@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10A4_HUMAN: (2016-01-11 )
MMWENWTIVSEFVLVSFSALSTELQALLFLLFLTIYLVTLMGNVLIILVTIADSALQSPMYFFLRNLSFLEIGFNLVIVPKMLGTLIIQDTTISFLGCATQMYFFFFFGAAECCLLATMAYDRYVAICDPLHYPVIMGHISCAQLAAASWFSGFSVATVQTTWIFSFPFCGPNRVNHFFCDSPPVIALVCADTSVFELEALTATVLFILFPFLLILGSYVRILSTIFRMPSAEGKHQAFSTCSAHLLVVSLFYSTAILTYFRPQSSASSESKKLLSLSSTVVTPMLNPIIYSSRNKEVKAALKRLIHRTLGSQKL
Atome Classification :
(20 SA)
------------.........10........20........30........40........50........60........70.......-.80........90........100.......110.......120.......130.......140.......150.......160......-----.170.......180.......190.......200.....--.--.210.......220-......---------.230.--------------------.--------.-------...---------.240....-------...250-------.......260..--.----.--.---.-.270.---------.--......280...--....290.......300.......310...------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MMWENW
T
I
V
S
E
F
V
L
V
S
F
S
A
L
S
T
E
L
Q
A
L
L
F
L
L
F
L
T
I
Y
L
V
T
L
MG
N
V
L
I
I
L
V
T
I
A
D
S
A
L
Q
S
P
M
Y
F
F
L
RN
L
S
F
L
E
IG
F
N
L
V
I
-
V
P
K
M
L
G
T
L
I
I
QDT
T
I
S
F
L
G
C
A
T
Q
M
Y
F
F
F
F
F
G
A
A
E
C
C
L
L
A
T
M
A
YD
R
Y
V
A
ICDPLHY
P
V
I
M
G
H
I
S
C
A
Q
L
A
A
A
S
WFSG
F
S
V
A
T
V
Q
T
T
W
I
F
SFP-----FCGPNRV
N
H
F
FCDSP
P
V
I
A
L
V
CADT
S
V
F
E
L
E
A
L
T
A
T
V
L
F
--
I
--
L
F
P
F
L
L
I
L
G
S
Y
V
R
I
-
L
S
T
I
F
R---------MPSAE--------------------G--------K-------
H
Q
A
---------
F
S
T
C
S
A
H
L
-------
L
V
V
S
L
F
-------
Y
S
T
A
I
L
T
Y
FRPQ--S----S--A---S-S
E
-
S
K
---------
K
--
L
L
S
L
S
S
T
V
V
T
P
M
--
L
N
P
I
IYSSRN
K
E
V
K
A
A
L
K
R
L
I
H
R
TLGSQKL------------------
9
PsiBlast_PDB
92.30
20%
-156
- C3 -
2YDV
6
?
A:
[14-311]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
K
Q
M
ESQ------------------------------------S
T
L
----
Q
K
E
---------
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
1
PsiBlast_PDB
90.63
21%
-152
- C3 -
3PWH
1
?
A:
[14-305]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
-------
H
I
I
N
C
F
-------------
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
90.50
20%
-155
- C3 -
4UG2
3
?
A:
[14-309]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L--------------------------------
A
--------
R
S
T
L
----
Q
K
E
---------
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
5
PsiBlast_PDB
90.03
21%
-157
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
-------
H
I
I
N
C
F
-------------
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
2
PsiBlast_PDB
89.66
21%
-156
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
-------
H
I
I
N
C
F
-------------
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
11
PsiBlast_PDB
89.56
20%
-152
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-311]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
----
Q
K
E
---------
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
-------
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
3
PsiBlast_PDB
89.52
21%
-155
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
-------
H
I
I
N
C
F
-------------
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
4
PsiBlast_PDB
89.11
21%
-154
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
-------
H
I
I
N
C
F
-------------
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
8
PsiBlast_PDB
88.53
20%
-149
- C3 -
2YDO
3
?
