@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10G6_HUMAN: (2016-01-11 )
MLEGVEHLLLLLLLTDVNSKELQSGNQTSVSHFILVGLHHPPQLGAPLFLAFLVIYLLTVSGNGLIILTVLVDIRLHRPMCLFLCHLSFLDMTISCAIVPKMLAGFLLGSRIISFGGCVIQLFSFHFLGCTECFLYTLMAYDRFLAICKPLHYATIMTHRVCNSLALGTWLGGTIHSLFQTSFVFRLPFCGPNRVDYIFCDIPAMLRLACADTAINELVTFADIGFLALTCFMLILTSYGYIVAAILRIPSADGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPCSQEPLDGVVAVFYTVITPLLNSIIYTLCNKEMKAALQRLGGHKEVQPH
Atome Classification :
(20 SA)
-----..-..-...-..10..-------------------...--...20........30----------..-.......-----40.-----...-.-...50...-------------------..--...60.......-.70....--....-80........90.......-.100.....-..110...------....120.....------------..130.-.-....--.140........150...-..---...160......-.170.----------.......-180-----------.-.....-.190...-...---------------.200..-.------....210.--.--....--..-----220.......230--------.........---240----.......------------250-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------......----.260.......270.......280.....-------------.-------------.--------------------------.290...-....300.......-.310.......320-.-------------.....------------.330------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----ML-
E
G
-
V
E
H
-
L
L
L
L
L
L
-------------------LTD--V
N
S
K
E
LQSGNQT
S
V
-----------
S
H
-
F
I
L
V
GLH-----HPP-----QL
G
-
A
-
P
L
F
L
A
F
L
V
-------------------
I
Y
--
L
L
T
VSGN
G
L
I
I
L
-
T
V
L
V
DIR--LHR
P
-
M
C
L
F
L
C
H
L
S
F
L
D
M
T
I
S
C
A
I
-
V
P
K
M
L
A
G
F
L
-
L
G
S
R
I
I
SF------
G
G
C
V
I
Q
L
F
S
F
H
F
------------
L
G
C
T
E
C
-
F
-
L
Y
T
L
--
M
A
Y
-
D
R
F
L
A
I
C
K
P
-
L
H
Y
A
-
T
I
---
M
T
H
R
V
C
N
S
L
A
L
G
-
T
W
L
-
G
----------
G
T
I
H
S
L
F
-QT
S
-----------
F
-
V
F
RLP-FCGPNRV-
D
Y
I
---------------
F
CD
I
P
A
-
M
------
L
R
L
A
C
A
-
D
--
T
--
A
I
N
E
--
L
V
-----
T
F
A
D
I
G
F
L
A
L
T
----------
C
F
M
L
I
L
TS
Y
---
G
Y
I
----
V
A
A
I
L
RI------------PS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------DGR
R
N
A
----
F
S
T
C
A
A
H
L
T
V
V
I
V
Y
YV
P
C
T
F
I
Y
L-RPCSQ-------------E-------------P--------------------------
L
D
G
V
V
A
V
-
F
Y
T
V
I
-
T
P
L
L
N
S
I
I
-
Y
T
L
C
N
K
E
M
K
A
A
L
Q
R-L-------------GGHKE------------VQPH------------------------------------------------
27
HHSearch
89.76
18%
-162
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
-------------------
I
C
--
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
V
R
S
E
R
K
--
L
H
T
V
-
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
------
P
L
C
L
F
W
L
S
M
D
Y
V
------------
A
S
T
A
S
I
-
F
-
S
V
F
I
--
L
C
I
-
D
R
Y
R
S
V
Q
Q
P
-
L
R
Y
L
-
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
-
A
W
F
-
L
----------
S
F
L
W
V
I
P
-
I
L
G
-------------
W
N
H
---------
R
-
R
E
D
---------------
K
C
E
T
D
F
-
Y
------
D
--------------
V
T
--
W
F
-----
K
V
M
T
A
I
I
N
F
Y
L
----------
P
T
L
L
M
L
W
F
Y
---
A
K
I
----
Y
K
A
V
R
Q
H
------------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
----
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
-
V
I
A
F
C
-------------
K
NCCN---------
E
--------------------------
H
L
H
M
F
T
I
-
W
L
G
Y
I
-
N
S
T
L
N
P
L
I
-
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
-
I
-------------
L
H
I
------------------------------------------------------------------
41
Fugue
88.03
16%
-136
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------
