@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10A7_HUMAN: (2016-01-11 )
MICENHTRVTEFILLGFTNNPEMQVSLFIFFLAIYTVTLLGNFLIVTVTSVDLALQTPMYFFLQNLSLLEVCFTLVMVPKMLVDLVSPRKIISFVGCGTQMYFFFFFGSSECFLLSMMAYDRFVAICNPLHYSVIMNRSLCLWMAIGSWMSGVPVSMLQTAWMMALPFCGPNAVDHFFCDGPPVLKLVTVDTTMYEMQALASTLLFIMFPFCLILVSYTRIIITILRMSSATGRQKAFSTCSSHLIVVSLFYGTASLTYLRPKSNQSPESKKLVSLSYTVITPMLNPIIYGLRNNEVKGAVKRTITQKVLQKLDVF
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10...----------------..----------------...20........30-........40....-....50...-----.....60....-....70......-..80........90........100.......110.......120.......130.......140.......150.......160......-----..170.........180.......190..--.....200-....--.--..210.......220....------..------------.230----------.--------------------.......240.......250------....------....260..---.--.-----.---.-.-270-.--.......280..-.....290.......300...----------------....310....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MICENHT
R
V
T
E
F
I
L
----------------
L
G----------------FTNNP
E
M
Q
V
S
L
F
I
F
F
-
L
A
I
Y
T
V
T
L
LG
N
F
L
I
-
V
T
V
T
SV
D
L
A
-----LQ
T
P
M
Y
F
F
L
Q
N
-
L
S
L
L
E
V
C
F
T
L
V
M
-
V
P
K
M
L
V
D
LV
S
P
R
K
I
I
S
F
VGCG
T
Q
M
Y
F
F
F
F
FGSS
E
C
F
L
L
S
M
M
A
Y
D
R
F
V
A
I
CN
P
L
H
Y
S
VIMNRS
L
C
L
W
M
A
I
G
S
W
MSGV
P
V
S
M
L
Q
T
A
-
W
M
M
ALP-----FCG--
P
N
A
V
D
HFFCDGP
P
V
L
K
L
V
TVD
T
T
M
--
Y
E
M
Q
A
L
A
S
-
T
L
L
F
--
I
--
M
F
P
F
C
L
I
L
V
S
Y
T
R
I
I
I
T
I
L
------RM------------SSA-----------T--------------------G
R
Q
K
A
F
S
T
CSS
H
L
I
V
V
S
L
F-------YGT
A
------
S
L
T
Y
LRPKS---N--Q-----S---P-E-S
K
--
K
--
L
V
S
L
S
Y
T
V
I
T
P
M
-
L
N
P
I
I
Y
GLRNN
E
V
K
G
A
V
K
R
T
I
----------------
T
Q
K
V
L
Q
KLDVF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
93.23
20%
-137
- C4 -
2YDV
6
?
A:
[3-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
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V
L
A
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P
F
A
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I
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T
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G
I
I
A
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W
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F
A
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L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L
K
Q
M
ESQ-------------------
S
--------------------
T
L
Q
K
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V
H
A
A
K
S
L
A
I
I
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L
F
A
L
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W
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F
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P
D
C
---
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--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
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L
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T
N
S
V
-
V
N
P
F
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Y
A
Y
R
I
R
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F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.25
20%
-134
- C4 -
2YDO
3
?
A:
[6-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
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C
A
A
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L
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V
L
V
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S
S
I
F
S
L
L
A
I
A
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D
R
Y
I
A
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L
R
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N
G
L
V
T
G
T
R
A
K
G
I
I
A
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C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L
K
Q
M
E
S-----------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.88
20%
-138
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[6-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
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A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
------
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.45
20%
-144
- C4 -
3REY
1
AA2AR_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
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I
L
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A
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A
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L
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F
S
L
L
A
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A
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D
R
Y
I
A
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A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
QP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
-
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.20
20%
-142
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
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V
L
A
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I
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C
A
A
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Y
N
G
L
V
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A
A
G
I
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A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
QP--------
G
C
G
E
G
Q
V
A
C
L
F
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D
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P
--
M
N
Y
M
V
Y
F
N
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F
F
A
C
--
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L
V
P
L
L
L
M
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G
V
Y
L
R
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F
A
A
A
R
------
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Q
L
K
Q
M
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S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
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S
A
A
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L
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L
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N
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P
D
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---
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--
H
-----
A
---
P
-
L
-
W
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Y
L
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L
A
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N
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V
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V
N
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F
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Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.80
20%
-139
- C4 -
4UG2
3
?
