.21
22%
-156
- C4 -
4UG2
3
?
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L-------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
S
--
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
11
PsiBlast_PDB
89.41
22%
-152
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[12-308]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPKEG
K
A
--------
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
--
C
---
H
---
A
-
P
L
---
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
-
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
33
HHSearch
79.62
16%
-133
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-333]
------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
--
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
-------------
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
----------
W
--
G
-----
A
Y
T
---
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
----------------
D
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
-
Y
F
N
I
V
M
S
V
---------------
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
---
M
R
L
A
K
I
S
--------
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
------
A
V
V
A
L
L
A
Q
--
F
G
--
P
LEW
V
-
T
P
---
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
A
-
I
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
30
HHSearch
78.40
18%
-133
* C4 *
2KS9
1
NK1R_HUMAN
A:
[35-325]
---------------------------------------------
W
A
A
A
Y
T
V
I
--
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
-------------
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
Y
-----------
S
-
T
-----
T
-
E
---
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
-----------
P
N
---
K
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
-
Y
T
V
V
G
I
T
L
---------------
W
A
---------
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
---
R
K
V
V
K
M
M
--------
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
------
H
I
F
F
L
L
P
Y
--
I
N
PD
L
---
Y
L
K
K
FI
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
T
-
M
Y
N
P
I
I
Y
C
C
-
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
------------------
38
Fugue
78.09
16%
-134
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-------------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
---------
S
R
Y
I
P
E
GMQC
S
C
G
I
--
D
----
Y
Y
T
P
H
E
E
T
N
---------------
N
E
S
F
V
--
I
Y
M
F
V
V
H
-----
F
I
I
P
L
I
V
I
F
F
C
-
Y
G
Q
L
V
F
T
V
---------------
K
E
---------
A
A
A
S
-----------
A
--------------------
T
T
---
Q
K
A
E
K
E
V
--------
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
G
--
S
---
D
-
F
G
---
P
I
F
-----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------
40
Fugue
72.78
15%
-123
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-------------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
---------
S
R
Y
I
P
E
GMQC
S
C
G
I
--
D
----
Y
Y
T
P
H
E
E
T
N
---------------
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
-----
I
I
P
L
I
V
I
F
F
C
-
Y
G
Q
L
V
F
T
V
---------------
K
E
---------
A
A
A
Q
-----------
Q
--------------------
Q
E
---
S
A
T
T
Q
K
A
--------
E
K
E
V
T
R
M
V
I
I
-------
M
V
I
A
------
F
L
I
C
W
L
P
Y
--
A
G
--
V
---
A
-
F
Y
---
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
44
Fugue
72.05
19%
-155
- C3 -
4L9B
5
?
A:
[2-393]
VLKGINFP
E
N
E
A
S
I
L
D
L
A
M
Q
N
R
S
G
V
L
D
G
M
T
I
D
I
L
N
T
---
T
S
N
Q
L
A
L
F
H
G
T
A
V
L
QG
Y
G
I
E
I
T
G
A
P
D
V
L
V
D
T
T
-
G
Q
S
N
E
T
M
L
L
C
L
T
I
D
L
N
Q
V
N
V
P
S
G
T
A
V
D
-
Y
K
Q
I
R
L
E
F
L
D
V
P
T
L
L
K
Q
YWRDHSLHDLIDP
R
R
V
I
S
M
P
L
Y
W
I
T
F
G
Q
T
G
T
T
P
L
Y
E
Q
I
K
S
N
Y
I
D
N
S
G
N
P
A
Y
G
I
A
A
R
C
E
N
F
N
H
F
-----
I
N
K
V
A
V
Q
-
S
I
P
I
N
G
---------
V
A
N
R
P
-----
V
S
S
T
A
S
Q
L
T
N
Y
K
V
W
R
N
P
Y
L
C
S
QDPRDKFAP
D
N
L
V
I
E
E
D
G
I
--
Y
R
I
D
-
I
S
G
S
I
N
I
A
N
Y
T
F
P
A
R
V
G
G
R
Y
F
Q
I
V
C
A
R
N
SSANNLAEFGAE
Q
H
L
P
---------
P
S
G
V
-----------
W
--------------------
T
R
---
R
V
L
V
G
E
Y
TAGMT
E
Q
A
F
S
S
V
A
T
I
S
L
F
-------
K
G
--------
D
N
F
F
L
Q
F
E
--
T
G
--
T
---
N
-
T
S
---
R
D
S
-----------
A
Y
N
N
G
Y
G
T
S
G
T
-
H
L
R
N
F
S
Y
T
L
E
R
V
G
D
L
N
G
T
---
A
Y
Y
D
N
---
G
T
F
------------------
31
HHSearch
71.11
14%
-128
- C4 -
1U19
14
OPSD_BOVIN
A:
[43-327]
---------------------------------------------
L
A
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-------------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
----------
W
S
-------
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
--------------
H
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
-
Y
G
Q
L
V
F
T
V
---------------
K
E
---------
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
---
K
E
V
T
R
M
V
--------
I
I
M
V
I
A
F
L
I
C
-------
W
L
P
Y
------
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
D--
F
-
G
P
---
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------
13
PsiBlast_PDB
70.58
23%
-168
- C4 -
3EML
8
ENLYS_BPT4
A:
[27-222]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQ-------
S
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
---------
Q
L
N
I
-----------
F
--------------------
E
M
---
L
R
I
D
E
G
L
--------
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
I
G
H
L
L
T
K
--
S
P
--
S
---
L
-
N
A
---
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
------------------
14
PsiBlast_PDB
69.90
23%
-169
- C4 -
3QAK
1
ENLYS_BPT4
A:
[27-222]
------------------------------------------------
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCG---------
Q
-----
G
C
G
E
--
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
-----------
M
V
-----
Y
--
F
N
F
F
A
------
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
---------
Q
L
N
I
-----------
F
--------------------
E
M
---
L
R
I
D
E
G
L
--------
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
I
G
H
L
L
T
K
--
S
P
--
S
---
L
-
N
A
---
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
------------------
26
HHSearch
68.48
21%
-180
- C4 -
3EML
8
ENLYS_BPT4
A:
[23-221]
--------------------------------------------
V
Y
I
T
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
-------------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
G
------------
W
N
-----
N
C
G
Q
------
S
Q
G
C
G
E
G
Q
--------------
V
A
C
L
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
-
Y
L
R
I
F
L
A
A
---------------
R
R
---------
Q
L
N
I
-----------
F
--------------------
E
M
---
L
R
I
D
E
G
L
--------
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
I
G
H
L
L
T
K
--
S
P
--
S
---
L
-
N
A
---
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
------------------