M
-
N
G
-
T
E
G
-
P
N
F
Y
V
P
-------------------
F
S
N
---
K
T
G
V
V
R
S
P
F
E
A
P
Q
-----------
Y
Y
-
L
-----------
A
E
P
-----
W
Q
F
-
S
-
M
L
A
A
Y
M
F
L
-------------------
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
--
L
R
T
P
-
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
------------
G
G
E
I
A
L
-
W
-
S
L
V
V
--
L
A
I
-
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
-
R
F
---
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
-
M
----------
A
L
A
C
A
---------------------
A
P
P
-
L
V
G
W
S
R
----------------------
Y
I
P
E
-
G
------
M
Q
C
S
C
G
I
D
YY
T
--
P
H
E
E
--
T
N
-----
N
E
S
F
V
I
Y
M
F
V
V
----------
H
F
I
I
P
L
I
V
I
---
F
F
C
----
Y
G
Q
L
V
F
T
------------
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
-
L
P
Y
A
G
-------------
V
A
F
Y
I
F
T
H
QGSDFG
P
--------------------------
I
F
M
T
I
P
A
-
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
-
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
L
C
CGKNPSTTVSK
T
E
T
S
Q
------------
V
A
P
A
------------------------------------------------
29
HHSearch
86.18
16%
-158
* C3 *
2Z73
5
OPSD_TODPA
A:
[30-333]
--------------------------------------------------------------------------------------
P
D
-----
A
V
Y
-
Y
-
S
L
G
I
F
I
G
I
-------------------
C
G
--
I
I
G
C
G
G
N
G
I
V
I
Y
-
L
F
T
K
T
K
S
--
L
Q
T
P
-
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
------
A
A
C
K
V
Y
G
F
I
G
G
I
------------
F
G
F
M
S
I
-
M
-
T
M
A
M
--
I
S
I
-
D
R
Y
N
V
I
G
R
P
-
M
A
A
S
-
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
-
W
----------
S
V
L
W
A
I
G
-
P
I
F
-----------
G
-
W
G
A
Y
T
-
L
----
E
G
-
V
L
C
---------------
N
C
S
F
D
Y
-
I
------
S
------
R
--
D
--
S
T
T
R
--
S
N
-----
I
L
C
M
F
I
L
G
F
F
G
----------
P
I
L
I
I
F
F
C
Y
---
F
N
I
----
V
M
S
V
S
N
H
------------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
----
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
-
L
A
Q
F
G
-------------
P
LEWVT--------
P
--------------------------
Y
A
A
Q
L
P
V
-
M
F
A
K
A
-
S
A
I
H
N
P
M
I
-
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
-
T
-------------
F
P
W
V
L
------------
T
C
C
Q
------------------------------------------------
24
HHSearch
84.18
18%
-160
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------------------------------------------------------
V
-
F
I
V
L
V
A
G
S
-------------------
L
S
--
L
V
T
I
I
G
N
I
L
V
M
V
-
S
I
K
V
N
R
H
--
L
Q
T
V
-
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
------
V
V
C
D
L
W
L
A
L
D
Y
V
------------
V
S
N
A
S
V
-
M
-
N
L
L
I
--
I
S
F
-
D
R
Y
F
C
V
T
K
P
-
L
T
Y
P
-
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
-
A
W
V
-
L
----------
S
F
I
L
W
A
P
-
A
I
L
-----------
F
-
W
Q
F
I
V
-
G
V
--
R
T
V
-
E
D
G
---------------
E
C
Y
I
Q
F
-
F
--------------------
S
N
A
--
A
V
-----
T
F
G
T
A
I
A
A
F
Y
L
----------
P
V
I
I
M
T
V
L
Y
---
W
H
I
----
S
R
A
S
K
S
R
------------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
----
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
-
I
N
T
F
C
-------------
A
PCIP---------
N
--------------------------
T
V
W
T
I
G
Y
-
W
L
C
Y
I
-
N
S
T
I
N
P
A
C
-
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
-
L
-------------
L
M
-------------------------------------------------------------------
42
Fugue
83.12
17%
-134
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----