A:
[6-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
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A
--
I
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C
A
A
C
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L
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A
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N
G
L
V
T
G
T
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A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L------------
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.66
20%
-144
- C4 -
3VG9
8
?
A:
[6-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.24
20%
-143
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
QP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
-
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.12
20%
-142
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[6-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
--
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
-
F
N
F
F
AC
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.98
20%
-140
- C4 -
3PWH
1
?
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
QP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
-
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.96
20%
-141
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
G
QP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
-
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
-----------
S
--------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
D
C
---
S
--
H
-----
A
---
P
-
L
-
W
L
--
M
--
Y
L
A
I
V
L
A
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.94
18%
-120
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
S
L
G
I
F
I
-
G
I
C
G
I
I
G
C
G
G
N
G
I
V
-
I
Y
L
F
T
K
T
K
S
-----
L
Q
T
P
A
N
M
F
I
I
N
-
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
-------
Y
-
T
---
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
T
--
T
R
S
N
I
L
C
M
-
F
I
L
G
--
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
------
N
H
------------
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
------
A
V
V
A
L
L
A
Q
F
---
G
--
P
LEW--
V
---
T
-
P
-
Y
A
--
A
--
Q
L
P
V
M
F
A
K
A
S
A
I
-
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
81.76
16%
-118
- C4 -
2KS9
1
NK1R_HUMAN
A:
[35-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
A
Y
-
T
V
I
V
V
T
S
V
V
G
N
V
V
V
-
M
W
I
I
L
A
H
K
R
-----
M
R
T
V
T
N
Y
F
L
V
N
-
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
---------
E
---
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
Y
--
E
K
V
Y
H
I
C
V
-
T
V
L
I
--
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
------
A
S
------------
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
------
H
I
F
F
L
L
P
Y
I
---
N
--
P
-----
D
LYL
K
-
K
F
I
Q
Q
V
Y
--
L
A
I
M
W
L
A
M
S
S
T
M
-
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
G
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
77.19
16%
-129
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
