@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10C1_HUMAN: (2016-01-11 )
MSANTSMVTEFLLLGFSHLADLQGLLFSVFLTIYLLTVAGNFLIVVLVSTDAALQSPMYFFLRTLSALEIGYTSVTVPLLLHHLLTGRRHISRSGCALQMFFFLFFGATECCLLAAMAYDRYAAICEPLRYPLLLSHRVCLQLAGSAWACGVLVGLGHTPFIFSLPFCGPNTIPQFFCEIQPVLQLVCGDTSLNELQIILATALLILCPFGLILGSYGRILVTIFRIPSVAGRRKAFSTCSSHLIMVSLFYGTALFIYIRPKASYDPATDPLVSLFYAVVTPILNPIIYSLRNTEVKAALKRTIQKTVPMEI
Atome Classification :
(20 SA)
------------.........10........--20........30........40........50........60........70----......-...80........90........100.......110.......120.......130.......140....---...150.......160....-----...-170.......180......--.-------190...------....200.......210.......220....---------..-----.230---------.--------------------..---......240.--------......250------....-------....260.--.---.-.-------...270.--.----......280........290.......---300..----------------.....310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MSA
N
T
S
M
V
T
E
F
L
L
L
G
F
S
H
L
--
A
D
L
Q
G
L
L
F
S
V
F
L
T
I
Y
L
L
T
VAG
N
F
L
I
V
V
L
VST
D
A
A
L
Q
S
P
M
Y
F
F
L
R
T
L
S
A
L
EI-----GYTS
V
T
-
V
P
L
L
L
H
H
L
L
TGRRHISRSG
C
A
L
Q
M
F
F
F
L
F
FG
A
T
E
C
C
L
L
A
A
M
A
Y
D
R
Y
A
A
I
C
E
P
LR
Y
P
L
L
L
S
H
R
V
C
L
Q
LAGS---A
W
A
C
G
V
L
VGLGHT
P
F
I
F
SLP-----FCG-P
N
T
I
P
Q
F
F
C
E
I
Q
P
V
L
Q
L
VC--G-------DT
S
L
N
E
------
L
Q
I
I
L
A
T
A
L
L
I
LC
P
F
G
L
I
L
GSY
G
R
I
L
V
T
I
F
R---------IP-----SV-----------A--------------------G
R
---
R
K
A
F
S
T
C
S
S
H
--------
L
I
M
V
S
LFY-------G
T
A
L
-------
F
I
Y
IRPKA--S---Y-D-------PAT
D
-
P
L
--
V
----
S
L
F
Y
A
V
V
T
-
P
I
L
N
P
I
I
Y
S
LRN
T
E
V
K
A
A
---
L
K
R
T
I
----------------
Q
K
TVPMEI----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.90
23%
-162
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.35
23%
-160
- C4 -
3REY
1
AA2AR_HUMAN
A:
[11-305]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--------
A
I
I
A
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.08
23%
-160
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[11-305]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--------
A
I
I
A
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.79
23%
-161
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[11-305]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--------
A
I
I
A
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.57
23%
-164
- C4 -
3VG9
8
?
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.44
23%
-156
- C4 -
3PWH
1
?
A:
[11-305]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--------
A
I
I
A
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.75
23%
-161
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[11-305]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
--
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--------
A
I
I
A
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.65
23%
-152
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
-----
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
------
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.59
23%
-153
- C4 -
2YDV
6
?
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ--------------------------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.13
23%
-155
- C4 -
4UG2
3
?
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.00
23%
-152
- C4 -
2YDO
3
?