M
N
-
G
T
-
E
G
P
-
N
F
Y
V
P
F
----------------------------
S
N
K
T
G
V
V
R
S
P
-----------
F
E
-
A
P
Q
Y
Y
L
A
-----
E
P
W
-----
Q
F
S
-
M
-
L
A
A
Y
M
F
L
L
-------------------
I
---
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
--
L
R
T
P
-
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
------------
G
G
E
I
A
L
-
W
-
S
L
V
V
--
L
A
I
-
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
-
R
F
---
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
-
M
----------
A
L
A
C
A
A
---------------------
P
P
-
L
V
G
W
S
R
Y
----------------------
I
P
E
-
G
------
M
Q
C
S
C
G
I
D
YY
T
--
P
H
E
E
--
T
N
-----
N
E
S
F
V
I
Y
M
F
V
V
----------
H
F
I
I
P
L
I
V
I
---
F
F
C
----
Y
G
Q
L
V
F
T
VKEAAAQQQESA
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
----
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
QGSDF--------
G
-------------
P
--------------------------
I
F
M
T
I
P
A
-
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
-
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
L
C
CGKNP------
L
G
D
D
E
A
S
T
T
V
S
K
TETSQ
V
A
P
A
------------------------------------------------
25
HHSearch
82.18
17%
-162
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
----------------------------------------------------------------------------------------------
W
V
-
V
-
G
M
G
I
V
M
S
L
-------------------
I
V
--
L
A
I
V
F
G
N
V
L
V
I
T
-
A
I
A
K
F
E
R
--
L
Q
T
V
-
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
------
F
W
C
E
F
W
T
S
I
D
V
L
------------
C
V
T
A
S
I
-
E
-
T
L
C
V
--
I
A
V
-
D
R
Y
F
A
I
T
S
P
-
F
K
Y
Q
-
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
-
V
W
I
-
V
----------
S
G
L
T
S
F
L
-
P
I
Q
-----------
M
H
W
Y
R
A
T
-
H
-----
Q
-
E
A
I
---------------
N
C
Y
A
E
E
-----------
T
C
C
-
D
--
F
--
F
T
N
Q
--
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
----------
P
L
V
I
M
V
F
V
Y
---
S
R
V
----
F
Q
E
A
K
R
Q
------------
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
----
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-
V
H
V
I
Q
-------------
D
NLIR---------
K
--------------------------
E
V
Y
I
L
L
N
-
W
I
G
Y
V
-
N
S
G
F
N
P
L
I
-
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
-
L
-------------
L
C
L
------------------------------------------------------------------
34
HHSearch
80.72
18%
-164
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
-------------------
L
I
--
L
A
I
V
F
G
N
G
L
V
C
M
-
A
V
L
K
E
R
A
--
L
Q
T
T
-
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
------
I
C
C
D
V
F
V
T
L
D
V
M
------------
M
C
T
A
S
I
-
W
-
N
L
C
A
--
I
S
I
-
D
R
Y
T
A
V
V
M
P
-
V
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
-
V
W
V
-
L
----------
A
F
A
V
S
C
P
-
L
L
F
-----------
G
-
F
N
T
T
--------
G
-
D
P
T
---------------
V
C
S
I
S
N
------------------------
P
--
D
F
-----
V
I
Y
S
S
V
V
S
F
Y
L
----------
P
F
G
V
T
V
L
V
Y
---
A
R
I
----
Y
V
V
L
K
Q
R
------------
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
----
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
-
L
N
T
H
C
-------------
Q
TCHVS--------
P
--------------------------
E
L
Y
S
A
T
T
-
W
L
G
Y
V
-
N
S
A
L
N
P
V
I
-
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
-
I
-------------
L
S
C
------------------------------------------------------------------
50
Fugue
77.46
17%
-157
- C4 -
5A07
3
?