A:
[14-311]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
K
Q
M
E
S-------------------------------------T
L
-----
Q
K
E
---------
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
7
PsiBlast_PDB
88.23
21%
-159
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
Q
M
E
--------------------
S
--------
Q
PLPG---
E
R
A
---------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
6
PsiBlast_PDB
86.99
21%
-163
- C3 -
3VG9
8
?
A:
[14-309]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
Q
M
E
--------------------
S
--------
Q
PLPG---
E
R
A
---------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
----
S
--
H
---
A
-
P
L
-
W
L
---------
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
32
HHSearch
78.05
18%
-130
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-332]
----------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
--------
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-----
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
--
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-
V
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
-------
M
R
L
---------
A
K
I
S
I
V
I
V
-------
S
Q
F
L
L
S
-------
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
G---
P
LE
W
---
V
-
T
P
-
Y
A
---------
A
--
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
31
HHSearch
77.18
17%
-135
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
--------
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
N
---
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
--
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-
G
I
T
L
W
A
---------
S
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
-------
R
K
V
---------
V
K
M
M
I
V
V
V
-------
C
T
F
A
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
NP--
D
--
L
---
Y
L
K
K
F
I
Q
Q
V
-------
Y
--
L
A
I
M
W
L
A
M
S
S
T
M
--
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
------------------
40
Fugue
77.10
15%
-122
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
-----------
T
N
N
E
S
F
V
I
Y
M
F
V
--
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
S
A
--------------------
T
--------
T
-------
Q
K
A
---------
E
K
E
V
T
R
M
V
-------
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
----
Y
--
I
---
F
-
T
H
-
Q
G
SDFGP----
I
--
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------
39
Fugue
71.84
15%
-124
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
---------
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
--------
E
-------
S
A
T
---------
T
Q
K
A
E
K
E
V
-------
T
R
M
V
I
I
-------
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
----
G
--
V
---
A
-
F
Y
-
I
F
T
H
QGSDFGP
I
--
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
29
HHSearch
70.87
15%
-122
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-326]
-----------------------------------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-------
Y
-
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
---------
A
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
-------
K
E
V
---------
T
R
M
V
I
I
M
V
-------
I
A
F
L
I
C
-------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
----
G
S-
D
---
F
-
G
P
-
I
F
---------
M
--
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------
27
HHSearch
70.68
16%
-111
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
----------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
-
Q
-
A
-----
Y
-
H
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----
T
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
--
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-
L
R
T
L
F
K
---------
A
H
-
M
G
--------------------
Q
--------
K
-------
H
R
A
---------
M
R
V
I
F
A
V
V
-------
L
I
F
L
L
C
-------
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
TQVI
Q
E-
S
C
E
R
R
-
N
N
-
I
G
---------
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
--
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------
14
PsiBlast_PDB
66.16
23%
-172
- C3 -
4EIY
22
AA2AR_HUMAN (first)
A:
[39-225]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
N
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
---------
Q
L
A
D
L
--------------------
E
--------
D
-------
N
W
E
---------
T
L
N
D
N
L
K
V
-------
I
E
K
A
D
N
-------
A
A
Q
V
K
D
A
L
T
K
M
R
--
A
----
A
--
A
---
L
-
D
A
-
Q
K
---------
M
--
K
D
F
R
H
G
F
D
I
L
V
G
--
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
------------------
13
PsiBlast_PDB
65.61
23%
-175
- C3 -
3QAK
1
ENLYS_BPT4
A:
[29-215]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
---------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
---------
Q
L
N
I
F
--------------------
E
--------
M
-------
L
R
I
---------
D
E
G
L
R
L
K
I
-------
Y
K
D
T
E
G
-------
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
----
P
--
S
---
L
-
N
A
-
A
K
---------
S
--
E
L
D
K
A
I
G
R
N
T
N
G
--
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
------------------
12
PsiBlast_PDB
65.38
23%
-176
- C3 -
3EML
8
ENLYS_BPT4
A:
[29-215]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-----
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
---------
Q
L
N
I
F
--------------------
E
--------
M
-------
L
R
I
---------
D
E
G
L
R
L
K
I
-------
Y
K
D
T
E
G
-------
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
----
P
--
S
---
L
-
N
A
-
A
K
---------
S
--
E
L
D
K
A
I
G
R
N
T
N
G
--
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
------------------