A:
[11-307]
-----------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
---
C
W
V
L
S
F
A
I
G
L
--
T
P
-
M
L
G
W
N
-----
N
C
G
-
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
------
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S---------------------------------------------T
L
-
Q
K
E
V
H
A
A
K
S
L
--------
A
I
I
V
G
L
F
A
-------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
---
H
-
A
-------
P
L
W
L
-
M
Y
--
L
----
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
---
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
86.90
18%
-139
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
-
I
D
----
Y
Y
T
P
-----------
H
-------
E
E
T
N
N
E
------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
-----
A
S
-----------
A
--------------------
T
T
---
Q
K
A
E
K
E
V
T
R
M
--------
V
I
I
M
V
I
A
F
-------
L
I
C
W
-------
L
P
Y
A
G
V
A
F
--
Y
---
I
-
F
T
H
QGSDF
G
P
I
F
-
M
T
--
I
----
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
---
M
V
T
T
L
C
CGKNPSTTVSKTET-
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
84.96
17%
-150
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-333]
------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-----
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
---
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
--------
T
-
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------------
R
D
S
T
T
R
------
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
-----
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
---
M
R
L
A
K
I
S
I
V
I
--------
V
S
Q
F
L
L
S
W
-------
S
P
Y
A
-------
V
V
A
L
L
A
Q
F
--
G
PLE
W
-
V
-------
T
P
Y
A
-
A
Q
--
L
----
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
---
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
84.10
16%
-151
* C4 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-----
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
---
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
---------
E
-
T
-
M
P
S
R
V
V
C
M
I
E
W
P
E
H
-----
P
-------
N
K
I
Y
E
K
------
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
E
-----
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
---
R
K
V
V
K
M
M
I
V
V
--------
V
C
T
F
A
I
C
W
-------
L
P
F
H
-------
I
F
F
L
L
P
Y
I
NP
D
---
L
Y
L
-------
K
K
F
I
Q
Q
V
Y
L
A
----
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
---
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
83.56
21%
-131
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
---
T
W
V
M
A
L
A
C
A
A
--------
P
P
-----
L
V
G
W
S
R
Y
I
P
E
G
-------
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
AQQQE
S
A
-----------
T
--------------------
T
Q
---
K
A
E
K
E
V
T
R
M
V
--------
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
--
D
---
F
-
G
-------
P
I
F
M
-
T
I
--
P
----
A
F
F
A
K
T
S
A
--
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
---
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
APA-------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.07
20%
-140
- C4 -
1F88
7
OPSD_BOVIN
A:
[55-321]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----------------
P
E
-------
G
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
---------
V
K
-----
E
A
-----------
A
--------------------
A
-------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
--
D
---
F
-
G
-------
P
I
F
M
--
T
--
I
----
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
---
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.60
20%
-142
- C4 -
3C9L
13
OPSD_BOVIN
A:
[55-321]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----------------
P
E
-------
G
M
Q
C
S
C
--
G
IDYYTPH
E
E
T
N
N
E
------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
---------
V
K
-----
E
A
-----------
A
--------------------
A
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
--
D
---
F
-
G
-------
P
I
F
M
--
T
--
I
----
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
---
M
V
T
T
L
----------------
C
C
G
K
N
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.31
20%
-146
- C4 -
3DQB
6
GNAT1_BOVIN (first)
A:
[55-321]
------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----------------
P
E
-------
G
M
Q
C
S
C
--
G
IDYYTPH
E
E
T
N
N
E
------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
---------
V
K
-----
E
A
-----------
A
--------------------
A
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
--
D
---
F
-
G
-------
P
I
F
M
--
T
--
I
----
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
---
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
77.89
16%
-131
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------
D
--
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
---
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
------------
H
-
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----------
D
F
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--------
L
N
-----
I
F
-----------
E
--------------------
M
L
---
R
I
D
E
G
L
R
L
K
I
--------
Y
K
D
T
E
G
Y
Y
-------
T
I
G
I
-------
G
H
L
L
T
K
S
P
--
S
---
L
-
N
-------
A
A
K
S
-
E
L
--
D
----
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
G
I
L
----------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
49
Fugue
76.72
18%
-147
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------
S
F
K
C
A
L
T
K
T
G
F
-------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
-----
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
---
V
W
L
---
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
-----------------
T
G
V
R
K
N
K
T
I
T
C
--
Y
-------
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
-------------------------------------------------------
K
M
K
K
Y
T
C
T
V
C
--------
G
Y
I
Y
N
P
E
D
-------
G
D
P
D
-------
N
-
G
V
N
P
G
T
--
D
---
F
-
K
-------
D
I
V
C
-
P
L
--
C
GVGK
D
Q
F
E
E
V
E
E
-
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
----------------
M
K
T
M
N
L
R
A
R
L
DFQTPAM
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR----------------------------------------------------------------------------------------------------------