A:
[40-434]
D
H
D
A
E
V
L
-
D
S
-
I
M
D
-
R
L
H
E
P
L
-------------------
Y
E
K
DT
F
D
P
N
E
V
L
A
E
N
K
Q
L
Y
-----------
E
E
-
F
L
L
Q
E
I
S
-----
E
P
K
VD
N
L
V
R
S
G
-
D
-
P
L
A
G
K
A
K
G
-------------------
T
I
--
L
S
L
V
R
N
S
D
L
E
D
I
-
I
S
S
I
Q
Q
L
--
E
E
E
Y
-
N
K
N
F
G
Y
P
Y
T
F
L
N
D
E
E
F
T
D
E
-
F
K
D
G
I
K
S
I
L
-
P
K
D
R
V
V
E
F
------
G
T
I
G
P
D
N
W
N
M
P
D
------------
S
I
D
R
E
R
-
Y
-
D
Q
E
M
--
D
K
M
-
S
K
-----
E
N
-
I
Q
Y
A
E
V
E
---
S
Y
H
N
M
C
R
F
Y
S
K
E
-
F
Y
H
-
H
----------
P
L
L
S
----
K
Y
K
-----------
Y
-
V
W
R
L
E
----
P
N
V
---
N
F
---------------
Y
C
K
I
N
Y
D
V
------
F
Q
F
M
N
K
-
N
--
D
--
K
I
Y
G
--
F
V
L
N
L
Y
D
S
P
Q
T
I
E
T
L
W
T
S
----------
T
M
D
F
V
E
E
H
P
---
N
Y
L
NVNG
A
F
A
W
L
K
D
------------
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
K
N
Y
D
Y
T
QG
Y
S
T
C
H
F
W
T
N
F
E
I
V
D
---
L
D
F
L
R
S
-
E
P
Y
E
K
Y
M
-----------
Q
-------------
Y
--------------------------
L
E
E
K
G
G
F
-
Y
Y
E
R
W
G
D
A
P
V
R
S
L
A
-
L
A
L
F
A
D
K
S
S
I
H
W
F
R
D
I
-------------
G
Y
H
H
T
------------
P
Y
T
N
C
P
T
C
PADSDRCNGNCVPGKFTPWSDLDNQNC
Q
A
T
W
I
R
HSMS
E
E
E
L
E
MY
31
HHSearch
77.44
16%
-165
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-471]
-------------------------------------------------------------------------------------------------
S
-
V
Y
I
T
V
E
L
A
-------------------
I
A
--
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
W
L
N
S
N
--
L
Q
N
V
-
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
------
H
G
C
L
F
I
A
C
F
V
L
V
------------
L
T
Q
S
S
I
-
F
-
S
L
L
A
--
I
A
I
-
D
R
Y
I
A
I
R
I
P
-
L
R
Y
N
-
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
-
L
----------
S
F
A
I
G
L
T
-
P
M
L
-----------
G
-
W
N
N
C
G
-
Q
--------
S
Q
---------------
G
C
G
E
G
Q
-
V
---------
A
C
L
-
F
--
E
DV
V
P
M
N
--
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
----------
P
L
L
L
M
L
G
V
Y
---
L
R
I
----
F
L
A
A
R
R
Q
------------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
----
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
-
F
T
F
F
C
PDCS---------
H
AP-----------
L
--------------------------
W
L
M
Y
L
A
I
-
V
L
S
H
T
-
N
S
V
V
N
P
F
I
-
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
-
I
-------------
I
R
S
H
V
------------
L
R
Q
-------------------------------------------------
33
HHSearch
75.88
14%
-143
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-328]
---------------------------------------------------------------------------------------------
W
Q
F
-
S
-
M
L
A
A
Y
M
F
L
-------------------
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
--
L
R
T
P
-
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
------------
G
G
E
I
A
L
-
W
-
S
L
V
V
--
L
A
I
-
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
-
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
-
M
----------
A
L
A
C
A
A
P
-
P
L
V
-----------
G
-
W
S
R
Y
I
-
P
----
E
G
-
M
Q
C
---------------
S
C
G
I
D
Y
-
Y
------
T
P
---
H
-
E
--
E
--
T
N
N
E
--
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
----------
P
L
I
V
I
F
F
C
Y
---
G
Q
L
----
V
F
T
V
K
E
A
------------
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
----
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
QGS----------
D
FG-----------
P
--------------------------
I
F
M
T
I
P
A
-
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
-
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
-------------
L
C
C
G
K
------------
N
P
L
G
------------------------------------------------