----------------
P
F
SNKTGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
K
-----
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
--
I
D
----
Y
Y
T
P
H
E
E
-------------
T
N
N
E
S
F
V
I
-
Y
M
F
V
--
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
A
------------
A
A
S
-----------
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
--
S
-----
D
---
F
-
G
-
P
I
--
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
74.47
16%
-123
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSPFEAP
Q
Y
----------------
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
K
-----
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
--
I
D
----
Y
Y
T
P
H
E
E
T
N
-----------
N
E
S
F
V
I
Y
M
-
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EAAAQQ
Q
E
------------
S
A
T
-----------
T
--------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
--
Y
A
G
V
------
A
F
Y
I
F
T
H
Q
G
---
S
--
D
-----
F
---
G
-
P
-
I
F
--
M
--
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
71.52
18%
-106
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
-
A
L
V
F
L
L
S
L
L
G
N
S
L
V
-
M
L
V
I
L
Y
S
R
V
-----
G
R
S
V
T
D
V
Y
L
L
N
-
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
-------
Y
-
H
--
P
N
-
N
S
S
P
V
C
Y
E
V
L
G
N
D
----
T
A
K
W
--
R
M
V
L
R
I
L
P
-
H
T
F
G
--
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
------
K
A
------------
H
-
M
-----------
G
--------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
-------
W
L
P
Y
------
N
L
V
L
L
A
D
T
L
M
RT
Q
VI
Q
E
S
C
E
R
R
---
N
-
N
-
I
G
--
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
-
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
----------------
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
71.13
14%
-125
* C4 *
1U19
14
OPSD_BOVIN
A:
[42-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
K
-----
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
-------
Y
-
I
--
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
N
--
N
E
S
F
V
I
Y
M
-
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
A
------------
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-------
W
L
P
Y
------
A
G
V
A
F
Y
I
F
T
H
--
Q
--
G
-----
S
---
D
F
G
P
I
F
--
M
--
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
65.65
18%
-155
- C4 -
3EML
8
ENLYS_BPT4
A:
[23-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
T
V
E
-
L
A
I
A
V
L
A
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
-----
Q
---------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
-
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
Q
------------
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
I
G
H
L
L
T
K
S
---
P
--
S
-----
L
---
N
-
A
-
A
K
--
S
--
E
L
D
K
A
I
G
R
N
T
N
G
-
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
----------------
I
L
R
N
A
K
L
K
P
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
65.53
17%
-147
- C2 -
4TZ4
-
DDB1_HUMAN
A:
[1-1146]
S
Y
N
Y
V
V
T
AQKPTAVN
G
C
V
T
G
HFTSAE
D
L
N
L
L
I
A
KNT
R
L
E
I
Y
V
V