30
HHSearch
74.80
13%
-158
- C3 -
2KS9
1
NK1R_HUMAN
A:
[32-325]
-----------------------------------------------------------------------------------------------
I
-
V
-
L
W
A
A
A
Y
T
V
-------------------
I
V
--
V
T
S
V
V
G
N
V
V
V
M
W
-
I
I
L
A
H
K
R
--
M
R
T
V
-
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
------
F
Y
C
K
F
H
N
F
F
P
I
A
------------
A
V
F
A
S
I
-
Y
-
S
M
T
A
--
V
A
F
-
D
R
Y
M
A
I
I
H
P
-
L
Q
P
R
-
L
-----
S
A
T
A
T
K
V
V
I
C
V
-
I
W
V
-
L
----------
A
L
L
L
A
F
P
-
Q
G
Y
-----------
Y
-
S
T
T
E
------
T
M
P
-
S
R
V
---------------
V
C
M
I
E
W
-
P
------
E
H
---
P
-
N
--
K
--
I
Y
E
K
--
V
Y
-----
H
I
C
V
T
V
L
I
Y
F
L
----------
P
L
L
V
I
G
Y
A
Y
---
T
V
V
----
G
I
T
L
W
A
S
------------
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
----
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
-
L
P
Y
I
N
-------------
P
DLYLKKFI-----
Q
--------------------------
Q
V
Y
L
A
I
M
-
W
L
A
M
S
-
S
T
M
Y
N
P
I
I
-
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
-
A
-------------
F
R
C
C
P
------------
F
I
S
A
------------------------------------------------
35
HHSearch
74.18
15%
-145
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
----------------------------------------------------------------------------------------------
N
K
-
Y
-
V
V
I
I
A
Y
A
L
-------------------
V
F
--
L
L
S
L
L
G
N
S
L
V
M
L
-
V
I
L
Y
S
R
V
--
G
R
S
V
-
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
------
F
L
C
K
V
V
S
L
L
K
E
V
------------
N
F
Y
S
G
I
-
L
-
L
L
A
C
--
I
S
V
-
D
R
Y
L
A
I
V
H
A
-
T
R
T
L
-
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
-
C
W
G
-
L
----------
S
M
N
L
S
L
P
-
F
F
L
-----------
F
-
R
Q
A
Y
H
-----
P
N
N
-
S
S
P
---------------
V
C
Y
E
V
L
-
G
------
N
----
D
-
T
--
A
--
K
W
R
M
--
V
L
-----
R
I
L
P
H
T
F
G
F
I
V
----------
P
L
F
V
M
L
F
C
Y
---
G
F
T
----
L
R
T
L
F
K
A
------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
----
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
-
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
N
I
------------
G
--------------------------
R
A
L
D
A
T
E
-
I
L
G
F
L
-
H
S
C
L
N
P
I
I
-
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
-
I
-------------
L
A
M
H
G
----------------------------------------------------------------
23
HHSearch
73.37
16%
-157
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-497]
--------------------------------------------------------------------------------------
A
N
-----
F
N
K
-
I
-
F
L
P
T
I
Y
S
I
-------------------
I
F
--
L
T
G
I
V
G
N
G
L
V
I
L
-
V
M
G
Y
Q
K
K
--
L
R
S
M
-
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
------
F
L
C
K
A
V
H
V
I
Y
T
V
------------
N
L
Y
S
S
V
-
W
-
I
L
A
F
--
I
S
L
-
D
R
Y
L
A
I
V
H
A
-
T
N
S
Q
-
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
-
V
W
I
-
P
----------
A
L
L
L
T
I
P
-
D
F
I
-----------
F
-
A
N
V
S
E
------
A
D
-
D
R
Y
---------------
I
C
D
R
F
Y
-
P
------
N
---------
D
--
L
W
V
V
--
V
F
-----
Q
F
Q
H
I
M
V
G
L
I
L
----------
P
G
I
V
I
L
S
C
Y
---
C
I
I
----
I
S
K
L
S
H
S
------------
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
----
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
-
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
------------
H
--------------------------
K
W
I
S
I
T
E
-
A
L
A
F
F
-
H
C
C
L
N
P
I
L
-
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
-
A
-------------
L
T
S
G
R
------------
P
L
E
V
------------------------------------------------
48
Fugue
73.12
19%
-176
* C4 *
4QT9
2
?
A:
[19-432]
-LS
D
D
A
L
M
D
T
-
V
Q
R
-
R
T
F
L
Y
F
W
EGAEPNSGLAPERYHVDG
V
Y
P
--
Q
N
D
A
N
V
V
T
S
G
G
S
G
F
-----------
G
I
M
A
I
L
A
G
I
D
R
GYVT
R
E
E
-----
G
L
A
-
R
M
E
R
I
V
S
F
L
E
K
ADRFHGAYPHWWYGDTGK
V
K
--
P
F
G
Q
K
D
N
G
G
D
L
V
-
E
T
A
F
--------
L
M
Q
G
L
L
A
V
H
Q
Y
Y
A
N
G
N
D
K
E
K
A
-
I
A
Q
R
I
D
R
L
W
-
R
E
V
D
W
D
W
Y
------
R
K
G
G
Q
N
V
L
Y
W
H
W
SPTYGWEMD
F
P
I
H
G
Y
N
E
C
M
I
M
Y
-----------
I
L
A
A
A
S
P
------------
T
H
G
V
P
A
A
V
Y
H
D
-
G
W
A
Q
N
----------
G
A
I
V
S
P
H
-
K
V
E
G----------
I
-
E
L
H
L
R
-
Y
Q
G
T
E
A
G
-
P
L
F
---------------
W
A
Q
Y
S
F
-
L
GLDPVG
L
K
D
E
Y
C
-
P
--
S
--
Y
F
H
E
M
R
N
L
-----
T
L
V
N
R
A
Y
C
I
R
N
PKHYKGFGPD
C
W
G
L
-
T
A
S
Y
SVD
G
Y
A
----
A
H
S
----------------
P
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
D
K
G
V
----
I
S
P
T
A
A
L
S
S
I
V
---
Y
T
P
E
Y
S
L
Q
V
M
R
H
L
Y
N
M
------------
G
-------------
D
KVFGPFGFYDAFSETDNWYPQRYL
A
I
D
Q
G
P
I
A
V
M
I
E
N
Y
R
-
T
G
L
L
W
K
L
F
M
S
---
H
P
D
V
Q
A
G
L
T
K
-
L
-------------
G
F
N
T
N
----------------------------------------------------------------
32
HHSearch
71.36
17%
-150
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
--------------------------------------------------------------------------------------
K
E
-----
N
S
I
-
K
-
L
T
S
V
V
F
I
L
-------------------
I
C
--
C
F
I
I
L
E
N
I
F
V
L
L
-
T
I
W
K
T
K
K
--
F
H
R
P
-
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
------
A
Q
W
F
L
R
E
G
S
M
F
V
------------
A
L
S
A
S
V
-
F
-
S
L
L
A
--
I
A
I
-
E
R
Y
I
T
M
L
K
-------------
N
N
F
R
L
F
L
L
I
S
A
-
C
W
V
-
I
----------
S
L
I
L
G
G
L
-
P
I
M
-----------
G
-
W
N
C
I
--------
S
-
A
L
S
---------------
S
C
S
T
V
L
-
P
------
L
--------------
Y
H
--
K
H
-----
Y
I
L
F
C
T
T
V
F
T
L
----------
L
L
L
S
I
V
I
L
Y
---
C
R
I
----
Y
S
L
V
R
T
R
------------
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
----
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
-
L
D
V
G
C
-------------
K
VKTC
D
I
-------
L
--------------------------
F
R
A
E
Y
F
L
-
V
L
A
V
L
-
N
S
G
T
N
P
I
I
-
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
-
I
-------------
M
G
R
P
L
----------------------------------------------------------------
44
Fugue
66.80
17%
-167
- C1 -
4KQ7
6
?