T
ALRPV
K
E
V
G
M
YGKIA
V
M
E
L
F
R
P
K
GES
K
D
L
L
F
I
L
T
AKY
N
A
C
I
L
E
Y
K
QS
I
D
I
I
T
R
A
H
G
N
VQDRIGRPSET
G
I
I
G
I
I
D
PECR
M
I
G
L
R
LYDG
L
F
K
V
I
P
LDRDNKEL
K
A
F
N
I
R
L
EELHVI
D
V
K
F
L
Y
GCQ
A
P
T
I
C
F
V
Y
Q
D
PQ
G
R
H
V
K
T
Y
E
V
S
LREKEFNKGPWKQNVEAEAS
M
V
I
A
V
P
EPF
G
G
A
I
I
I
G
QE
S
I
T
Y
H
N
GD
K
Y
L
A
I
A
P
PIIKQ
S
T
I
V
C
HNRVDPNGS
R
Y
L
L
G
D
ME
G
R
L
F
M
L
L
L
E
KTLK
D
L
R
V
E
L
LGETSIAE
C
L
T
Y
L
D
NG
V
V
F
V
G
S
RL
G
D
S
Q
L
V
K
L
NEQ
G
S
Y
V
V
A
M
E
T
F
T
N
LGPIV
D
M
C
V
V
DLEQ
G
Q
L
V
T
CSGAFKE
G
S
L
R
I
I
R
N
G
I
G
I
H
E
H
A
S
I
D
L
P
GIK
G
L
W
P
L
R
SDPETDD
T
L
V
L
S
F
VG
Q
T
R
V
L
M
L
N
G
E
E
V
E
E
T
E
--
L
----------------
M
G
----------------
F
V
D
D
Q
Q
-----------
T
F
F
C
G
N
V
A
H
Q
Q
L
I
Q
I
T
S
A
S
V
R
L
V
-----
S
Q
E
P
K
A
---------
L
V
S
E
W
K
E
P
Q
-
A
K
N
I
S
V
A
S
C
N
S
S
Q
V
V
V
A
V
G
--
R
A
L
Y
Y
L
Q
I
H
P
Q
E
---
L
R
Q
I
S
H
T
E
M
E
V
A
C
L
D
------
I
T
P
L
G
L
S
P
L
C
A
I
G
--
L
T
D
I
S
A
R
I
L
K
-------
L
P
-----
S
F
---
E
L
H
K
E
M
L
G
G
I
I
P
R
S
I
L
M
T
T
F
E
S
S
H
--
Y
L
L
C
A
L
G
D
G
A
L
F
Y
--
F
--
G
L
N
I
E
T
G
L
L
S
D
K
K
V
T
-----------
L
------------
G
T
Q
-----------
P
--------------------
T
V
L
R
T
F
R
S
S
T
T
N
V
F
A
C
S
----------
D
R
P
------
T
V
I
Y
S
N
H
K
L
---
V
--
F
-----
S
---
N
-
V
-
N
L
--
K
--
E
V
N
Y
M
C
P
L
N
S
D
G
-
Y
P
D
S
L
A
L
A
N
N
S
T
L
T
I
G
T
I
D
E
I
----------------
Q
K
L
H
I
R
T
V
P
L
Y
E
S
P
R
K
I
C
Y
Q
EVSQ
C
F
G
V
L
S
S
R
I
E
V
Q
DTTALRPSASTQAL
S
S
S
V
SSE
E
V
E
V
H
N
L
L
I
I
D
QHTFEVL
H
A
H
Q
F
L
QN
E
Y
A
L
S
L
V
S
C
K
L
GKDP
N
T
Y
F
I
V
G
T
A
M
V
Y
PEEAEPK
Q
G
R
I
V
V
F
Q
Y
S
DGKLQTV
A
E
K
E
V
KGAVY
S
M
V
E
F
NG
K
L
L
A
S
I
NS
T
V
R
L
Y
E
W
T
TEK
E
L
R
T
E
C
N
H
Y
N
NIMAL
Y
L
K
T
K
GD
F
I
L
V
G
D
LMR
S
V
L
L
L
A
Y
K
PMEG
N
F
E
E
I
A
R
D
F
N
P
N
WMS
A
V
E
I
LDDD
N
F
L
G
A
E
N
AF
N
L
F
V
C
Q
KDEERQHLQEV
G
L
F
HLGEFVN
V
F
C
H
G
S
LVT
Q
G
S
V
L
F
G
T
VNG
M
I
G
L
V
T
S
L
S
E
S
W
Y
N
L
L
L
D
M
Q
N
R
L
N
K
V
IKSVGKIE
H
S
F
W
R
SFHTKTEPATGFID
G
D
L
I
E
S
F
LDIS
R
P
K
M
Q
E
V
V
A
N
L
Q
Y
D
D
GKREAT
A
D
D
L
I
K
V
V
E
E
L
T
R
I
H
W
S
H
P
Q
FE
44
Fugue
65.19
14%
-133
* C3 *
4TQ3
3
?
A:
[15-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
K
Y
L
R
L
L
R
P
V
A
W
L
C
F
L
L
P
Y
A
V
G
----------------
F
G
----------------
F
G
I
T
P
N
A
S
L
Q
H
A
V
L
G
-
L
L
S
F
A
F
W
M
A
F
S
F
T
I
-
N
A
L
Y
D
R
D
V
D
RLHDG
L
N
L
S
M
Q
P
L
V
T
G
E
I
S
V
R
E
A
W
L
Y
C
I
A
-
F
L
A
L
S
L
A
T
A
A
A
--------
I
N
E
K
F
F
L
A
M
L
G
A
N
I
I
G
Y
V
Y
S
A
P
P
R
F
K
A
W
P
V
M
D
V
I
C
N
A
L
A
A
V
L
A
F
Y
A
G
L
S
I
G
G
--
A
E
V
P
I
A
I
Y
P
A
A
-
F
F
L
A
A
T
-----
F
Y
I
--
P
T
A
V
S
D
Y
E
F
D
K
K
A
G
L
K
----
N
T
P
V
--
F
F
G
P
E
R
A
L
-
K
S
L
Y
--
P
--
L
S
A
I
T
V
I
L
W
A
Y
V
F
L
M
A
E
R
I
------
E
I
------------
K
V
I
-----------
S
--------------------
P
L
I
I
A
Y
T
L
I
Y
T
F
I
I
N
S
R
-
W
-------
D
G
--------------
E
K
L
---
N
--
V
-----
S
---
P
-------
N
--
L
I
L
T
P
F
G
I
I
S
A
L
-
F
I
A
Y
G
F
A
V
I
S
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------