A:
[2-374]
------
Q
-
S
N
M
T
N
E
M
F
D
L
A
K
L
-------------------
K
S
G
--
V
K
N
K
R
I
S
S
T
D
P
T
G
G
NRDHLEPFKPG
E
K
-
R
I
I
A
D
I
K
---------------
G
M
G
-
V
I
N
H
I
W
V
T
-------------------
I
A
PP
P
P
T
L
S
R
N
D
I
I
I
R
M
Y
W
D
G
N
D
Y
PS
V
E
S
P
-
I
G
P
F
F
G
Q
G
--
W
D
E
R
Y
N
Y
A
S
-
L
P
-
L
S
A
G
P
E
-
N
G
T
G
L
S
C
Y
F
A
M
P
F
E
K
G
A
R
I
E
I
E
N
Q
S
D
------------
R
N
I
D
A
F
-
Y
-
F
Y
V
D
--
Y
L
E
M
A
K
L
P
---
K
D
M
G
R
F
H
-
A
W
---
Y
N
H
N
L
T
E
A
L
P
E
G
E
T
E
W
-
G
VT
G
A
Q
K
P
N
TT
G
E
R
N
Y
V
F
M
E
T
Q
G
K
G
H
F
V
G
I
N
Y
Y
V
-
H
C
P
T
P
M
W
Y
G
E
G
D
D
M
W
F
I
DGEKVPS
L
I
G
T
G
T
E
D
F
F
N
T
A
W
-
C
------
P
K
E
A
F
S
-
H
--
P
--
Y
F
G
Y
--
P
R
-----
V
N
N
D
I
G
W
L
G
R
T
----------
H
V
Y
R
F
F
I
E
D
---
P
I
F
----
F
E
K
S
L
K
G
------------
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
S
N
N
N
----
L
T
---
L
D
L
S
T
V
A
Y
W
Y
Q
D
S
A
V
A
L
P
-
E
A
P
T
K
-------------
A
-------------
Q
--------------------------
R
A
P
-----------
K
P
F
I
N
----
H
V
D
I
H
R
W
R
D
A
W
R
K
S
-
K
-------------
G
N
K
A
T
------------
L
W
G
N
E-----------------------------------------------
1
PsiBlast_PDB
56.30
24%
-165
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-147]
-------------------------------------------------------------------------------------------------
M
-
P
L
V
V
V
L
S
T
-------------------
I
C
--
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
V
R
S
E
R
K
--
L
H
T
V
-
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
------
P
L
C
L
F
W
L
S
M
D
Y
V
------------
A
S
T
A
S
I
-
F
-
S
V
F
I
--
L
C
I
-
D
R
Y
R
S
V
Q
Q
P
-
L
R
Y
L
-
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
-
A
W
F
---------------------
L
S
-----------
F
-
L
W
V
I
P
-
I
L
G
W
N
H
R
-
R
E
D
---------------
K
C
E
T
D
F
-
Y
------
D
V
T
W
F
K
-
V
--
M
--
T
A
I
I
--
N
F
-----
Y
L
P
T
L
L
M
L
W
F
Y
----------
A
K
I
Y
K
A
V
R
Q
---
H
C
N
----
I
F
E
M
L
R
I
------------
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
K
I
Y
----
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
-
A
K
S
E
L
-------------
D
-------------
K
--------------------------
A
I
G
R
N
T
N
-
G
V
I
T
K
-
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-
K
-------------
L
K
P
V
Y
------------
D
S
L
D
------------------------------------------------
11
PsiBlast_PDB
56.21
29%
-168
- C3 -
2Y03
3
ADRB1_MELGA
A:
[6-125]
------------------------------------------------------------------------------
L
S
-----
Q
Q
W
-----
E
A
G
-
M
-
S
L
L
M
A
L
V
V
-----------------------
L
L
I
V
A
G
N
V
L
V
I
A
-
A
I
G
S
T
Q
R
--
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
--
W
------
G
S
F
L
C
E
L
W
T
S
L
D
------------
V
L
C
V
T
A
-
S
-
I
E
T
L
C
V
I
A
I
-
D
R
Y
L
A
I
T
S
P
-
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
-
V
W
A
-
I
----------
S
A
L
V
S
F
L
-
P
I
M
-----------
M
-
H
W
W
R
D
-
E
D
P
Q
A
L
K
-
C
Y
Q
---------------
D
P
G
C
C
D
-
F
------
V
T
N
R
A
Y
-
A
--
I
--
A
S
S
I
--
I
S
-----
F
Y
I
P
L
L
I
M
I
F
V
----------
A
L
R
V
Y
R
E
A
K
---
E
Q
I
----
R
S
R
V
M
L
M
------------
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
V
-------------
P
-------------
D
--------------------------
W
L
F
V
A
F
N
-
W
L
G
Y
A
-
N
S
A
M
N
P
I
I
-
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
-
L
-------------
A
--------------------------------------------------------------------
8
PsiBlast_PDB
54.66
29%
-172
- C3 -
2Y00
5
ADRB1_MELGA
A:
[6-125]
------------------------------------------------------------------------------
L
S
-----
Q
Q
W
-----
E
A
G
-
M
-
S
L
L
M
A
L
V
V
-----------------------
L
L
I
V
A
G
N
V
L
V
I
A
-
A
I
G
S
T
Q
R
--
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
--
W
------
G
S
F
L
C
E
L
W
T
S
L
D
------------
V
L
C
V
T
A
-
S
-
I
E
T
L
C
V
I
A
I
-
D
R
Y
L
A
I
T
S
P
-
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
-
V
W
A
-
I
----------
S
A
L
V
S
F
L
-
P
I
M
-----------
M
-
H
W
W
R
D
-
E
D
P
Q
A
L
K
-
C
Y
Q
---------------
D
P
G
C
C
D
-
F
------
V
T
N
R
A
Y
-
A
--
I
--
A
S
S
I
--
I
S
-----
F
Y
I
P
L
L
I
M
I
F
V
----------
A
L
R
V
Y
R
E
A
K
---
E
Q
S
----
R
V
M
L
M
R
E
------------
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
-------------
W
-------------
L
--------------------------
F
V
A
F
N
W
L
-
G
Y
A
N
S
-
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.55
29%
-173
- C3 -
4AMJ
3
ADRB1_MELGA
A:
[6-125]
------------------------------------------------------------------------------
L
S
-----
Q
Q
W
-----
E
A
G
-
M
-
S
L
L
M
A
L
V
V
-----------------------
L
L
I
V
A
G
N
V
L
V
I
A
-
A
I
G
S
T
Q
R
--
L
Q
T
L
-
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
--
W
------
G
S
F
L
C
E
L
W
T
S
L
D
------------
V
L
C
V
T
A
-
S
-
I
E
T
L
C
V
I
A
I
-
D
R
Y
L
A
I
T
S
P
-
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
-
V
W
A
-
I
----------
S
A
L
V
S
F
L
-
P
I
M
-----------
M
-
H
W
W
R
D
-
E
D
P
Q
A
L
K
-
C
Y
Q
---------------
D
P
G
C
C
D
-
F
------
V
T
N
R
A
Y
-
A
--
I
--
A
S
S
I
--
I
S
-----
F
Y
I
P
L
L
I
M
I
F
V
----------
A
L
R
V
Y
R
E
A
K
---
E
Q
S
----
R
V
M
L
M
R
E
------------
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
-------------
W
-------------
L
--------------------------
F
V
A
F
N
W
L
-
G
Y
A
N
S
-
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------